RxnID rxnEq rxnCTrans rates rxnType basis deviation ala-L_IN ala-L_i = ala-L_v abc = abc F ala-L_OUT ala-L_e = ala-L_o abc = abc F arg-L_IN arg-L_i = arg-L_v abcdef = abcdef F arg-L_OUT arg-L_e = arg-L_o abcdef = abcdef B asp-L_IN asp-L_i = asp-L_v abcd = abcd F asp-L_OUT asp-L_e = asp-L_o abcd = abcd B co2_IN co2_i = co2_c a = a F co2_OUT co2_c = co2_o a = a B glc-D_IN glc-D_i = glc-D_v abcdef = abcdef F glc-D_OUT glc-D_e = glc-D_o abcdef = abcdef B gln-L_IN gln-L_i = gln-L_v abcde = abcde F gln-L_OUT gln-L_e = gln-L_o abcde = abcde B glu-L_IN glu-L_i = glu-L_v abcde = abcde F glu-L_OUT glu-L_e = glu-L_o abcde = abcde B gly_IN gly_i = gly_v ab = ab F gly_OUT gly_e = gly_o ab = ab B glyc_OUT glyc_c = glyc_o abc = abc B glycogen_IN glycogen_i = glycogen_c abcdef = abcdef F h2o_IN h2o_i = h2o_c X = X F h2o_OUT h2o_c = h2o_o X = X B h_IN h_i = h_c X = X F h_OUT h_c = h_o X = X B lac-L_OUT lac-L_c = lac-L_o abc = abc B mlthf_IN mlthf_i = mlthf_c a = a F mlthf_OUT mlthf_c = mlthf_o a = a B nh4_IN nh4_i = nh4_c X = X F nh4_OUT nh4_c = nh4_o X = X B o2_IN o2_i = o2_c X = X F pmt_IN pmt_i = pmt_c abcdefghijklmnop = abcdefghijklmnop F prot_ala_IN prot_ala_i = prot_ala_l abc = abc F prot_ala_OUT prot_ala_c = prot_ala_o abc = abc B prot_arg_IN prot_arg_i = prot_arg_l abcdef = abcdef F prot_arg_OUT prot_arg_c = prot_arg_o abcdef = abcdef b prot_asp_IN prot_asp_i = prot_asp_l abcd = abcd F prot_asp_OUT prot_asp_c = prot_asp_o abcd = abcd B prot_gln_IN prot_gln_i = prot_gln_l abcde = abcde F prot_gln_OUT prot_gln_c = prot_gln_o abcde = abcde B prot_glu_IN prot_glu_i = prot_glu_l abcde = abcde F prot_glu_OUT prot_glu_c = prot_glu_o abcde = abcde B prot_gly_IN prot_gly_i = prot_gly_l ab = ab F prot_gly_OUT prot_gly_c = prot_gly_o ab = ab B prot_ser_IN prot_ser_i = prot_ser_l abc = abc F prot_ser_OUT prot_ser_c = prot_ser_o abc = abc B ser-L_IN ser-L_i = ser-L_v abc = abc F ser-L_OUT ser-L_e = ser-L_o abc = abc B thf_IN thf_i = thf_c X = X F thf_OUT thf_c = thf_o X = X B urea_OUT urea_c = urea_o a = a B 2AMACHYD 2amac_c + h2o_c = pyr_c + nh4_c abc + X = abc + X F ACONTm cit_m = icit_m abcdef = afcbed FR ACONTm_R icit_m = cit_m abcdef = adcfeb R ADK1 amp_c + atp_c = adp_c + adp_c X + X = X + X F AKGDm akg_m + coa_m + nad_m = co2_m + succoa_m + nadh_m abcde + X + X = e + badc + X FR AKGDm_R co2_m + succoa_m + nadh_m = akg_m + coa_m + nad_m a + bcde + X = cbeda + X + X R AKGtm akg_c = akg_m abcde = abcde FR AKGtm_R akg_m = akg_c abcde = abcde R ALATA_L akg_c + ala-L_c = glu-L_c + pyr_c abcde + fgh = abcde + fgh FR ALATA_L_R glu-L_c + pyr_c = akg_c + ala-L_c abcde + fgh = abcde + fgh R ALAmix ala-L_v = ala-L_e abc = abc F ALAtl ala-L_l = ala-L_c abc = abc F ALAtin ala-L_v = ala-L_c abc = abc F ALAtout ala-L_c = ala-L_e abc = abc F ARGN arg-L_c + h2o_c = orn_c + urea_c abcdef + X = abcde + f F ARGSL argsuc_c = arg-L_c + 0.5 fum_c + 0.5 fum_c abcdefghij = abcehj + 0.5 dfgi + 0.5 fdig F ARGSS asp-L_c + citr-L_c + atp_c = argsuc_c + amp_c + h_c + ppi_c abcd + efghij + X = efgahbcidj + X + X + X F ARGmix arg-L_v = arg-L_e abcdef = abcdef F ARGtl arg-L_l = arg-L_c abcdef = abcdef F ARGtin arg-L_v = arg-L_c abcdef = abcdef F ARGtout arg-L_c = arg-L_e abcdef = abcdef F ASPTA akg_c + asp-L_c = glu-L_c + oaa_c abcde + fghi = abcde + fghi FR ASPTA_R glu-L_c + oaa_c = akg_c + asp-L_c abcde + fghi = abcde + fghi R ASPTAm glu-L_m + oaa_m = akg_m + asp-L_m abcde + fghi = abcde + fghi FR ASPTAm_R akg_m + asp-L_m = glu-L_m + oaa_m abcde + fghi = abcde + fghi R ASPtl asp-L_l = asp-L_c abcd = abcd F ASPmix asp-L_v = asp-L_e abcd = abcd F ASPtin asp-L_v = asp-L_c abcd = abcd F ASPtout asp-L_c = asp-L_e abcd = abcd F ASPtm asp-L_m = asp-L_c abcd = abcd FR ASPtm_R asp-L_c = asp-L_m abcd = abcd R ATPS4m adp_m + h_ims_m + h_ims_m + h_ims_m + h_ims_m + pi_m = atp_m + h2o_m + h_m + h_m + h_m X + X + X + X + X + X = X + X + X + X + X F ATPtm adp_c + atp_m = adp_m + atp_c X + X = X + X FR ATPtm_R adp_m + atp_c = adp_c + atp_m X + X = X + X R CBPSam hco3_m + atp_m + atp_m + nh4_m = cbp_m + adp_m + adp_m + h_m + h_m + pi_m a + X + X + X = a + X + X + X + X + X F ATPASES atp_c + h2o_c = adp_c + h_c + pi_c X + X = X + X + X F CO2tm co2_c = co2_m a = a FR CO2tm_R co2_m = co2_c a = a R CSm accoa_m + oaa_m + h2o_m = cit_m + coa_m + h_m ab + cdef + X = caebfd + X + X F CYOOm focytC_m + focytC_m + focytC_m + focytC_m + h_m + h_m + h_m + h_m + h_m + h_m + h_m + h_m + o2_m = ficytC_m + ficytC_m + ficytC_m + ficytC_m + h2o_m + h2o_m + h_ims_m + h_ims_m + h_ims_m + h_ims_m X + X + X + X + X + X + X + X + X + X + X + X + X = X + X + X + X + X + X + X + X + X + X F CYOR-u10m ficytC_m + ficytC_m + h_m + h_m + q10h2_m = focytC_m + focytC_m + h_ims_m + h_ims_m + h_ims_m + h_ims_m + q10_m X + X + X + X + X = X + X + X + X + X + X + X F ENO 2pg_c = pep_c + h2o_c abc = abc + X FR ENO_R pep_c + h2o_c = 2pg_c abc + X = abc R ETF fadh2_m + q10_m = fad_m + q10h2_m X + X = X + X F FAO16 pmtcoa_m + coa_m + nad_m + fad_m + h2o_m = tdcoa_m + accoa_m + nadh_m + fadh2_m + h_m abcdefghijklmnop + X + X + X + X = abcdefghijklmn + op + X + X + X F FAO14 tdcoa_m + coa_m + nad_m + fad_m + h2o_m = ddcacoa_m + accoa_m + nadh_m + fadh2_m + h_m abcdefghijklmn + X + X + X + X = abcdefghijkl + mn + X + X + X F FAO12 ddcacoa_m + coa_m + nad_m + fad_m + h2o_m = dcacoa_m + accoa_m + nadh_m + fadh2_m + h_m abcdefghijkl + X + X + X + X = abcdefghij + kl + X + X + X F FAO10 dcacoa_m + coa_m + nad_m + fad_m + h2o_m = occoa_m + accoa_m + nadh_m + fadh2_m + h_m abcdefghij + X + X + X + X = abcdefgh + ij + X + X + X F FAO8 occoa_m + coa_m + nad_m + fad_m + h2o_m = hexcoa_m + accoa_m + nadh_m + fadh2_m + h_m abcdefgh + X + X + X + X = abcdef + gh + X + X + X F FAO6 hexcoa_m + coa_m + nad_m + fad_m + h2o_m = btcoa_m + accoa_m + nadh_m + fadh2_m + h_m abcdef + X + X + X + X = abcd + ef + X + X + X F FAO4 btcoa_m + coa_m + nad_m + fad_m + h2o_m = accoa_m + accoa_m + nadh_m + fadh2_m + h_m abcd + X + X + X + X = ab + cd + X + X + X F FBA fdp_c = dhap_c + g3p_c abcdef = ebf + dac FR FBA_R dhap_c + g3p_c = fdp_c abc + def = ebfdac R FBP fdp_c + h2o_c = f6p_c + pi_c abcdef + X = abcdef + X F FUMm fum_m + h2o_m = mal-L_m abcd + X = abcd F FUMtm fum_c = 0.5 fum_m + 0.5 fum_m abcd = 0.5 abcd + 0.5 badc F G3PD1 dhap_c + nadh_c + h_c = glyc3p_c + nad_c abc + X + X = abc + X F G5SDxm glu5sa_m + nad_m + h2o_m = glu-L_m + nadh_m + h_m + h_m abcde + X + X = abcde + X + X + X F G6PDH2r g6p_c + nadp_c = 6pgl_c + h_c + nadph_c abcdef + X = abcdef + X + X F G6PPer g6p_r + h2o_r = glc-D_r + pi_r abcdef + X = abcdef + X F G6Pter g6p_c = g6p_r abcdef = abcdef FR G6Pter_R g6p_r = g6p_c abcdef = abcdef R GAPD g3p_c + nad_c + pi_c = 13dpg_c + h_c + nadh_c abc + X + X = bca + X + X FR GAPD_R 13dpg_c + h_c + nadh_c = g3p_c + nad_c + pi_c abc + X + X = cab + X + X R GHMT2r ser-L_c + thf_c = gly_c + mlthf_c + h2o_c abc + X = bc + a + X FR GHMT2r_R gly_c + mlthf_c + h2o_c = ser-L_c + thf_c ab + c + X = cab + X R GLCmix glc-D_v = glc-D_e abcdef = abcdef F GLCtin glc-D_v = glc-D_c abcdef = abcdef F GLCtout glc-D_r = glc-D_e abcdef = abcdef F GLNmix gln-L_v = gln-L_e abcde = abcde F GLNtin gln-L_v = gln-L_c abcde = abcde F GLNtl gln-L_l = gln-L_c abcde = abcde F GLNtout gln-L_c = gln-L_e abcde = abcde F GLNtm gln-L_c = gln-L_m abcde = abcde FR GLNtm_R gln-L_m = gln-L_c abcde = abcde R GLNS glu-L_c + nh4_c + atp_c = gln-L_c + adp_c + pi_c + h_c abcde + X + X = abcde + X + X + X F GLUDxm glu-L_m + h2o_m + nad_m = akg_m + h_m + nadh_m + nh4_m abcde + X + X = abcde + X + X + X FR GLUDxm_R akg_m + h_m + nadh_m + nh4_m = glu-L_m + h2o_m + nad_m abcde + X + X + X = abcde + X + X R GLUNm gln-L_m + h2o_m = glu-L_m + nh4_m abcde + X = abcde + X F GLUtl glu-L_l = glu-L_c abcde = abcde F GLUt2m glu-L_c = glu-L_m abcde = abcde FR GLUt2m_R glu-L_m = glu-L_c abcde = abcde R GLUmix glu-L_v = glu-L_e abcde = abcde F GLUtin glu-L_v = glu-L_c abcde = abcde F GLUtout glu-L_c = glu-L_e abcde = abcde F GLYtl gly_l = gly_c ab = ab F GLYmix gly_v = gly_e ab = ab F GLYtin gly_v = gly_c ab = ab F GLYtout gly_c = gly_e ab = ab F GLYCOGEN_BREAK glycogen_c + pi_c = g1p_c abcdef + X = fedcba F GLYCPH glyc3p_c + h2o_c = glyc_c + pi_c abc + X = abc + X F GND 6pgc_c + nadp_c = ru5p-D_c + co2_c + nadph_c abcdef + X = eadbc + f + X F H2Oter h2o_c = h2o_r X = X F H2Otm h2o_c = h2o_m X = X FR H2Otm_R h2o_m = h2o_c X = X R HCO3Em co2_m + h2o_m = hco3_m + h_m a + X = a + X F HEX1 glc-D_c + atp_c = g6p_c + adp_c + h_c abcdef + X = abcdef + X + X F Htm2 h_m = h_c X = X FR Htm2_R h_c = h_m X = X R ICDHxm icit_m + nad_m = akg_m + co2_m + nadh_m abcdef + X = bdafc + e + X FR ICDHxm_R akg_m + co2_m + nadh_m = icit_m + nad_m abcde + f + X = caebfd + X R LDH_L pyr_c + h_c + nadh_c = lac-L_c + nad_c abc + X + X = abc + X FR LDH_L_R lac-L_c + nad_c = pyr_c + h_c + nadh_c abc + X = abc + X + X R MALtm mal-L_c = mal-L_m abcd = abcd FR MALtm_R mal-L_m = mal-L_c abcd = abcd R MDH mal-L_c + nad_c = oaa_c + h_c + nadh_c abcd + X = abcd + X + X FR MDH_R oaa_c + h_c + nadh_c = mal-L_c + nad_c abcd + X + X = abcd + X R MDHm mal-L_m + nad_m = oaa_m + h_m + nadh_m abcd + X = abcd + X + X FR MDHm_R oaa_m + h_m + nadh_m = mal-L_m + nad_m abcd + X + X = abcd + X R NADH2-u10m h_m + h_m + h_m + h_m + h_m + nadh_m + q10_m = h_ims_m + h_ims_m + h_ims_m + h_ims_m + nad_m + q10h2_m X + X + X + X + X + X + X = X + X + X + X + X + X F NADPH_REDOX nadph_c + nadph_c + o2_c = nadp_c + nadp_c + h2o_c X + X + X = X + X + X F NDPK1 atp_c + gdp_c = adp_c + gtp_c X + X = X + X F NH4tm nh4_c = nh4_m X = X FR NH4tm_R nh4_m = nh4_c X = X R O2tm o2_c = o2_m X = X F ORNTArm orn_m + akg_m = glu5sa_m + glu-L_m abcde + fghij = abcde + fghij F OCBTm cbp_m + orn_m = citr-L_m + h_m + pi_m a + bcdef = bcdefa + X + X F ORNtm orn_c = orn_m abcde = abcde F ORNt4m citr-L_m + orn_c = citr-L_c + orn_m abcdef + ghijk = abcdef + ghijk F PCm hco3_m + pyr_m + atp_m = oaa_m + adp_m + h_m + pi_m a + bcd + X = bcad + X + X + X F PDHm pyr_m + coa_m + nad_m = accoa_m + co2_m + nadh_m abc + X + X = ab + c + X F PEPCK oaa_c + gtp_c = co2_c + pep_c + gdp_c abcd + X = c + abd + X F PFK f6p_c + atp_c = fdp_c + adp_c + h_c abcdef + X = abcdef + X + X F PGCD 3pg_c + nad_c = 3php_c + h_c + nadh_c abc + X = abc + X + X F PGI g6p_c = f6p_c abcdef = afbcde FR PGI_R f6p_c = g6p_c abcdef = acdefb R PGK 13dpg_c + adp_c = 3pg_c + atp_c abc + X = abc + X FR PGK_R 3pg_c + atp_c = 13dpg_c + adp_c abc + X = abc + X R PGL 6pgl_c + h2o_c = 6pgc_c + h_c abcdef + X = abcdef + X F PGM 3pg_c = 2pg_c abc = abc FR PGM_R 2pg_c = 3pg_c abc = abc R PGMT g1p_c = g6p_c abcdef = abcdef F PIt2m pi_c = pi_m X = X F PIter pi_r = pi_c X = X F PPA h2o_c + ppi_c = h_c + pi_c + pi_c X + X = X + X + X F PMTtm pmt_c = pmt_m abcdefghijklmnop = abcdefghijklmnop F PMTCOAT pmt_m + coa_m = pmtcoa_m abcdefghijklmnop + X = abcdefghijklmnop F PROTDEG_ALA prot_ala_l = ala-L_l abc = abc F PROTDEG_ARG prot_arg_l = arg-L_l abcdef = abcdef F PROTDEG_ASP prot_asp_l = asp-L_l abcd = abcd F PROTDEG_GLN prot_gln_l = gln-L_l abcde = abcde F PROTDEG_GLU prot_glu_l = glu-L_l abcde = abcde F PROTDEG_GLY prot_gly_l = gly_l ab = ab F PROTDEG_SER prot_ser_l = ser-L_l abc = abc F PROTSYN_ALA ala-L_c = prot_ala_c abc = abc F PROTSYN_ARG arg-L_c = prot_arg_c abcdef = abcdef F PROTSYN_ASP asp-L_c = prot_asp_c abcd = abcd F PROTSYN_GLN gln-L_c = prot_gln_c abcde = abcde F PROTSYN_GLU glu-L_c = prot_glu_c abcde = abcde F PROTSYN_GLY gly_c = prot_gly_c ab = ab F PROTSYN_SER ser-L_c = prot_ser_c abc = abc F PROTSYN_ATP 4 atp_c + 4 h2o_c = 4 adp_c + 4 pi_c + 4 h_c X + X = X + X + X F PSERT 3php_c + glu-L_c = akg_c + pser-L_c abc + defgh = defgh + abc F PSP_L pser-L_c + h2o_c = ser-L_c + pi_c abc + X = abc + X F PYK pep_c + adp_c + h_c = pyr_c + atp_c abc + X + X = abc + X F PYRt2m pyr_c = pyr_m abc = abc FR PYRt2m_R pyr_m = pyr_c abc = abc R RPE ru5p-D_c = xu5p-D_c abcde = abcde F RPI ru5p-D_c = r5p_c abcde = bdeca F SERHL ser-L_c = 2amac_c + h2o_c abc = abc + X F SERmix ser-L_v = ser-L_e abc = abc F SERtl ser-L_l = ser-L_c abc = abc F SERtin ser-L_v = ser-L_c abc = abc F SERtout ser-L_c = ser-L_e abc = abc F SUCD1m succ_m + q10_m = 0.5 fum_m + 0.5 fum_m + q10h2_m abcd + X = 0.5 badc + 0.5 abcd + X F SUCOASm succoa_m + adp_m + pi_m = 0.5 succ_m + 0.5 succ_m + atp_m + coa_m abcd + X + X = 0.5 badc + 0.5 abcd + X + X F TALA g3p_c + s7p_c = f6p_c + e4p_c abc + defghij = bdcahf + jeig F TKT1 r5p_c + xu5p-D_c = s7p_c + g3p_c abcde + fghij = fahbecd + jgi F TKT2 e4p_c + xu5p-D_c = f6p_c + g3p_c abcd + efghi = bedcag + ifh F TPI dhap_c = g3p_c abc = abc FR TPI_R g3p_c = dhap_c abc = abc R ## excludedMetabolites # ala-L_i # ala-L_o # arg-L_i # arg-L_o # asp-L_i # asp-L_o # co2_i # co2_o # glc-D_i # glc-D_o # gln-L_i # gln-L_o # glu-L_i # glu-L_o # gly_i # gly_o # glyc_o # glycogen_i # gthrd_o # h2o_i # h2o_o # h_i # h_o # lac-L_o # mlthf_i # mlthf_o # nh4_i # nh4_o # o2_i # pi_i # pi_o # pmt_i # prot_ala_i # prot_ala_o # prot_arg_i # prot_arg_o # prot_asp_i # prot_asp_o # prot_glu_i # prot_glu_o # prot_gln_i # prot_gln_o # prot_gly_i # prot_gly_o # prot_ser_i # prot_ser_o # ser-L_i # ser-L_o # thf_i # thf_o # urea_o ## simulatedMDVs # ala-L_c#111 # ala-L_e#111 # ala-L_l#111 # arg-L_c#111111 # arg-L_e#111111 # arg-L_l#111111 # asp-L_c#1111 # asp-L_e#1111 # asp-L_l#1111 # asp-L_m#1111 # cit_m#111111 # citr-L_c#111111 # citr-L_m#111111 # glc-D_c#111111 # glc-D_r#111111 # glc-D_e#111111 # gln-L_c#11111 # gln-L_e#11111 # gln-L_l#11111 # gln-L_m#11111 # glu-L_c#11111 # glu-L_e#11111 # glu-L_l#11111 # glu-L_m#11111 # gly_c#11 # gly_e#11 # gly_l#11 # glyc3p_c#111 # mal-L_c#1111 # mal-L_m#1111 # orn_c#11111 # orn_m#11111 # ser-L_c#111 # ser-L_e#111 # ser-L_l#111 ## inputSubstrates # ala-L_i # arg-L_i # asp-L_i # co2_i # glc-D_i # glu-L_i # gln-L_i # gly_i # glycogen_i # mlthf_i # pmt_i # prot_ala_i # prot_arg_i # prot_asp_i # prot_gln_i # prot_glu_i # prot_gly_i # prot_ser_i # ser-L_i ## measurements ## error