Supporting information for Kline et al. (January 15, 2002) Proc. Natl. Acad. Sci. USA, 10.1073/pnas.022634199.

Table 6. Respiratory responses to 100% O2 and 3 and 5% CO2 in Hif1a+/+ and Hif1a+/– mice after chronic hypoxia


100% O2

3% CO2

5% CO2

Hif1a+/+

RR

167 ± 8

200 ± 7

255 ± 11

V

T

2.35 ± 0.22

2.78 ± 0.23

3.50 ± 0.11

V

E

0.38 ± 0.03

0.55 ± 0.04

0.89 ± 0.10

Hif1a+/–

RR

160 ± 7

200 ± 11

232 ± 10

V

T

2.14 ± 0.17

2.68 ± 0.22

3.36 ± 0.33

V

E

0.32 ± 0.03

0.49 ± 0.05

0.73 ± 0.10

Data expressed as mean ± SE. Hif1a+/+, n = 8; Hif1a+/–, n = 8. RR, breaths per minute;
VT, ml/BW; VE, ml/min/BW.