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Activity of Gal-ARV-771 in senescent A549 and HeLa cells. A, B) Cell toxicity of n-A549 and s-A549 cells treated with ARV-771 or Gal-ARV-771 for 72 h. C, D) Flow cytometry profiles showing the effects of ARV-771 and Gal-ARV-771 on the induction of apoptosis in normal A549 and senescent A549 cells. Cells were cultured with 1 μM of ARV-771 or Gal-ARV-771 for 24 h, and then flow cytometry analysis was carried out with FITC and PI staining.
