Supporting information for Kline et al. (January 15, 2002) Proc. Natl. Acad. Sci. USA, 10.1073/pnas.022634199.

Table 2. Respiratory responses to 100% O2 and 3 and 5% CO2 in Hif1a+/+ and Hif1a+/– mice


100% O2

3% CO2

5% CO2

Hif1a+/+

RR

157 ± 9

202 ± 10

246 ± 11

V

T

2.02 ± 0.14

2.40 ± 0.20

2.95 ± 0.25

V

E

0.32 ± 0.03

0.48 ± 0.05

0.73 ± 0.07

Hif1a+/–

RR

145 ± 9

198 ± 9

214 ± 7

V

T

1.96 ± 0.10

2.43 ± 0.16

2.73 ± 0.16

V

E

0.29 ± 0.02

0.46 ± 0.04

0.56 ± 0.04

Data expressed as mean ± SE. Hif1a+/+, n = 8; Hif1a+/–, n = 8. RR, breaths per minute;
VT, ml/BW; VE, ml/min/BW.