>al_E_sigismundi ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -MSSITATNNIS------------------------------------------------ ------------------------------------------------------------ ---TASIFG-----------------------------------------YGNED----- -KL-----NQRKQRRYRTTFSSTQLDELERVFGETHYPDVFIREELALRINLTEARVQVW FQNRRAKHRKQDKNELQSI-P------------INPVMN---NFAL-------------- ------------------------------LMQQQ---------------------QQQQ N-------EMQFHS--GLQ----------------------------------------- ------------------------------------------------------------ -----------------------QQPQPQQQ----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------HQ---------------------------- --------------- >al_H_exemplaris M----------------------VGHDERPK----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------KENDCVV------------------------------------ -----------------------------------------PERISPS----------I- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------ASAGSLDDKESFV------------ -----DDDSEDS------------------------------------------------ ---ASFGAG--------------------------------------GGAGARSG----- -AG-----LSSKQRRYRTTFTAFQLQELEKCFGKTHYPDIFTRDELAMRIHLTEARIQVW FQNRRAKWRKTEKSSAPHP-ISG--------VEPSPAVQSFNTTHPIPNSNCS------- ------FSKGHTDPFLQSPHGPSSADYNVRMNPGWPLIPPSNKYSRSSLTQNFYPEQAAA AA------AAAAMA--ATTNMWNQRWLQQMAVNSLLHRDVPPS-WTTQTSAGSAVSPAHH LTFH---------P------------------------------EFRPFFH--------- -------------------------PHPNGTTTAGQ------------------------ -----------------------------------------------------LTGPSAT AAQW---------------TGP-------------------------------------- ----------------------------------GVTADAMQKYGAFRSI---ARN---- DGGGGGR----------------------------------------------------- --------------- >al_Dmel_Q06453 -----------------------MGISEEIK----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LEELPQEA KLAHPDA----------------------------------------------------- --------------VVLVDRAPGSSAA-------SAGAALTVS----------------- ---MSVSGG--------------------------APSGASGASGGTN------------ ---SPVSDG--------------------------------------------------- ------NSD-----------------------------------------CEADE----- -YA-----PKRKQRRYRTTFTSFQLEELEKAFSRTHYPDVFTREELAMKIGLTEARIQVW FQNRRAKWRKQEKVGPQSH-P------------YNPYL----PGGAATMQTVV------- ------GAALPPNPFTH-------------LGFQL---------------------RKPF DAQHAANLAAFRYP--HLS--------------------------AAPMIPSGYFNQFQR AP-----------P--------------HMLPH-GMAGMYSPSSSFQSLLANMTAVPRGT PLGKPPALLVGSPDLHSPNHMLASPPTSPASGHASQHQQH-------------------- --PTAHPP-----PPQAPPQMPVGVQ--------PAQLSPQHLVGIALTQQASSLSPTQT SPVALTLSHSPQRQL----PPP-------------------------------------- SHQAPPPPP------------------------RAATPPEDRRTSSIAALRLKARE---- ------------------------------HELKLELLRQNGH--------------GND VVS------------ >al_Anopheles_gambiae_A0A1S4GWX6 -----------------------MGISDEGS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----RLEDIGPHE-ARPPQGSPL-----------ERSASTGQL----------------- ---MGSSGGDPN------------------------------------------------ ---SPLSDP--------------------------------------------------- ------HSD-----------------------------------------DGGDD----- -FA-----PKRKQRRYRTTFTSFQLEELEKAFSRTHYPDVFTREELAMKIGLTEARIQVW FQNRRAKWRKQEKVGPQGH-P------------YNPYLA---SAGQVPSATVV------- ------APSLPPNPFSH-------------LGFNL---------------------RKPF DA---ASLAAFRYP--SLG--------------------------GSHMLPSAYFNQFHR VS-----------PLSSFVDEFCRAPPPPLLPP-GVGTFYTPSASFQTLLANISAAQRAP ----------------------PAMPSKPPTSGVDYMPPG-------------------- --PPGIPP-----PP--PPGSQVPTS--------PA---------------SPPISPTAL PPVVP----VPQAAL----PAP-------------------------------------- ----PQPPP-----------------------GSASPPQADRRSSSIAALRLKARE---- ------------------------------HELRLEMLRQNGH---------------SD ILS------------ >al_Tribolium_castaneum_A0A139WH33 MDSE----------------CVEMDLSTRQR----------------------------- ------------------------------------------------------------ -----------------------------------------------------------D PQDNAKMRV-------------------------AKSVFSIRS----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----LVDLGDAA-DAPDDDAPKEPVA-------SDRNPEVMG----------------- ------VSEEVT-----------------------PNAGVEPRPPGPD------------ -----NSDG--------------------------------------------------- -------SD-----------------------------------------PEPDE----- -FA-----PKRKQRRYRTTFTSYQLEELEKAFSRTHYPDVFTREELAMKIGLTEARIQVW FQNRRAKWRKQEKVGPQGH-P------------YNPYLS---PGGGGPAPSVV------- ------APSL-PNPFN--------------LPFGL---------------------RKPF DS------LSFRYP----------------------PHVLP---SYLPSPPGYHRGG--- -------------P--------------ALLPP-SVS-LYPSASSFQTLLANISAAQR-- ----------------------PKLPAQEFTT---------------------------- ---------------------------------------------------SPPLSPGGS A------------------VTP-------------------------------------- -------------------------------------PDVDRRSSSIASLRLKARE---- ------------------------------HELRLEMLRQNG-----------------D LIS------------ >al_Strigamia_maritima_T1IYK9 MVS--------------------MDLSTKTR----------------------------- ------------------------------------------------------------ --------------------------------------------------------PGSD PILTQESLQKNS-----------------------RNNFSISK---LVDIED-------- --NCTTTV----KITFPSRPA-------------------------------------LT LPPVLSALALALAFALGRPPHYIHIY-------------------------------PAL LTEATRDLMGCPEATHVHC-----------SLQLHSNANS-PAIITVN------HHFH-- --HNA------------------------------------------------------- ------------------------MGLSSLSERNHINT-SSTEDE--------------- --------------SADDDDEENHRPN-------KDESPHRVE----------------- ------SSSDIT-----------------------AGHELGNVRNLDD------------ ------------------------------------------------------------ ---VSGNSE-----------------------------------------ADLDE----- -FA-----PKRKQRRYRTTFTSFQLEELEKAFARTHYPDVFTREELAMRVDLTEARVQVW FQNRRAKWRKQEKVGPQSH-P------------YTHFST---TELTLPTNPSR------- ------NNAAIPSPFGA-------------LTYLQ---------------------RKPP Y-------EATLPP--SVTFLPP-------------ARSLPPTHTFLPVPPAHFLTPFQL RD-----------PRVPLM--------PTVLPPLSVGIGTYPANTFQTLLASLGSR---- ----------------------PKLPTPTSESAPSV------------------------ --------------------------------------------------------PT-- -------------------VTP-------------------------------------- -----------------------------------SNGSEDRRSSSIAALRMKARE---- ------------------------------HELRMEMIRNN------------------D VLS------------ >al_C_elegans_Q21836 M--------------------PELKKEDSSK----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------DEKDLDMNC-------------------------------PPL ---------------HRPN-----------GADLNQYSKS-------------------- ----------------------------------------------------LMEQLQAQ LFANPA------------------------------------------------------ --------------LQFPSFPPAFSIAA----LTNNQHELKED-----D----------- -GKKTPTGDNIL-----------------------EAASVLDNRENGS------------ -----PSDG--------------------------------------------------- --------------------------------------------------TNSPD----- -DN-----GKRKQRRYRTTFSAFQLDELEKVFARTHYPDVFTREELATRVQLTEARVQVW FQNRRAKYRKQERSSTHHP-YQA--------PMSIPNSNGDNPYQMMLSQEAI------- ------FAAINQQAAAHL------------LNEQV---------------------RIAT SD------RRSQSP--SVPVT-----------------------TSSPILPTSVTPTFQN ADALNML-FGGITPVTQ-----------QLL---YVQQFSRAMDAFRTQL--LGSVPAGA TAEVTDVVALKTEDSKSNSRAGSSSPTPTESSGAA------------------------- ---------------------------------------------------ATSTSPTNF ADM---------NSLIS-DVKP-------------------------------------- ------------------------------------------------------KE---- ------------------------------------------------------------ ---ESS--------- >al_Rattus_norvegicus_A6YP62 MSNQ----------------YQEEGCSERPE----------------------------- ------------------------------------------------------------ -------------------------------------------------------CKSKS PT--------------------------------LLSSYCIDS---ILGRRS-------- --PCKMRL---------------LGAAQSLPAPLASRTDQEKAMQGSPKGSSAPFEAELH LPPKLRRLYGP------GGGRLLQGAAAAAAAAAAAAAAAATATGTAGPRGEVPPPPPPA ARPGERQDSAG-----AVAAAAAAAWD---TLKISQAPQV---SISRS------KSYR-- --ENGAPFVPP----------P-PA---------------------------LDELGGPG GVAHPEERLSAASGPGSAPA----AGGGTGTEEDEEELLEDEEDEDEEEELLEDDEEE-- ----LLEDDARAL-LKEPRRCSVATTGTVA--AAAAAAAAAAA----------------- ---VATEGGELS-----------------------PKEELLLHPEDAE------------ -----GKDGEDS------------------------------------------------ ---VCLSAG-----------------------------------------SDSEE----- -GL-----LKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVW FQNRRAKWRKREKAGAQTH-PPG-------LPFPGPLSATH------------------- P----LSPYLDASPFPPH-HPA--------LDSAW---------------------TAAA AA------AAAAFP--SLPPPPG-------------SASLPP--SGAPLGLSTFLGAAVF RH-----------P--------------AFISP-----------AFGRLFS--------- ----------------------TMAPLTSASTAAAL------------------------ ---------------------------------------------------LRQPTPAVE GAVA-------SGAL----ADP-------------------------------------- -----------------------------------ATAAADRRASSIAALRLKAKE---- ------------------------------HAAQLTQL---------------------N ILPGTSTGKEVC--- >al_Danio_rerio_B3DKI9 MSSQ----------------YD-DDSRDRSE----------------------------- ------------------------------------------------------------ -------------------------------------------------------CKSKS PT--------------------------------VLSSYCIDS---ILGRRS-------- --PCKVRQ---------------LG-AQSLPAPV--RPDHEMTTEVTSKENS--FDSDMH LPPKLRRLYGP------GGKYLDSG------------------------RGFHE-----H LEKGERE--------RLLDQACE-------SLKISQAPQV---SISRS------KSYR-- --EN-APF---------------SQ---------------------------SDEGQSPE HMAQE-------------------LVELSTLKFEEDV--VKEE----------------- ------------------------------------------------------------ ----ACGDNSLS-----------------------PKDEESLH-NDGD------------ -----VKDGEDS------------------------------------------------ ---VCLSAG-----------------------------------------SDSEE----- -GM-----LKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVW FQNRRAKWRKREKAGVQAH-PTG-------LPFPGPLAAAH------------------- P----LSHYLEGGPFPPHPHPA--------LESAW---------------------T-AA AA------AAAAFP--GLAPPPN-------------SSALPP---ATPLGLGTFLGTAMF RH-----------P--------------AFIGP-----------TFGRLFS--------- ----------------------SMGPLTSASTAAAL------------------------ ---------------------------------------------------LRQTAPPVE SPVQ------PSAAL----PEP-------------------------------------- --------P-----------------------SSSSSTAADRRASSIAALRLKAKE---- ------------------------------HSAQLTQL---------------------N ILPSGTAGKEVC--- >al_Human_Q96QS3 MSNQ----------------YQEEGCSERPE----------------------------- ------------------------------------------------------------ -------------------------------------------------------CKSKS PT--------------------------------LLSSYCIDS---ILGRRS-------- --PCKMRL---------------LGAAQSLPAPLTSRADPEKAVQGSPKSSSAPFEAELH LPPKLRRLYGP------GGGRLLQGA-AAAAAAAAAAAAAA-ATATAGPRGEAPPPPPPT ARPGERPDGAGA--AAAAAAAAAAAWD---TLKISQAPQV---SISRS------KSYR-- --ENGAPFVPP----------P-PA---------------------------LDELGGPG GVTHPEERLGVAGGPGSAPA----AGGGTGTEDDEEELLEDEEDEDEEEELLEDDEEE-- ----LLEDDARAL-LKEPRRCPVAATG-------AVAAAAAAA----------------- ---VATEGGELS-----------------------PKEELLLHPEDAE------------ -----GKDGEDS------------------------------------------------ ---VCLSAG-----------------------------------------SDSEE----- -GL-----LKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVW FQNRRAKWRKREKAGAQTH-PPG-------LPFPGPLSATH------------------- P----LSPYLDASPFPPH-HPA--------LDSAW---------------------TAAA AA------AAAAFP--SLPPPPG-------------SASLPP--SGAPLGLSTFLGAAVF RH-----------P--------------AFISP-----------AFGRLFS--------- ----------------------TMAPLTSASTAAAL------------------------ ---------------------------------------------------LRQPTPAVE GAVA-------SGAL----ADP-------------------------------------- -----------------------------------ATAAADRRASSIAALRLKAKE---- ------------------------------HAAQLTQL---------------------N ILPGTSTGKEVC--- >al_Mus_musculus_O35085 MSNQ----------------YQEEGCSERPE----------------------------- ------------------------------------------------------------ -------------------------------------------------------CKSKS PT--------------------------------LLSSYCIDS---ILGRRS-------- --PCKMRL---------------LGAAQSLPAPLASRADQEKAMQGSPKSSSAPFEAELH LPPKLRRLYGP------GGGRLLQGA-AAAAAAAAAAAAAATATGTAGPRGEVPPPPPPA ARPGERQDSAG----AVAAAAAAAAWD---TLKISQAPQV---SISRS------KSYR-- --ENGAPFVPP----------P-PA---------------------------LDELSGPG GVAHPEERLSAASGPGSAPA----AGGGTGAEDDEEELLEDEEDEEEEEELLEDDDEE-- ----LLEDDARAL-LKEPRRCSVATTGTV----AAAAAAAAAA----------------- ---VATEGGELS-----------------------PKEELLLHPEDAE------------ -----GKDGEDS------------------------------------------------ ---VCLSAG-----------------------------------------SDSEE----- -GL-----LKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVW FQNRRAKWRKREKAGAQTH-PPG-------LPFPGPLSATH------------------- P----LSPYLDASPFPPH-HPA--------LDSAW---------------------TAAA AA------AAAAFP--SLPPPPG-------------SASLPP--SGAPLGLSTFLGAAVF RH-----------P--------------AFISP-----------AFGRLFS--------- ----------------------TMAPLTSASTAAAL------------------------ ---------------------------------------------------LRQPTPAVE GAVA-------SGAL----ADP-------------------------------------- -----------------------------------ATAAADRRASSIAALRLKAKE---- ------------------------------HAAQLTQL---------------------N ILPGTSTGKEVC--- >al_Xenopus_tropicalis_A0A6I8S3E9 MSSH----------------YP-EETSERPE----------------------------- ------------------------------------------------------------ -------------------------------------------------------CKSKS PT--------------------------------LLSSYCIDS---ILGRRS-------- --PCKMRL---------------LG-AQSLPS-LAHRLDPDKTLEGSPKGNAA-FEADLH LPPKLRRLYGPV----GGSGRIHLQA-------------------VADARSGVP-----R SEKTDRI--------LLLGGAGENTWD-NHSLKISQAPQV---SISRS------KSYR-- --ENSAPL--------------------------------------------LREEHSPE GLLQQSQQQIQTSATTACTSLQDRLGALSQSPRDEDD--DDEEDEDEEEEEEEEDEANKQ HNPNNSSNPNRAH-LQEQQHPQFQSQQ-------SQQQQPPPG----------------- ----CGTDAELS-----------------------PKEELMLHSSDAD------------ -----GKDGEDS------------------------------------------------ ---VCLSAG-----------------------------------------SDSEE----- -GM-----LKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVW FQNRRAKWRKREKAGAQTH-APG-------LPFPGPLSASH------------------- P----LGPYLDASPFPPH-HPA--------LDSAW---------------------TAAA AA------AAAAFP--SLPPPPHG------------SAALPP--SGSPLGLSTFLGAAVF RH-----------P--------------AFISP-----------AFGRLFS--------- ----------------------TMAPLTSASTAAAL------------------------ ---------------------------------------------------LRQPSPAVE SSVQ-------SSGL----SDP-------------------------------------- -----------------------------------VTAAADRRASSIAALRLKAKE---- ------------------------------HAAQLTQL---------------------N IIPGNSAGKEVC--- >ap_Esigismundi ILFP-------------------MDLNEEITTT--------------------------- --------------------------TTTATTIAPPLINISSS----------------- -----SVENI------------------------------------------------NT PAITETQSLS-------------TSDICNACFLPIQERYLLML----GDSLL-YHSHCLK CLDCGVQLCEDDRSCFFNSGN------------VYCRQDYQKRFNQR------------- ---QCTRCNVTF-----QSTDLVMTV-P-----------------CEDLQNNSNSNNTPT LPSS-LPIQF-----HVDCFSCA-----ICERVLASGELYRYIPMPHN-TLLCCEHLE-- ------------------------------------------------------------ ------------------------------------------------------------ --WSNFKDDSGKL----------------------------------------------- -----------------------------------STKVGRPRKRKSQ------------ -------DS--------------------------------------------------- ---SHSTCS-----------------------------------------GGNGG----- -NNE---HSMQRPKRMRTSFKHPQIKVMKQFFISNQNPDAKMLKTLSARTSLSKRVLQVW FQNQRAKFRREHSKRQHQH-QSVGM----------------------------------- -----------NGPDGYN------------------------------------------ ------------------------------------------------------------ -------------P---------------------------------------------- -----------------------HGP---------------------------------- ------------------------------------------------------------ -------------DVYQLHIPP-------------------------------------- ---------------------TVQSLPSVASYSPGGTVTSRNNGNNNNLGQQQQQQ---- -----------------------------------------------------QQQKPSD SYS------------ >ap_Hexemplaris -----------------------MPILERSN----------------------------- ----SGHNEQEEAINSH----------VTAHGEEPSCLQLDHD----HDHGLLP------ -----GNEDV------------------------------------------------AH PQHHVQHPAAGY----------FPALICSGCRNGISEQYFLSV----SNSQDFYHCHCLK CSVCSVTL-DRQMICYYKDGM------------ILCKEDYYKYKSRRLSPEGYQNS---- ---RCHGCNYPI-----RADEFVM------------------------------------ --RV-REFVF-----HVPCFRCL-----ACTATLHTGDEF---TMRDDGAILCQRHFH-- --PAAAVAHVGGGGGGGVG-----------------------------------SSSNPA SDTLSS------------------TAALLPPHSSHDSFSAASSDI--------------- ----PTTTATAAS-LRLPILMADHGAPV-SPHFAQLQNRIVPRHDDGGDGNDGRKDLFHH HHHQTSASSSAS-----------------------SRMKSRIRRTKRNL----------- ---ISFDDGSGGVINQRHTAGGLNGSGGELHGDPVGQAELLQQRQAAAAMQLEQQCYHHF SSAASPNAALPVQTAQQSSFTSSSEESSPSRLASSSPGLQMAHLTHSITDSSSPN----- -NQ-----QHQRTKRMRTSFKHQQLRSMKQYFGINHNPDAKDLKQLAQKTGLTKRVLQVW FQNARAKYRRSLLKQDPNRVLEA------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------SPIAKAQ----------------------------------------- ----------------------SNSPSPRPDYGL-------------------------- --------------------------------------------------------PDNA S-----------AKQHDLNHYP-------------------------------------- ---------------------------------MSNGSNSQDNGAEYY------------ ------------------------------------------------------------ --------------- >ap_Dmel_E1JGX9 MGVCTEE-------------RPVMHWQQSARFLGP-----GAREKSPTPPVAHQG----- ---SNQCGSAAGANNNHPLFRACSS--SSCPD------ICDHSTKPFG--------NAYG TESFRSYETADRATFEDSAAKFSISRSRTDCTEVSDETTSGISFK------TEPFGPPSS PESTSDSKIT------------RNLDDCSGCGRQIQDRFYLSA----VEKR--WHASCLQ CYACRQPL-ERESSCYSRDGN------------IYCKNDYYSFFGTR------------- ---RCSRCLASI-----SSNELVM------------------------------------ --RA-RNLVF-----HVNCFCCT-----VCHTPLTKGDQY---GIIDA-LIYCRTHYS-- --IAREGDTASS----------SM----------------------------SATYPYSA QFGSPH---------------------------NDSSSPHSD------------------ --PSRSIVPTGIF-VPAS----------------HVINGLPQP----------------- -----------------------------------ARQKGRPRKRKPK------------ -------DI--------------------------------------------------- ---EAFTAN-------IDLNTEYVD------------------------FGRGSH----- -LS-----SSSRTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLSQKTGLPKRVLQVW FQNARAKWRRMMMKQDGSG-L-L--------EKGEGAL----DLDSIS------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------VHSPTSFILGGPN------------------------- ------------------------------------------------------------ ------------------STPPLNLD---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------- >ap_Human_P50458 M----------------------------------------------------------- ---------------------------------------LFHSLSGPEVHGVI------- -------DEMDRR-----------------AKSEAPAISSAIDRG-----DTETTMPSIS SD---------------------RAALCAGCGGKISDRYYLLA----VDKQ--WHMRCLK CCECKLNL-ESELTCFSKDGS------------IYCKEDYYRRFSVQ------------- ---RCARCHLGI-----SASEMVM------------------------------------ --RA-RDLVY-----HLNCFTCT-----TCNKMLTTGDHF---GMKDS-LVYCRLHFE-- --ALLQGE---------------------------------------------------- ----------------------------YPAHFNHADVAAAAAAAAA------------- -AKSAGLGAAGANPLGLPYY-----------------NGVGTV----------------- -------------------------------------QKGRPRKRKSP------------ ---GPGADL--------------------------------------------------- ---AAYNAA-------LSCNENDAEH-----------------------LDRDQP----- -YP-----SSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVW FQNARAKFRRNLLRQENTG-VDK--------STDAA-------LQTG-T----------- ------------------------------------------------------------ ------------------------------------------------------------ -------------P---------------------------------------------- -----------------------SGPASELSN---------------------------- ----------------------------------------------------ASLSPSST P-----------TTLTDLTSPTLPTVTSV------------------------------- --------------------------------LTSVPGNLEGHEPHSP------------ ------------------------------SQTTLTNLF--------------------- --------------- >ap_Rattus_norvegicus_P36198 M----------------------------------------------------------- ---------------------------------------LFHSLSGPEVHGVI------- -------DEMDRR------------------QERGSGISSAIDRG-----DTETTMPSIS SD---------------------RAALCAGCGGKISDRYYLLA----VDKQ--WHMRCLK CCECKLNL-ESELTCFSKDGS------------IYCKEDYYRRFSVQ------------- ---RCARCHLGI-----SESEMVM------------------------------------ --RA-RDLVY-----HLNCFTCT-----TCNKMLTTGDHF---GMKDS-LVYCRLHFE-- --ALLQGE---------------------------------------------------- ----------------------------YPPHFNHADVARAAAAAEQ------------- -LRVQDWAQLGLT-LGLPYY-----------------NGVGTV----------------- -------------------------------------QKGRPRKRKSP------------ ---GPGADL--------------------------------------------------- ---AAYNAA-------LSCNENDAEH-----------------------LDRDQP----- -YP-----SSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVW FQNARAKFRRNLLRQENTG-VDK--------TSDAT-------LQTG-T----------- ------------------------------------------------------------ ------------------------------------------------------------ -------------P---------------------------------------------- -----------------------SGPASELSN---------------------------- ----------------------------------------------------ASLSPSST P-----------TTLTDLTSPTLPTVTSV------------------------------- --------------------------------LTSVPGNLEATSPTAL------------ ------------------------------HKRLLPTFSNDS--------------PPPS PLSPHDFFKKEIIFS >ap_Mus_musculus_Q9Z0S2 M----------------------------------------------------------- ---------------------------------------LFHSLSGPEVHGVI------- -------DEMDRR-----------------AKSEAPAISSAIDRG-----DTETTMPSIS SD---------------------RAALCAGCGGKISDRYYLLA----VDKQ--WHMRCLK CCECKLNL-ESELTCFSKDGS------------IYCKEDYYRRFSVQ------------- ---RCARCHLGI-----SASEMVM------------------------------------ --RA-RDLVY-----HLNCFTCT-----TCNKMLTTGDHF---GMKDS-LVYCRLHFE-- --ALLQGE---------------------------------------------------- ----------------------------YPAHFNHADVAAAAAAAAA------------- -AKSAGLGSAGANPLGLPYY-----------------NGVGTV----------------- -------------------------------------QKGRPRKRKSP------------ ---GPGADL--------------------------------------------------- ---AAYNAA-------LSCNENDAEH-----------------------LDRDQP----- -YP-----SSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVW FQNARAKFRRNLLRQENTG-VDK--------TSDAT-------LQTG-T----------- ------------------------------------------------------------ ------------------------------------------------------------ -------------P---------------------------------------------- -----------------------SGPASELSN---------------------------- ----------------------------------------------------ASLSPSST P-----------TTLTDLTSPTLPTVTSV------------------------------- --------------------------------LTSVPGNLEGHEPHSP------------ ------------------------------SQTTLTNLF--------------------- --------------- >ap_Xenopus_tropicalis_A0A6I8QAN8 MEIV-------------------------------------------------------- ---------------------GCRTD-ESAYPFRPAA-MLFHGITGGHIQGIM------- -------EEMERR-----------------SKSADSRLAKGIQVN-----GRETRMPSLS PE---------------------KPALCAGCGGKISDRYYLLA----VDKQ--WHLRCLK CCECKLAL-ESELTCFAKDGS------------IYCKEDYYRRFSVQ------------- ---RCARCHLGI-----SASEMVM------------------------------------ --RA-RESVY-----HLSCFTCT-----TCNKTLSTGDHF---GMKEN-LVYCRIHFE-- --LLVQGD---------------------------------------------------- ----------------------------FHQQLNYTEL---------------------- ------SAKGGGI-ATLPYFS----------------NGTGTV----------------- -------------------------------------QKGRPRKRKSP------------ ---ALGVDI--------------------------------------------------- ---INYSSG---------CNENETD------------------------LDRDQT----- -YP-----PSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVW FQNARAKFRRNLLRQENGG-GDK--------VEGPS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------LSAPASAES----------------------------- ----------------------------------------------------AALTPTGA T-----------STLSDLTSPSL----NV------------------------------- --------------------------------GASVTPNMDTHESGSP------------ ------------------------------SQTTLTNLF--------------------- --------------- >ap_Danio_rerio_B0R107 MNCTGLEVRLTEI----------------------------------------------- --------------------LGCRSDGNTCYSVSSAATMLFHGLPGGEMHGVM------- -------EEMERR-----------------GKSDSATISSAIDMG-----ETETNMPSIS GD---------------------RVALCAGCGGKISDRYYLLA----VDKQ--WHMRCLK CCECKLNL-ESELTCFSKDGS------------IYCKEDYYRRFSVQ------------- ---RCARCHLGI-----SASEMVM------------------------------------ --RA-RDLVY-----HLNCFTCT-----TCNKMLTTGDHF---GMKDS-LVYCRLHFE-- --TLIQGD---------------------------------------------------- ----------------------------FPTHFNHTDVAP-------------------- ---NKGLSSTGP--LGLSYY-----------------NGVNTV----------------- -------------------------------------QKGRPRKRKSP------------ ---GPGADL--------------------------------------------------- ---AAYNAA-------LSCNENDGDP-----------------------MDRDSQ----- -YS-----SSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVW FQNARAKFRRNLLRQENTG-VDK--------ASDGS------NLAGG-T----------- ------------------------------------------------------------ ------------------------------------------------------------ -------------P---------------------------------------------- -----------------------SGPASEISN---------------------------- ----------------------------------------------------ASMSPSST P-----------TTLTDLTNPTMPTVTSV------------------------------- --------------------------------LTSVPGSLDVHECRSP------------ ------------------------------SQSTLTSLF--------------------- --------------- >ap_C_elegans_G5EE86 MYFQSLSADPLDS------VNTTTDFNQLAQLL--------------------------- --LMLTNSSSKETIATH-----------VVTNSVPSAFQFDWSSHFKEEYDLV------- -------EKLNSP--------------------------------------QYTNLTSIS PSSSTDSNNLILRQIQIPKIEPALLNQCCLCTFAIVDKEISVV----DGKY--YHNNCLR CQMCDIPF-EYSDKCYVRDGV------------FLCRADHAKRYQK-------------- ---CCRKCEIPL-----NREDMVM------------------------------------ --KA-KEMIF-----HHACFVCF-----ICGIKLNPGDYY---TMSPQGHLYCHAHYN-- --AVRS----------------------------------------------TVLCEEAA VATVPA------------------------------------------------------ --------------VVAPPPPP------------PTTTTAPPP----------------- -----------------------------------AAPEQPPREASTE------------ ------------------------------------------------------------ -----AEAS----------------------------------------TDEDGN----- -GS-----GSQRSKRMRTSFKHHQLRAMKTYFALNHNPDAKDLKQLAAKTNLTKRVLQVW FQNARAKYRRELHDGGRSS----------------------------------------- ------------SPLCVS------------------------------------------ ------------------------------------------------------------ ------------APLASMD----------------------------------------- ----------------------MNPPLSSSSSGHS------------------------- ------------------------------------------------------------ ------------TDGYQLNTPP-------------------------------------- ---------------------------------LSSEIYSPNSNYTHL------------ ------------------------------------------------------------ --------------- >ap_Anopheles_gambiae_A0A1S4GZT4 MGVCAEE-------------RPIMHWHPSARFLGP------PRERSPDL----------- -----SNACQLNSNNNNLNHRTCISCTDTC----------EHSLKVAGGNGLLGVNHHLY ADSCHSFESPDRLIAD--RPNYYADLNRSDCSDSSSVLNSCIQLK------SEPPGGPSS PESSNELPST-------------GLDECAGCDMPIQDRFYLSA----VERK--WHASCLQ CCICRQTL-EGANSCFSRDGN------------IYCKTDYYRVFGSR------------- ---RCSKCLASI-----SSSELVM------------------------------------ --RA-RHLVF-----HIRCFSCA-----VCNTPLNKGDHY---TIRDS-AVFCRSHIE-- --LPLEAATTPGL--------PGM----------------------------PMQCPYQS QYGT-------------------------------SPVAPLS------------------ --PSDSTTSGGKL-NPATYYPP------------HGVTGLPQQ----------------- -----------------------------------PRQKGRPRKRKPK------------ -------DI--------------------------------------------------- ---EAMTAS-------LDLNTEYLD------------------------LGFSRG----- -LG-----SSSRAKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLSQKTGLPKRVLQVW FQNARAKWRRMMMKQEGKI-IDS--------DKGDGSL----DLDGYV------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------SHSPGSYIMGGPG------------------------- ------------------------------------------------------------ ------------------SPSSLD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------- >ap_Stegodyphus_mimosarum_A0A087T3Z4 M----------------------LVVCGSSGS---------------------------- ------------------------------------------------------------ ----------------------------------------------------EGGYIPED SRSTVNGRPSIT----------TTPVRCAGCGGSISDRYYLLA----VDRQ--WHVSCLT CCQCKVQL-DSELTCFSRDGH------------IYCKEDYYRMFSVK------------- ---RCTRCHLSI-----SPSDLVM------------------------------------ --RA-REHVY-----HLHCFTCA-----TCNKPLTKGEYF---GLKED-IIYCKVHYE-- --MLLQYERPYLC--------PQPCLKEEEDVTNCEKSSSALDEERLCPHIRCQNFQQTS NLQIPCNL---------------EVFPNFHQQRTNGSL---------------------- ------EHPTRTV------------------------TTIVKT----------------- -----------------------------------SGQKGRPRKQKSFLSSSLLLPHRG- ------------------------------------------------------------ ---PSVTSS-------DDHCSLSGDHQSPLQHSSSSLA--------AVGSDSSTS----- -SE-----HLTRPKRMRTSFKHHQLRAMKSYFSINHNPDAKDLKQLSQKTGLSKRVLQVW FQNARAKWRRNLLRQQSQG-PEI--------AQDCKPLS---ELASQ------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------P---------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------QFCDPFRL G-----------SSLIDIQPTP-------------------------------------- -------------------------------------ITQEEQNIQ-------------- ---------------------------------TFTNLL--------------------- --------------- >ap_Strigamia_maritima_T1J7L2 MPVISAED---------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------SS PG---------------------EPSVCAGCGDKIVDRFYLLA----VDQQ--WHIHCLK CSECQLRL-DSELTCFARDGH------------IYCKEDYFRLFAVK------------- ---RCARCHLGI-----SSSELVM------------------------------------ --RA-RDLVY-----HVHCFTCA-----SCNKPLTKGDHF---GMKNS-MVYCRLHYE-- --LIGHHPHLP-----------HP----------------------------AAPLSSAP PLGDPT------------------IAGLTPSELVNNSTSP-------------------- --GGDSPYATPSL-GRMPYY-----------------NGVGAV----------------- -------------------------------------QKGRPRKRKIPVDHDSALA---- -VMTPGMEI--------------------------------------------------- -----MPSA-------SDLCNMDQS------------------------SGYDTTPPPPS GPGAN-PLQPTRTKRMRTSFKHHQLRTMKSYFALNQNPDAKDLKQLAQKTGLSKRVLQVW FQNARAKWRRNMMRQDSQN-SDK--------PPDANSL----DMNST------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------SHLSDPLSS T-----------HPLSELQPPHLP------------------------------------ -------------------------------------PSSDDQGS--------------- ------------------------------SPLTFGDLY--------------------- --------------- >ap_Tribolium_castaneum_C0KZ21 MGVFEERAS----------HTPGMHWQQHEQYIGPA--YDPSRDLSPNLPSCDSSMGDAD PSVSSGSSCSTPSNNNH---QSCGS--DTC---RPPPPALNHPPPPPG------------ ----------------------------ELCRPHSSFEHHIPKLE-----PLQTPGTPPT PPPSCADDGG-------------GGAVCAGCGMRITDRFYLQA----VDRR--WHASCLQ CCQCRNTL-DGEITCFSRDGN------------IYCKKDYYRLFGMK------------- ---RCARCQATI-----ISSELVM------------------------------------ --RA-RDLVF-----HVHCFSCA-----VCNSPLTKGDHF---GMRDG-AVLCRLHFE-- --MPVTEPLPPGM---------FP----------------------------PGMHHYPP PFPSPE---------------------------FHHQIPP-------------------- ------PTPVESI-GKVPFF-----------------NGAPTT----------------- -----------------------------------PRQKGRPRKRKPK------------ -------DL--------------------------------------------------- ---EGMTAN-------LDLNSDYLD------------------------MSFGRSPGTPG MHG-----SSQRTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLSQKTGLPKRVLQVW FQNARAKWRRMMLKQEGKS-GDK--------CSGSESMS---DLDLY------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------P---------------------------------------------- -----------------------HGPGSMASS---------------------------- ---------------------------------------------------IQSMAPHSP P-----------FILPSGSPSSLDCS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------- >barh1_E_sigismundi Q----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------TLNKL--------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------HYD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---DDSDDCEDY------------------------------------------------ CDKTNKTTT----------------------------------------TTHNNN----- -KQQNLHLLSKKARKPRTAFTEHQLDVLEKSFQGQKYLSVQERLELAAKLCLTDAQVKCW FQNRRTKWKRTMEAEQFNQ-ALYNVYNGHHHLHHNNLLIG-------------------- ------------------------------------------------------------ ---------------------------------------------------NTTQQQQQQ QQ---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------- >barh1_H_exemplaris M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------DRDNGERSSSK------------- -----------------SPLDMTA------------------------------------ ---------------H-------------------------------------------- ---------------------P----------------------------------AHPQ PLTSPS------------------------------------------------------ ----ITSHVKVTS-SNCAPQNLSMRHSFLIKDILSQVNPRQQE----------------- -SSRSGAGDGMGAGTFPP-----------------GSQEDGDSDVQSE------------ -----LSDTESK------------------------------------------------ DDHDGADST-----------------------------------------ATSRN----- -SP-----KGKKSRKARTAFTDSQLQTLEKRFERQKYLSVQDRMELAASLSLSDAQVKCW FQNRRTKWKRQTSVTIELL-AEA---------TGNYAAM---QRML-------------- Q----YWSCGGPAAMLAA------------------------------------------ --------PAAAYP--AQNQLFQM--------------------QELYYRSLQQQQQQQQ QVGGRVVGGPGGIPQMPMN---------------------PVTTRFWPTPANMTFP---- --------------------TGNSAPNVHLIASSTA------------------------ -----------------------------------------------------VATPAAP A------------------SPP-------------------------------------- ---------------SRS--T-----------GIKTAAQSDDGTD--------------- ------------------------------------------------------------ --------------- >barh1_Dmel_Q24255 MK-------------------DSMSILTQTP----------------------------- ----SEPNAAHPQLHHH-------------------LSTLQQQHHQHHLHYGL------- ----------------------------------------------------------QP PAVAHSIHSTTTMS------SGGSTTTASGIGKPNRSRFMIND---ILAGS--------- -----------AAAAFYKQQQHHQ-------QLHHHNNNNNSGSSGGSSPAHS------- -----------------NNNNNINGDN--------------------------------- -----------------------------CEASNVAGVGVLPSALHHP------------ --------------------QPHPP---------------------------THPHTHPH ALMHPHGK---------------------------------------------------- -LGHFPPTAGGNG-LNVAQYAAAMQQHYAAAAAAAAARNNAAA----------------- -AAAAAAAAAAAGVAAPPVDGGVDGGVGLAPPAGGDLDDSSDYHEENE------------ -----DCDSGNMDD---HSV-----------------------------------CSNGG KDDDGNSVK--------------------SG-------------------STSDM----- -SG-----LSKKQRKARTAFTDHQLQTLEKSFERQKYLSVQERQELAHKLDLSDCQVKTW YQNRRTKWKRQTAVGLELL-AEA----------GNFAAF---QRLY-------------- ----------GGSPYLGA------------------------------------------ ----WPYAAAAGAAHGATPHTN----------------------IDIYYRQAAAAAAMQK PL-----------PYNLYAGV-------------------PSVGVGVGVGV--------- ----------------------GPAPFSHLSASSSLSSLSSYYQSAAAAASAAN------ ---PGGPHPVAP-PPSVGGGSPPS----GLVKPIPA----HSASA--SPPPRPPSTPSPT L---------------NPGSPP-------------------------------------- ---------------GR---------------SVDSCSQSDD-EDQIQV----------- ------------------------------------------------------------ --------------- >barh1_Anopheles_gambiae_A7UTE6 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G KDEDGNSIK--------------------NGL------------------GLSSS----- -SG-----LSKKQRKARTAFTDHQLQTLEKSFERQKYLSVQDRMELANKLGLSDTQVKTW YQNRRTKWKRQTAVGLELL-AEA----------GNYAAF---QRLY-------------- ----------GGPPYIGA------------------------------------------ ----WPYPTPSGPP--GTSQSA----------------------VDAYYRHAAAAAALQK PL-----------PYRMYPGV-------------------PTIGTLNPISG--------- ----------------------PSGPFPHLSASSSLSTLSSYYQANCGQQPAGSLLQQPH QTPSGGSNQLRDGETSVGAGSQHDISNLNSLTSISN----HSLN------SQIRHSPSPM L---------------NPGSPP-------------------------------------- ---------------GQ---------------SESNPPDSDDEEDNIQV----------- ------------------------------------------------------------ --------------- >barh1_C_elegans_Q22909 MS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------LLDPR--------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QFLLPAFYL-- ------------------------------------------------------------ ---DPT------------------------------------------------------ ----TQALLAQAA-STSPCNKISSSSSFRISDILEQSPN--------------------- -----------------------------------NSSHSNDHDPSPQ------------ ---SIKSDFS-------------------------------------------------T SPRASSPGG-----------------------------------------DRMGS----- -PG-----SCKKSRKARTIFTDKQLQELENTFEKQKYLSVQDRMDLAHRMGLTDTQVKTW YQNRRTKWKRQATSGMDLL-SEP----------GNLSAV---QNLI-------------- ----------RSSPYWAN------------------------------------------ --------YITALPM-GTQLPM-------------------------------------- ----------MGLPMSMIV---------------------PPAHAFQPSSS--------- ----------------------SNSPSTHISS---------------------------- ------------------------------------------------------------ -------------------ESP-------------------------------------- --------------------------------QLDVSSNSE------------------- ------------------------------------------------------------ --------------- >barh1_Danio_rerio_Q53B63 -----------------------MEVSNG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------SSFGIES---ILSHR--ASSPCMS KGECRSPA------------------------ELSPRSDLDSGCSSPPSPRRS------- -----------------SVEDAVQ------------------------------------ --RRARA-----------------------------------LGLDSP------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LQISQQPRTVTSSFLIRDILADCKPLAAC----------------- -APYSSTGQSAQ-----------------------DAEDCMDKLHSNS------------ -----SSDSEYRV----------------------------------------------- KDEADREIS----------------------------------------SSRDSP----- -NS-----RLKKPRKARTAFTDHQLAQLERSFERQKYLSVQDRMELAASLNLTDTQVKTW YQNRRTKWKRQTAVGLELL-AEA----------GNYSAL---QRMF-------------- -----------PSPYFYP------------------------------------------ -----QSLVSNLDP--GPGL-------------------------YLYRGPSAPPPPVQR PL----------VPRILLHGL--------------------------------------- --------------------QGGGDPASLSGVIPR------------------------- ------------------------------------------------------------ -------------------HPPR------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------- >cll_E_sigismundi N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------NNNNNVN------------------------------------ ------------------------------EKSTSTSAFT-------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------PVIKHQQPQQQQQN---------HHLNQH----------------- -QQHQNALNSVLATHLAWNDP--------------------------------------- ------------------------------------------------------------ ---SIRRLG--------------------RRI------------------GHPYQ----- -QR-----TPPKRKKPRTSFTRIQICELEKRFQRQKYLASAERATLAKSLKMTDAQVKTW FQNRRTKWRRQTAEEREAE-RQA----------ASRMLL---SLQAELAQKAP------- ------PMSAQPDPICMS------------------------------------------ ---------------------------------------------------NKSLYALHN LQ-----------PWAS------------------------------------------- ----------------------NMVQTTTTSPISSVYN---------------------- -----------------------------------------------DD----------- ------------------------------------------------------------ ----------------------------KCNSSDVIDDDDDDLDD--------------- ----------------------------------------------------------YD IID------------ >cll_H_exemplaris MM---------------------------------------------------------- -------------------------------ENPPARSVFKAPSSR-------------- -----------------------------------------------------------S PVAEKPLKK--------------------------RTPFSIDS---ILSTD--------- -------------------------------------TDTSPKEECFSPSLSET------ ---KC------------SNNENIHT----------------------------------- ---------------AMDAYA-------AAAAAATTAMYS-SSGYYSS--PADAYNYG-- ------------------------------------------------------------ ------------------------------------------------------------ ------SMVNSHV-VKVPAQRVQQQQQ---QQHLAPCGGVSPH----------------- -PALFGIGHHVGMSAYQWMDP--------------------------------------- ------------------------------------------------------------ ---ARRLLT--------------------RRI------------------GHPYQ----- -NR-----TPPKRKKPRTSFTRIQICELEKRFHRQKYLASAERASLAKSLKMTDAQVKTW FQNRRTKHRRQTNEEREAD-RQA----------ANRMLL---SQLAEVTKTSG------- ------AYD-STDALCLN------------------------------------------ ---------------------------------------------------NASLHALHN LR-----------PWVN------------------------------------------- ----------------------AGDGGGSLSNNNH------------------------- -------------------------------------------------HPHIITCPQTN S------------------SSP-------------------------------------- ---------------NNN--NTNNNCSSRCSSSSETSHEEEDRDDDDNRSEVSSDE---- -----------------------------------------------------------D ALSV----------- >cll_Dmel_Q7KS72 MSSHEEDDHEHENEHGEEVEEQEIHVDVDSD----------------------------- --SRMSCGSGS-DVDMDG---------GSCYDESETPL--SESLQS-------------- -----------------------------------------------------------E QTRSSSSE---------------------------NLPFSISR---LLSKP--------- ---------FETSHHHHNNNNH--------------LLSSSPGSSSNNNNSGEKG----- -----------------EEKELLQ------------------------------------ --QEDHDLAYK-----------------LATSIANSTYGS-AAALYSY-----PHLYP-- ------------------------------------------------------------ ------------------------------------------------------------ ------SAAGGHV-LRVPPQR-------------------TPL----------------- ----------------TWALP-------PLHHAALAHQAVKDRLA--------------- ------------------------------------------------------------ ---AAFPIA--------------------RRI------------------GHPYQ----- -NR-----TPPKRKKPRTSFTRIQVAELEKRFHKQKYLASAERAALARGLKMTDAQVKTW FQNRRTKWRRQTAEEREAE-RQA----------ANRLML---SLQAEAISKGF------- ------AP--PSAPLGSQGGV--------------------------------------- --------------------------------------------------NGAPLAALHG LQ-----------PWAE------------------------------------------- ----------------------ASHAA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GC------------------------------ ------------------------------------------------------------ --------------- >cll_Anopheles_gambiae_Q7PQE6 MSSPHEDEDQD--------LDQEINVDADSDCQ--------------------------- --SRVSYNSGSEDIDLDGD--G----NGSCYEESDIAS--DHQTHS-------------- ----------------------------------------------------------TE PTTRSPNE---------------------------NLPFSISR---LLGKS--------- ---------YDRDQ--------------------------------KDKDAGSED----- -----------------TGPEGLI------------------------------------ --KNGHH---------------------ITVSSPSSLQYA-AGALYSY------PMYP-- ------------------------------------------------------------ ------------------------------------------------------------ ---------GGHV-LRVPPQR----------------GPCNPL----------------- ----------------SWTLP-------PLHPAALAHQAVKDRL---------------- ------------------------------------------------------------ ---AAFPIA--------------------RRI------------------GHPYQ----- -NR-----TPPKRKKPRTSFTRIQVAELEKRFHKQKYLASAERAALARGLKMTDAQVKTW FQNRRTKWRRQTAEEREAE-RQA----------ANRLML---SLQAEALSKGF------- ------GQP-PPSAAAPSATT--------------------------------------- --------------------------------------------------PGAPLAALHG LQ-----------PWAE------------------------------------------- ----------------------AHTA---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GC------------------------------ ------------------------------------------------------------ --------------- >cll_Tribolium_castaneum_D6WZY0 MSDHELTED-----------DHEINVLDTDS----------------------------- ---RLS------------------------HSDSEARS--SRSRCS-------------- -----------------------------------------------------------T PENSGSHHNST-----------------------TVLPFSISN---LLGKN--------- ---------FEQK----------------------------------------------- -----------------SEPDQLYPS-------------------------------PGL FPQR-------------G-----------------------LGGLMPS------GFYG-- ------------------------------------------------------------ ------------------------------------------------------------ ----------QGV-LRVPAHRPL--------------GPGSPA----------------- -----------GGVFSPWTLGLDPVLQRSAAAAAFATQVVKDRLA--------------- ------------------------------------------------------------ ---ATFPMT--------------------RRI------------------GHPYQ----- -NR-----TPPKRKKPRTSFTRLQIAELEKRFHKQKYLASAERAALAKTLKMTDAQVKTW FQNRRTKWRRQTAEEREAE-RQA----------ANRLML---SLQAEALSKGY------- ------MSEGPPPSSGPG------------------------------------------ ---------------------------------------------------DTALSALQN LQ-----------PWAGP------------------------------------------ ----------------------YSAPQPALAE---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SMC------------------------------ ------------------------------------------------------------ --------------- >cll_Stegodyphus_mimosarum_A0A087SVI5 MLCDRSSRTS------PPVASNAIEVTNVTT----------------------------- ---RIAGIMDREYMEQAPM--S----TATVQSASPPTS--ENNSSS-------------- -----------------------------------------------------------S PVNHSSSNK-------------------------PKLSFSISR---LLGDD--------- ---------SRQDNDNNHRKED-----------SRSSTDNNSGHGGDSSSARTTPAS--- -----------S-----SAASPMM------------------------------------ ---------------VMSSGGCCVGL--SAQAYFSTADLK-TSCVPVM-----TPHYD-- --PLQ------------------------------------------------------- ------------------------------------------------------------ ------SGANGTV-IRVPAHRPAPLSYP-------------------------------- -----------TTVNFPWV---------------GSHGMGKDRIP--------------- ------------------------------------------------------------ ---VPFPLAAGLP------------PVPPRRI------------------GHPYQ----- -NR-----TPPKRKKPRTSFTRMQICELEKRFHKQKYLASAERASLAKTLKMTDAQVKTW FQNRRTKWRRQTAEEREAE-RQA----------ANRLMM---SLQAEVVSKSI------- ------YDQ-ARDPVCLS------------------------------------------ ---------------------------------------------------NSSLHALQT LQ-----------PWAS------------------------------------------- ----------------------ENVAAAHMAAAAAAG----------------------- ----------------------------------------HHQ-G--VDRPSYLAPPHS- ------------------LSSP-------------------------------------- ----------------------------IC------------------------------ ------------------------------------------------------------ --------------- >cll_Strigamia_maritima_T1JC39 MIAS-------------CVIMDELNVDSNSS----------------------------- --------------------------PSAHMPISPACSPLPNPGHK-------------- -----------------------------------------------------------T PLSRRATPA-------------------------AKLSFGISR---LLGED--------- ---------SDRDRDRDRDRE-------------------EPLDDEDDDDAKKTI----- -----------------SENSIVV------------------------------------ --STQNH--------MFDAYSASVPR--PLPAFLASVSLA-TGGLSSL------PHYD-- --PLL------------------------------------------------------- ------------------------------------------------------------ ------SGANGTV-IRVPAHRPSPLTLG-------------------------------- -------------SAYSWINA-----MGNAQGPANSAQLVKDRLQ--------------- ------------------------------------------------------------ ---VPFSVT--------------------RRI------------------GHPYQ----- -NR-----TPPKRKKPRTSFTRMQICELEKRFHKQKYLASAERASLAKALKMTDAQVKTW FQNRRTKWRRQTAEEREAE-RQA----------ANRFMM---SLQAEALSKAG------- ------MYD-SRDPLCIN------------------------------------------ ---------------------------------------------------NASLNALQN LQ-----------PWSS------------------------------------------- ----------------------SEGDAPSRSG---------------------------- --------------------------------------------------PTFLPTPA-- ------------------LASP-------------------------------------- ----------------------------IC------------------------------ ------------------------------------------------------------ --------------- >cll_Danio_rerio_Q8JI11 M----------------------------------------------------------- -------------------------------DRAPSSSPSGTSQTS-------------- -----------------------------------------------------------Q PTQHE------------------------------PISFGIDQ---ILSGT--------- ----------DQESQQNSTRN---------------SSESSSGSSSASGGCY-------- ------------------------------------------------------------ ---------------HLGSPTGASATPY------TTLTGT-FHGIAAP--YEESSPYG-- --VNL------------------------------------------------------- ------------------------------------------------------------ ------TLAPGGV-IRVPAHRPLAAAV---PPPMASAVP--------------------- ---------GLGSLSFPWMES--------------SQRFAKDRFA--------------- ------------------------------------------------------------ AALTPFTVA--------------------RRI------------------GHPYQ----- -NR-----TPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERAALAKTLKMTDAQVKTW FQNRRTKWRRQTAEEREAE-RQQ----------ANRLMI---QLQHDAFQKSL------- ------TDSVPTDPLCIH------------------------------------------ ---------------------------------------------------NSSLFALQN LQ-----------PWASE------------------------------------------ ----------------------ESSKLGGVTALV-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------- >cll_Xenopus_tropicalis_F6TEU6 M----------------------------------------------------------- -------------------------------------DHIG-AHHI-------------- -----------------------------------------------------------H QTHAE------------------------------PISFGIDQ---ILNNP--------- ----------DQGSCMISGPR---------------LQDSDYGLGCIVSSAYNT------ ------------------------------------------------------------ ---------------MTGNYSNSGTGGY------SNSACS-MASLT--------GSYN-- --MNMGV----------------------------------------------------- ------------------------------------------------------------ -TMNGNNLNSAGV-IRVPAHRPLATSV---HQPISTGMPTVPS----------------- -VGSMNNMNNLTGLTFPWMES--------------NRRYTKDRFT--------------- ------------------------------------------------------------ VALSPFTVT--------------------RRI------------------GHPYQ----- -NR-----TPPKKKKPRTSFTRLQICELEKRFHRQKYLASAERAALAKALKMTDAQVKTW FQNRRTKWRRQTAEEREAE-RQQ----------ANRILL---QLQQEAFQKTI------- ------NQPLQPDPICLH------------------------------------------ ---------------------------------------------------NSSLYALQN LQ-----------PWSD------------------------------------------- ----------------------DMSKITSVTSVAS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------ACE----------------------------- ------------------------------------------------------------ --------------- >cll_Mus_musculus_O55144 M----------------------------------------------------------- --------------------------------EAPASA---------------------- ----------------------------------------------------------QT PHPHE------------------------------PISFGIDQ---ILNSP--------- ----------DQ--------------------------DSAPAPRGPDGASY-------- ------------------------------------------------------------ ---------------LGGPPGGRPGAAY------PSLPAS-FAGLGAP--FEDAGSYS-- --VNL------------------------------------------------------- ------------------------------------------------------------ ------SLAPAGV-IRVPAHRPLPGAV---PPPLPSALPAMPS----------------- -VPT---VSSLGGLNFPWMES--------------SRRFVKDRFTA-------------- -----------------------------------------------------------A AALTPFTVT--------------------RRI------------------GHPYQ----- -NR-----TPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERAALAKSLKMTDAQVKTW FQNRRTKWRRQTAEEREAE-RQQ----------ASRLML---QLQHDAFQKSL------- ------NDSIQPDPLCLH------------------------------------------ ---------------------------------------------------NSSLFALQN LQ-----------PWEE------------------------------------------- ----------------------DSSKVPAVTSLV-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------- >cll_Human_O43711 M----------------------------------------------------------- --------------------------------EAPASA---------------------- ----------------------------------------------------------QT PHPHE------------------------------PISFGIDQ---ILNSP--------- ----------DQ--------------------------DSAPAPRGPDGASY-------- ------------------------------------------------------------ ---------------LGGPPGGRPGATY------PSLPAS-FAGLGAP--FEDAGSYS-- --VNL------------------------------------------------------- ------------------------------------------------------------ ------SLAPAGV-IRVPAHRPLPGAV---PPPLPSALPAMPS----------------- -VPT---VSSLGGLNFPWMES--------------SRRFVKDRFTA-------------- -----------------------------------------------------------A AALTPFTVT--------------------RRI------------------GHPYQ----- -NR-----TPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERAALAKSLKMTDAQVKTW FQNRRTKWRRQTAEEREAE-RQQ----------ASRLML---QLQHDAFQKSL------- ------NDSIQPDPLCLH------------------------------------------ ---------------------------------------------------NSSLFALQN LQ-----------PWEE------------------------------------------- ----------------------DSSKVPAVTSLV-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------- >cll_Rattus_norvegicus_D4A270 M----------------------------------------------------------- -------------------------------------EHLG-PHHL-------------- -----------------------------------------------------------H PGHAE------------------------------PISFGIDQ---ILNSP--------- ----------DQGGCMGPASR---------------LQDGEYGLGCLVGGAYTYGGGG-- ---SAAGAGAG------------------------------------------------- ---------------GTGAYGTGGPGGPGGPAGGGGGACS-MGPLA--------GSYN-- --VNMALAGGPGPGGGGGG----------------------------------------- -----------------------------------------------A------------ GAGGAGALSAAGV-IRVPAHRPLAGAVA-HPQPLATGLPTVPS----------------- -VPAVPGVNNLTGLTFPWMES--------------NRRYTKDRFT--------------- ------------------------------------------------------------ --------------------------------------------------GHPYQ----- -NR-----TPPKKKKPRTSFTRLQICELEKRFHRQKYLASAERAALAKALKMTDAQVKTW FQNRRTKWRRQTAEEREAE-RQQ----------ANRILL---QLQQEAFQKSL------- ------AQPLPADPLCVH------------------------------------------ ---------------------------------------------------NSSLFALQN LQ-----------PWSD------------------------------------------- ----------------------DSTKITSVTSVAS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------ACE----------------------------- ------------------------------------------------------------ --------------- >lim1_Esigismundi M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------QVVKCCACDQLINDKFIMNV----LDRT--WHAECLR CCICSMIL---TDKCFSRHGK------------VYCRDHFYKAFGA-------------- ---KCCVCFEGI-----NPDELVR------------------------------------ --RTVQGGVY-----HIKCFKCN-----ECHKELTTGEQF--YCIDES-RFLCKSDFL-- --MKQIPLTTSSN---------------------------------------QVNNSWPK SIKSEN---------------------------DDEEI-------------------E-- --------------QGSPQQQLY------NTNNAHSNNCTTPN----------------- -----------------------------------AHQSSSEKEEEFD------------ -------DS--------------------------------------------------- ---DSTNKD----------NKIKHD-------------------------NDSTH----- -QP-----SGTKRRGPRTTIKQKQLEQLKEIFDSQPKPPKAIRDQLASKTGLSKRVIQVW FQNRRSKERRMKTSQNLRG-RNA-YAR---HRNGGRSSS---SGRPELEQHAQ------- -------GGPPPHIFGFYTDNGV------------------------------------- ------------------------------------------------------------ -------------P---------------------------------------------- -----------------------NGPPPPDMFGAS------------------------- ------------------------------------------------PGNFYPNDPNNF N--------------FNLAPPP---------------PPPPPPDVMNNNNGGANGGGNLS AMSQHFPPS---SISNESPVPPSLVINGIQP-NESLNANNNNTNSQQQQKFNGTRD---- ------------HFLPSPTSI---------DGYQASNFQDPCSMQFSGMRIQQQQPPPAT QISPESAG----LIN >lim1_Hexemplaris M---------------------------------PVRH--RYLQQHPQPP---------- --PPPSSSSGPEDFESHNNRR--------------------------------------- ----------------------------------------------------IVSGKMQN PGG--------------------MYDKCHGCGMVILDPFIMAIATPTASQV--WHADCLR CCECKCPL---QERCFCNGGR------------FFCREDYFRAFGQ-------------- ---PCKGCGVGI-----DPTELVR------------------------------------ --QT-QRGNF-----HLKCFICT-----ACRKQLSTGEEC--YNIGDC-EFNCKDDYV-- --TSKHAKAASST------LQSFSC---------------------------KAEQSSPG AATSPC------------------LLGGGGRDLSRSESLKPDQHDCL------------- ----STTGPSDVT-NGAPM----------NNNNSNTATPIIGS----------------- -----GIGRAMDGHLL-------------------HRGEDCEDDDEED-EDAMKCSESGS HVPASDRDCCDK------------------------------------------------ ---DGKSVN--------GDNTSSIDESEP---------------------RNGND----- -EN-----VSTKRRGPRTTIKAKQLELLKNAFAQTPKPTRHIRDQLSQETGLTMRVIQVW FQNRRSKERRMKQQNIMGPGRRCNMFR--SRRSGGRSLR---EFDGDSGDMGV------- ---------QGPPGFAYFPDGPGN------------------------------------ ----------------------------------------------------------HG MDFF---------P---------------------------------------------- ---------------------GQVSPHG-------------------------------- -----------------------------------------------GPHAGPLGHPPGI FEFAHY-------------RPPQNAAEAAAMQAHFNE--------MSPNAHGMPGNINHP GMDGHFRQE---MLSQSS--TPERTLNSL----TPDGYGHPAFDT-----------LPLH PGGNGGIG-------PVPGGMNG--SNSP------------------------------- ------VWQSMTMAQ >lim1_Dmel_Q9V472 MAFGA-----------------VLHTSQHNI----------------------------- ------------------------------------------------------------ -------------------------------------------------------GRSEP PVG--------------------VGDPCAGCNKPILDKFLLNV----LERA--WHASCVR CCECLQPL---TDKCFSRESK------------LYCRNDFFRRYGT-------------- ---KCSGCGQGI-----APSDLVR------------------------------------ --KP-RDKVF-----HLNCFTCC-----ICRKQLSTGEQL--YVLDDN-KFICKDDYL-- --LGKA----------------------------------------------------PS CGHNSL---------------SDSLMGSASEDDDDDDPPHLRATA--------------- ------LGLGVLG----------------PNGPDSAGGPLGTS----------------- ---------DIS-----------------------VQSMSTDSKNTHD------------ -------DS--------------------------------------------------- ---DQGSLD--------GDPDGRGDSQAE---------------------NKSPD----- -DA-----NGSKRRGPRTTIKAKQLEVLKTAFNQTPKPTRHIREQLAKETGLPMRVIQVW FQNKRSKERRMKQITSMG--RPP-FF-----GGARK-MR---GFPMNLSPGGL------- ---------DDGPGFPYFAADAK-------FEFG-------------------------- --------------------------------------------------YGGP-FHPHD GPYFP------GHP---------------------------------------------- -----------------------GGPMP-------------------------------- -----------------------------------------------------FNAPGGP MDHS--------------GPIPMVNEFGLTPEATFLGQAGGPPM-------------QLQ SAVGPPPPP--------P--PPSAEHLM-----AAAAAAAQQQAAQQQQQQQQQQQQQQQ QNAQQAA-----NQTQQQQQQNGPRTNSP-EFMSSANFSE-----------------PQN MQNEGLVW------- >lim1_Human_P48742 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------VHCAGCKRPILDRFLLNV----LDRA--WHVKCVQ CCECKCNL---TEKCFSREGK------------LYCKNDFFRCFGT-------------- ---KCAGCAQGI-----SPSDLVR------------------------------------ --RA-RSKVF-----HLNCFTCM-----MCNKQLSTGEEL--YIIDEN-KFVCKEDYL-- --SNSS------------------------------------------------------ ----------------------------VAKENSLHSA---------------------- ---------------------------------TTGSDPSLSP----------------- -----------------------------------DSQDPSQDDAK-------------- -------DS--------------------------------------------------- ---ESANVS---------------DKEAG--------------------SNENDD----- -QN-----LGAKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVW FQNRRSKERRMKQLSALGA-RRHAFF-----RSPRR-MR---PLVDRLEPGEL------- ---------IPNGPFSFYGDYQS-----------E------------------------- -------------------------------------------------YYGPG----GN YDFF---------P---------------------------------------------- -----------------------QGPPSSQAQTPVD------------------------ ---------------------------------LPF-----------VPSSGPSGTPLGG LEH----------------PLP--GHHPSSEAQRFTDILAHPPG---------------- --DSPSPEP--------S--LPGPLHSM-----SAEVFGPSPPFSSLSVNG--------- ------------------------GASYG------NHLSH-----------------PP- EMNEAAVW------- >lim1_Rattus_norvegicus_P63007 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------VHCAGCKRPILDRFLLNV----LDRA--WHVKCVQ CCECKCNL---TEKCFSREGK------------LYCKNDFFRCFGT-------------- ---KCAGCAQGI-----SPSDLVR------------------------------------ --RA-RSKVF-----HLNCFTCM-----MCNKQLSTGEEL--YIIDEN-KFVCKEDYL-- --SNSS------------------------------------------------------ ----------------------------VAKENSLHSA---------------------- ---------------------------------TTGSDPSLSP----------------- -----------------------------------DSQDPSQDDAK-------------- -------DS--------------------------------------------------- ---ESANVS---------------DKEGG--------------------SNENDD----- -QN-----LGAKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVW FQNRRSKERRMKQLSALGA-RRHAFF-----RSPRR-MR---PLVDRLEPGEL------- ---------IPNGPFSFYGDYQS-----------E------------------------- -------------------------------------------------YYGPG----GN YDFF---------P---------------------------------------------- -----------------------QGPPSSQAQTPVD------------------------ ---------------------------------LPF-----------VPSSGPSGTPLGG LDH----------------PLP--GHHPSSEAQRFTDILAHPPG---------------- --DSPSPEP--------S--LPGPLHSM-----SAEVFGPSPPFSSLSVNG--------- ------------------------GASYG------NHLSH-----------------PP- EMNEAAVW------- >lim1_Mus_musculus_P63006 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------VHCAGCKRPILDRFLLNV----LDRA--WHVKCVQ CCECKCNL---TEKCFSREGK------------LYCKNDFFRCFGT-------------- ---KCAGCAQGI-----SPSDLVR------------------------------------ --RA-RSKVF-----HLNCFTCM-----MCNKQLSTGEEL--YIIDEN-KFVCKEDYL-- --SNSS------------------------------------------------------ ----------------------------VAKENSLHSA---------------------- ---------------------------------TTGSDPSLSP----------------- -----------------------------------DSQDPSQDDAK-------------- -------DS--------------------------------------------------- ---ESANVS---------------DKEGG--------------------SNENDD----- -QN-----LGAKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVW FQNRRSKERRMKQLSALGA-RRHAFF-----RSPRR-MR---PLVDRLEPGEL------- ---------IPNGPFSFYGDYQS-----------E------------------------- -------------------------------------------------YYGPG----GN YDFF---------P---------------------------------------------- -----------------------QGPPSSQAQTPVD------------------------ ---------------------------------LPF-----------VPSSGPSGTPLGG LDH----------------PLP--GHHPSSEAQRFTDILAHPPG---------------- --DSPSPEP--------S--LPGPLHSM-----SAEVFGPSPPFSSLSVNG--------- ------------------------GASYG------NHLSH-----------------PP- EMNEAAVW------- >lim1_Xenopus_tropicalis_A4QNI6 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------VHCAGCERPILDRFLLNV----LDRA--WHVKCVQ CCECKCNL---TEKCFSREGK------------LYCKNDFFRRFGT-------------- ---KCAGCAQGI-----SPSDLVR------------------------------------ --RA-RSKVF-----HLNCFTCM-----MCNKQLSTGEEL--YIIDEN-KFVCKEDYLNN NNNNNN------------------------------------------------------ ----------------------------AAKENSFISV---------------------- ----------------------------------TGSDPSLSP----------------- -----------------------------------ESQDPLQDDAK-------------- -------DS--------------------------------------------------- ---ESANIS---------------DKEAG--------------------VNENDD----- -QN-----LGAKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVW FQNRRSKERRMKQLSALGA-RRHAFF-----RSPRR-MR---PLVDRLEPGEL------- ---------IPNGPFSFYGDYQS-----------E------------------------- -------------------------------------------------YYGPG----SN YDFF---------P---------------------------------------------- -----------------------QGPPSSQAQTPVD------------------------ ---------------------------------LPF-----------VPSSGPAGTPLGA MDH----------------PIP--GHHPSSDAQRFTDIMSHPPG---------------- --DSPSPEP--------N--LPGSMHSM-----SAEVFGQSPPFSSLSVNG--------- ------------------------AAGYG------NHLSH-----------------PP- EMNETAVW------- >lim1_Danio_rerio_Q90476 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------VHCAGCERPILDRFLLNV----LDRA--WHIKCVQ CCECKCNL---TEKCFSREGK------------LYCKNDFFRRFGT-------------- ---KCAGCAQGI-----SPNDLVR------------------------------------ --RA-RSKVF-----HLNCFTCM-----MCNKQLSTGEEL--YIIDEN-KFVCKDDYL-- --SNTN------------------------------------------------------ -----------------------------GKDSNLLSV---------------------- ---------------------------------TACSDPSLSP----------------- -----------------------------------DSQDQLQDDVK-------------- -------DA--------------------------------------------------- ---EIANLS---------------DKETG--------------------NNENDD----- -QN-----LGGKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVW FQNRRSKERRMKQLSALGA-RRHAFF-----RSPRR-MR---TLVDRLEPGEL------- ---------IPNGPFSYYGDYQS-----------E------------------------- -------------------------------------------------YYGPG----GN YDFF---------P---------------------------------------------- -----------------------QGPPSSQAQTPVD------------------------ ---------------------------------LPF-----------VPSSGPTGTPLGG MDH----------------PIP--GHHPSSEVQRFSDIMSHHPG---------------- --DSPSPEP--------G--IPGPLHSM-----SSDVFGPSPSFTSLSLNG--------- -------------------------SGYS------NHLSH-----------------PPS EMNEGTVW------- >lim1_C_elegans_P20154 MHSSS--------------SFIITSLEEEEK----------------------------- ---------------------------------KPPAHHLHQQ----------------- -----SIEDV------------------------GSVTSSATLL-------LLDSATWMM PSSTTQPHIS-----------EISGNECAACAQPILDRYVFTV----LGKC--WHQSCLR CCDCRAPM---SMTCFSRDGL------------ILCKTDFSRRYSQ-------------- ---RCAGCDGKL-----EKEDLVR------------------------------------ --RA-RDKVF-----HIRCFQCS-----VCQRLLDTGDQL--YIMEGN-RFVCQSDFQ-- --TATK-------------------------------------------------TSTPT SIHRPV------------------------------------------------------ ------------------------------------------------------------ -----------------------------------SNGSECNSDVEED------------ -----NVDAC-------------------------------------------------- ---DEVGLD-----------DGEGD-----------------------CGKDNSD----- -DS-----NSAKRRGPRTTIKAKQLETLKNAFAATPKPTRHIREQLAAETGLNMRVIQVW FQNRRSKERRMKQLRFGGY-RQS--------RRPRRDDI-----------------VDMF PNDQQFYPPPPPSNVQFFCD---------------------------------------- ------------------------------------------------------------ -------------P---------Y------------------------------------ ----------------------TTSPNNPETIQMAP------------------------ ----------------------------------------------------QFAVPTEN M---------------NMVPEP------------YTEQSATPPE---------------- --------------------FNEDTFACI----YSTDLGKPTPVS--------------- ------------------------------------------------------------ -------W------- >lim1_Anopheles_gambiae_Q7QHD1 MAFGS-----------------VLQHNQHNI----------------------------- ------------------------------------------------------------ -------------------------------------------------------GRGEP PSG--------------------LGDPCAGCNKPILDKFLLNV----LERG--WHATCVR CCECHQPL---ADKCFSRESK------------LYCRNDFFRRYGT-------------- ---KCSGCGQGI-----APSDLVR------------------------------------ --KP-RDKVF-----HLNCFTCC-----ICRKQISTGEQL--YVLDDN-KFICKDDYI-- --LGKG----------------------------------------------------P- ---HPM---------------TDSLMGSASEDEDEEDQMRPGVLA--------------- -----GLVSGGAG----------------AAGLHHGDGPLGAS----------------- ---------DLS-----------------------VQSMSTDSKTGHD------------ -------DS--------------------------------------------------- ---DQGSLD--------GDPDCRGDSQAE---------------------NKSPD----- -DG-----AGSKRRGPRTTIKAKQLEVLKNAFSQTPKPTRHIREQLAKETGLPMRVIQVW FQNKRSKERRLKQLTSMG--RGP-FF-----GGARK-MR---GFPMNLSPGGL------- ----------DEPGFPYFAADGK-------FDFG-------------------------- --------------------------------------------------YGGPPFHPHD APFFG------GHP---------------------------------------------- ----------------------GAGPMP-------------------------------- -----------------------------------------------------FGGPGGP MDH----------------PIPMVGDFGMA------GPDGGPGG-------------MLG GPGGPGGPG--------G--GPGGFMGG-----PGGPGGPQQGHGPDGMMGGGVGGGGGG GGGGGGGGGGGPHAPSRPGGGGGGGGGSPVEFLTSGNFSE-----------------SQN MQSEGLVW------- >lim1_Stegodyphus_mimosarum_A0A087TMA9 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------H-------------------------------------------- --------------------------------------------------------TTPG SVGGPA------------------------------------------------------ ----------------------------------SGPNPASAG----------------- -----------------------------------PNGNNSSSETTNS------------ -----STSA--------------------------------------------------- --------------------------------------------------AQNDE----- -NT-----PGTKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVW FQNRRSKERRMKQLSTLGA-RRH-FF-----RSPRRAMR---PLRPGMSPDGLDDSPDMV --------SGPNSGYAYFSDSGSP------GDFG-------------------------- --------------------------------------------------YGAQ---PGF YDFF---------P---------------------------------------------- -----------------------GQPPPDGMAYHG------------------------- -----------------------------------------------------VLGPGQN V------------------PPP-----PTSMEQPLSAVVGPGPV-------------NL- GADAPYLTPHGDLMSQRS--SPDSVLSL-----ASDAYGPPRSSS--------------- -------------------------AGFP------GNLGGH----------------P-- AISETQVW------- >lim1_Strigamia_maritima_T1J2T7 E----------------------KQNAERCTLPFP----------HPDPPLR-------- -------SPVTRTNRVH----------SLAVSHRPSRLLLAASSRFHDNAPLIDT----- -----NLEARPSFLASI--------GHQRACARHRTRVDSCRALSTRELARGAGNGALAA AAAA-------------------AMVHCAGCDRPILDRFLLHV----LDRA--WHAKCVQ CFDCKCNL---TEKCFSREGK------------LYCRNDFFRRFGT-------------- ---KCAGCTQGI-----SPSDLVR------------------------------------ --RA-RNKVF-----HLKCFTCM-----VCRKQLSTGEEL--YVLDEN-KFICKEDYL-- --LGTIKPPVP-----------------------------------------------PH HHHHHHHH------------HHHSIGSDLGEDMDEVEL-KASETGVV------------- ----CGSGSGGGA----------------ATPPSSGTTPASTP----------------- -------GGDAS-----------------------EHTNGSEKDLSGR------------ -------DS--------------------------------------------------- ----GGSVD--------GDRENRDHENT----------------------APNDE----- -NN-----MGTKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVW FQNRRSKERRMKQLSSLGA-RRH-FF-----RNPRR-MR---ALRPGMSPDPLDDSPEMV ----------PNPGFAYFS-----------GDFG-------------------------- --------------------------------------------------YGTQ----GF YDFF---------P---------------------------------------------- ----------------------GQQPPPGGGGGVG------------------------- ------------------------------------------------------GGPEGL S------------------FPP-------------------------------------- GMGAQSPAV--------S--TPSSMEQAIG--P--------------------------- -------------------------MGTG------------------------------- ---------------