"Table S17. Significantly altered gene pathways (alpha = 0.05) found in the brains of Atlantic killifish Fundulus heteroclitus in this study. Significant trends and FDR value are reported (Ctrl = Control treatment, Neg = significant negative trend, Pos = significant positive trend, SCO = Scorton Creek larvae, NBH = New Bedford Harbor larvae, Hg = methylmercury). Blanks indicate comparison was tested but did not result in a significant difference." Type ONTOLOGY Pathway ID Pathway Description SCO-Ctrl vs SCO-Hg SCO-Ctrl vs SCO-PCB 40 ng/L SCO-Ctrl vs NBH-Ctrl SCO-PCB 40 ng/L vs NBH-PCB 40 ng/L SCO-PCB 40 ng/L vs NBH-PCB 400 ng/L NBH-Ctrl vs NBH-PCB 40 ng/L NBH-Ctrl vs NBH-PCB 400 ng/L NBH-PCB 40 ng/L vs NBH-PCB 400 ng/L GO BP GO:0000003 reproduction Pos Pos Pos 0.000128247 0.003810654 0.000517595 GO BP GO:0000027 ribosomal large subunit assembly Pos Pos 0.041332611 0.048147204 GO BP GO:0000070 mitotic sister chromatid segregation Neg Neg Pos Pos Pos 0.004241242 0.002924348 1.16E-08 1.23E-09 4.27E-13 GO BP GO:0000075 cell cycle checkpoint Pos Pos Pos 3.99E-05 1.27E-05 2.62E-06 GO BP GO:0000077 DNA damage checkpoint Pos Pos 0.005704058 0.004660258 GO BP GO:0000082 G1/S transition of mitotic cell cycle Pos 0.029210008 GO BP GO:0000086 G2/M transition of mitotic cell cycle Pos Pos Pos 0.005903725 0.038210997 0.004293061 GO BP GO:0000122 negative regulation of transcription by RNA polymerase II Pos 0.002963592 GO BP GO:0000154 rRNA modification Pos Pos Pos 0.019606494 0.004228418 0.002942233 GO BP GO:0000165 MAPK cascade Neg 0.034513104 GO BP GO:0000226 microtubule cytoskeleton organization Pos Pos Pos 0.00081606 0.009118526 0.004445676 GO BP GO:0000245 spliceosomal complex assembly Pos 0.025704082 GO BP GO:0000278 mitotic cell cycle Pos Pos Pos 8.78E-14 4.60E-11 4.54E-16 GO BP GO:0000280 nuclear division Neg Pos Pos Pos 0.004171034 2.70E-10 1.39E-08 3.55E-12 GO BP GO:0000281 mitotic cytokinesis Pos 0.035837446 GO BP GO:0000291 "nuclear-transcribed mRNA catabolic process, exonucleolytic" Pos Pos Pos 0.016783536 0.003119339 0.000344417 GO BP GO:0000302 response to reactive oxygen species Neg 0.044290312 GO BP GO:0000375 "RNA splicing, via transesterification reactions" Neg Pos Pos Pos 0.000636444 0.001889088 1.45E-08 9.72E-09 GO BP GO:0000377 "RNA splicing, via transesterification reactions with bulged adenosine as nucleophile" Neg Pos Pos Pos 0.000636444 0.001889088 1.45E-08 9.72E-09 GO BP GO:0000387 spliceosomal snRNP assembly Neg Pos Pos Pos 0.006062312 0.005346249 1.75E-05 0.000395523 GO BP GO:0000398 "mRNA splicing, via spliceosome" Neg Pos Pos Pos 0.000636444 0.001889088 1.45E-08 9.72E-09 GO BP GO:0000413 protein peptidyl-prolyl isomerization Neg Pos 0.010422767 0.008388292 GO BP GO:0000422 autophagy of mitochondrion Neg 0.023244242 GO BP GO:0000460 maturation of 5.8S rRNA Pos Pos Pos 0.032379264 0.004007042 0.00015716 GO BP GO:0000462 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" Pos Pos 0.04290049 0.015736609 GO BP GO:0000463 "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" Pos Pos Pos 0.003829783 0.030569243 0.014331619 GO BP GO:0000466 "maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" Pos Pos 0.037254692 0.001994656 GO BP GO:0000469 cleavage involved in rRNA processing Pos 0.004402234 GO BP GO:0000470 maturation of LSU-rRNA Pos Pos Pos 0.001905293 0.00424323 0.000771099 GO BP GO:0000723 telomere maintenance Pos 0.035757007 GO BP GO:0000724 double-strand break repair via homologous recombination Neg Pos Pos Pos 0.014567459 0.000214907 6.66E-06 3.37E-06 GO BP GO:0000725 recombinational repair Neg Pos Pos Pos 0.014567459 0.000214907 6.66E-06 3.37E-06 GO BP GO:0000819 sister chromatid segregation Neg Neg Pos Pos Pos 0.007091463 0.003053079 1.42E-07 2.23E-09 2.51E-12 GO BP GO:0000902 cell morphogenesis Pos 7.92E-08 GO BP GO:0000904 cell morphogenesis involved in differentiation Pos 4.02E-09 GO BP GO:0000910 cytokinesis Pos Pos 0.00221198 0.00461188 GO BP GO:0000956 nuclear-transcribed mRNA catabolic process Pos Pos 0.019895236 0.018365526 GO BP GO:0001522 pseudouridine synthesis Pos Pos Pos 0.039179602 0.013819343 0.003167968 GO BP GO:0001525 angiogenesis Pos 0.013423894 GO BP GO:0001568 blood vessel development Pos 0.017321305 GO BP GO:0001578 microtubule bundle formation Pos 0.044841857 GO BP GO:0001654 eye development Pos Pos Pos 0.003531603 0.019606494 0.017289794 GO BP GO:0001667 ameboidal-type cell migration Pos Pos 0.029153886 6.64E-05 GO BP GO:0001702 gastrulation with mouth forming second Pos 0.040165299 GO BP GO:0001707 mesoderm formation Pos 0.032653607 GO BP GO:0001755 neural crest cell migration Pos Pos 0.015098592 0.014642526 GO BP GO:0001764 neuron migration Pos 0.008324127 GO BP GO:0001944 vasculature development Pos 0.011512121 GO BP GO:0001945 lymph vessel development Pos 0.020386176 GO BP GO:0001946 lymphangiogenesis Pos 0.014902017 GO BP GO:0002009 morphogenesis of an epithelium Pos 7.93E-05 GO BP GO:0002065 columnar/cuboidal epithelial cell differentiation Pos 0.018269625 GO BP GO:0002181 cytoplasmic translation Pos Pos Pos 0.031075145 0.036652802 0.005428854 GO BP GO:0002262 myeloid cell homeostasis Pos 0.015046494 GO BP GO:0002573 myeloid leukocyte differentiation Neg 0.043366784 GO BP GO:0003008 system process Neg Neg Neg 0.020003195 0.041274971 0.011857241 GO BP GO:0003018 vascular process in circulatory system Neg Neg 0.042250103 0.046252386 GO BP GO:0003407 neural retina development Pos 0.022082018 GO BP GO:0005996 monosaccharide metabolic process Neg 0.011253488 GO BP GO:0006066 alcohol metabolic process Pos Pos Pos 0.01262693 0.026792665 0.01443312 GO BP GO:0006082 organic acid metabolic process Neg Pos Pos 7.91E-08 0.006190052 0.012662002 GO BP GO:0006090 pyruvate metabolic process Pos 0.049399835 GO BP GO:0006091 generation of precursor metabolites and energy Neg Pos Pos 1.27E-05 0.000221737 0.01443485 GO BP GO:0006119 oxidative phosphorylation Neg Pos Pos 4.01E-07 5.13E-05 0.03787059 GO BP GO:0006120 "mitochondrial electron transport, NADH to ubiquinone" Neg Pos 0.005190533 0.027409387 GO BP GO:0006163 purine nucleotide metabolic process Neg 0.00915163 GO BP GO:0006164 purine nucleotide biosynthetic process Neg 0.02228574 GO BP GO:0006220 pyrimidine nucleotide metabolic process Neg Pos Pos 0.018564076 0.002105483 0.036655923 GO BP GO:0006221 pyrimidine nucleotide biosynthetic process Neg Pos 0.021776137 0.005986015 GO BP GO:0006259 DNA metabolic process Neg Neg Pos Pos Pos 1.41E-06 0.000779063 3.85E-16 3.45E-13 3.14E-16 GO BP GO:0006260 DNA replication Neg Neg Pos Pos Pos 0.001148563 0.011031982 8.43E-14 9.34E-15 1.29E-17 GO BP GO:0006261 DNA-dependent DNA replication Neg Pos Pos Pos 0.004171034 6.53E-12 1.38E-10 8.87E-14 GO BP GO:0006270 DNA replication initiation Pos Pos Pos 2.00E-06 5.18E-06 8.50E-08 GO BP GO:0006271 DNA strand elongation involved in DNA replication Pos Pos Pos 0.001883613 0.003151459 0.000106381 GO BP GO:0006275 regulation of DNA replication Pos Pos Pos 0.007780873 0.002866804 0.000209769 GO BP GO:0006281 DNA repair Neg Neg Pos Pos Pos 0.000151626 0.000387542 1.80E-11 2.84E-11 2.89E-12 GO BP GO:0006289 nucleotide-excision repair Pos Pos Pos 0.000917215 0.000343833 0.000232635 GO BP GO:0006301 postreplication repair Pos 0.00228584 GO BP GO:0006302 double-strand break repair Neg Pos Pos Pos 0.01382749 0.000148092 0.00079939 0.00019358 GO BP GO:0006310 DNA recombination Neg Neg Pos Pos Pos 0.002115767 0.033104224 1.16E-06 0.000122181 1.25E-06 GO BP GO:0006323 DNA packaging Pos Pos 0.009343114 0.004660258 GO BP GO:0006325 chromatin organization Pos Pos Pos 0.007630696 0.001400795 0.000590209 GO BP GO:0006352 "DNA-templated transcription, initiation" Neg Pos 0.022492803 0.00813687 GO BP GO:0006354 "DNA-templated transcription, elongation" Pos 0.027337893 GO BP GO:0006357 regulation of transcription by RNA polymerase II Pos 0.001931201 GO BP GO:0006364 rRNA processing Neg Pos Pos Pos 0.028250342 5.27E-11 1.31E-11 8.64E-14 GO BP GO:0006366 transcription by RNA polymerase II Pos 0.005995231 GO BP GO:0006367 transcription initiation from RNA polymerase II promoter Pos Pos 0.006031392 0.003970274 GO BP GO:0006396 RNA processing Neg Neg Pos Pos Pos 0.004002684 2.42E-06 9.45E-13 7.73E-20 1.70E-23 GO BP GO:0006397 mRNA processing Neg Pos Pos Pos 0.000827476 0.001586169 1.44E-08 4.88E-09 GO BP GO:0006399 tRNA metabolic process Neg Neg Pos Pos Pos 0.03446602 3.67E-06 0.046410535 4.69E-05 7.58E-06 GO BP GO:0006400 tRNA modification Neg Pos Pos 0.028990823 0.022723934 0.01310215 GO BP GO:0006401 RNA catabolic process Pos Pos Pos 0.009933537 0.036950288 0.014331619 GO BP GO:0006402 mRNA catabolic process Pos Pos 0.011438359 0.028422598 GO BP GO:0006403 RNA localization Pos Pos Pos 0.000124857 1.69E-07 1.07E-06 GO BP GO:0006405 RNA export from nucleus Pos Pos Pos 0.000181214 2.31E-07 7.51E-06 GO BP GO:0006406 mRNA export from nucleus Pos Pos 0.0047759 0.008345541 GO BP GO:0006412 translation Pos Pos Pos 1.07E-05 1.16E-06 7.68E-08 GO BP GO:0006417 regulation of translation Pos 0.049725253 GO BP GO:0006418 tRNA aminoacylation for protein translation Pos Pos 0.013209915 0.026487801 GO BP GO:0006457 protein folding Pos Pos Pos 0.014368185 4.20E-06 4.83E-05 GO BP GO:0006468 protein phosphorylation Pos Pos 0.021309632 0.005171001 GO BP GO:0006470 protein dephosphorylation Pos 0.0134335 GO BP GO:0006476 protein deacetylation Pos 0.015384532 GO BP GO:0006479 protein methylation Pos Pos Pos 0.040903366 0.029335557 0.01443485 GO BP GO:0006518 peptide metabolic process Pos Pos Pos 9.86E-05 5.97E-07 5.33E-08 GO BP GO:0006520 cellular amino acid metabolic process Neg Pos Pos 0.002896739 0.018145442 0.003970274 GO BP GO:0006605 protein targeting Pos Pos 0.040454411 0.04229127 GO BP GO:0006606 protein import into nucleus Pos Pos 0.00262065 0.000163239 GO BP GO:0006611 protein export from nucleus Pos Pos Pos 0.000611734 1.16E-06 6.55E-06 GO BP GO:0006626 protein targeting to mitochondrion Neg Pos Pos 0.031677501 0.00016905 0.000411866 GO BP GO:0006631 fatty acid metabolic process Neg 0.021776137 GO BP GO:0006633 fatty acid biosynthetic process Pos 0.035319578 GO BP GO:0006635 fatty acid beta-oxidation Neg 0.027542457 GO BP GO:0006636 unsaturated fatty acid biosynthetic process Pos 0.029839742 GO BP GO:0006644 phospholipid metabolic process Pos 0.027104365 GO BP GO:0006650 glycerophospholipid metabolic process Pos 0.045944275 GO BP GO:0006694 steroid biosynthetic process Pos Pos Pos 0.006217532 0.000569638 0.000545615 GO BP GO:0006695 cholesterol biosynthetic process Pos Pos Pos 0.031456027 0.027199376 0.025431287 GO BP GO:0006743 ubiquinone metabolic process Neg 0.025807216 GO BP GO:0006744 ubiquinone biosynthetic process Neg 0.025807216 GO BP GO:0006753 nucleoside phosphate metabolic process Neg Pos 0.001033018 0.021277248 GO BP GO:0006754 ATP biosynthetic process Pos 0.024101952 GO BP GO:0006790 sulfur compound metabolic process Neg 0.004822805 GO BP GO:0006811 ion transport Pos Neg Neg 0.003953838 0.038136084 0.001878518 GO BP GO:0006812 cation transport Neg Neg 0.027308569 0.002977771 GO BP GO:0006813 potassium ion transport Pos Neg Neg 0.00590933 0.015087481 0.010818452 GO BP GO:0006820 anion transport Pos 0.000611333 GO BP GO:0006836 neurotransmitter transport Pos 0.029153886 GO BP GO:0006839 mitochondrial transport Pos Pos 0.007538444 0.008952941 GO BP GO:0006886 intracellular protein transport Pos Pos 0.022197013 0.020196132 GO BP GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport Neg Pos Pos 0.019411723 0.001183929 0.003816157 GO BP GO:0006913 nucleocytoplasmic transport Pos Pos Pos 0.00200233 2.93E-08 2.82E-08 GO BP GO:0006928 movement of cell or subcellular component Pos 3.63E-08 GO BP GO:0006935 chemotaxis Pos 7.92E-08 GO BP GO:0006950 response to stress Neg Pos Pos 2.32E-05 5.85E-05 0.000138532 GO BP GO:0006974 cellular response to DNA damage stimulus Neg Neg Pos Pos Pos 0.002172191 0.000555401 7.25E-10 1.24E-11 2.34E-12 GO BP GO:0006979 response to oxidative stress Neg 0.000645346 GO BP GO:0006986 response to unfolded protein Pos Pos 0.035706063 0.042980347 GO BP GO:0007005 mitochondrion organization Neg Pos Pos 0.000201382 0.006764625 0.030594283 GO BP GO:0007010 cytoskeleton organization Pos Pos 0.014902017 0.025131001 GO BP GO:0007017 microtubule-based process Pos Pos Pos 0.002595284 0.046626881 0.008869829 GO BP GO:0007049 cell cycle Neg Pos Pos Pos 0.023448504 1.55E-17 2.25E-11 1.38E-17 GO BP GO:0007051 spindle organization Pos Pos 0.00221198 0.006391555 GO BP GO:0007052 mitotic spindle organization Pos 0.025015494 GO BP GO:0007059 chromosome segregation Neg Neg Pos Pos Pos 0.030751755 0.019411723 4.61E-08 3.10E-09 8.94E-13 GO BP GO:0007088 regulation of mitotic nuclear division Pos Pos Pos 4.25E-05 9.31E-07 8.36E-08 GO BP GO:0007091 metaphase/anaphase transition of mitotic cell cycle Neg Pos Pos Pos 0.039619775 0.002435663 2.29E-05 2.65E-06 GO BP GO:0007093 mitotic cell cycle checkpoint Pos Pos Pos 0.000280334 0.000357336 6.11E-05 GO BP GO:0007098 centrosome cycle Pos 0.038831719 GO BP GO:0007127 meiosis I Pos Pos Pos 0.016112107 0.045806031 0.028422598 GO BP GO:0007131 reciprocal meiotic recombination Pos 0.01149283 GO BP GO:0007155 cell adhesion Pos 5.40E-05 GO BP GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules Pos Neg 5.07E-05 0.013279608 GO BP GO:0007166 cell surface receptor signaling pathway Pos Neg Neg 0.000126676 0.001191991 0.001713745 GO BP GO:0007167 enzyme linked receptor protein signaling pathway Pos Neg Neg Neg 0.017321305 0.04448287 0.006314252 0.008635544 GO BP GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway Pos Neg Neg 0.000125825 0.002328664 0.006983772 GO BP GO:0007186 G protein-coupled receptor signaling pathway Pos Neg Neg Neg 0.002758067 1.31E-10 5.11E-08 1.41E-08 GO BP GO:0007187 "G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger" Neg Neg 0.001371659 0.001401638 GO BP GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway Neg Neg 0.002029286 0.002770698 GO BP GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway Neg Neg Neg 0.02954075 0.0063133 0.002751381 GO BP GO:0007212 dopamine receptor signaling pathway Pos 0.007694648 GO BP GO:0007218 neuropeptide signaling pathway Neg Neg Neg 0.015274802 0.014981446 0.000409876 GO BP GO:0007267 cell-cell signaling Pos Pos Neg Neg Neg 0.002230622 0.012666095 1.62E-05 0.001191991 3.07E-06 GO BP GO:0007268 chemical synaptic transmission Pos Pos Neg Neg 0.000326407 0.034623732 0.00021599 0.000932093 GO BP GO:0007346 regulation of mitotic cell cycle Pos Pos Pos 3.04E-08 2.56E-08 9.30E-10 GO BP GO:0007368 determination of left/right symmetry Pos 0.047981887 GO BP GO:0007369 gastrulation Pos Pos 0.020453246 0.00096336 GO BP GO:0007409 axonogenesis Pos 7.85E-09 GO BP GO:0007411 axon guidance Pos 4.39E-09 GO BP GO:0007417 central nervous system development Pos 0.019980615 GO BP GO:0007422 peripheral nervous system development Pos 0.010195926 GO BP GO:0007423 sensory organ development Pos Pos Pos 0.005179522 0.013789885 0.018269625 GO BP GO:0007498 mesoderm development Pos 0.036147564 GO BP GO:0007610 behavior Neg 0.013370325 GO BP GO:0008033 tRNA processing Neg Pos Pos 0.000308714 0.006603694 0.00140614 GO BP GO:0008037 cell recognition Pos 0.005995566 GO BP GO:0008038 neuron recognition Pos 0.005995566 GO BP GO:0008202 steroid metabolic process Pos Pos Pos 0.00840824 0.001233306 0.000395523 GO BP GO:0008203 cholesterol metabolic process Pos Pos Pos 0.006999159 0.009159407 0.012241108 GO BP GO:0008213 protein alkylation Pos Pos Pos 0.040903366 0.029335557 0.01443485 GO BP GO:0008286 insulin receptor signaling pathway Pos 0.015455452 GO BP GO:0008360 regulation of cell shape Neg Neg 0.030439846 0.02619994 GO BP GO:0008361 regulation of cell size Pos 0.015172566 GO BP GO:0008380 RNA splicing Neg Pos Pos Pos 5.42E-05 0.001181759 1.13E-08 7.94E-09 GO BP GO:0008589 regulation of smoothened signaling pathway Pos 0.033777352 GO BP GO:0008610 lipid biosynthetic process Pos Pos Pos 0.032916963 0.000775613 0.000526405 GO BP GO:0008652 cellular amino acid biosynthetic process Neg Pos 0.028685119 0.04059777 GO BP GO:0009060 aerobic respiration Pos Pos 0.004372082 0.027394543 GO BP GO:0009069 serine family amino acid metabolic process Neg Neg 0.045089169 0.000622905 GO BP GO:0009081 branched-chain amino acid metabolic process Neg 0.021568433 GO BP GO:0009112 nucleobase metabolic process Neg 0.031166743 GO BP GO:0009117 nucleotide metabolic process Neg Pos 0.001564354 0.02577244 GO BP GO:0009124 nucleoside monophosphate biosynthetic process Pos 0.027284716 GO BP GO:0009141 nucleoside triphosphate metabolic process Neg Pos 0.04027929 0.005683961 GO BP GO:0009142 nucleoside triphosphate biosynthetic process Pos 0.021521045 GO BP GO:0009144 purine nucleoside triphosphate metabolic process Neg Pos 0.03796471 0.021521045 GO BP GO:0009145 purine nucleoside triphosphate biosynthetic process Pos 0.022978321 GO BP GO:0009150 purine ribonucleotide metabolic process Neg 0.005344829 GO BP GO:0009152 purine ribonucleotide biosynthetic process Neg 0.011315028 GO BP GO:0009165 nucleotide biosynthetic process Neg 0.007061262 GO BP GO:0009199 ribonucleoside triphosphate metabolic process Neg Pos 0.024759747 0.006910953 GO BP GO:0009201 ribonucleoside triphosphate biosynthetic process Neg Pos 0.044511993 0.007484591 GO BP GO:0009205 purine ribonucleoside triphosphate metabolic process Neg Pos 0.03796471 0.021521045 GO BP GO:0009206 purine ribonucleoside triphosphate biosynthetic process Pos 0.022978321 GO BP GO:0009259 ribonucleotide metabolic process Neg Pos 0.001234727 0.033630115 GO BP GO:0009260 ribonucleotide biosynthetic process Neg 0.002379184 GO BP GO:0009451 RNA modification Pos Pos Pos 0.007577812 0.00276308 0.000418152 GO BP GO:0009607 response to biotic stimulus Neg 0.004551959 GO BP GO:0009620 response to fungus Pos Pos 0.011831365 0.041098985 GO BP GO:0009719 response to endogenous stimulus Neg 0.02233593 GO BP GO:0009755 hormone-mediated signaling pathway Neg 0.037338998 GO BP GO:0009790 embryo development Pos Pos 2.79E-06 0.024819577 GO BP GO:0009792 embryo development ending in birth or egg hatching Pos Pos 0.012863179 0.020497052 GO BP GO:0009799 specification of symmetry Pos 0.024444201 GO BP GO:0009855 determination of bilateral symmetry Pos 0.024444201 GO BP GO:0009887 animal organ morphogenesis Pos 0.000931538 GO BP GO:0009888 tissue development Pos 0.001282562 GO BP GO:0009890 negative regulation of biosynthetic process Pos 0.00209516 GO BP GO:0009891 positive regulation of biosynthetic process Pos Pos 0.007631413 0.002442499 GO BP GO:0009892 negative regulation of metabolic process Pos Pos 0.006468592 0.044501847 GO BP GO:0009893 positive regulation of metabolic process Pos 0.002423145 GO BP GO:0009966 regulation of signal transduction GO BP GO:0009968 negative regulation of signal transduction Pos 0.04222115 GO BP GO:0010001 glial cell differentiation Pos 0.009257004 GO BP GO:0010033 response to organic substance Neg 0.023315813 GO BP GO:0010389 regulation of G2/M transition of mitotic cell cycle Pos Pos Pos 0.004440769 0.026882585 0.003237507 GO BP GO:0010499 proteasomal ubiquitin-independent protein catabolic process Neg Pos Pos 0.005316294 7.14E-06 9.97E-05 GO BP GO:0010557 positive regulation of macromolecule biosynthetic process Pos Pos 0.033033118 0.012454218 GO BP GO:0010558 negative regulation of macromolecule biosynthetic process Pos 0.00179325 GO BP GO:0010564 regulation of cell cycle process Pos Pos Pos 1.08E-12 7.20E-11 3.51E-14 GO BP GO:0010604 positive regulation of macromolecule metabolic process Pos 0.011844827 GO BP GO:0010605 negative regulation of macromolecule metabolic process Pos 0.00850703 GO BP GO:0010608 posttranscriptional regulation of gene expression Pos Pos 0.035319578 0.015218088 GO BP GO:0010628 positive regulation of gene expression Pos Pos 0.033287727 0.023400304 GO BP GO:0010629 negative regulation of gene expression Pos Pos 0.005103454 0.025131001 GO BP GO:0010639 negative regulation of organelle organization Pos 0.025993689 GO BP GO:0010646 regulation of cell communication Pos Neg Neg 0.017686607 0.002293704 0.027911904 GO BP GO:0010647 positive regulation of cell communication GO BP GO:0010721 negative regulation of cell development Pos 0.015172566 GO BP GO:0010769 regulation of cell morphogenesis involved in differentiation Pos 0.000628147 GO BP GO:0010948 negative regulation of cell cycle process Pos Pos Pos 1.31E-05 0.000343025 2.02E-05 GO BP GO:0010965 regulation of mitotic sister chromatid separation Neg Pos Pos Pos 0.030157231 0.00081606 4.20E-06 2.00E-07 GO BP GO:0010975 regulation of neuron projection development Pos 0.001699456 GO BP GO:0010977 negative regulation of neuron projection development Pos 0.043687789 GO BP GO:0014031 mesenchymal cell development Pos 0.033144393 GO BP GO:0014032 neural crest cell development Pos 0.033144393 GO BP GO:0014033 neural crest cell differentiation Pos 0.024444201 GO BP GO:0014070 response to organic cyclic compound Neg 0.037527715 GO BP GO:0015672 monovalent inorganic cation transport Neg 0.012626879 GO BP GO:0015711 organic anion transport Pos 0.006361842 GO BP GO:0015748 organophosphate ester transport Pos 0.012981183 GO BP GO:0015914 phospholipid transport Pos 0.006633685 GO BP GO:0015931 nucleobase-containing compound transport Pos Pos Pos 0.000347063 2.39E-07 1.90E-06 GO BP GO:0015980 energy derivation by oxidation of organic compounds Neg Pos Pos 0.003403039 0.000611869 0.006838063 GO BP GO:0015985 "energy coupled proton transport, down electrochemical gradient" Pos 0.043311304 GO BP GO:0015986 ATP synthesis coupled proton transport Pos 0.043311304 GO BP GO:0016052 carbohydrate catabolic process Neg 0.033384113 GO BP GO:0016053 organic acid biosynthetic process Neg Pos Pos 0.001205429 0.043311304 0.017289794 GO BP GO:0016054 organic acid catabolic process Neg Neg 0.039973624 0.002025267 GO BP GO:0016055 Wnt signaling pathway Pos Neg Neg 0.012050622 0.023856502 0.024286287 GO BP GO:0016071 mRNA metabolic process Pos Pos Pos 1.79E-05 1.54E-08 3.53E-09 GO BP GO:0016072 rRNA metabolic process Neg Neg Pos Pos Pos 0.023448504 0.04091875 7.66E-11 6.51E-12 4.01E-14 GO BP GO:0016073 snRNA metabolic process Pos Pos Pos 0.033448905 0.007722843 0.000259339 GO BP GO:0016075 rRNA catabolic process Pos 0.01443312 GO BP GO:0016125 sterol metabolic process Pos Pos Pos 0.005547944 0.000946558 0.001301614 GO BP GO:0016126 sterol biosynthetic process Pos Pos Pos 0.007604937 0.001624781 0.001475594 GO BP GO:0016180 snRNA processing Pos Pos 0.014847983 0.001227508 GO BP GO:0016192 vesicle-mediated transport Neg 0.026988968 GO BP GO:0016226 iron-sulfur cluster assembly Neg 0.005434043 GO BP GO:0016310 phosphorylation GO BP GO:0016311 dephosphorylation Pos 0.025838095 GO BP GO:0016331 morphogenesis of embryonic epithelium Pos 0.034968874 GO BP GO:0016358 dendrite development Pos 0.017446224 GO BP GO:0016477 cell migration Pos Pos 0.039448723 7.91E-05 GO BP GO:0016569 covalent chromatin modification Pos Pos Pos 0.016703106 0.007170713 0.004267229 GO BP GO:0016570 histone modification Pos Pos Pos 0.016703106 0.007170713 0.004267229 GO BP GO:0016571 histone methylation Pos Pos 0.013313937 0.012197889 GO BP GO:0017004 cytochrome complex assembly Neg 0.018564076 GO BP GO:0017038 protein import Pos Pos 0.000725251 0.000232948 GO BP GO:0017148 negative regulation of translation Pos 0.018138062 GO BP GO:0018208 peptidyl-proline modification Neg 0.00413182 GO BP GO:0019226 transmission of nerve impulse Neg 0.026988968 GO BP GO:0019318 hexose metabolic process Neg 0.023722493 GO BP GO:0019395 fatty acid oxidation Neg 0.005050383 GO BP GO:0019439 aromatic compound catabolic process Pos Pos Pos 0.008948949 0.037855989 0.01443485 GO BP GO:0019693 ribose phosphate metabolic process Neg Pos 0.005873803 0.045806031 GO BP GO:0019751 polyol metabolic process Pos 0.012981183 GO BP GO:0019752 carboxylic acid metabolic process Neg Pos Pos 7.43E-08 0.00353784 0.006187224 GO BP GO:0019932 second-messenger-mediated signaling Neg Neg Neg 0.002834809 0.016211624 0.000762933 GO BP GO:0019933 cAMP-mediated signaling Neg Neg Neg 0.003430312 0.00415261 0.003180151 GO BP GO:0019935 cyclic-nucleotide-mediated signaling Neg Neg Neg 0.001989743 0.005410086 0.002467825 GO BP GO:0021545 cranial nerve development Pos 0.002006554 GO BP GO:0021548 pons development Pos 0.032630413 GO BP GO:0021603 cranial nerve formation Pos 0.041450965 GO BP GO:0021675 nerve development Pos 0.000587218 GO BP GO:0021700 developmental maturation Pos 0.008950437 GO BP GO:0021954 central nervous system neuron development Pos 0.033144393 GO BP GO:0022008 neurogenesis Pos 8.32E-09 GO BP GO:0022402 cell cycle process Neg Pos Pos Pos 0.004002684 8.78E-14 1.03E-08 8.64E-14 GO BP GO:0022407 regulation of cell-cell adhesion Pos 0.006886847 GO BP GO:0022414 reproductive process Pos Pos Pos 5.28E-05 0.00353784 0.000795407 GO BP GO:0022603 regulation of anatomical structure morphogenesis Pos 0.019157842 GO BP GO:0022604 regulation of cell morphogenesis Pos 0.01138166 GO BP GO:0022610 biological adhesion Pos 5.40E-05 GO BP GO:0022613 ribonucleoprotein complex biogenesis Neg Neg Pos Pos Pos 0.028250342 0.014567459 2.06E-16 7.73E-20 5.61E-24 GO BP GO:0022616 DNA strand elongation Pos Pos Pos 0.001883613 0.002918127 0.000157633 GO BP GO:0022618 ribonucleoprotein complex assembly Pos Pos Pos 0.000187683 5.18E-06 1.59E-08 GO BP GO:0022900 electron transport chain Neg Pos Pos 0.000115572 0.001690376 0.047478167 GO BP GO:0022904 respiratory electron transport chain Neg Pos 0.000247986 0.00253852 GO BP GO:0023014 signal transduction by protein phosphorylation Neg 0.047881436 GO BP GO:0023051 regulation of signaling Pos Neg Neg 0.015098592 0.002413274 0.029291365 GO BP GO:0023056 positive regulation of signaling GO BP GO:0023061 signal release Neg 0.002385326 GO BP GO:0030001 metal ion transport Pos Neg 0.038124013 0.006599823 GO BP GO:0030010 establishment of cell polarity Pos 0.024444201 GO BP GO:0030029 actin filament-based process Pos 0.01291403 GO BP GO:0030030 cell projection organization Pos 7.52E-05 GO BP GO:0030036 actin cytoskeleton organization Pos 0.012909266 GO BP GO:0030071 regulation of mitotic metaphase/anaphase transition Neg Pos Pos Pos 0.039619775 0.002435663 2.29E-05 2.65E-06 GO BP GO:0030111 regulation of Wnt signaling pathway Pos 0.035391709 GO BP GO:0030150 protein import into mitochondrial matrix Pos 0.021442178 GO BP GO:0030155 regulation of cell adhesion Pos 0.001264652 GO BP GO:0030177 positive regulation of Wnt signaling pathway Pos 0.007694648 GO BP GO:0030182 neuron differentiation Pos 9.47E-08 GO BP GO:0030218 erythrocyte differentiation Pos 0.006763284 GO BP GO:0030278 regulation of ossification Neg 0.032636177 GO BP GO:0030308 negative regulation of cell growth Pos 0.031404447 GO BP GO:0030334 regulation of cell migration Pos 0.005013317 GO BP GO:0030490 maturation of SSU-rRNA Pos Pos Pos 0.029628507 0.021222362 0.006461738 GO BP GO:0030516 regulation of axon extension Pos 0.045754082 GO BP GO:0031032 actomyosin structure organization Pos 0.015327652 GO BP GO:0031076 embryonic camera-type eye development Pos 0.043010988 GO BP GO:0031123 RNA 3'-end processing Pos Pos Pos 0.017707561 0.002593651 3.20E-05 GO BP GO:0031163 metallo-sulfur cluster assembly Neg 0.005434043 GO BP GO:0031175 neuron projection development Pos 1.99E-07 GO BP GO:0031290 retinal ganglion cell axon guidance Pos 0.005197211 GO BP GO:0031324 negative regulation of cellular metabolic process Pos 0.003905809 GO BP GO:0031325 positive regulation of cellular metabolic process Pos 0.003198678 GO BP GO:0031327 negative regulation of cellular biosynthetic process Pos 0.003190777 GO BP GO:0031328 positive regulation of cellular biosynthetic process Pos Pos 0.032653607 0.009813924 GO BP GO:0031344 regulation of cell projection organization Pos 0.001211728 GO BP GO:0031570 DNA integrity checkpoint Pos Pos Pos 0.009273061 0.000611869 0.000229217 GO BP GO:0032200 telomere organization Pos 0.035757007 GO BP GO:0032259 methylation Neg Pos Pos Pos 0.038652965 0.002038843 0.00139529 0.000356487 GO BP GO:0032409 regulation of transporter activity Neg 0.039952968 GO BP GO:0032412 regulation of ion transmembrane transporter activity Neg 0.036229518 GO BP GO:0032465 regulation of cytokinesis Pos Pos Pos 5.33E-05 0.004691755 0.000413959 GO BP GO:0032508 DNA duplex unwinding Pos 0.032482987 GO BP GO:0032543 mitochondrial translation Neg Pos Pos 0.000636444 0.004977516 0.024237632 GO BP GO:0032784 "regulation of DNA-templated transcription, elongation" Pos 0.009507527 GO BP GO:0032786 "positive regulation of DNA-templated transcription, elongation" Pos 0.0217926 GO BP GO:0032787 monocarboxylic acid metabolic process Neg Pos 0.000779063 0.022456139 GO BP GO:0032868 response to insulin Pos 0.012981183 GO BP GO:0032869 cellular response to insulin stimulus Pos 0.014642526 GO BP GO:0032879 regulation of localization Pos Neg Neg Neg 0.041578414 0.000542406 0.03260908 1.55E-05 GO BP GO:0032886 regulation of microtubule-based process Pos 0.009591022 GO BP GO:0032940 secretion by cell Neg 0.034007892 GO BP GO:0032989 cellular component morphogenesis Pos 6.77E-09 GO BP GO:0032990 cell part morphogenesis Pos 2.83E-08 GO BP GO:0033043 regulation of organelle organization Pos 0.036892437 GO BP GO:0033044 regulation of chromosome organization Pos Pos Pos 0.002716254 0.012615339 0.001505835 GO BP GO:0033045 regulation of sister chromatid segregation Neg Pos Pos Pos 0.025516395 7.05E-05 2.58E-07 7.18E-09 GO BP GO:0033047 regulation of mitotic sister chromatid segregation Neg Pos Pos Pos 0.030157231 0.00081606 4.20E-06 2.00E-07 GO BP GO:0033108 mitochondrial respiratory chain complex assembly Neg Pos 0.000815462 0.029831572 GO BP GO:0033260 nuclear DNA replication Pos Pos Pos 3.38E-05 1.64E-05 8.83E-07 GO BP GO:0033365 protein localization to organelle Neg Pos Pos 0.033258508 0.000413176 0.000112409 GO BP GO:0033554 cellular response to stress Neg Neg Pos Pos Pos 0.032911304 0.000173717 0.00015312 3.28E-08 5.85E-08 GO BP GO:0033674 positive regulation of kinase activity Neg Neg 0.041717916 0.018486478 GO BP GO:0033866 nucleoside bisphosphate biosynthetic process Neg 0.047784666 GO BP GO:0034030 ribonucleoside bisphosphate biosynthetic process Neg 0.047784666 GO BP GO:0034033 purine nucleoside bisphosphate biosynthetic process Neg 0.047784666 GO BP GO:0034101 erythrocyte homeostasis Pos 0.006763284 GO BP GO:0034220 ion transmembrane transport Neg Neg 0.019668578 0.000863349 GO BP GO:0034243 regulation of transcription elongation from RNA polymerase II promoter Pos 0.035757007 GO BP GO:0034248 regulation of cellular amide metabolic process Pos Pos 0.044971337 0.035932335 GO BP GO:0034249 negative regulation of cellular amide metabolic process Pos 0.024750414 GO BP GO:0034330 cell junction organization Pos Neg 4.18E-05 0.013204118 GO BP GO:0034332 adherens junction organization Pos 0.010727033 GO BP GO:0034440 lipid oxidation Neg 0.005050383 GO BP GO:0034470 ncRNA processing Neg Neg Pos Pos Pos 0.002076764 0.000166657 6.76E-11 1.45E-13 4.13E-17 GO BP GO:0034472 snRNA 3'-end processing Pos Pos 0.018587795 0.001484821 GO BP GO:0034504 protein localization to nucleus Pos Pos 0.002357244 0.000192789 GO BP GO:0034599 cellular response to oxidative stress Neg 0.03796471 GO BP GO:0034613 cellular protein localization Pos Pos 0.022978321 0.032467799 GO BP GO:0034622 cellular protein-containing complex assembly Neg Neg Pos Pos Pos 0.013837619 9.24E-06 0.000753492 1.59E-07 1.32E-08 GO BP GO:0034655 nucleobase-containing compound catabolic process Pos Pos Pos 0.008537526 0.028230731 0.009617465 GO BP GO:0034660 ncRNA metabolic process Neg Neg Pos Pos Pos 0.002115767 1.57E-05 3.12E-10 9.34E-15 1.38E-17 GO BP GO:0034661 ncRNA catabolic process Pos Pos 0.021428225 0.005215525 GO BP GO:0034762 regulation of transmembrane transport Neg Neg Neg 0.003268079 0.029988383 1.55E-05 GO BP GO:0034765 regulation of ion transmembrane transport Neg Neg Neg 0.003268079 0.029695119 1.55E-05 GO BP GO:0035088 establishment or maintenance of apical/basal cell polarity Pos 0.004242414 GO BP GO:0035150 regulation of tube size Neg 0.049415918 GO BP GO:0035239 tube morphogenesis Pos 0.000125825 GO BP GO:0035249 "synaptic transmission, glutamatergic" Pos 0.012981183 GO BP GO:0035295 tube development Pos 0.000694212 GO BP GO:0035296 regulation of tube diameter Neg 0.049415918 GO BP GO:0035384 thioester biosynthetic process Neg 0.02954075 GO BP GO:0035418 protein localization to synapse Pos 0.026908184 GO BP GO:0035556 intracellular signal transduction Pos Neg Neg Neg 0.004270074 0.021394814 0.0063133 0.00049571 GO BP GO:0035601 protein deacylation Pos 0.003198678 GO BP GO:0035825 homologous recombination Pos 0.01149283 GO BP GO:0036303 lymph vessel morphogenesis Pos 0.014902017 GO BP GO:0040011 locomotion Pos Pos 0.015146935 4.39E-09 GO BP GO:0040012 regulation of locomotion Pos 0.006451315 GO BP GO:0040013 negative regulation of locomotion Pos 0.012666095 GO BP GO:0042063 gliogenesis Pos 0.006532828 GO BP GO:0042074 cell migration involved in gastrulation Pos 0.006896123 GO BP GO:0042181 ketone biosynthetic process Neg 0.018583032 GO BP GO:0042221 response to chemical Pos Neg Neg Neg 0.032630413 0.044433854 0.002170884 0.003106953 GO BP GO:0042254 ribosome biogenesis Neg Pos Pos Pos 0.045089169 8.78E-14 5.49E-14 2.57E-17 GO BP GO:0042255 ribosome assembly Pos 0.016984503 GO BP GO:0042273 ribosomal large subunit biogenesis Pos Pos Pos 7.39E-07 1.90E-05 9.19E-07 GO BP GO:0042274 ribosomal small subunit biogenesis Pos Pos Pos 0.007133998 0.031319681 0.004445676 GO BP GO:0042310 vasoconstriction Neg 0.047784666 GO BP GO:0042330 taxis Pos 1.01E-06 GO BP GO:0042462 eye photoreceptor cell development Pos 0.016552409 GO BP GO:0042773 ATP synthesis coupled electron transport Neg Pos Pos 8.92E-06 9.44E-05 0.045421839 GO BP GO:0042775 mitochondrial ATP synthesis coupled electron transport Neg Pos Pos 8.66E-06 6.02E-05 0.039502809 GO BP GO:0043009 chordate embryonic development Pos Pos 0.012863179 0.020497052 GO BP GO:0043010 camera-type eye development Pos Pos 0.003305399 0.037963241 GO BP GO:0043038 amino acid activation Pos Pos 0.016522771 0.030326244 GO BP GO:0043039 tRNA aminoacylation Pos Pos 0.016522771 0.030326244 GO BP GO:0043043 peptide biosynthetic process Pos Pos Pos 1.15E-05 1.07E-06 8.55E-08 GO BP GO:0043085 positive regulation of catalytic activity Neg 0.047881436 GO BP GO:0043207 response to external biotic stimulus Neg 0.004261437 GO BP GO:0043269 regulation of ion transport Neg Neg Neg 0.000227047 0.007850203 7.33E-07 GO BP GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Pos 0.030906375 GO BP GO:0043414 macromolecule methylation Pos Pos Pos 0.003328477 0.003377854 0.001640786 GO BP GO:0043436 oxoacid metabolic process Neg Pos Pos 1.29E-07 0.005213945 0.010194258 GO BP GO:0043603 cellular amide metabolic process Pos Pos Pos 0.007149724 4.36E-06 4.75E-07 GO BP GO:0043604 amide biosynthetic process Pos Pos Pos 0.002468478 2.75E-05 3.37E-06 GO BP GO:0043628 ncRNA 3'-end processing Pos Pos Pos 0.007311973 0.004977516 0.00019867 GO BP GO:0043933 protein-containing complex subunit organization Pos Pos Pos 0.003942384 0.00011461 7.42E-06 GO BP GO:0043954 cellular component maintenance Pos 0.035028969 GO BP GO:0044057 regulation of system process Neg 0.037683886 GO BP GO:0044093 positive regulation of molecular function Pos 0.022354912 GO BP GO:0044270 cellular nitrogen compound catabolic process Pos Pos Pos 0.008137547 0.023125718 0.004524144 GO BP GO:0044272 sulfur compound biosynthetic process Neg 0.041251011 GO BP GO:0044281 small molecule metabolic process Neg Pos Pos 1.91E-06 1.50E-05 7.29E-05 GO BP GO:0044282 small molecule catabolic process Neg 0.022386767 GO BP GO:0044283 small molecule biosynthetic process Neg Pos Pos 0.011825463 0.001502112 0.00086986 GO BP GO:0044419 interspecies interaction between organisms Neg 0.004649389 GO BP GO:0044770 cell cycle phase transition Pos Pos Pos 0.000556252 0.002403813 4.31E-05 GO BP GO:0044772 mitotic cell cycle phase transition Pos Pos Pos 0.000911585 0.005987025 0.000177013 GO BP GO:0044784 metaphase/anaphase transition of cell cycle Neg Pos Pos Pos 0.04027929 0.002122532 1.57E-05 1.90E-06 GO BP GO:0044786 cell cycle DNA replication Pos Pos Pos 7.39E-07 1.07E-06 1.86E-08 GO BP GO:0044839 cell cycle G2/M phase transition Pos Pos Pos 0.008537526 0.049399835 0.004897262 GO BP GO:0045005 DNA-dependent DNA replication maintenance of fidelity Pos 0.015218088 GO BP GO:0045132 meiotic chromosome segregation Pos 0.030326244 GO BP GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity Pos 0.004242414 GO BP GO:0045292 "mRNA cis splicing, via spliceosome" Pos Pos 0.031585949 0.04989513 GO BP GO:0045333 cellular respiration Neg Pos Pos 0.002853229 0.000308408 0.003977459 GO BP GO:0045454 cell redox homeostasis Pos 0.002779198 GO BP GO:0045664 regulation of neuron differentiation Pos 0.012981183 GO BP GO:0045665 negative regulation of neuron differentiation Pos 0.031837918 GO BP GO:0045786 negative regulation of cell cycle Pos Pos Pos 8.27E-06 0.002403813 0.00015354 GO BP GO:0045787 positive regulation of cell cycle Pos Pos Pos 0.008137547 0.000479665 2.63E-05 GO BP GO:0045879 negative regulation of smoothened signaling pathway Pos 0.032653607 GO BP GO:0045892 "negative regulation of transcription, DNA-templated" Pos 0.005470661 GO BP GO:0045893 "positive regulation of transcription, DNA-templated" Pos 0.025437475 GO BP GO:0045930 negative regulation of mitotic cell cycle Pos Pos Pos 4.30E-05 0.000142449 4.29E-05 GO BP GO:0045931 positive regulation of mitotic cell cycle Pos Pos Pos 0.009263292 0.003523587 0.000153178 GO BP GO:0045934 negative regulation of nucleobase-containing compound metabolic process Pos 0.005995566 GO BP GO:0045935 positive regulation of nucleobase-containing compound metabolic process Pos Pos 0.026870707 0.013959431 GO BP GO:0045944 positive regulation of transcription by RNA polymerase II Pos 0.004538076 GO BP GO:0046034 ATP metabolic process Neg Pos 2.75E-06 0.000113974 GO BP GO:0046165 alcohol biosynthetic process Pos 0.043618124 GO BP GO:0046390 ribose phosphate biosynthetic process Neg 0.011253488 GO BP GO:0046394 carboxylic acid biosynthetic process Neg Pos Pos 0.002643362 0.021277248 0.008406899 GO BP GO:0046395 carboxylic acid catabolic process Neg Neg 0.039973624 0.002025267 GO BP GO:0046486 glycerolipid metabolic process Pos 0.018894588 GO BP GO:0046700 heterocycle catabolic process Pos Pos Pos 0.016703106 0.037826789 0.018365526 GO BP GO:0046834 lipid phosphorylation Pos Pos 0.041578414 0.009331455 GO BP GO:0046839 phospholipid dephosphorylation Pos 0.03637139 GO BP GO:0046879 hormone secretion Neg 0.016860682 GO BP GO:0046883 regulation of hormone secretion Neg 0.01407121 GO BP GO:0046903 secretion Neg 0.034007892 GO BP GO:0046907 intracellular transport Pos 0.013205892 GO BP GO:0048048 embryonic eye morphogenesis Pos 0.012981183 GO BP GO:0048285 organelle fission Neg Neg Pos Pos Pos 0.002172191 0.04091875 2.40E-09 2.13E-07 5.66E-11 GO BP GO:0048332 mesoderm morphogenesis Pos 0.031404447 GO BP GO:0048468 cell development Pos Pos 0.01216459 1.99E-10 GO BP GO:0048469 cell maturation Pos 0.014642526 GO BP GO:0048511 rhythmic process Pos 0.047344063 GO BP GO:0048514 blood vessel morphogenesis Pos 0.006144488 GO BP GO:0048546 digestive tract morphogenesis Pos 0.024750414 GO BP GO:0048562 embryonic organ morphogenesis Pos 0.014902017 GO BP GO:0048568 embryonic organ development Pos 0.003022753 GO BP GO:0048583 regulation of response to stimulus GO BP GO:0048585 negative regulation of response to stimulus Pos 0.031780625 GO BP GO:0048589 developmental growth Pos 0.022934723 GO BP GO:0048592 eye morphogenesis Pos 0.001195054 GO BP GO:0048593 camera-type eye morphogenesis Pos 0.000870519 GO BP GO:0048596 embryonic camera-type eye morphogenesis Pos 0.022797124 GO BP GO:0048598 embryonic morphogenesis Pos 8.90E-05 GO BP GO:0048646 anatomical structure formation involved in morphogenesis Pos 1.83E-05 GO BP GO:0048666 neuron development Pos 4.08E-08 GO BP GO:0048667 cell morphogenesis involved in neuron differentiation Pos 5.21E-09 GO BP GO:0048699 generation of neurons Pos 6.77E-09 GO BP GO:0048709 oligodendrocyte differentiation Pos 0.046881012 GO BP GO:0048729 tissue morphogenesis Pos 1.79E-05 GO BP GO:0048812 neuron projection morphogenesis Pos 8.32E-09 GO BP GO:0048857 neural nucleus development Pos 0.005439338 GO BP GO:0048858 cell projection morphogenesis Pos 8.32E-09 GO BP GO:0048864 stem cell development Pos 0.033144393 GO BP GO:0048870 cell motility Pos 0.000143178 GO BP GO:0048872 homeostasis of number of cells Pos 0.038124013 GO BP GO:0048880 sensory system development Pos 0.00032268 GO BP GO:0050657 nucleic acid transport Pos Pos Pos 0.000117904 1.59E-07 1.48E-06 GO BP GO:0050658 RNA transport Pos Pos Pos 0.000117904 1.59E-07 1.48E-06 GO BP GO:0050673 epithelial cell proliferation Pos 0.034604162 GO BP GO:0050767 regulation of neurogenesis Pos 0.000154127 GO BP GO:0050768 negative regulation of neurogenesis Pos 0.012981183 GO BP GO:0050770 regulation of axonogenesis Pos 0.006763284 GO BP GO:0050793 regulation of developmental process Pos Neg 0.006986429 0.038136084 GO BP GO:0050795 regulation of behavior Neg 0.023158279 GO BP GO:0050803 regulation of synapse structure or activity Pos 0.000125825 GO BP GO:0050804 modulation of chemical synaptic transmission Neg Neg 0.020003195 0.042001007 GO BP GO:0050807 regulation of synapse organization Pos 0.013610384 GO BP GO:0050808 synapse organization Pos Pos Neg 0.015146935 0.000628147 0.027223152 GO BP GO:0050877 nervous system process Neg Neg 0.005012678 0.02362254 GO BP GO:0051028 mRNA transport Pos Pos Pos 0.019606494 0.000339714 0.000209153 GO BP GO:0051046 regulation of secretion Neg 0.01776325 GO BP GO:0051049 regulation of transport Neg Neg Neg 4.12E-05 0.037527715 1.81E-06 GO BP GO:0051051 negative regulation of transport Neg 0.026988968 GO BP GO:0051052 regulation of DNA metabolic process Pos 0.04032037 GO BP GO:0051093 negative regulation of developmental process Pos 0.036348551 GO BP GO:0051168 nuclear export Pos Pos Pos 5.28E-05 2.66E-08 1.36E-06 GO BP GO:0051169 nuclear transport Pos Pos Pos 0.00200233 2.93E-08 2.82E-08 GO BP GO:0051170 import into nucleus Pos Pos 0.00361518 0.000339514 GO BP GO:0051172 negative regulation of nitrogen compound metabolic process Pos 0.001264652 GO BP GO:0051173 positive regulation of nitrogen compound metabolic process Pos 0.011512121 GO BP GO:0051225 spindle assembly Pos 0.035718343 GO BP GO:0051236 establishment of RNA localization Pos Pos Pos 0.000117904 1.59E-07 1.48E-06 GO BP GO:0051253 negative regulation of RNA metabolic process Pos 0.00372635 GO BP GO:0051254 positive regulation of RNA metabolic process Pos Pos 0.015917801 0.01900075 GO BP GO:0051259 protein complex oligomerization Pos 0.008024394 GO BP GO:0051260 protein homooligomerization Pos Neg 0.007265096 0.047881436 GO BP GO:0051270 regulation of cellular component movement Pos 0.012666095 GO BP GO:0051271 negative regulation of cellular component movement Pos 0.012666095 GO BP GO:0051276 chromosome organization Neg Pos Pos Pos 0.006172882 3.67E-11 7.20E-11 2.96E-15 GO BP GO:0051301 cell division Pos Pos Pos 0.000161194 0.000606289 1.10E-06 GO BP GO:0051302 regulation of cell division Pos Pos Pos 0.000897656 0.029770998 0.005588049 GO BP GO:0051304 chromosome separation Neg Pos Pos Pos 0.040556614 5.95E-05 8.39E-07 1.51E-08 GO BP GO:0051306 mitotic sister chromatid separation Neg Pos Pos Pos 0.030157231 0.00081606 4.20E-06 2.00E-07 GO BP GO:0051321 meiotic cell cycle Neg Pos Pos Pos 0.007047132 6.34E-07 5.20E-05 1.46E-06 GO BP GO:0051347 positive regulation of transferase activity Neg Neg 0.046643166 0.022551456 GO BP GO:0051592 response to calcium ion Neg 0.034756373 GO BP GO:0051674 localization of cell Pos 0.000143178 GO BP GO:0051707 response to other organism Neg 0.004261437 GO BP GO:0051726 regulation of cell cycle Pos Pos Pos 1.03E-09 2.33E-06 4.88E-09 GO BP GO:0051783 regulation of nuclear division Pos Pos Pos 3.53E-05 6.02E-07 5.80E-08 GO BP GO:0051784 negative regulation of nuclear division Pos Pos Pos 3.60E-05 1.72E-06 3.78E-08 GO BP GO:0051960 regulation of nervous system development Pos 0.000154835 GO BP GO:0051961 negative regulation of nervous system development Pos 0.012981183 GO BP GO:0051962 positive regulation of nervous system development Pos 0.026870707 GO BP GO:0051983 regulation of chromosome segregation Neg Pos Pos Pos 0.027950251 1.77E-05 5.44E-08 9.95E-10 GO BP GO:0055085 transmembrane transport Neg 0.010076132 GO BP GO:0055086 nucleobase-containing small molecule metabolic process Neg Pos 0.003403039 0.021428225 GO BP GO:0055113 epiboly involved in gastrulation with mouth forming second Pos 0.042409652 GO BP GO:0055114 oxidation-reduction process Neg Neg Pos Pos 0.002172191 1.57E-14 0.000402247 0.003644842 GO BP GO:0060026 convergent extension Pos 0.003241222 GO BP GO:0060027 convergent extension involved in gastrulation Pos 0.00017477 GO BP GO:0060041 retina development in camera-type eye Pos Pos 0.010245883 0.004919462 GO BP GO:0060070 canonical Wnt signaling pathway Neg 0.040451842 GO BP GO:0060284 regulation of cell development Pos 0.000233583 GO BP GO:0060429 epithelium development Pos 0.000205721 GO BP GO:0060560 developmental growth involved in morphogenesis Pos 0.025437475 GO BP GO:0060562 epithelial tube morphogenesis Pos 0.01386835 GO BP GO:0060840 artery development Pos 0.041744506 GO BP GO:0061013 regulation of mRNA catabolic process Pos 0.026870707 GO BP GO:0061053 somite development Pos 0.033596351 GO BP GO:0061061 muscle structure development Pos 0.049921664 GO BP GO:0061245 establishment or maintenance of bipolar cell polarity Pos 0.004242414 GO BP GO:0061387 regulation of extent of cell growth Pos 0.014642526 GO BP GO:0061564 axon development Pos 3.94E-08 GO BP GO:0061640 cytoskeleton-dependent cytokinesis Pos 0.018535193 GO BP GO:0061726 mitochondrion disassembly Neg 0.023244242 GO BP GO:0061982 meiosis I cell cycle process Pos Pos Pos 0.001312403 0.009141545 0.002758969 GO BP GO:0062197 cellular response to chemical stress Neg 0.047738782 GO BP GO:0062237 protein localization to postsynapse Pos 0.034623732 GO BP GO:0065003 protein-containing complex assembly Neg Pos Pos Pos 0.043348288 0.01149283 0.000326446 2.02E-05 GO BP GO:0065004 protein-DNA complex assembly Neg Pos Pos Pos 0.039988924 0.000564713 0.000229249 6.54E-06 GO BP GO:0070507 regulation of microtubule cytoskeleton organization Pos 0.006809564 GO BP GO:0070585 protein localization to mitochondrion Neg Pos Pos 0.022492803 0.000536597 0.00066776 GO BP GO:0070727 cellular macromolecule localization Pos Pos 0.019936542 0.02707901 GO BP GO:0070887 cellular response to chemical stimulus Neg Neg Neg 0.02954075 0.0063133 0.007483719 GO BP GO:0070925 organelle assembly Pos Pos 0.009842341 0.004744173 GO BP GO:0070972 protein localization to endoplasmic reticulum Pos Pos 0.036090737 0.025431287 GO BP GO:0071025 RNA surveillance Pos Pos Pos 0.032379264 0.006769442 0.00089385 GO BP GO:0071103 DNA conformation change Pos Pos Pos 0.005241068 0.007883362 0.000226167 GO BP GO:0071166 ribonucleoprotein complex localization Pos Pos Pos 0.002056505 1.04E-05 4.00E-05 GO BP GO:0071241 cellular response to inorganic substance Neg 0.030183571 GO BP GO:0071248 cellular response to metal ion Neg 0.030183571 GO BP GO:0071277 cellular response to calcium ion Neg Neg 0.029412226 0.037240874 GO BP GO:0071310 cellular response to organic substance Neg 0.036119401 GO BP GO:0071396 cellular response to lipid Pos 0.013423894 GO BP GO:0071426 ribonucleoprotein complex export from nucleus Pos Pos Pos 0.002056505 1.04E-05 4.00E-05 GO BP GO:0071427 mRNA-containing ribonucleoprotein complex export from nucleus Pos Pos 0.0047759 0.008345541 GO BP GO:0071495 cellular response to endogenous stimulus Neg 0.03260908 GO BP GO:0071526 semaphorin-plexin signaling pathway Pos 0.035380124 GO BP GO:0071616 acyl-CoA biosynthetic process Neg 0.02954075 GO BP GO:0071695 anatomical structure maturation Pos 0.004909151 GO BP GO:0071805 potassium ion transmembrane transport Pos Neg Neg 0.024444201 0.025687813 0.017780471 GO BP GO:0071824 protein-DNA complex subunit organization Neg Neg Pos Pos Pos 0.044978014 0.048066154 0.000134033 0.00010981 3.37E-06 GO BP GO:0071826 ribonucleoprotein complex subunit organization Pos Pos Pos 0.000235827 6.66E-06 1.85E-08 GO BP GO:0071867 response to monoamine Pos 0.016890371 GO BP GO:0071868 cellular response to monoamine stimulus Pos 0.016890371 GO BP GO:0071869 response to catecholamine Pos 0.016890371 GO BP GO:0071870 cellular response to catecholamine stimulus Pos 0.016890371 GO BP GO:0071897 DNA biosynthetic process Pos Pos Pos 0.000713538 0.025228717 0.020786734 GO BP GO:0072330 monocarboxylic acid biosynthetic process Pos Pos 0.010944973 0.006732808 GO BP GO:0072359 circulatory system development Pos 0.000828468 GO BP GO:0072521 purine-containing compound metabolic process Neg 0.015112535 GO BP GO:0072522 purine-containing compound biosynthetic process Neg 0.031491113 GO BP GO:0072527 pyrimidine-containing compound metabolic process Pos Pos Pos 0.030740017 0.004383493 0.029005435 GO BP GO:0072528 pyrimidine-containing compound biosynthetic process Neg Pos 0.021776137 0.005986015 GO BP GO:0072594 establishment of protein localization to organelle Pos Pos 0.00052122 0.000632995 GO BP GO:0072655 establishment of protein localization to mitochondrion Neg Pos Pos 0.022492803 0.000536597 0.00066776 GO BP GO:0090068 positive regulation of cell cycle process Pos Pos Pos 3.53E-05 4.22E-05 2.88E-07 GO BP GO:0090305 nucleic acid phosphodiester bond hydrolysis Pos Pos Pos 0.01149283 0.007883362 0.000547826 GO BP GO:0090501 RNA phosphodiester bond hydrolysis Neg Pos Pos 0.014567459 0.017819442 0.001729897 GO BP GO:0090596 sensory organ morphogenesis Pos Pos 0.001890413 0.03008341 GO BP GO:0097120 receptor localization to synapse Pos 0.024480663 GO BP GO:0097485 neuron projection guidance Pos 4.39E-09 GO BP GO:0097746 regulation of blood vessel diameter Neg 0.049415918 GO BP GO:0097756 negative regulation of blood vessel diameter Neg 0.047784666 GO BP GO:0098542 defense response to other organism Neg 0.031491113 GO BP GO:0098609 cell-cell adhesion Pos Neg Neg 4.21E-06 0.018696874 0.006667603 GO BP GO:0098655 cation transmembrane transport Neg Neg 0.041251011 0.003661154 GO BP GO:0098657 import into cell Neg Neg Neg 0.046446033 0.024994723 0.00699853 GO BP GO:0098659 inorganic cation import across plasma membrane Pos 0.038124013 GO BP GO:0098660 inorganic ion transmembrane transport Neg Neg 0.022511284 0.003579074 GO BP GO:0098662 inorganic cation transmembrane transport Neg 0.007191661 GO BP GO:0098732 macromolecule deacylation Pos 0.003198678 GO BP GO:0098739 import across plasma membrane Pos 0.043081513 GO BP GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules Pos Neg 2.00E-05 0.008763978 GO BP GO:0098813 nuclear chromosome segregation Neg Neg Pos Pos Pos 0.004244732 0.00137909 7.39E-07 8.55E-09 9.24E-12 GO BP GO:0098916 anterograde trans-synaptic signaling Pos Pos Neg Neg 0.000326407 0.034623732 0.00021599 0.000932093 GO BP GO:0099003 vesicle-mediated transport in synapse Pos 0.049234393 GO BP GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels Pos 0.041327993 GO BP GO:0099177 regulation of trans-synaptic signaling Neg Neg 0.020003195 0.042001007 GO BP GO:0099504 synaptic vesicle cycle Pos 0.049234393 GO BP GO:0099536 synaptic signaling Pos Neg Neg 0.00015542 2.48E-05 0.000932093 GO BP GO:0099537 trans-synaptic signaling Pos Pos Neg Neg 0.000326407 0.043425146 0.000187019 0.000973588 GO BP GO:0099587 inorganic ion import across plasma membrane Pos 0.038124013 GO BP GO:0120035 regulation of plasma membrane bounded cell projection organization Pos 0.001077032 GO BP GO:0120036 plasma membrane bounded cell projection organization Pos 0.000115415 GO BP GO:0120039 plasma membrane bounded cell projection morphogenesis Pos 8.32E-09 GO BP GO:0140013 meiotic nuclear division Pos Pos Pos 0.00228584 0.005987025 0.002221063 GO BP GO:0140014 mitotic nuclear division Neg Pos Pos Pos 0.045089169 2.57E-08 1.25E-07 4.39E-11 GO BP GO:0140053 mitochondrial gene expression Neg Pos Pos 0.000180514 0.013819343 0.029392559 GO BP GO:0140352 export from cell Neg 0.036473312 GO BP GO:0150063 visual system development Pos Pos Pos 0.003531603 0.019606494 0.017289794 GO BP GO:0198738 cell-cell signaling by wnt Pos Neg Neg 0.012050622 0.023856502 0.024286287 GO BP GO:1901135 carbohydrate derivative metabolic process Neg 0.003034998 GO BP GO:1901136 carbohydrate derivative catabolic process Neg 0.002025267 GO BP GO:1901137 carbohydrate derivative biosynthetic process Neg 0.036526288 GO BP GO:1901293 nucleoside phosphate biosynthetic process Neg 0.018241875 GO BP GO:1901361 organic cyclic compound catabolic process Pos Pos 0.02723366 0.030125655 GO BP GO:1901568 fatty acid derivative metabolic process Neg Neg 0.048956844 0.034371272 GO BP GO:1901570 fatty acid derivative biosynthetic process Neg Neg 0.049732233 0.029765998 GO BP GO:1901605 alpha-amino acid metabolic process Pos 0.034736755 GO BP GO:1901607 alpha-amino acid biosynthetic process Neg Pos 0.046921534 0.038210997 GO BP GO:1901615 organic hydroxy compound metabolic process Pos Pos Pos 0.033282469 0.019936542 0.003114785 GO BP GO:1901617 organic hydroxy compound biosynthetic process Pos Pos Pos 0.035718343 0.016417414 0.003366555 GO BP GO:1901661 quinone metabolic process Neg 0.025807216 GO BP GO:1901663 quinone biosynthetic process Neg 0.025807216 GO BP GO:1901888 regulation of cell junction assembly Pos 0.032225796 GO BP GO:1901987 regulation of cell cycle phase transition Pos Pos Pos 5.84E-07 2.13E-07 5.77E-09 GO BP GO:1901988 negative regulation of cell cycle phase transition Pos Pos Pos 0.00023845 0.003598643 0.000947094 GO BP GO:1901989 positive regulation of cell cycle phase transition Pos Pos 0.042400853 0.002942233 GO BP GO:1901990 regulation of mitotic cell cycle phase transition Pos Pos Pos 8.81E-07 1.05E-06 4.60E-08 GO BP GO:1901991 negative regulation of mitotic cell cycle phase transition Pos Pos Pos 0.000291405 0.005126785 0.001358141 GO BP GO:1901992 positive regulation of mitotic cell cycle phase transition Pos Pos Pos 0.046311709 0.021692461 0.001729985 GO BP GO:1902099 regulation of metaphase/anaphase transition of cell cycle Neg Pos Pos Pos 0.04027929 0.002122532 1.57E-05 1.90E-06 GO BP GO:1902414 protein localization to cell junction Pos Neg 0.019425765 0.042001007 GO BP GO:1902532 negative regulation of intracellular signal transduction Neg 0.045739882 GO BP GO:1902600 proton transmembrane transport Neg Pos 0.005050383 0.034515625 GO BP GO:1902652 secondary alcohol metabolic process Pos Pos Pos 0.008868681 0.005674266 0.007131588 GO BP GO:1902653 secondary alcohol biosynthetic process Pos Pos Pos 0.031456027 0.027199376 0.025431287 GO BP GO:1902679 negative regulation of RNA biosynthetic process Pos 0.005470661 GO BP GO:1902680 positive regulation of RNA biosynthetic process Pos 0.026870707 GO BP GO:1902749 regulation of cell cycle G2/M phase transition Pos Pos Pos 0.006974129 0.035917492 0.00389317 GO BP GO:1902850 microtubule cytoskeleton organization involved in mitosis Pos 0.007413082 GO BP GO:1903046 meiotic cell cycle process Neg Pos Pos Pos 0.032563921 1.16E-05 7.14E-05 7.06E-06 GO BP GO:1903047 mitotic cell cycle process Pos Pos Pos 1.24E-10 4.09E-07 2.65E-11 GO BP GO:1903305 regulation of regulated secretory pathway Neg 0.047340573 GO BP GO:1903313 positive regulation of mRNA metabolic process Pos 0.041714804 GO BP GO:1903350 response to dopamine Pos 0.016890371 GO BP GO:1903351 cellular response to dopamine Pos 0.016890371 GO BP GO:1903507 negative regulation of nucleic acid-templated transcription Pos 0.005470661 GO BP GO:1903508 positive regulation of nucleic acid-templated transcription Pos 0.026870707 GO BP GO:1903530 regulation of secretion by cell Neg 0.024682327 GO BP GO:1903539 protein localization to postsynaptic membrane Pos 0.041327993 GO BP GO:1904062 regulation of cation transmembrane transport Neg 0.029834792 GO BP GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling Pos Neg Neg 0.015187829 0.030439846 0.024286287 GO BP GO:1905818 regulation of chromosome separation Pos Pos Pos 0.00071619 3.84E-06 2.88E-07 GO BP GO:1990542 mitochondrial transmembrane transport Pos Pos 0.023452073 0.029207691 GO BP GO:1990778 protein localization to cell periphery Pos 0.036147564 GO BP GO:2000026 regulation of multicellular organismal development Pos 0.003004889 GO BP GO:2000113 negative regulation of cellular macromolecule biosynthetic process Pos 0.00179325 GO BP GO:2000145 regulation of cell motility Pos 0.007782636 GO BP GO:2001056 positive regulation of cysteine-type endopeptidase activity Pos 0.019425765 GO BP GO:2001251 negative regulation of chromosome organization Pos Pos Pos 0.003833626 0.043311304 0.002541634 GO CC GO:0000178 exosome (RNase complex) Pos Pos 0.035826618 0.014054092 GO CC GO:0000228 nuclear chromosome Pos Pos 0.004440769 0.017540412 GO CC GO:0000307 cyclin-dependent protein kinase holoenzyme complex Pos 0.014054092 GO CC GO:0000313 organellar ribosome Neg Pos Pos 2.19E-09 9.55E-09 7.60E-05 GO CC GO:0000314 organellar small ribosomal subunit Neg Pos Pos 0.011185711 0.004775883 0.01443312 GO CC GO:0000315 organellar large ribosomal subunit Neg Pos Pos 2.42E-06 5.81E-06 0.003044893 GO CC GO:0000323 lytic vacuole Neg 0.001862614 GO CC GO:0000428 DNA-directed RNA polymerase complex Neg Pos Pos Pos 0.027445016 0.037023382 1.06E-06 2.63E-05 GO CC GO:0000502 proteasome complex Neg Pos Pos Pos 4.83E-05 0.003042196 1.49E-11 7.57E-11 GO CC GO:0000775 "chromosome, centromeric region" Neg Neg Pos Pos Pos 0.003383002 0.000856165 2.54E-09 8.17E-11 2.65E-11 GO CC GO:0000776 kinetochore Neg Pos Pos Pos 0.015683288 4.91E-06 1.59E-07 9.51E-07 GO CC GO:0000777 condensed chromosome kinetochore Neg Pos Pos Pos 0.039796941 0.000556252 0.000221737 0.002413815 GO CC GO:0000779 "condensed chromosome, centromeric region" Neg Neg Pos Pos Pos 0.034403429 0.016722198 2.06E-05 4.55E-06 2.60E-05 GO CC GO:0000793 condensed chromosome Neg Neg Pos Pos Pos 0.007091463 0.010672988 2.71E-07 1.56E-07 6.37E-07 GO CC GO:0000794 condensed nuclear chromosome Neg Neg Pos Pos Pos 0.007047132 0.011645312 4.15E-06 2.02E-06 1.55E-06 GO CC GO:0000932 P-body Pos 0.014642526 GO CC GO:0005576 extracellular region Neg Neg 6.75E-07 0.000712799 GO CC GO:0005615 extracellular space Neg Neg 0.000247986 0.003786436 GO CC GO:0005635 nuclear envelope Pos 0.040434826 GO CC GO:0005643 nuclear pore Pos Pos Pos 0.004857567 8.30E-06 1.17E-05 GO CC GO:0005654 nucleoplasm Pos Pos Pos 1.31E-05 1.53E-06 6.03E-09 GO CC GO:0005657 replication fork Neg Pos Pos Pos 0.045089169 6.42E-06 1.08E-05 6.79E-07 GO CC GO:0005665 "RNA polymerase II, core complex" Neg Pos Pos 0.048956844 0.000279642 0.004744173 GO CC GO:0005666 RNA polymerase III complex Neg Pos Pos 0.037742567 0.00521822 0.011296923 GO CC GO:0005667 transcription regulator complex Pos 0.008871368 GO CC GO:0005681 spliceosomal complex Neg Pos Pos Pos 0.000272218 0.000574421 6.17E-08 6.62E-08 GO CC GO:0005684 U2-type spliceosomal complex Neg Pos Pos Pos 0.022177107 0.008105671 5.76E-05 3.89E-05 GO CC GO:0005685 U1 snRNP Pos Pos Pos 0.001672328 4.24E-05 0.000243053 GO CC GO:0005686 U2 snRNP Neg Pos Pos Pos 0.016910453 0.028690935 6.80E-06 5.87E-05 GO CC GO:0005689 U12-type spliceosomal complex Pos 0.014113873 GO CC GO:0005694 chromosome Neg Pos Pos Pos 0.011067439 6.67E-07 0.00353784 3.38E-05 GO CC GO:0005730 nucleolus Neg Neg Pos Pos Pos 0.030751755 0.002821175 7.37E-12 1.18E-17 1.29E-17 GO CC GO:0005732 small nucleolar ribonucleoprotein complex Pos Pos Pos 0.015276626 0.002725941 0.001047576 GO CC GO:0005736 RNA polymerase I complex Pos Pos 0.004558056 0.014054092 GO CC GO:0005740 mitochondrial envelope Neg Pos Pos 2.19E-09 3.13E-10 4.83E-05 GO CC GO:0005743 mitochondrial inner membrane Neg Pos Pos 2.31E-07 2.37E-09 3.26E-05 GO CC GO:0005746 mitochondrial respirasome Neg Neg Pos Pos 6.40E-09 0.040528365 8.38E-07 0.006838063 GO CC GO:0005747 mitochondrial respiratory chain complex I Neg Pos 0.000166657 1.95E-05 GO CC GO:0005751 mitochondrial respiratory chain complex IV Neg 0.018583032 GO CC GO:0005758 mitochondrial intermembrane space Pos Pos 0.021277248 0.034736755 GO CC GO:0005759 mitochondrial matrix Neg Pos Pos 6.42E-08 3.99E-07 0.000352769 GO CC GO:0005761 mitochondrial ribosome Neg Pos Pos 2.19E-09 9.55E-09 7.60E-05 GO CC GO:0005762 mitochondrial large ribosomal subunit Neg Pos Pos 2.42E-06 5.81E-06 0.003044893 GO CC GO:0005763 mitochondrial small ribosomal subunit Neg Pos Pos 0.011185711 0.004775883 0.01443312 GO CC GO:0005764 lysosome Neg 0.001862614 GO CC GO:0005765 lysosomal membrane Neg Neg 0.026535719 0.008095644 GO CC GO:0005768 endosome Neg Neg 0.037340143 0.004775346 GO CC GO:0005773 vacuole Neg Neg 0.000161383 0.011868679 GO CC GO:0005774 vacuolar membrane Neg Neg Neg 0.011253488 0.001773054 0.009883514 GO CC GO:0005776 autophagosome Neg 0.032713998 GO CC GO:0005783 endoplasmic reticulum Pos Pos Pos 0.042509801 0.000847404 0.002413815 GO CC GO:0005788 endoplasmic reticulum lumen Pos Pos 0.036652802 0.0347339 GO CC GO:0005789 endoplasmic reticulum membrane Pos Pos 0.000189716 0.000168416 GO CC GO:0005798 Golgi-associated vesicle Pos 0.019083114 GO CC GO:0005813 centrosome Pos Pos Pos 0.002817746 0.043311304 0.000871023 GO CC GO:0005819 spindle Pos Pos 0.041332611 0.002863148 GO CC GO:0005829 cytosol Pos Pos 0.007333438 0.025407914 GO CC GO:0005838 proteasome regulatory particle Neg Pos Pos 0.015683288 2.32E-05 1.13E-05 GO CC GO:0005839 proteasome core complex Neg Pos Pos 0.005316294 7.14E-06 9.97E-05 GO CC GO:0005840 ribosome Pos Pos Pos 0.002435663 0.003119339 0.000749021 GO CC GO:0005856 cytoskeleton Pos Pos 0.027468964 0.037198896 GO CC GO:0005874 microtubule Pos Pos Pos 0.000945234 1.75E-05 7.40E-05 GO CC GO:0005875 microtubule associated complex Pos 0.03885248 GO CC GO:0005887 integral component of plasma membrane Pos Neg Neg Neg 0.000978157 2.06E-06 7.79E-10 8.24E-13 GO CC GO:0008021 synaptic vesicle Pos 0.044039643 GO CC GO:0008076 voltage-gated potassium channel complex Pos Neg 0.035170195 0.045964417 GO CC GO:0008328 ionotropic glutamate receptor complex Neg 0.016722527 GO CC GO:0009898 cytoplasmic side of plasma membrane Pos 0.025383715 GO CC GO:0014069 postsynaptic density Pos 0.012303217 GO CC GO:0015630 microtubule cytoskeleton Pos Pos Pos 0.001889429 0.000177234 1.13E-05 GO CC GO:0015934 large ribosomal subunit Pos Pos Pos 0.01101215 0.026878995 0.004636817 GO CC GO:0016469 proton-transporting two-sector ATPase complex Neg Pos 0.005050383 0.043311304 GO CC GO:0016591 "RNA polymerase II, holoenzyme" Pos Pos 4.90E-05 0.001484821 GO CC GO:0016592 mediator complex Pos Pos Pos 0.032379264 0.012721918 0.027356381 GO CC GO:0016604 nuclear body Pos 0.033838024 GO CC GO:0017053 transcription repressor complex Pos Pos 0.041315548 0.015736609 GO CC GO:0019866 organelle inner membrane Neg Pos Pos 8.04E-07 6.17E-09 3.54E-05 GO CC GO:0019897 extrinsic component of plasma membrane Pos 0.011512121 GO CC GO:0022624 proteasome accessory complex Neg Pos Pos 0.004995758 9.30E-06 7.25E-06 GO CC GO:0022625 cytosolic large ribosomal subunit Pos Pos 5.88E-06 0.007133998 GO CC GO:0022626 cytosolic ribosome Pos 4.21E-06 GO CC GO:0022627 cytosolic small ribosomal subunit Pos 0.030268064 GO CC GO:0030018 Z disc Pos 0.04125566 GO CC GO:0030054 cell junction Pos Pos Neg Neg Neg 0.02040123 0.012981183 0.010727689 0.041274971 0.000402956 GO CC GO:0030134 COPII-coated ER to Golgi transport vesicle Pos 0.043311304 GO CC GO:0030135 coated vesicle Pos 0.049399835 GO CC GO:0030176 integral component of endoplasmic reticulum membrane Pos Pos 0.00252057 0.01310215 GO CC GO:0030424 axon Pos Pos Neg 0.008659305 0.006896123 0.001713745 GO CC GO:0030532 small nuclear ribonucleoprotein complex Neg Pos Pos Pos 0.00049208 0.000809752 3.86E-09 5.41E-08 GO CC GO:0030684 preribosome Pos Pos Pos 3.79E-09 1.18E-10 9.30E-10 GO CC GO:0030686 90S preribosome Pos Pos Pos 0.000137072 1.50E-05 5.77E-05 GO CC GO:0030687 "preribosome, large subunit precursor" Pos Pos Pos 0.001766132 0.000122181 0.00061788 GO CC GO:0030880 RNA polymerase complex Neg Pos Pos Pos 0.027445016 0.037023382 1.06E-06 2.63E-05 GO CC GO:0030894 replisome Pos Pos Pos 0.01149283 0.001646731 0.001371467 GO CC GO:0030964 NADH dehydrogenase complex Neg Pos 0.000166657 1.95E-05 GO CC GO:0031226 intrinsic component of plasma membrane Pos Neg Neg Neg 0.00013655 5.59E-06 4.39E-10 1.56E-12 GO CC GO:0031227 intrinsic component of endoplasmic reticulum membrane Pos Pos 0.00276308 0.015736609 GO CC GO:0031234 extrinsic component of cytoplasmic side of plasma membrane Pos 0.039684092 GO CC GO:0031252 cell leading edge Pos Neg 0.000537939 0.040451842 GO CC GO:0031256 leading edge membrane Pos Neg 0.012981183 0.037240874 GO CC GO:0031300 intrinsic component of organelle membrane Pos Pos 0.004977516 0.004733685 GO CC GO:0031301 integral component of organelle membrane Pos Pos 0.004640979 0.003987792 GO CC GO:0031304 intrinsic component of mitochondrial inner membrane Pos Pos 0.027874692 0.048529474 GO CC GO:0031305 integral component of mitochondrial inner membrane Pos 0.036652802 GO CC GO:0031410 cytoplasmic vesicle Neg Neg 0.02954075 0.001502303 GO CC GO:0031674 I band Pos 0.026882585 GO CC GO:0031966 mitochondrial membrane Neg Pos Pos 7.31E-09 2.23E-09 0.000169532 GO CC GO:0031967 organelle envelope Neg Pos Pos 3.71E-10 1.00E-10 9.82E-07 GO CC GO:0031970 organelle envelope lumen Pos Pos 0.021277248 0.034736755 GO CC GO:0031975 envelope Neg Pos Pos 3.71E-10 1.00E-10 9.82E-07 GO CC GO:0031982 vesicle Neg Neg 0.020003195 0.000932093 GO CC GO:0032040 small-subunit processome Pos Pos Pos 1.31E-05 6.27E-06 6.54E-06 GO CC GO:0032279 asymmetric synapse Pos 0.016460866 GO CC GO:0032281 AMPA glutamate receptor complex Neg 0.042001007 GO CC GO:0032592 integral component of mitochondrial membrane Pos 0.03503761 GO CC GO:0032806 carboxy-terminal domain protein kinase complex Pos Pos 0.040263421 0.037198896 GO CC GO:0032993 protein-DNA complex Neg Neg Pos Pos Pos 0.033603673 0.031166743 0.006974129 0.013366613 0.004744173 GO CC GO:0033176 proton-transporting V-type ATPase complex Neg 0.01386732 GO CC GO:0033178 "proton-transporting two-sector ATPase complex, catalytic domain" Neg 0.019930074 GO CC GO:0034702 ion channel complex Neg Neg Neg 0.011942808 0.026825156 3.62E-05 GO CC GO:0034703 cation channel complex Pos Neg Neg Neg 0.033144393 0.019808083 0.013550844 7.36E-05 GO CC GO:0034705 potassium channel complex Pos Neg 0.010427946 0.016722527 GO CC GO:0035770 ribonucleoprotein granule Pos 0.034623732 GO CC GO:0036464 cytoplasmic ribonucleoprotein granule Pos 0.025383715 GO CC GO:0036477 somatodendritic compartment Pos Neg 0.039448723 0.011605931 GO CC GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network Pos Pos 0.00016905 0.000147662 GO CC GO:0042575 DNA polymerase complex Pos Pos Pos 0.01149283 0.015664011 0.014331619 GO CC GO:0042995 cell projection Pos Pos Neg Neg Neg 0.003033097 0.00105592 0.000495051 0.000603749 7.17E-07 GO CC GO:0043005 neuron projection Pos Pos Neg Neg Neg 3.38E-05 5.40E-05 9.66E-05 0.002013798 2.81E-07 GO CC GO:0043197 dendritic spine Pos 0.032653607 GO CC GO:0043235 receptor complex Pos Neg Neg Neg 0.001242719 0.0055553 0.000301251 5.87E-06 GO CC GO:0043596 nuclear replication fork Pos Pos Pos 0.003095322 0.000238923 0.000103906 GO CC GO:0043601 nuclear replisome Pos Pos Pos 0.01149283 0.001646731 0.001371467 GO CC GO:0044309 neuron spine Pos 0.032653607 GO CC GO:0044391 ribosomal subunit Pos Pos Pos 0.0061107 0.030922495 0.00584576 GO CC GO:0045202 synapse Pos Pos Neg Neg Neg 0.000326407 0.001835902 0.003268079 0.041274971 8.94E-05 GO CC GO:0045211 postsynaptic membrane Pos Neg Neg Neg 0.035391709 0.020003195 0.016211624 0.000285742 GO CC GO:0045271 respiratory chain complex I Neg Pos 0.000166657 1.95E-05 GO CC GO:0045277 respiratory chain complex IV Neg 0.046741699 GO CC GO:0046540 U4/U6 x U5 tri-snRNP complex Pos Pos Pos 0.044960745 0.00103401 0.000632995 GO CC GO:0055029 nuclear DNA-directed RNA polymerase complex Neg Pos Pos Pos 0.027445016 0.037023382 1.06E-06 2.63E-05 GO CC GO:0061695 "transferase complex, transferring phosphorus-containing groups" Pos Pos Pos 0.028453194 0.000219042 0.000229217 GO CC GO:0070069 cytochrome complex Neg Pos 0.008608862 0.031111034 GO CC GO:0070382 exocytic vesicle Pos 0.035797199 GO CC GO:0070469 respirasome Neg Pos Pos 6.42E-08 1.79E-06 0.01443312 GO CC GO:0071011 precatalytic spliceosome Pos Pos Pos 0.033282469 0.00016905 0.000386862 GO CC GO:0071013 catalytic step 2 spliceosome Pos Pos Pos 0.0010351 7.62E-06 1.08E-05 GO CC GO:0072686 mitotic spindle Pos Pos 0.033596351 0.03787059 GO CC GO:0090575 RNA polymerase II transcription regulator complex Pos Pos Pos 0.002749874 0.007325897 0.006732808 GO CC GO:0097060 synaptic membrane Neg Neg Neg 0.011605931 0.023315813 0.000412295 GO CC GO:0097525 spliceosomal snRNP complex Neg Pos Pos Pos 0.001033018 0.000508259 5.29E-09 7.47E-08 GO CC GO:0097526 spliceosomal tri-snRNP complex Neg Pos Pos Pos 0.039667769 0.013713208 3.56E-05 3.96E-05 GO CC GO:0097708 intracellular vesicle Neg Neg 0.02954075 0.001502303 GO CC GO:0098552 side of membrane Neg 0.041274971 GO CC GO:0098562 cytoplasmic side of membrane Pos 0.029638034 GO CC GO:0098573 intrinsic component of mitochondrial membrane Pos 0.026882585 GO CC GO:0098588 bounding membrane of organelle Neg 0.017056474 GO CC GO:0098590 plasma membrane region Neg Neg Neg 0.013370325 0.003752122 3.86E-06 GO CC GO:0098687 chromosomal region Neg Neg Pos Pos Pos 0.00387201 0.000422907 3.04E-08 3.27E-10 5.05E-11 GO CC GO:0098794 postsynapse Pos Pos Neg Neg Neg 0.005489084 0.000537939 0.01776325 0.01336596 0.000542479 GO CC GO:0098796 membrane protein complex Neg Pos 0.001373477 0.029839742 GO CC GO:0098797 plasma membrane protein complex Pos Neg Neg 0.024941008 0.0063133 1.55E-05 GO CC GO:0098798 mitochondrial protein complex Neg Neg Pos Pos 1.49E-16 0.000245634 9.34E-15 1.68E-07 GO CC GO:0098800 inner mitochondrial membrane protein complex Neg Neg Pos Pos 4.66E-09 0.014981446 4.26E-08 0.001484821 GO CC GO:0098802 plasma membrane signaling receptor complex Neg Neg 0.04238438 0.002288028 GO CC GO:0098803 respiratory chain complex Neg Pos Pos 3.10E-07 4.36E-06 0.020890415 GO CC GO:0098805 whole membrane Neg Neg 0.011167847 0.022921705 GO CC GO:0098852 lytic vacuole membrane Neg Neg 0.026535719 0.008095644 GO CC GO:0098878 neurotransmitter receptor complex Neg 0.016722527 GO CC GO:0098984 neuron to neuron synapse Pos 0.016460866 GO CC GO:0099080 supramolecular complex Pos Pos Pos 2.03E-06 9.67E-09 4.66E-08 GO CC GO:0099081 supramolecular polymer Pos Pos Pos 0.003095322 1.58E-05 9.36E-05 GO CC GO:0099512 supramolecular fiber Pos Pos Pos 0.002349514 1.16E-05 5.09E-05 GO CC GO:0099513 polymeric cytoskeletal fiber Pos Pos Pos 0.006605888 8.68E-05 0.000458399 GO CC GO:0099572 postsynaptic specialization Pos 0.008024394 GO CC GO:0120025 plasma membrane bounded cell projection Pos Pos Neg Neg Neg 0.000342442 1.77E-05 0.003786436 0.002170884 3.86E-06 GO CC GO:0120114 Sm-like protein family complex Neg Pos Pos Pos 0.000121817 7.77E-05 3.27E-10 1.44E-08 GO CC GO:1902494 catalytic complex Neg Neg Pos Pos Pos 7.47E-06 0.040528365 0.002357061 5.72E-14 3.26E-13 GO CC GO:1902495 transmembrane transporter complex Pos Neg Neg Neg 0.048320769 0.018552989 0.034179085 6.07E-05 GO CC GO:1902554 serine/threonine protein kinase complex Pos Pos 0.029770998 0.00584576 GO CC GO:1902911 protein kinase complex Pos 0.043618124 GO CC GO:1905354 exoribonuclease complex Pos Pos 0.035826618 0.014054092 GO CC GO:1905368 peptidase complex Neg Pos Pos Pos 3.67E-06 0.011525501 4.02E-11 4.41E-10 GO CC GO:1905369 endopeptidase complex Neg Pos Pos Pos 5.42E-05 0.005182957 2.67E-11 1.75E-10 GO CC GO:1990204 oxidoreductase complex Neg Pos Pos 1.28E-08 5.58E-08 0.002758969 GO CC GO:1990234 transferase complex Pos Pos 0.001182915 0.00105719 GO CC GO:1990351 transporter complex Neg Neg 0.016155766 0.000925819 GO CC GO:1990904 ribonucleoprotein complex Pos Pos Pos 3.39E-13 3.56E-16 1.46E-17 GO MF GO:0000030 mannosyltransferase activity Neg 0.017976233 GO MF GO:0000976 transcription regulatory region sequence-specific DNA binding Pos Neg 0.001996097 0.007493667 GO MF GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding Pos Neg 0.007617676 0.018243941 GO MF GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding Pos Neg Neg 0.000397703 0.0063133 0.048806155 GO MF GO:0000981 "DNA-binding transcription factor activity, RNA polymerase II-specific" Pos Neg 0.001426864 0.011159969 GO MF GO:0000987 cis-regulatory region sequence-specific DNA binding Pos Neg Neg 0.000202198 0.005491582 0.047901928 GO MF GO:0001067 regulatory region nucleic acid binding Pos Neg 0.001996097 0.007493667 GO MF GO:0001216 DNA-binding transcription activator activity Pos Neg Neg 0.048166931 0.041274971 0.047881436 GO MF GO:0001228 "DNA-binding transcription activator activity, RNA polymerase II-specific" Pos Neg Neg 0.048166931 0.041274971 0.047881436 GO MF GO:0001653 peptide receptor activity Neg Neg Neg 0.00511674 0.01336596 0.006671587 GO MF GO:0001664 G protein-coupled receptor binding Neg 0.003268079 GO MF GO:0003678 DNA helicase activity Pos Pos Pos 0.041332611 0.00456806 0.000755801 GO MF GO:0003682 chromatin binding Pos Pos 0.036352679 0.045820513 GO MF GO:0003688 DNA replication origin binding Pos Pos Pos 1.27E-05 4.50E-05 9.57E-07 GO MF GO:0003690 double-stranded DNA binding Pos 0.007709636 GO MF GO:0003697 single-stranded DNA binding Pos Pos Pos 1.04E-07 3.93E-08 1.11E-09 GO MF GO:0003700 DNA-binding transcription factor activity Pos Neg 0.000611333 0.012380413 GO MF GO:0003707 steroid hormone receptor activity Pos Neg Neg 0.019135617 0.006238888 0.003906429 GO MF GO:0003723 RNA binding Pos Pos Pos 5.27E-11 2.27E-08 1.03E-12 GO MF GO:0003735 structural constituent of ribosome Pos Pos Pos 1.97E-05 0.004977516 8.63E-05 GO MF GO:0003743 translation initiation factor activity Pos 0.044696786 GO MF GO:0003755 peptidyl-prolyl cis-trans isomerase activity Neg Pos 0.006699652 0.007681688 GO MF GO:0003887 DNA-directed DNA polymerase activity Pos 0.033063812 GO MF GO:0003899 DNA-directed 5'-3' RNA polymerase activity Neg Pos Pos Pos 0.018583032 0.02714363 8.42E-05 0.000632995 GO MF GO:0003954 NADH dehydrogenase activity Neg Pos 0.001676213 0.029646783 GO MF GO:0004129 cytochrome-c oxidase activity Neg 0.018583032 GO MF GO:0004298 threonine-type endopeptidase activity Neg Pos Pos 0.005316294 7.14E-06 9.97E-05 GO MF GO:0004386 helicase activity Pos Pos Pos 0.004698456 4.04E-05 1.32E-05 GO MF GO:0004497 monooxygenase activity Neg 0.04296078 GO MF GO:0004518 nuclease activity Neg Pos Pos Pos 0.032911304 0.00200233 0.041619638 0.000887913 GO MF GO:0004519 endonuclease activity Neg Pos Pos 0.039973624 0.02714363 0.038831719 GO MF GO:0004520 endodeoxyribonuclease activity Pos 0.035718343 GO MF GO:0004527 exonuclease activity Pos Pos Pos 0.004541771 0.030569243 0.00584576 GO MF GO:0004536 deoxyribonuclease activity Pos 0.011790604 GO MF GO:0004672 protein kinase activity Pos Pos 0.002218052 4.30E-07 GO MF GO:0004674 protein serine/threonine kinase activity Pos Pos 0.007602148 0.000115415 GO MF GO:0004693 cyclin-dependent protein serine/threonine kinase activity Pos Pos Pos 0.028848099 0.030909043 0.005903621 GO MF GO:0004713 protein tyrosine kinase activity Pos Neg Neg 0.001953853 0.034005429 0.017868944 GO MF GO:0004714 transmembrane receptor protein tyrosine kinase activity Pos Neg Neg 0.018434258 0.017403714 0.001276277 GO MF GO:0004721 phosphoprotein phosphatase activity Pos 0.00294015 GO MF GO:0004722 protein serine/threonine phosphatase activity Pos Neg 0.00179325 0.030439846 GO MF GO:0004812 aminoacyl-tRNA ligase activity Pos Pos 0.006206673 0.01443485 GO MF GO:0004842 ubiquitin-protein transferase activity Pos Neg 0.006532828 0.048806155 GO MF GO:0004879 nuclear receptor activity Pos Neg Neg 0.016890371 0.002328664 0.001713745 GO MF GO:0004888 transmembrane signaling receptor activity Pos Pos Neg Neg Neg 0.019354684 6.82E-05 7.87E-09 1.42E-13 8.90E-15 GO MF GO:0004930 G protein-coupled receptor activity Pos Neg Neg Neg 0.01602108 4.95E-07 7.48E-09 1.48E-08 GO MF GO:0005048 signal sequence binding Pos Pos 0.044641875 0.043688633 GO MF GO:0005085 guanyl-nucleotide exchange factor activity Pos 0.041744506 GO MF GO:0005088 Ras guanyl-nucleotide exchange factor activity Neg 0.041274971 GO MF GO:0005096 GTPase activator activity Pos 0.004226169 GO MF GO:0005102 signaling receptor binding Neg 0.000452572 GO MF GO:0005179 hormone activity Neg Neg Neg 0.000211002 0.014981446 0.001773054 GO MF GO:0005184 neuropeptide hormone activity Neg Neg Neg 0.001281525 0.040528365 0.003430312 GO MF GO:0005198 structural molecule activity Pos Pos Pos 0.000432876 2.62E-05 1.25E-06 GO MF GO:0005200 structural constituent of cytoskeleton Pos Pos 0.000382613 0.008693599 GO MF GO:0005215 transporter activity Pos 0.010195926 GO MF GO:0005216 ion channel activity Neg Neg Neg 0.001989743 0.007850203 1.83E-05 GO MF GO:0005230 extracellular ligand-gated ion channel activity Neg 0.006773915 GO MF GO:0005244 voltage-gated ion channel activity Neg 0.000542479 GO MF GO:0005249 voltage-gated potassium channel activity Pos Neg Neg 0.010727033 0.038537255 0.006372704 GO MF GO:0005261 cation channel activity Neg Neg Neg 0.003430312 0.008922044 3.70E-05 GO MF GO:0005267 potassium channel activity Pos Neg Neg 0.001486404 0.004261327 0.001653355 GO MF GO:0005319 lipid transporter activity Pos 0.019425765 GO MF GO:0005326 neurotransmitter transmembrane transporter activity Pos Pos 0.032245993 0.000978157 GO MF GO:0005342 organic acid transmembrane transporter activity Pos 0.001242719 GO MF GO:0005506 iron ion binding Neg Neg 0.032911304 0.001929941 GO MF GO:0005507 copper ion binding Neg 0.003250886 GO MF GO:0005524 ATP binding Pos Pos Pos Pos 0.012909266 0.001655614 0.02785147 0.004660258 GO MF GO:0008017 microtubule binding Pos 0.045944275 GO MF GO:0008047 enzyme activator activity Pos 0.026870707 GO MF GO:0008094 DNA-dependent ATPase activity Neg Neg Pos Pos Pos 0.026036509 0.028290956 5.28E-05 6.80E-06 2.53E-07 GO MF GO:0008135 "translation factor activity, RNA binding" Pos 0.04063659 GO MF GO:0008137 NADH dehydrogenase (ubiquinone) activity Neg Pos 0.008578128 0.043311304 GO MF GO:0008168 methyltransferase activity Neg Neg Pos Pos Pos 0.007970925 0.008578128 0.007133998 0.014272607 0.001667209 GO MF GO:0008170 N-methyltransferase activity Pos Pos Pos 0.009870588 0.044696786 0.013993125 GO MF GO:0008173 RNA methyltransferase activity Neg 0.048956844 GO MF GO:0008175 tRNA methyltransferase activity Neg 0.038710988 GO MF GO:0008194 UDP-glycosyltransferase activity Pos 0.026870707 GO MF GO:0008201 heparin binding Neg 0.031276969 GO MF GO:0008227 G protein-coupled amine receptor activity Neg Neg Neg 0.044433854 0.011246478 0.008898164 GO MF GO:0008236 serine-type peptidase activity Neg 0.005050383 GO MF GO:0008238 exopeptidase activity Neg 0.025101477 GO MF GO:0008242 omega peptidase activity Pos 0.041033657 GO MF GO:0008276 protein methyltransferase activity Pos 0.046410535 GO MF GO:0008324 cation transmembrane transporter activity Neg 0.003860408 GO MF GO:0008408 3'-5' exonuclease activity Pos Pos 0.017707561 0.042406583 GO MF GO:0008509 anion transmembrane transporter activity Pos 0.021139142 GO MF GO:0008514 organic anion transmembrane transporter activity Pos Pos Pos 0.032331185 0.036464316 0.025340565 GO MF GO:0008528 G protein-coupled peptide receptor activity Neg Neg Neg 0.00511674 0.01336596 0.006671587 GO MF GO:0008536 Ran GTPase binding Pos Pos 0.04247212 0.042104019 GO MF GO:0008757 S-adenosylmethionine-dependent methyltransferase activity Neg Pos Pos Pos 0.022384235 0.040532129 0.038107817 0.011567675 GO MF GO:0009055 electron transfer activity Neg Pos 0.000668276 0.000685853 GO MF GO:0009678 pyrophosphate hydrolysis-driven proton transmembrane transporter activity Neg 0.024167441 GO MF GO:0015002 heme-copper terminal oxidase activity Neg 0.018583032 GO MF GO:0015035 protein disulfide oxidoreductase activity Pos 0.027409387 GO MF GO:0015036 disulfide oxidoreductase activity Neg Pos 0.010831346 0.036090737 GO MF GO:0015078 proton transmembrane transporter activity Neg Pos 0.003607916 0.019660181 GO MF GO:0015079 potassium ion transmembrane transporter activity Pos Neg Neg 0.001217109 0.0063133 0.002406821 GO MF GO:0015081 sodium ion transmembrane transporter activity Pos 0.006886847 GO MF GO:0015171 amino acid transmembrane transporter activity Pos 7.52E-05 GO MF GO:0015179 L-amino acid transmembrane transporter activity Pos 0.012981183 GO MF GO:0015252 proton channel activity Neg 0.048956844 GO MF GO:0015267 channel activity Neg Neg Neg 0.003786436 0.018963982 6.07E-05 GO MF GO:0015276 ligand-gated ion channel activity Pos Neg Neg Neg 0.042440872 0.0225284 0.0063133 0.000412295 GO MF GO:0015291 secondary active transmembrane transporter activity Pos 0.000157378 GO MF GO:0015293 symporter activity Pos 0.002163555 GO MF GO:0015294 solute:cation symporter activity Pos 0.001699456 GO MF GO:0015318 inorganic molecular entity transmembrane transporter activity Pos Neg 0.031404447 0.015833066 GO MF GO:0015370 solute:sodium symporter activity Pos 0.012646802 GO MF GO:0016209 antioxidant activity Neg Neg 0.037310826 0.004170923 GO MF GO:0016247 channel regulator activity Neg 0.023528176 GO MF GO:0016278 lysine N-methyltransferase activity Pos 0.0380484 GO MF GO:0016279 protein-lysine N-methyltransferase activity Pos 0.0380484 GO MF GO:0016301 kinase activity Pos 1.37E-06 GO MF GO:0016409 palmitoyltransferase activity Pos 0.044430327 GO MF GO:0016417 S-acyltransferase activity Pos 0.033144393 GO MF GO:0016462 pyrophosphatase activity Pos Pos Pos 0.025979905 0.000611869 0.001358141 GO MF GO:0016491 oxidoreductase activity Neg Neg Pos Pos 0.000529701 1.57E-14 0.014272607 0.034736755 GO MF GO:0016614 "oxidoreductase activity, acting on CH-OH group of donors" Neg 0.001003702 GO MF GO:0016616 "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor" Neg 0.000433982 GO MF GO:0016627 "oxidoreductase activity, acting on the CH-CH group of donors" Neg 0.00101622 GO MF GO:0016651 "oxidoreductase activity, acting on NAD(P)H" Neg 5.33E-05 GO MF GO:0016655 "oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor" Neg Pos 0.008578128 0.043311304 GO MF GO:0016667 "oxidoreductase activity, acting on a sulfur group of donors" Neg 0.00814228 GO MF GO:0016675 "oxidoreductase activity, acting on a heme group of donors" Neg 0.018583032 GO MF GO:0016676 "oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor" Neg 0.018583032 GO MF GO:0016709 "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen" Pos 0.04063659 GO MF GO:0016741 "transferase activity, transferring one-carbon groups" Neg Neg Pos Pos Pos 0.004897553 0.012570384 0.002357061 0.010196063 0.000413959 GO MF GO:0016746 "transferase activity, transferring acyl groups" Pos 0.044430327 GO MF GO:0016765 "transferase activity, transferring alkyl or aryl (other than methyl) groups" Neg 0.028990823 GO MF GO:0016772 "transferase activity, transferring phosphorus-containing groups" Pos 0.000219516 GO MF GO:0016773 "phosphotransferase activity, alcohol group as acceptor" Pos Pos 0.001261192 1.33E-08 GO MF GO:0016779 nucleotidyltransferase activity Pos Pos Pos 0.008556107 0.000524145 0.00105719 GO MF GO:0016791 phosphatase activity Pos 0.015776383 GO MF GO:0016796 "exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters" Pos Pos 0.017309558 0.02326744 GO MF GO:0016817 "hydrolase activity, acting on acid anhydrides" Pos Pos Pos 0.017639547 0.000611869 0.001164828 GO MF GO:0016818 "hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides" Pos Pos Pos 0.019949968 0.000593312 0.001261718 GO MF GO:0016829 lyase activity Neg 0.036553118 GO MF GO:0016853 isomerase activity Neg Pos Pos Pos 0.000247986 0.005324508 1.01E-05 4.08E-06 GO MF GO:0016859 cis-trans isomerase activity Neg Pos 0.006699652 0.007681688 GO MF GO:0016860 intramolecular oxidoreductase activity Pos Pos 0.045668056 0.006144719 GO MF GO:0016866 intramolecular transferase activity Pos Pos 0.020261148 0.016823062 GO MF GO:0016874 ligase activity Neg Pos 0.00915163 0.048944944 GO MF GO:0016875 "ligase activity, forming carbon-oxygen bonds" Pos Pos 0.006206673 0.01443485 GO MF GO:0016887 ATPase activity Pos Pos Pos 2.88E-06 1.38E-06 6.79E-07 GO MF GO:0016893 "endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters" Pos 0.04789287 GO MF GO:0017016 Ras GTPase binding Pos 0.000428903 GO MF GO:0017048 Rho GTPase binding Pos 0.006896123 GO MF GO:0017069 snRNA binding Neg Pos Pos Pos 0.037144497 0.047726689 0.012762875 0.010381662 GO MF GO:0017111 nucleoside-triphosphatase activity Pos Pos 0.001044764 0.003076994 GO MF GO:0017171 serine hydrolase activity Neg 0.005050383 GO MF GO:0019199 transmembrane receptor protein kinase activity Pos Neg Neg 0.006889522 0.011187719 0.000968394 GO MF GO:0019205 nucleobase-containing compound kinase activity Pos Pos 0.031456027 0.049110295 GO MF GO:0019706 protein-cysteine S-palmitoyltransferase activity Pos 0.006654427 GO MF GO:0019707 protein-cysteine S-acyltransferase activity Pos 0.006654427 GO MF GO:0019787 ubiquitin-like protein transferase activity Pos 0.015384532 GO MF GO:0019829 ATPase-coupled cation transmembrane transporter activity Neg 0.022384235 GO MF GO:0019843 rRNA binding Pos Pos Pos 0.005577755 0.045162416 0.027394543 GO MF GO:0019900 kinase binding Neg 0.033918067 GO MF GO:0019901 protein kinase binding Neg 0.022921705 GO MF GO:0022803 passive transmembrane transporter activity Neg Neg Neg 0.003786436 0.018963982 6.07E-05 GO MF GO:0022824 transmitter-gated ion channel activity Neg 0.005204535 GO MF GO:0022832 voltage-gated channel activity Neg Neg 0.041274971 0.000297072 GO MF GO:0022834 ligand-gated channel activity Pos Neg Neg Neg 0.042440872 0.0225284 0.0063133 0.000412295 GO MF GO:0022835 transmitter-gated channel activity Neg 0.005204535 GO MF GO:0022836 gated channel activity Pos Neg Neg Neg 0.02211094 0.002834809 0.002283937 7.33E-07 GO MF GO:0022843 voltage-gated cation channel activity Pos Neg Neg 0.039684092 0.015302861 0.000384593 GO MF GO:0022857 transmembrane transporter activity Pos Neg 0.04557437 0.048811649 GO MF GO:0022890 inorganic cation transmembrane transporter activity Neg 0.003906429 GO MF GO:0030246 carbohydrate binding Neg 0.02311362 GO MF GO:0030276 clathrin binding Neg 0.035604475 GO MF GO:0030515 snoRNA binding Pos Pos Pos 0.006974129 0.000703454 0.000367379 GO MF GO:0030545 receptor regulator activity Neg Neg Neg 0.002924348 0.014981446 0.000343393 GO MF GO:0030546 signaling receptor activator activity Neg Neg Neg 0.003403039 0.014981446 0.000417985 GO MF GO:0030594 neurotransmitter receptor activity Neg Neg Neg 0.018985512 0.013550844 0.000914977 GO MF GO:0030695 GTPase regulator activity Pos 0.001931201 GO MF GO:0031267 small GTPase binding Pos 0.000334695 GO MF GO:0031683 G-protein beta/gamma-subunit complex binding Pos 0.028311367 GO MF GO:0032182 ubiquitin-like protein binding Pos Pos 0.044101355 0.042919799 GO MF GO:0034061 DNA polymerase activity Pos 0.033063812 GO MF GO:0034062 5'-3' RNA polymerase activity Neg Pos Pos Pos 0.018583032 0.02714363 8.42E-05 0.000632995 GO MF GO:0038023 signaling receptor activity Pos Pos Neg Neg Neg 0.002218052 2.29E-07 1.34E-10 1.54E-17 1.63E-18 GO MF GO:0042054 histone methyltransferase activity Pos Pos Pos 0.011662602 0.008590486 0.004636817 GO MF GO:0042393 histone binding Pos Pos Pos 0.017882303 0.03935936 0.013965467 GO MF GO:0042578 phosphoric ester hydrolase activity Pos 0.020715028 GO MF GO:0042625 ATPase-coupled ion transmembrane transporter activity Neg 0.022384235 GO MF GO:0043138 3'-5' DNA helicase activity Pos 0.03787059 GO MF GO:0043178 alcohol binding Pos 0.012981183 GO MF GO:0043565 sequence-specific DNA binding Pos 0.004666562 GO MF GO:0044769 "ATPase activity, coupled to transmembrane movement of ions, rotational mechanism" Neg 0.018583032 GO MF GO:0046873 metal ion transmembrane transporter activity Pos Pos Neg Neg 0.042776917 0.000256219 0.037527715 0.001502303 GO MF GO:0046943 carboxylic acid transmembrane transporter activity Pos 0.001264652 GO MF GO:0046961 "proton-transporting ATPase activity, rotational mechanism" Neg 0.018583032 GO MF GO:0046982 protein heterodimerization activity Pos 0.022978321 GO MF GO:0046983 protein dimerization activity Pos 0.02707901 GO MF GO:0048018 receptor ligand activity Neg Neg Neg 0.003403039 0.014981446 0.000417985 GO MF GO:0048038 quinone binding Pos 0.023125718 GO MF GO:0050136 NADH dehydrogenase (quinone) activity Neg Pos 0.008578128 0.043311304 GO MF GO:0051020 GTPase binding Pos 0.000162765 GO MF GO:0051082 unfolded protein binding Pos Pos Pos 0.009898575 0.000601132 0.000190298 GO MF GO:0051213 dioxygenase activity Neg 0.046357423 GO MF GO:0051536 iron-sulfur cluster binding Neg 0.002643362 GO MF GO:0051540 metal cluster binding Neg 0.002643362 GO MF GO:0060089 molecular transducer activity Pos Pos Neg Neg Neg 0.002218052 2.29E-07 1.34E-10 1.54E-17 1.63E-18 GO MF GO:0060589 nucleoside-triphosphatase regulator activity Pos 0.031327998 GO MF GO:0070003 threonine-type peptidase activity Neg Pos Pos Pos 0.032636177 0.017309558 6.58E-06 0.000116056 GO MF GO:0071855 neuropeptide receptor binding Neg Neg 0.000277771 0.001587392 GO MF GO:0097472 cyclin-dependent protein kinase activity Pos Pos Pos 0.028848099 0.030909043 0.005903621 GO MF GO:0097747 RNA polymerase activity Neg Pos Pos Pos 0.018583032 0.02714363 8.42E-05 0.000632995 GO MF GO:0098531 ligand-activated transcription factor activity Pos Neg Neg 0.016890371 0.002328664 0.001713745 GO MF GO:0098960 postsynaptic neurotransmitter receptor activity Neg 0.009298608 GO MF GO:0099094 ligand-gated cation channel activity Neg Neg 0.01336596 0.001401638 GO MF GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential Neg 0.021599914 GO MF GO:0140097 "catalytic activity, acting on DNA" Neg Pos Pos Pos 0.007047132 1.38E-06 0.000640597 2.62E-05 GO MF GO:0140098 "catalytic activity, acting on RNA" Neg Neg Pos Pos Pos 0.04955393 4.42E-05 0.00042055 3.37E-08 3.01E-08 GO MF GO:0140101 "catalytic activity, acting on a tRNA" Neg Pos Pos 0.00044114 0.004383493 0.003816157 GO MF GO:0140110 transcription regulator activity Pos 0.000963237 GO MF GO:0140142 nucleocytoplasmic carrier activity Pos Pos 0.002626193 0.001446979 GO MF GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Neg 0.021599914 GO MF GO:1990837 sequence-specific double-stranded DNA binding Pos 0.002357083 KEGG 10 Glycolysis / Gluconeogenesis Neg 0.000922772 KEGG 100 Steroid biosynthesis Neg Pos Pos Pos 0.017155664 0.001685711 3.23E-07 2.25E-05 KEGG 1040 Biosynthesis of unsaturated fatty acids Pos 0.036025067 KEGG 1200 Carbon metabolism Neg Pos Pos 0.002036725 0.003651403 0.004801096 KEGG 1212 Fatty acid metabolism Neg 0.026516353 KEGG 190 Oxidative phosphorylation Neg Pos Pos Pos 1.09E-11 0.029666213 3.32E-10 0.005203758 KEGG 240 Pyrimidine metabolism Neg Neg Pos 0.048043944 0.02114926 0.02509482 KEGG 260 "Glycine, serine and threonine metabolism" Pos Pos 0.042665803 0.019241864 KEGG 280 "Valine, leucine and isoleucine degradation" Neg 3.23E-05 KEGG 3008 Ribosome biogenesis in eukaryotes Pos Pos Pos 1.87E-05 3.13E-06 1.03E-06 KEGG 3010 Ribosome Pos Pos Pos 2.25E-05 2.08E-05 0.004787786 KEGG 3013 RNA transport Pos Pos Pos 0.000220612 3.23E-07 1.26E-06 KEGG 3018 RNA degradation Pos 0.040505774 KEGG 3020 RNA polymerase Neg Pos Pos 0.003031767 1.07E-05 0.00018625 KEGG 3022 Basal transcription factors Pos 0.011043356 KEGG 3030 DNA replication Neg Pos Pos Pos 0.048043944 1.73E-09 1.87E-11 2.58E-12 KEGG 3040 Spliceosome Neg Pos Pos Pos 0.000156361 6.45E-06 2.71E-12 2.58E-12 KEGG 3050 Proteasome Neg Pos Pos Pos 6.99E-06 0.004054034 1.87E-11 1.50E-10 KEGG 3060 Protein export Pos Pos 0.026863242 0.016420325 KEGG 3320 PPAR signaling pathway Pos 0.015153434 KEGG 3420 Nucleotide excision repair Neg Pos Pos Pos 0.0318658 2.08E-05 1.65E-06 1.03E-06 KEGG 3430 Mismatch repair Pos Pos Pos 3.15E-05 1.68E-06 1.03E-06 KEGG 3440 Homologous recombination Neg Pos Pos Pos 0.024856572 0.001651104 0.000263262 0.000883837 KEGG 3460 Fanconi anemia pathway Pos Pos Pos 0.002081132 0.003651403 0.0009913 KEGG 380 Tryptophan metabolism Neg 0.023042568 KEGG 4010 MAPK signaling pathway Pos Pos Neg Neg Neg 0.01260235 0.000448413 0.015346747 0.000480697 0.001377156 KEGG 4012 ErbB signaling pathway Pos Pos Neg 4.41E-07 2.88E-06 0.03450797 KEGG 4020 Calcium signaling pathway Pos Pos Neg Neg Neg 0.018590348 0.001949424 0.002721569 0.000480697 2.71E-05 KEGG 4070 Phosphatidylinositol signaling system Pos Pos 0.022533913 0.008767938 KEGG 4080 Neuroactive ligand-receptor interaction Pos Neg Neg Neg 0.005035461 8.29E-11 0.000659416 9.10E-06 KEGG 4110 Cell cycle Pos Pos Pos 1.73E-09 1.44E-08 6.21E-12 KEGG 4141 Protein processing in endoplasmic reticulum Pos Pos Pos 0.001399725 0.015893118 0.001446892 KEGG 4142 Lysosome Neg 0.022774629 KEGG 4145 Phagosome Neg Pos 0.037713125 0.024827895 KEGG 4146 Peroxisome Neg Neg 0.048043944 0.004159365 KEGG 4150 mTOR signaling pathway Pos 0.037526469 KEGG 4218 Cellular senescence Pos 0.011833193 KEGG 4261 Adrenergic signaling in cardiomyocytes Pos Pos Neg Neg 0.009591685 0.002739754 0.045262169 0.016987381 KEGG 4270 Vascular smooth muscle contraction Pos Neg 0.04916429 0.028781358 KEGG 4310 Wnt signaling pathway Pos Neg Neg 0.000362406 0.006388779 0.028781358 KEGG 4371 Apelin signaling pathway Neg 0.045262169 KEGG 4510 Focal adhesion Pos 8.06E-05 KEGG 4520 Adherens junction Pos Neg 7.15E-06 0.049099491 KEGG 4540 Gap junction Pos 0.000427318 KEGG 4623 Cytosolic DNA-sensing pathway Neg Pos Pos 0.029618563 0.002237422 0.004801096 KEGG 480 Glutathione metabolism Neg 0.000922772 KEGG 4810 Regulation of actin cytoskeleton Pos 2.25E-05 KEGG 4910 Insulin signaling pathway Pos Pos 0.000407541 5.88E-07 KEGG 4912 GnRH signaling pathway Pos Pos 0.000246658 0.000516819 KEGG 4916 Melanogenesis Pos Pos Neg Neg 0.04916429 0.001599499 0.004045075 0.035006029 KEGG 564 Glycerophospholipid metabolism Pos 0.008515023 KEGG 590 Arachidonic acid metabolism Neg 0.008753564 KEGG 62 Fatty acid elongation Pos 0.037676571 KEGG 620 Pyruvate metabolism Neg 0.002036725 KEGG 640 Propanoate metabolism Neg 0.00125121 KEGG 71 Fatty acid degradation Neg Neg 0.048043944 0.008753564 KEGG 860 Porphyrin and chlorophyll metabolism Neg 0.045483314 KEGG 970 Aminoacyl-tRNA biosynthesis Neg Pos Pos 0.013228892 0.011043356 0.026383893 KEGG 983 Drug metabolism - other enzymes Neg Neg 0.048043944 0.002807513 KEGG 2D 100 Steroid biosynthesis Pos Pos 9.94E-05 0.001114247 KEGG 2D 3030 DNA replication Pos 0.003826625 KEGG 2D 3320 PPAR signaling pathway Pos 0.013109423 KEGG 2D 4080 Neuroactive ligand-receptor interaction Pos 0.006411018 KEGG 2D 4110 Cell cycle Pos Pos Pos 0.025421646 0.048972873 0.000199076 KEGG 2D 4115 p53 signaling pathway Pos 0.029039521 KEGG 2D 4210 Apoptosis Pos 0.029039521