Ahmed et al. 10.1073/pnas.0504438102. |
Table 1. Escalation (ESC) genes found by using four analysis strategies
Gene name | Probe set ID | ANOVA | SAM | Brain region | Direction of change | ||
MAS4 | MAS5 | dChip | RMA | ||||
Growth/structure/plasticity |
|
|
|
|
|
|
|
Delta 2 catenin (Ctnnd2)* | AB008752_at | X |
|
|
| LH | ↑ |
Microtubule-associated protein 1A (MAP-1A)* | M83196_at | X | X | X | X | LH | ↑ |
Fibroblast growth factor receptor 1 (Fgfr1)* | D12498_s_at | X | X |
| X | LH | ↑ |
S54008_i_at | X | X |
| X | LH | ↑ | |
Bcl-x alpha (Bcl-2 like 1)* | U72350_at | X | X |
| X | LH | ↑ |
Bcl-x alpha Short (splice variant)* | S78284_s_at | X | X |
| X | LH | ↑ |
Bcl-x alpha Long (splice variant)* | U34963_s_at | X | X | X | X | LH | ↑ |
Lifeguard/ Neural membrane protein 35 (NMP35) | AF044201_at | X | X | X | X | LH | ↑ |
Purkinje cell protein 4 (Pcp4, PEP-19) | M24852_at | X | X |
|
| LH | ↓ |
Neurofilament, light polypeptide (NF-L)* | M25638_s_at | X |
|
|
| NAc | ↓ |
Microtubule-associated protein 2 (MAP-2) | rc_AI228850_s_at | X |
|
|
| NAc | ↓ |
Caspase 2 (Casp2, Ich-1, Nedd2)* | U77933_at | X | X |
|
| NAc | ↑ |
BOD-L/BCL2-like gene 11 (apoptosis facilitator)* | AF065433_at |
| X |
|
| SP | ↑ |
insulin-like growth factor binding protein-2, exon 1* | M91595exon_s_at |
|
|
| X | SP | ↓ |
Insulin-like growth factor 2 (IGF2) | X17012mRNA_s_at | X |
|
| X | AMY | ↓ |
Neurodap1* | rc_AA894089_s_at |
|
| X |
| VTA | ↓ |
Transferrin (Tf)* | U31866_g_at |
|
| X |
| VTA | ↓ |
Neurotransmitters/receptors/enzymes/signal transduction | |||||||
Glutamate receptor NMDA2D (Grin2d)* | D13213_s_at | X | X | X |
| LH | ↑ |
U08260_at | X | X |
|
| LH | ↑ | |
Neurofibromin/ Neurofibromatosis 1 (Nf1)* | D45201_at | X |
|
| LH | ↑ | |
Glutamate receptor interacting protein 2 (GRIP2)* | AF090113_at | X |
|
|
| LH | ↑ |
Activity and neurotransmitter-induced early gene 6 (ania-6)* | AF030091UTR#1_g_at |
| X |
|
| LH | ↑ |
Guanine nucleotide binding protein, beta 1 (Gnb1, rGbeta1)* | rc_AI227660_s_at |
| X |
|
| LH | ↓ |
U88324_at |
| X |
|
| LH | ↓ | |
Adrenergic receptor kinase beta-1 (AdrbK1) | S48813_s_at | X | X |
|
| LH | ↑ |
Glutamate-binding protein (GBP, Grina) | S61973_at | X | X | X | X | LH | ↑ |
S61973_g_at | X | X |
|
| LH | ↑ | |
Phospholipase D2 (Pld2) | rc_AA998338_s_at | X | X |
|
| LH | ↓ |
Protein kinase C, gamma (PKCg , Prkcc)* | X07287cds_s_at |
| X | X | X | LH | ↑ |
Inositol 1,4,5-trisphosphate 3-kinase B (Itpkb) | X74227cds_at | X |
| X | X | LH | ↑ |
metabotropic glutamate receptor 7 (mGluR7, Grm7)* | D16817_g_at |
| X |
|
| NAc | ↑ |
5-Ht receptor 2C (5-HT2C) | M21410_s_at | X | X |
|
| NAc | ↓ |
Gamma-aminobutyric acid (GABA) B receptor, 1 (Gabbr1)* | AB016160_g_at | X |
|
| X | SP | ↓ |
AB016161UTR#1_g_at | X |
|
|
| SP | ↓ | |
rc_AA926213_g_at | X |
|
| X | SP | ↓ | |
Neuropeptide Y (NPY)* | M15880_at | X |
|
|
| SP | ↓ |
Neuronal pentraxin receptor (Nptxr)* | rc_AI045501_s_at | X |
|
|
| SP | ↓ |
Guanine nucleotide binding protein, beta 1 (rGbeta1, Gnb1)* | U88324_g_at | X |
|
|
| SP | ↑ |
Ion pumps/channels | |||||||
K+ voltage-gated channel, shaker related, member 6 Kv1.6 (KCNA6)* | M27159cds_s_at | X | X |
| X | LH | ↑ |
K+ inward rectifier 10 Kir4.1 (KCNJ10)* | X83585cds_s_at |
| X |
|
| LH | ↑ |
U27558_at |
| X |
|
| LH | ↑ | |
ATPase, Na+/K+ transporting, beta 2 polypeptide (Atp1b2)* | D90048exon_g_at | X | X | X | X | LH | ↑ |
J04629_at | X | X | X | X | LH | ↑ | |
ATPase, Na+/K+ transporting, alpha 3 polypeptide (Atp1a3)* | M28648_s_at | X |
|
|
| LH | ↑ |
Vesicular inhibitory amino acid transporter (5VIAAT) | AF030253_at | X | X |
|
| LH | ↑ |
rc_AA996551_s_at | X | X |
| X | LH | ↑ | |
K+ voltage gated channel, Shal-related, member 2 Kv4.2 (KCND2)* | M59980_s_at | X |
|
|
| SP | ↓ |
Na+ channel, voltage-gated, type II, beta polypeptide (SCNB2)* | U37147_at | X |
|
|
| AMY | ↑ |
ATPase, Na+/K+ transporting, alpha 3 polypeptide (Atp1a3)* | M28648_s_at | X | X |
|
| VTA | ↑ |
Release machinery | |||||||
Synaptotagmin 11 (Syt11) | AF000423_at | X | X | X | X | LH | ↑ |
Synaptotagmin 3 (Syt3)* | D28512_at | X | X |
| X | LH | ↑ |
Syntaxin 1B2 (Stx1b2) | M95735_at | X |
| X | X | LH | ↑ |
Synaptophysin (Syp)* | X06655_at |
|
| X | X | LH | ↑ |
RAB3A | X06889cds_at | X | X | X | X | LH | ↑ |
Tissue/response | |||||||
Fractalkine/ chemokine (C-X3-C motif) ligand1 (Cx3cl1)* | AF030358_at | X | X |
|
| LH | ↑ |
rc_AA800602_s_at | X | X |
|
| LH | ↑ | |
rc_AI227647_s_at | X |
|
|
| LH | ↑ |
NAc, nucleus accumbens; AMY, amygdala; LH, lateral hypothalamus; SP, septum; VTA, ventral tegmental area.
*Validated by RT-PCR.