Supporting information for Kline et al. (January 15, 2002) Proc. Natl. Acad. Sci. USA, 10.1073/pnas.022634199.
Table 1. Respiratory responses to 100, 21, and 12% O2 in Hif1a+/+ and Hif1a+/– mice
100% O2 | 21% O2 | 12% O2 | |
Hif1a+/+ | |||
RR | 156 ± 2 | 154 ± 15 | 192 ± 20 |
V T | 2.13 ± 0.15 | 2.18 ± 0.18 | 2.54 ± 0.25 |
V E | 0.33 ± 0.03 | 0.33 ± 0.03 | 0.48 ± 0.04 |
V O2 | 0.17 ± 0.02 | 0.08 ± 0.01 | 0.03 ± 0.01 |
V CO2 | 0.03 ± 0.00 | 0.02 ± 0.00 | 0.02 ± 0.00 |
Hif1a+/– | |||
RR | 155 ± 8 | 147 ± 3 | 190 ± 7 |
V T | 2.02 ± 0.15 | 2.03 ± 0.18 | 2.48 ± 0.20 |
V E | 0.31 ± 0.03 | 0.30 ± 0.02 | 0.47 ± 0.05 |
V O2 | 0.22 ± 0.01 | 0.08 ± 0.01 | 0.03 ± 0.00 |
V CO2 | 0.02 ± 0.00 | 0.02 ± 0.00 | 0.02 ± 0.00 |
Data expressed as mean ± SE. Hif1a+/+, n = 8; Hif1a+/–, n = 8. RR, breaths per minute; VT, ml/body weight (BW); VE, ml/min/BW; VO2 and VCO2, ml/min/BW.