Supporting information for Akashi and Gojobori (2002) Proc. Natl. Acad. Sci. USA 99 (6), 3695–3700. (10.1073/pnas.062526999)

Table 5. Metabolic costs of precursor metabolites in E. coli

Precursor

Abbrev.

Energetic cost

Glucose

Acetate

Malate

~P

H

~P

H

~P

H

Ribose 5-phosphate

penP

7

10

19

10

11

10

5-Phosphoribosyl pyrophosphate

PRPP

9

10

21

10

13

10

Erythrose 4-phosphate

eryP

5

8

11

8

7

8

3-Phosphoglycerate

3pg

4

6

4

6

3

6

Phosphoenolpyruvate

pep

2

4

3

5

2

5

Pyruvate

pyr

2

4

3

5

2

5

Acetyl-CoA

acCoA

0

4

2

5

1

4

a-ketoglutarate

akg

0

2

1

4

1

2

Oxaloacetate

oaa

1

4

5

7

2

5

~P and H refer to numbers of high-energy phosphate bonds carried in ATP and GTP molecules and numbers of available hydrogen atoms carried in NADH, NADPH, and FADH2 molecules, respectively.