Cinanserin Is an Inhibitor of the 3C-Like Proteinase of Severe Acute Respiratory Syndrome Coronavirus and Strongly Reduces Virus Replication In Vitro -- Chen et al. 79 (11): 7095 Data Supplement - HTML Page

Cinanserin Is an Inhibitor of the 3C-Like Proteinase of Severe Acute Respiratory Syndrome Coronavirus and Strongly Reduces Virus Replication In Vitro
J. Virol. Chen et al. 79: 7095

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Supplemental file 1 - Table S1. Predicted binding affinity of cinanserin to 3CL proteinases of SARS-CoV, TGEV, and human coronavirus 229E.
Fig. S1. Chemical structures of the 10 best binding candidates to SARS-CoV 3CL^pro in the MDL-CMC database identified by virtual screening.
Fig. S2. Superposition of the homology model of SARS-CoV 3CL^pro to the X-ray crystal structure.
Fig. S3. Model of the interaction of cinanserin with the crystal structure of 3CL proteinases of human coronavirus 229E and TGEV.
Appendix SI. Syntheses of Cinanserin and Its Hydrochloride.
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