Extended Data Fig.1A,,,,,
labelname,beta,HR,lower,upper,pval
Exercise (yes/no),-0.32,0.73,0.54,0.99,4.21E-02
HDL per s.d.,-0.27,0.77,0.67,0.88,2.11E-04
BMI per s.d.,0.02,1.02,0.90,1.15,7.85E-01
Systolic BP per s.d.,0.10,1.11,0.99,1.23,6.36E-02
Total cholesterol per s.d.,0.15,1.16,1.05,1.29,4.69E-03
PRS per s.d.,0.52,1.68,1.50,1.88,2.25E-19
Family history (yes/no),0.53,1.69,1.35,2.11,3.69E-06
Smoking (yes/no),0.57,1.76,1.38,2.25,6.29E-06
Baseline age per s.d.,0.94,2.56,2.20,2.98,6.52E-34
Prevalent diabetes (yes/no),1.06,2.89,1.91,4.37,4.66E-07
,,,,,
,,,,,
Extended Data Fig.1B,,,,,
labelname,beta,HR,lower,upper,pval
HDL per s.d.,-0.20,0.82,0.73,0.92,5.43E-04
Exercise (yes/no),-0.19,0.83,0.65,1.06,1.33E-01
Total cholesterol per s.d.,-0.04,0.96,0.88,1.05,3.48E-01
Systolic BP per s.d.,0.09,1.10,1.01,1.19,3.63E-02
Triglyceride per s.d.,0.15,1.16,1.10,1.24,8.14E-07
Smoking (yes/no),0.27,1.31,1.08,1.59,6.66E-03
Baseline age per s.d.,0.30,1.35,1.22,1.50,6.42E-09
PRS per s.d.,0.35,1.42,1.30,1.55,6.48E-15
Family history (yes/no),0.48,1.61,1.36,1.91,2.36E-08
BMI per s.d.,0.60,1.82,1.68,1.97,1.73E-47
,,,,,
,,,,,
Extended Data Fig.1C,,,,,
labelname,beta,HR,lower,upper,pval
Exercise (yes/no),-0.15,0.86,0.62,1.20,3.69E-01
Systolic BP per s.d.,-0.06,0.94,0.82,1.07,3.48E-01
Total cholesterol per s.d.,-0.04,0.96,0.84,1.09,5.07E-01
Diastolic BP per s.d.,-0.02,0.98,0.84,1.14,7.80E-01
Prevalent stroke (yes/no),0.04,1.04,0.59,1.82,9.03E-01
Alcohol consumption per s.d.,0.05,1.05,0.93,1.19,4.21E-01
BMI per s.d.,0.07,1.08,0.94,1.23,2.77E-01
HDL per s.d.,0.08,1.08,0.94,1.24,2.88E-01
Prevalent T2D (yes/no),0.16,1.17,0.71,1.92,5.34E-01
Smoking (yes/no),0.40,1.49,1.07,2.08,1.97E-02
PRS per s.d.,0.65,1.92,1.73,2.15,4.27E-32
Prevalent psychiatric disorders (yes/no),0.82,2.27,1.26,4.10,6.58E-03
Baseline age per s.d.,2.29,9.85,7.77,12.48,1.05E-79
,,,,,
,,,,,
Extended Data Fig.1D,,,,,
labelname,beta,HR,lower,upper,pval
Smoking (yes/no),-0.44,0.65,0.40,1.03,6.79E-02
BMI per s.d.,-0.06,0.94,0.79,1.12,4.70E-01
Exercise (yes/no),0.01,1.01,0.68,1.50,9.52E-01
Alcohol consumption per s.d.,0.12,1.12,0.97,1.31,1.29E-01
Family history (yes/no),0.15,1.16,0.83,1.63,3.71E-01
PRS per s.d.,0.55,1.73,1.47,2.04,5.50E-11
Baseline age per s.d.,1.10,3.00,2.40,3.76,5.21E-22