Recombinatoric exploration of novel folded structures: A heteropolymer-based model of protein evolutionary landscapes -- Data Supplement - Supporting Figure -- Proceedings of the National Academy of Sciences

Supporting information for Cui et al. (2002) Proc. Natl. Acad. Sci. USA 99 (2), 809–814. (10.1073/pnas.022240299)

Supporting Figure 7 Fig. 7.
A model of molecular evolution and structural innovation. Each red dot denotes a neutral net of protein sequences encoding for the same structure. Neutral nets often are linked together by point mutations (blue lines) to form larger networks. The large model network depicted here contains 897 neutral nets and encompasses a total of 4,553 (n = 18) two-dimensional hydrophobic polar model protein sequences (see Table 1). Structures outside (green dots) of this large network are unreachable by nonlethal point mutations alone, but sequences encoding for many such structures can be produced as offspring from crossovers (yellow line pairs) between sequences belonging to the large network.