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. Author manuscript; available in PMC: 2024 Jul 6.
Published in final edited form as: J Med Chem. 2024 Apr 18;67(9):7301–7311. doi: 10.1021/acs.jmedchem.4c00152

Figure 2.

Figure 2.

Degradation ability of Gal-ARV-771 in senescent A549 cells. SA-β-gal staining: control (A) and etoposide (5 μM) induced senescent A549 cells (B). C) Western blot detection of BRD4 in n-A549 and s-A549 cells treated with ARV-771 for 16 h. D) Western blot analysis of BRD4 in n-A549 and s-A549 cells treated with ARV-771 or Gal-ARV-771 for 16 h. Gal-ARV-771 had DC50 = 18.3 nM in senescent A549 cells. E) Western blot analysis of BRD4 levels in s-A549 cells co-treated with 5 μM MG-132 or 10 μM VHL ligand for 16 h.