Table 1. Genes with increased expression under orthotopic conditions as compared with monolayer culture in both U251 and U87 cells
Hs no.* | Gene symbol | Gene description |
Regulation of cell cycle | ||
6090 | DBC1 | Deleted in bladder cancer 1 |
368078 | DNAJA2 | DnaJ (Hsp40) homolog, subfamily A, member 2 |
29353 | p25 | Brain-specific protein p25 a |
283743 | PNUTL1 | Peanut-like 1 (Drosophila) |
14125 | SESN1 | Sestrin 1 |
Cell signal transduction | ||
200586 | BAI2 | Brain-specific angiogenesis inhibitor 2 |
109798 | C6orf48 | Chromosome 6 open reading frame 48 |
282410 | CALM1 | Calmodulin 1 |
425808 | CALM2 | Calmodulin 2 |
129729 | CAPON | C-terminal PDZ domain ligand of neuronal nitric oxide |
458426 | CCK | Cholecystokinin |
355832 | CDC42 | Cell division cycle 42 (GTP binding protein, 25 kDa) |
2281 | CHGB | Chromogranin B (secretogranin 1) |
150917 | CTNNA2 | Catenin (cadherin-associated protein), a 2 |
410086 | CTNNB1 | Catenin (cadherin-associated protein), b 1, 88 kDa |
436421 | CTNND2 | Catenin (cadherin-associated protein), d 2 (neural) |
159311 | DKK4 | Dickkopf homolog 4 (Xenopus laevis) |
381928 | DVL3 | Dishevelled, dsh homolog 3 |
30687 | GAB2 | GRB2-associated binding protein 2 |
79000 | GAP43 | Growth-associated protein 43 |
437710 | GAS6 | Growth arrest-specific 6 |
157307 | GNAS | GNAS complex locus |
232004 | NRGN | Neurogranin (protein kinase C substrate, RC3) |
232004 | NRN1 | Neurogranin |
154437 | PDE2A | Phosphodiesterase 2A, cGMP-stimulated |
188 | PDE4B | Phosphodiesterase 4B, cAMP-specific |
349845 | PRKCB1 | Protein kinase C, b 1 |
155281 | PRKCE | Protein kinase C, e |
407181 | PRKCZ | PKC z = protein kinase C, z |
387553 | PTPN13 | Protein tyrosine phosphatase, nonreceptor type 13 |
156114 | PTPNS1 | Protein tyrosine phosphatase, nonreceptor type substrate 1 |
75216 | PTPRF | Protein tyrosine phosphatase, receptor type, F |
295449 | PVALB | Parvalbumin |
106185 | RALGDS | Ral guanine nucleotide dissociation stimulator |
306307 | ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 |
296323 | SGK | Serum/glucocorticoid-regulated kinase |
76930 | SNCA | Synuclein, a (non-A4 component of amyloid precursor) |
323833 | SNPH | Syntaphilin |
435277 | SYNGR3 | Synaptogyrin 3 |
401730 | SYNJ1 | Synaptojanin 1 |
75667 | SYP | Synaptophysin |
154679 | SYT1 | Synaptotagmin I |
DNA repair and transcription | ||
150557 | BTEB1 | Basic transcription element binding protein 1 |
511952 | CBX6 | Chromobox homolog 6 |
211610 | CUGBP2 | CUG triplet repeat, RNA binding protein 2 |
326035 | EGR1 | Early growth response 1 |
104134 | HMX1 | Homeo box (H6 family) 1 |
1569 | LHX2 | LIM homeobox 2 |
283063 | LMO2 | LIM domain only 2 (rhombotin-like 1) |
118630 | MXI1 | MAX interactor 1 |
410692 | PER2 | Period homolog 2 (Drosophila) |
29117 | PURA | Purine-rich element binding protein A |
48375 | SNRPN | SNRPN upstream reading frame |
152207 | SSBP2 | Single-stranded DNA binding protein 2 |
210862 | TBR1 | T-box, brain, 1 |
114360 | TGFB1I4 | Transforming growth factor b 1-induced transcript 4 |
231840 | WBP2 | WW domain binding protein 2 |
446677 | ZNF238 | Zinc finger protein 238 |
9568 | ZNF261 | Zinc finger protein 261 |
Cell adhesion and surface antigen | ||
199593 | AP3B2 | Adaptor-related protein complex 3, b 2 subunit |
75196 | BAT8 | HLA-B associated transcript 8 |
95327 | CD3D | CD3D antigen, d polypeptide |
54457 | CD81 | CD81 antigen |
26126 | CLDN10 | Claudin 10 |
6132 | CPNE6 | Copine VI (neuronal) |
48998 | FLRT2 | Fibronectin leucine-rich transmembrane protein 2 |
385634 | LOC90139 | Tetraspanin similar to uroplakin 1 |
132311 | MAP2K1 | Mitogen-activated protein kinase kinase 1 |
25209 | MAPK10 | Mitogen-activated protein kinase 10 |
3821 | NBEA | Neurobeachin |
78792 | NCAM1 | Neural cell adhesion molecule 1 |
154729 | PDPK1 | 3-Phosphoinositide-dependent protein kinase-1 |
275775 | SEPP1 | Selenoprotein P, plasma, 1 |
304330 | SNAP91 | Synaptosomal-associated protein, 91-kDa homolog (mouse) |
75671 | STX1A | Syntaxin 1A (brain) |
325862 | STXBP1 | Syntaxin binding protein 1 |
134643 | THY1 | Thy-1 cell surface antigen |
446641 | TIMP1 | Tissue inhibitor of metalloproteinase 1 |
Cell structure | ||
378063 | APBB1 | Amyloid b (A4) precursor protein binding |
194684 | BSN | Basson (presynaptic cytomatrix protein) |
369579 | CAPZA2 | Capping protein muscle Z-line, a 2 |
41683 | CART1 | Cartilage paired-class homeoprotein 1 |
211201 | CYFIP2 | Cytoplasmic FMR1 interacting protein 2 |
74617 | DCTN1 | Dynactin 1 |
436132 | DNM1 | Dynamin 1 |
79226 | FEZ1 | Fasciculation and elongation protein z 1 |
75819 | GPM6B | Glycoprotein M6A |
2178 | HIST2H2BE | Histone 2, H2be |
6641 | KIF5C | Kinesin family member 5C |
101174 | MAPT | Microtubule-associated protein t |
280311 | MYH10 | Myosin, heavy polypeptide 10, nonmuscle |
2830 | MYOG | Myogenin (myogenic factor 4) |
458657 | NEF3 | Neurofilament 3 (150-kDa medium) |
12376 | PCLO | Piccolo (presynaptic cytomatrix protein) |
80296 | PCP4 | Purkinje cell protein 4 |
75445 | SPARCL1 | SPARC-like 1 (mast9, hevin) |
205401 | SPTBN1 | CDNA: FLJ21418 fis, clone COL04072 |
512712 | TUBB | Tubulin, b polypeptide |
Apotosis | ||
79241 | BCL2 | B-cell CLL/lymphoma 2 |
433901 | COX8A | Cytochrome c oxidase subunit 8A (ubiquitous) |
82548 | MADD | Mitogen-associated protein kinase-activating death domain |
Oncogene | ||
8004 | HAPIP | Huntingtin-associated protein interacting protein (duo) |
80205 | PIM2 | Pim-2 oncogene |
78305 | RAB2 | RAB2, member of RAS oncogene family |
8186 | TUSC2 | Tumor suppressor candidate 2 |
25292 | JUNB | Jun B protooncogene |
Receptor | ||
1259 | ASGR2 | Asialoglycoprotein receptor 2 |
924 | CRYM | Crystallin, m |
80420 | CX3CL1 | Chemokine (C-X3-C motif) ligand 1 |
26988 | EFNB3 | Ephrin-B3 |
6540 | FGF13 | Fibroblast growth factor 13 |
167017 | GABBR1 | GABA B receptor, 1 |
175934 | GABRA1 | GABA A receptor, a 1 |
89768 | GABRB1 | GABA A receptor, b 1 |
198612 | GPR51 | G protein-coupled receptor 51 |
418105 | GRCA | Gene rich cluster, A gene |
7117 | GRIA1 | Glutamate receptor, ionotropic, AMPA 1 |
335051 | GRIA2 | Glutamate receptor, ionotropic, AMPA 2 |
450230 | IGFBP3 | Insulin-like growth factor binding protein 3 |
149900 | ITPR1 | Inositol 1,4,5-triphosphate receptor, type 1 |
435290 | NISCH | Nischarin |
82120 | NR4A2 | Nuclear receptor subfamily 4, group A, member 2 |
22998 | NRXN1 | Neurexin 1 |
431010 | RELN | Reelin |
12409 | SST | Somatostatin |
439586 | TM4SF2 | Transmembrane 4 superfamily member 2 |
Protein synthesis/degradation | ||
74561 | A2M | a -2-macroglobulin |
374638 | FKBP1A | FK506 binding protein 1A, 12 kDa |
407482 | FKBP1B | Hypothetical gene supported by BX647146 |
117546 | NNAT | Neuronatin |
434961 | SCA1 | Spinocerebellar ataxia 1 (olivopontocerebellar ataxia 1, autosomal dominant, ataxin 1) |
433680 | TG | Thyroglobulin |
4552 | UBQLN2 | Ubiquilin 2 |
8015 | USP21 | Ubiquitin-specific protease 21 |
Transporter/channel | ||
194720 | ABCG2 | ATP-binding cassette, family G, member 2 |
389415 | CACNA2D2 | Calcium channel, a 2/d subunit 2 |
417091 | CLCN4 | Chloride channel 4 |
408883 | SCN1B | Sodium channel, voltage-gated, type I |
375616 | SLC17A7 | Solute carrier family 17 |
371369 | SLC1A3 | DKFZP547J0410 protein |
2043 | SLC25A4 | Solute carrier family 25 (mitochondrial carrier) |
111967 | SLC30A3 | Solute carrier family 30 (zinc transporter) |
306000 | SLC4A1AP | Solute carrier family 4 (anion exchanger) |
5462 | SLC4A4 | Solute carrier family 4 |
Metabolism | ||
334707 | ACY1 | Aminoacylase 1 |
454199 | ADCY2 | Adenylate cyclase 2 |
429896 | ADH6 | Alcohol dehydrogenase 6 |
435689 | ALDH1A2 | Aldehyde dehydrogenase 1 family, mamber A2 |
155247 | ALDOC | Aldolase C, fructose-bisphosphate |
182215 | ARL3 | ADP-ribosylation factor-like 3 |
34114 | ATP1A2 | ATPase, a 2 polypeptide |
106876 | ATP6V0D1 | ATPase, lysosomal 38 kDa, V0 subunit d isoform 1 |
283140 | CA10 | Carbonic anhydrase X |
155097 | CA2 | Carbonic anhydrase II |
173724 | CKB | Creatine kinase, brain |
155392 | CRMP1 | Collapsin response mediator protein 1 |
45127 | CSPG5 | Neuroglycan C |
87417 | CTSL2 | Cathepsin L2 |
211201 | CYFIP2 | Cytoplasmic FMR1 interacting protein 2 |
152096 | CYP2J2 | Cytochrome P450, family 2, subfamily J, polypeptide 2 |
21355 | DCAMKL1 | Doublecortin and CaM kinase-like 1 |
277445 | DGKZ | Diacylglycerol kinase, z 104 kDa |
511915 | ENO2 | ENO2=Enolase 2 (gamma, neuronal) |
112669 | FABP3 | Fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) |
420036 | GAD1 | Glutamate decarboxylase 1, brain |
86724 | GCH1 | GTP cyclohydrolase 1 |
185172 | GNB2 | Guanine nucleotide binding protein, b polypeptide 2 |
435970 | GSK3A | Glycogen synthase kinase 3 a |
155376 | HBB | Hemoglobin, b |
25220 | LARGE | Like-glycosyltransferase |
234734 | LYZ | Lysozyme (renal amyloidosis) |
79026 | MLF2 | Myeloid leukemia factor 2 |
438737 | MT1F | Metallothionein 1F (functional) |
21907 | MYST2 | MYST histone acetyltransferase 2 |
293007 | NPEPPS | Aminopeptidase puromycin sensitive |
431279 | NSF | N -ethylmaleimide-sensitive factor |
74376 | OLFM1 | Olfactomedin 1 |
77318 | PAFAH1B1 | Platelet-activating factor acetylhydrolase, isoform Ib |
57856 | PFTK1 | PFTAIRE protein kinase 1 |
277132 | PKP4 | Plakophilin 4 |
410477 | PLA2R1 | Phospholipase A2 receptor 1, 180 kDa |
1787 | PLP1 | Proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated) |
183994 | PPP1CA | Protein phosphatase 1, catalytic subunit, a isoform |
269777 | PPP1R12B | Protein phosphatase 1, regulatory (inhibitor) subunit 12B |
272458 | PPP3CA | Protein phosphatase 3 (formerly 2B), catalytic subunit, a isoform |
280604 | PPP3R1 | Protein phosphatase 3 (formerly 2B), regulatory subunit B |
283667 | RNPEP | Arginyl aminopeptidase (aminopeptidase B) |
422181 | S100B | S100 calcium binding protein |
384598 | SERPING1 | Serine (or cysteine) proteinase inhibitor |
75149 | SH3GL2 | SH3 domain GRB2-like 2 |
251754 | SLPI | Secretory leukocyte protease inhibitor |
48513 | SPATA2 | Spermatogenesis associated 2 |
79876 | STS | Steroid sulfatase (microsomal) |
210862 | TBR1 | T-box, brain, 1 |
433923 | TF | Transferrin |
25001 | YWHAG | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation |
226755 | YWHAH | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation |
*Unigene cluster number, Homo sapiens.