Related to Figure 1e,,Genetic strain/RNAi,No. of worms,Censored worms,Median survival,p-value ,genotype being compared,,
,Trial 1,,,,,,,,
,,Wildtype (pL4440),87,0,17,,,,
,,Wildtype (ubql-1),87,0,17,ns,wildtype (pL4440) vs wildtype (ubql-1),,
,,hsf-1 OE (pL4440),71,0,21,<0.0001,wildtype (pL4440) vs hsf-1 OE (pL4440),,
,,hsf-1 OE (ubql-1),71,0,19,0.0002,hsf-1 OE (pL4440) vs hsf-1 OE (ubql-1),,
,,,,,,,,,
Related to Figure 1f,,Genetic strain/RNAi,No. of worms,Censored worms,Median survival,p-value ,genotype being compared,,
,Trial 1,,,,,,,,
,,Wildtype,117,43,17,,,,
,,ubql-1(tm1574),130,30,17,0.0002,wildtype vs ubql-1(tm1574),,
,,hsf-1 OE ,90,107,24,<0.0001,wildtype vs hsf-1 OE,,
,,hsf-1 OE;ubql-1(tm1574),134,67,19,<0.0001,hsf-1 OE vs hsf-1 OE;ubql-1(tm1574),,
,Trial 2,,,,,,,,
,,Wildtype,135,24,16,,,,
,,ubql-1(tm1574),115,40,14,<0.0001,wildtype vs ubql-1(tm1574),,
,,hsf-1 OE ,86,74,24,<0.0001,wildtype vs hsf-1 OE,,
,,hsf-1 OE;ubql-1(tm1574),102,56,18,<0.0001,hsf-1 OE vs hsf-1 OE;ubql-1(tm1574),,
,Trial 3,,,,,,,,
,,Wildtype,47,33,15,,,,
,,ubql-1(tm1574),41,39,14,0.005,wildtype vs ubql-1(tm1574),,
,,hsf-1 OE ,51,29,19,0.0352,wildtype vs hsf-1 OE,,
,,hsf-1 OE;ubql-1(tm1574),43,37,15,0.0834,hsf-1 OE vs hsf-1 OE;ubql-1(tm1574),,
,,,,,,,,,
Related to Supplementary Figure 1d,,Genetic strain/RNAi,No. of worms,Censored worms,Median survival,p-value ,genotype being compared,,
AM583,Trial 1,,,,,,,,
,,Wildtype (pL4440),68,0,17,,,,
,,Wildtype (ubql-1),142,0,17,0.0047,wildtype (pL4440) vs wildtype (ubql-1),,
,,hsf-1 OE (pL4440),98,0,23,<0.0001,wildtype (pL4440) vs hsf-1 OE (pL4440),,
,,hsf-1 OE (ubql-1),91,0,17,<0.0001,hsf-1 OE (pL4440) vs hsf-1 OE (ubql-1),,
,Trial 2,,,,,,,,
,,Wildtype (pL4440),111,0,17,,,,
,,Wildtype (ubql-1),103,0,16,0.0017,wildtype (pL4440) vs wildtype (ubql-1),,
,,hsf-1 OE (pL4440),96,0,22,<0.0001,wildtype (pL4440) vs hsf-1 OE (pL4440),,
,,hsf-1 OE (ubql-1),111,0,17,<0.0001,hsf-1 OE (pL4440) vs hsf-1 OE (ubql-1),,
,,,,,,,,,
Related to Supplementary Figure 3g-h,,Genetic strain/RNAi,No. of worms,Censored worms,Median survival,p-value ,genotype being compared,p-value ,genotype being compared
,Trial 1,,,,,,,,
,,Wildtype (pL4440),113,8,21,,,,
,,ubql-1(tm1574) (pL4440),103,17,19,<0.0001,wildtype vs ubql-1(tm1574),,
,,Wildtype (nhr-49),116,4,17,,,<0.0001,wildtype vs wildtype (nhr-49)
,,ubql-1(tm1574) (nhr-49),117,2,15,,,<0.0001,ubql-1(tm1574) vs ubql-1(tm1574) (nhr-49)
,,hsf-1 OE (pL4440),102,17,23,0.001,wildtype vs hsf-1 OE,,
,,hsf-1 OE;ubql-1(tm1574) (pL4440),103,16,17,<0.0001,hsf-1 OE vs hsf-1 OE;ubql-1(tm1574),,
,,hsf-1 OE (nhr-49),114,6,17,0.0004,hsf-1 OE;ubql-1(tm1574) vs  hsf-1 OE (nhr-49),<0.0001,hsf-1 OE vs hsf-1 OE (nhr-49)
,,hsf-1 OE;ubql-1(tm1574) (nhr-49),114,6,16,,,<0.0001,hsf-1 OE;ubql-1(tm1574)vs hsf-1 OE; ubql-1(tm1574)(nhr-49)
,Trial 2,,,,,,,,
,,Wildtype (pL4440),116,4,21,,,,
,,ubql-1(tm1574) (pL4440),115,5,17,<0.0001,wildtype vs ubql-1(tm1574),,
,,Wildtype (nhr-49),120,1,15,,,<0.0001,wildtype vs wildtype (nhr-49)
,,ubql-1(tm1574) (nhr-49),115,5,15,,,<0.0001,ubql-1(tm1574) vs ubql-1(tm1574) (nhr-49)
,,hsf-1 OE (pL4440),92,18,21,0.0006,wildtype vs hsf-1 OE,,
,,hsf-1 OE;ubql-1(tm1574) (pL4440),113,7,15,<0.0001,hsf-1 OE vs hsf-1 OE;ubql-1(tm1574),,
,,hsf-1 OE (nhr-49),119,1,15,0.9438,hsf-1 OE;ubql-1(tm1574) vs  hsf-1 OE (nhr-49),<0.0001,hsf-1 OE vs hsf-1 OE (nhr-49)
,,hsf-1 OE;ubql-1(tm1574) (nhr-49),117,2,15,,,0.001,hsf-1 OE;ubql-1(tm1574)vs hsf-1 OE; ubql-1(tm1574)(nhr-49)
,Trial 3,,,,,,,,
,,Wildtype (pL4440),119,1,17,,,,
,,ubql-1(tm1574) (pL4440),119,1,15,<0.0001,wildtype vs ubql-1(tm1574),,
,,Wildtype (nhr-49),118,2,15,,,<0.0001,wildtype vs wildtype (nhr-49)
,,ubql-1(tm1574) (nhr-49),115,5,15,,,<0.0001,ubql-1(tm1574) vs ubql-1(tm1574) (nhr-49)
,,hsf-1 OE (pL4440),114,6,23,0.0065,wildtype vs hsf-1 OE,,
,,hsf-1 OE;ubql-1(tm1574) (pL4440),113,9,17,<0.0001,hsf-1 OE vs hsf-1 OE;ubql-1(tm1574),,
,,hsf-1 OE (nhr-49),116,4,17,0.4016,hsf-1 OE;ubql-1(tm1574) vs  hsf-1 OE (nhr-49),<0.0001,hsf-1 OE vs hsf-1 OE (nhr-49)
,,hsf-1 OE;ubql-1(tm1574) (nhr-49),117,4,15,,,<0.0001,hsf-1 OE;ubql-1(tm1574)vs hsf-1 OE; ubql-1(tm1574)(nhr-49)
,,,,,,,,,
Related to Figure 4e,,Genetic strain/RNAi,No. of worms,Censored worms,Median survival,p-value ,genotype being compared,,
,Trial 1,,,,,,,,
,,Wildtype (pL4440),112,8,17,,,,
,,Wildtype (sel-11),103,15,13,<0.0001,wildtype (pL4440) vs wildtype (sel-11),,
,,hsf-1 OE (pL4440),110,10,23,<0.0001,wildtype (pL4440) vs hsf-1 OE (pL4440),,
,,hsf-1 OE (sel-11),114,6,19,<0.0001,hsf-1 OE (pL4440) vs hsf-1 OE (sel-11),,
,,,,,,,,,
,Trial 2,,,,,,,,
,,Wildtype (pL4440),112,4,20,,,,
,,Wildtype (sel-11),106,13,14,<0.0001,wildtype (pL4440) vs wildtype (sel-11),,
,,hsf-1 OE (pL4440),69,49,22,0.0002,wildtype (pL4440) vs hsf-1 OE (pL4440),,
,,hsf-1 OE (sel-11),91,28,18,<0.0001,hsf-1 OE (pL4440) vs hsf-1 OE (sel-11),,
,,,,,,,,,
"Related to Figure 4f,g,h",,Genetic strain/RNAi,No. of worms,Censored worms,Median survival,p-value ,genotype being compared,p-value ,genotype being compared
,Trial 1,,,,,,,,
,,Wildtype (pL4440),102,17,17,,,,
,,ubql-1(tm1574) (pL4440),102,18,16,0.0008,wildtype vs ubql-1(tm1574),,
,,Wildtype (npl-4.1/4.2),77,43,16,,,<0.0001,wildtype vs wildtype (npl-4.1/4.2)
,,ubql-1(tm1574)  (npl-4.1/4.2),35,5,16,,,<0.0001,ubql-1(tm1574) vs ubql-1(tm1574) (npl-4.1/4.2)
,,Wildtype (ufd-1),76,5,16,,,<0.0001,wildtype vs wildtype (ufd-1)
,,ubql-1(tm1574)  (ufd-1),114,6,14,,,<0.0001,ubql-1(tm1574) vs ubql-1(tm1574) (ufd-1)
,,Wildtype (cdc-48.1),110,6,12,,,<0.0001,wildtype vs wildtype (cdc-48.1)
,,ubql-1(tm1574)  (cdc-48.1),110,11,10,,,<0.0001,ubql-1(tm1574) vs ubql-1(tm1574) (cdc-48.1)
,,hsf-1 OE (pL4440),84,37,21,<0.0001,wildtype vs hsf-1 OE,,
,,hsf-1 OE;ubql-1(tm1574) (pL4440),80,40,17,<0.0001,hsf-1 OE vs hsf-1 OE;ubql-1(tm1574),,
,,hsf-1 OE  (npl-4.1/4.2),104,17,14,<0.0001,wildtype (npl-4.1/4.2) vs hsf-1 OE (npl-4.1/4.2),<0.0001,hsf-1 OE vs hsf-1 OE (npl-4.1/4.2)
,,hsf-1 OE;ubql-1(tm1574) ( (npl-4.1/4.2),110,9,12,,,<0.0001,hsf-1 OE;ubql-1(tm1574)vs hsf-1 OE; ubql-1(tm1574)(npl-4.1/4.2)
,,hsf-1 OE  (ufd-1),111,14,14,<0.0001,wildtype (ufd-1) vs hsf-1 OE (ufd-1),<0.0001,hsf-1 OE vs hsf-1 OE (ufd-1)
,,hsf-1 OE;ubql-1(tm1574) (ufd-1),90,30,12,,,<0.0001,hsf-1 OE;ubql-1(tm1574)vs hsf-1 OE; ubql-1(tm1574)(ufd-1)
,,hsf-1 OE  (cdc-48.1),119,2,10,<0.0001,wildtype (cdc-48.1) vs hsf-1 OE (cdc-48.1),<0.0001,hsf-1 OE vs hsf-1 OE (cdc-48.1)
,,hsf-1 OE;ubql-1(tm1574) (cdc-48.1),113,7,10,,,<0.0001,hsf-1 OE;ubql-1(tm1574)vs hsf-1 OE; ubql-1(tm1574)(cdc-48.1)
,,,,,,,,,
,Trial 2,,,,,,,,
,,Wildtype (pL4440),105,15,17,,,,
,,ubql-1(tm1574) (pL4440),107,13,17,0.0029,wildtype vs ubql-1(tm1574),,
,,Wildtype (npl-4.1/4.2),81,39,14,,,<0.0001,wildtype vs wildtype (npl-4.1/4.2)
,,ubql-1(tm1574)  (npl-4.1/4.2),106,14,14,,,<0.0001,ubql-1(tm1574) vs ubql-1(tm1574) (npl-4.1/4.2)
,,Wildtype (ufd-1),86,39,14,,,<0.0001,wildtype vs wildtype (ufd-1)
,,ubql-1(tm1574)  (ufd-1),111,9,12,,,<0.0001,ubql-1(tm1574) vs ubql-1(tm1574) (ufd-1)
,,Wildtype (cdc-48.1),117,2,12,,,<0.0001,wildtype vs wildtype (cdc-48.1)
,,ubql-1(tm1574)  (cdc-48.1),118,1,8,,,<0.0001,ubql-1(tm1574) vs ubql-1(tm1574) (cdc-48.1)
,,hsf-1 OE (pL4440),60,52,21,<0.0001,wildtype vs hsf-1 OE,,
,,hsf-1 OE;ubql-1(tm1574) (pL4440),90,30,16,<0.0001,hsf-1 OE vs hsf-1 OE;ubql-1(tm1574),,
,,hsf-1 OE  (npl-4.1/4.2),108,12,12,<0.0001,wildtype (npl-4.1/4.2) vs hsf-1 OE (npl-4.1/4.2),<0.0001,hsf-1 OE vs hsf-1 OE (npl-4.1/4.2)
,,hsf-1 OE;ubql-1(tm1574) ( (npl-4.1/4.2),117,3,12,,,<0.0001,hsf-1 OE;ubql-1(tm1574)vs hsf-1 OE; ubql-1(tm1574)(npl-4.1/4.2)
,,hsf-1 OE  (ufd-1),105,15,12,<0.0001,wildtype (ufd-1) vs hsf-1 OE (ufd-1),<0.0001,hsf-1 OE vs hsf-1 OE (ufd-1)
,,hsf-1 OE;ubql-1(tm1574) (ufd-1),111,8,12,,,<0.0001,hsf-1 OE;ubql-1(tm1574)vs hsf-1 OE; ubql-1(tm1574)(ufd-1)
,,hsf-1 OE  (cdc-48.1),120,0,10,<0.0001,wildtype (cdc-48.1) vs hsf-1 OE (cdc-48.1),<0.0001,hsf-1 OE vs hsf-1 OE (cdc-48.1)
,,hsf-1 OE;ubql-1(tm1574) (cdc-48.1),118,2,8,,,<0.0001,hsf-1 OE;ubql-1(tm1574)vs hsf-1 OE; ubql-1(tm1574)(cdc-48.1)
,,,,,,,,,
,,,,,,,,,
,,,,,,,,,
"Related to Figure 5g,h,i",,Genetic strain/RNAi,No. of worms,Censored worms,Median survival,p-value ,genotype being compared,,
,Trial 1,,,,,,,,
,,Wildtype (pL4440),101,19,18,,,,
,,Wildtype (fzo-1),111,9,22,<0.0001,wildtype (pL4440) vs wildtype (fzo-1),,
,,Wildtype (eat-3),108,12,26,<0.0001,wildtype (pL4440) vs wildtype (eat-3),,
,,Wildtype (drp-1),106,14,20,0.0086,wildtype (pL4440) vs wildtype (drp-1),,
,,hsf-1 OE (pL4440),94,26,24,<0.0001,wildtype (pL4440) vs hsf-1 OE (pL4440),,
,,hsf-1 OE (fzo-1),104,17,24,0.3953,hsf-1 OE (pL4440) vs hsf-1 OE (fzo-1),,
,,hsf-1 OE (eat-3),105,10,24,0.0134,hsf-1 OE (pL4440) vs hsf-1 OE (eat-3),,
,,hsf-1 OE (drp-1),68,7,20,<0.0001,hsf-1 OE (pL4440) vs hsf-1 OE (drp-1),,
,,,,,,,,,
,Trial 2,,,,,,,,
,,Wildtype (pL4440),115,1,16,,,,
,,Wildtype (fzo-1),106,13,19,<0.0001,wildtype (pL4440) vs wildtype (fzo-1),,
,,Wildtype (eat-3),89,27,22,<0.0001,wildtype (pL4440) vs wildtype (eat-3),,
,,Wildtype (drp-1),91,27,19,<0.0001,wildtype (pL4440) vs wildtype (drp-1),,
,,hsf-1 OE (pL4440),88,33,22,<0.0001,wildtype (pL4440) vs hsf-1 OE (pL4440),,
,,hsf-1 OE (fzo-1),84,33,22,0.3331,hsf-1 OE (pL4440) vs hsf-1 OE (fzo-1),,
,,hsf-1 OE (eat-3),114,31,22,0.0524,hsf-1 OE (pL4440) vs hsf-1 OE (eat-3),,
,,hsf-1 OE (drp-1),121,13,16,0.0001,hsf-1 OE (pL4440) vs hsf-1 OE (drp-1),,
,,,,,,,,,
Related to Figure 5j,,Genetic strain/RNAi,No. of worms,Censored worms,Median survival,p-value ,genotype being compared,,
,Trial 1,,,,,,,,
,,Wildtype (pL4440),110,9,18,,,,
,,Wildtype (pink-1),86,34,20,0.0386,wildtype (pL4440) vs wildtype (pink-1),,
,,hsf-1 OE (pL4440),105,15,22,0.0001,wildtype (pL4440) vs hsf-1 OE (pL4440),,
,,hsf-1 OE (pink-1),77,8,22,0.6165,hsf-1 OE (pL4440) vs hsf-1 OE (pink-1),,
,,,,,,,,,
,Trial 2,,,,,,,,
,,Wildtype (pL4440),105,14,18,,,,
,,Wildtype (pink-1),102,18,22,0.0166,wildtype (pL4440) vs wildtype (pink-1),,
,,hsf-1 OE (pL4440),113,7,22,0.002,wildtype (pL4440) vs hsf-1 OE (pL4440),,
,,hsf-1 OE (pink-1),114,6,24,0.1268,hsf-1 OE (pL4440) vs hsf-1 OE (pink-1),,
,,,,,,,,,
,,,,,,,,,
Related to Figure 2d,,Genetic strain/RNAi,No. of worms,Censored worms,Median survival,p-value ,genotype being compared,,
,Trial 1,,,,,,,,
,,Wildtype,40,0,1,,,,
,,ubql-1(tm1574),41,1,4,<0.0001,wildtype vs ubql-1(tm1574),,
,,hsf-1 OE ,41,2,4,0.0001,wildtype vs hsf-1 OE,,
,,hsf-1 OE;ubql-1(tm1574),39,6,4,0.938,hsf-1 OE vs hsf-1 OE;ubql-1(tm1574),,
,Trial 2,,,,,,,,
,,Wildtype,41,1,2,,,,
,,ubql-1(tm1574),46,1,5,0.0346,wildtype vs ubql-1(tm1574),,
,,hsf-1 OE ,44,4,5,0.0034,wildtype vs hsf-1 OE,,
,,hsf-1 OE;ubql-1(tm1574),49,1,5,0.4367,hsf-1 OE vs hsf-1 OE;ubql-1(tm1574),,
,,,,,,,,,
,,,,,,,,,
Related to Figure 4a,,Genetic strain/RNAi,No. of worms,Censored worms,Median survival,p-value ,genotype being compared,,genotype being compared
,Trial 1,,,,,,,,
,,wildtype vehicle DMSO,23,8,15,,,,
,,wildtype Tunicamycin,14,14,7,<0.0001,wildtype vehicle DMSO vs wildtype Tunicamycin,,
,,hsf-1 OE vehicle DMSO,24,5,18,0.0055,wildtype vehicle DMSO vs hsf-1OE vehicle DMSO,,
,,hsf-1 OE Tunicamycin,10,20,5,<0.0001,hsf-1OE vehicle DMSO vs hsf-1OE Tunicamycin,<0.0001,wildtype Tunicamycin vs hsf-1OE tunicamycin
,Trial 2,,,,,,,,
,,wildtype vehicle DMSO,47,2,10,,,,
,,wildtype Tunicamycin,27,2,7,<0.0001,wildtype vehicle DMSO vs wildtype Tunicamycin,,
,,hsf-1 OE vehicle DMSO,31,16,23,0.0003,wildtype vehicle DMSO vs hsf-1OE vehicle DMSO,,
,,hsf-1 OE Tunicamycin,29,4,4,<0.0001,hsf-1OE vehicle DMSO vs hsf-1OE Tunicamycin,<0.0001,wildtype Tunicamycin vs hsf-1OE tunicamycin