Compound_ID;SMILES;KCNT1 IC50 (µM, fluorimetric);% of KCNT1 inhibition (10 µM, patch-clamp);% of KCNT1 current recovery after 8 minutes  (patch-clamp);KCNT1 Time constants of activation (τon, patch clamp);% of hERG inhibition (10 µM, patch-clamp);% of Kv7.2 inhibition;% of KCNT1 G288S inhibition                        (10 µM, patch-clamp) ;% of KCNT1 A934T inhibition                        (10 µM, patch-clamp)
Quinidine;O[C@@H](C1=C2C=C(C=CC2=NC=C1)OC)[C@@H]3N4CC[C@@]([H])(C3)[C@@H](C=C)C4;147 ± 31 ;35.0±3.7;84.7± 6.1 (1 mM);1.7±0.1 sec (1 mM);74;20;;
CPK1;O=C1N(C2=CC=CC(C(F)(F)F)=C2)C(N([C@@H]1C3)[C@@H](C4=CC=C(F)C=C4)C5=C3C=C(O)C(O)=C5)=O;ND;;;;;;;
CPK2;O=C(OC)[C@@H](CC1=CNC2=C1C=CC=C2)N(CC3=CC=CC=C3)CC4=CC=C(OCCC5CCCCC5)C=C4;ND;;;;;;;
CPK3;O=C([C@H](N1)CC(C=C2)=CC=C2OCC3=CC=CC=C3)N(C4CCNCC4)C1=O;ND;;;;;;;
CPK4;O=C(NCC(C)(C)C)NC1=CC2=C(N(CC3=CC=C(F)C=C3)CC2)C=C1;5.5±2.4;90.6±2.0;30.4±10.0 (10 µM);49.0±9.6 sec (10 µM);25;NA;;
CPK5;O=C(OCC1=CC=CC=C1Br)OC2=CC=C(C[C@H](C(NC3CCN(C(C4=CC=C(Cl)C=C4)=O)CC3)=O)NC(OC(C)(C)C)=O)C=C2;ND;;;;;;;
CPK6;NC1=CC(NCCC2=CC=C(F)C=C2)=CC=C1NC(CCCCCC)=O;ND;;;;;;;
CPK7;C1(C2=CC=C(CN3C=C(CC4=CN(CC5=CC=C(C6=CC=CC=C6)C=C5)C7=C4C=CC=C7)C8=C3C=CC=C8)C=C2)=CC=CC=C1;ND;;;;;;;
CPK8;O=C1N(CC2=CC=CC=C2)C([C@@H]3CS[C@@H]([C@@H](CCCNC(N)=N)NC(OCC4C(C=CC=C5)=C5C6=C4C=CC=C6)=O)N31)=O;ND;;;;;;;
CPK9;O=C1N(C(C2CCCCC2)=O)C3=C(C=C(C)C=C3)C14N(CCCNC(C5=C(F)C(F)=C(F)C(F)=C5F)=O)C(CS4)=O;ND;;;;;;;
CPK10;O=C(NC1CCN(S(=O)(C2=CC=C(Cl)C=C2)=O)CC1)[C@@H](NC(OC(C)(C)C)=O)CC3=CC=C(OCC4=CC=C(C(F)(F)F)C=C4)C=C3;ND;;;;;;;
CPK11;O=[N+]([O-])C1=CC=C(SC2=C(CCN(CC3=CC=CC=C3)CC4=CC=CC=C4)C5=CC=CC=C5N2)C([N+]([O-])=O)=C1;ND;;;;;;;
CPK12;O=C(C1=CC=C(F)C=C1)N2C3=CC=C(NS(C4CCCCC4)(=O)=O)C=C3CC2;ND;;;;;;;
CPK13;OC(C=CC1=C2C=CC=C1)=C2CNCCC3=CNC4=CC=CC=C43;8.7±1.5;96.2±1.5;15.7±4.8 (10 µM);17.7±9.6 sec (10 µM);40;NA;;
CPK14;CN1C2=CC=C(CNC3=CC=C(F)C=C3)C=C2C(CN(C)CCC4=CC=C(C5=CC=CC=C5)C=C4)=C1;ND;;;;;;;
CPK15;CC1=CC=C2C([C@]3(SC[C@@H](C(N4CC5=CC(OC)=C(OC)C(OC)=C5)=O)N3C4=O)C(N2C(C6=CC=C(Cl)C=C6)=O)=O)=C1;ND;;;;;;;
CPK16;O=C(N1)[C@]2(N(C(C3=CC=C(Cl)C=C3)=O)[C@@H](C(OCC)=O)CS2)C4=C1C=CC(Br)=C4;12.2±2.6;89.1±1.2;49.3±4.7 (10 µM);30.8±4.8 sec (10 µM);10;NA;;
CPK17;O=C(C1=CC=CC=C1)CN(CC2)[C@H](C3=CC=CC=C3)C4=C2C5=CC=CC=C5N4;ND;;;;;;;
CPK18;O=C(NCC1=CC=CC=C1)[C@@H](NCC2=CC=C(OC3=CC=CC=C3)C=C2)CC4=CNC5=CC=CC=C54;3.4±0.7;97.4±0.7;55.3±15.9 (10 µM);15.2±2.6 sec (10 µM);10;NA;;
CPK19;OC1=CC2=C(C[C@@H](C(NCC3=CC=C(F)C=C3)=O)N[C@@H]2C4=CC=C(F)C=C4)C=C1O;ND;;;;;;;
CPK20;O=S(NC1=CC=C(N(CC2=CC=C(C(F)(F)F)C=C2C(F)(F)F)CC3)C3=C1)(C4CCCCC4)=O;6.4±1.61 ;90.5±1.2;25.0±6.9 (10 µM);16.6±1.8 sec (10 µM);10;really weak activator;79.4±2.2;80.4±2.6