CLUSTAL W (1.81) multiple sequence alignment Mycobacterium_leprae ----------------VSAS--VEIFSDSKTMVGAAGKRLASTIQSAVAA Mycobacterium_tuberculosis ----------------VSSS--IEIFPDSDILVAAAGKRLVGAIGAAVAA Streptomyces_coelicolor ----------------MSDTPQLVVHRDKELMAEAAAARLITKIVDAQAS Chlamydophila_pneumoniae ----------MATLINFNDTNKLLLTKQPSLFIDLASKDWIASANQAIKQ Chlamydia_trachomatis ----------MATLISLNDANRMLIADSQEEFLQIACYDWISTANKAIHK Anabaena_sp. ------------------MKKTVEVLP-DQTRSIRSLDLILTKLDTAIKQ Synechocystis_sp. ----MEGKNKIIHSPEVSMAPQVDVLINKQILIERALVCVTTRITKAIAE 1Saccharomyces_cerevisiae ---------------MTTTVPKVFAFHEFAGVAEAVADHVIHAQNSALKK 2Saccharomyces_cerevisiae ---------------MTTTVPKIFAFHEFSDVAEAVADHVVHAQDGALAP Schizosaccharomyces_pombe ---------------MS-----VYSFSDVSLVAKALGAFVKEKSEASIKR Homo_sapiens --------------MAAPAPGLISVFSSSQELGAALAQLVAQRAACCLAG Rhizobium_meliloti ------------------MSANMHIFENPSALAEALADDVGARLAAAIAA Mesorhizobium_loti ---------MAREQLNG-ASYNWNAFPDRPQLAVALAGRVADRLTRAIAE Bartonella_henselae_ VMGVYGTIWFRAINMYG-INIDHLDFATPTALALALADRVAAELSVSVLE Pseudomonas_aeruginosa ----MGGVGMAISELKLPAGVGLQVWGSAAEQARGLAAEVAGRLRSALAE Helicobacter_pylori ------------------MGYQLFEFENLEDCHKALIERFKEFFNAALKK Thermotoga_maritima -------------------MEKTVIYLLEDGYVDFVVEKIRTKMEKLLEE Treponema_pallidum --------------------MKKHIFEDARAIAAFLVSVFDSRLKT---- Caenorhabditis_elegans ------MCLVNEFVSNSNMKPALNVSGDEKELILQLRRYLEEKLTYLLDQ Borrelia_burgdorferi --------------------MEFLYSDEENYLKDRFFDFFNMNVDK---- Mycobacterium_leprae -------------------------------------------------- Mycobacterium_tuberculosis -------------------------------------------------- Streptomyces_coelicolor -------------------------------------------------- Chlamydophila_pneumoniae -------------------------------------------------- Chlamydia_trachomatis -------------------------------------------------- Anabaena_sp. -------------------------------------------------- Synechocystis_sp. -------------------------------------------------- 1Saccharomyces_cerevisiae GKVSRSTQMSGTSLNGNGNTESKTMERVNSVRSNASSRGGSEDGATKKLK 2Saccharomyces_cerevisiae -KNERKHSVPNISMNALDMTREASCKSTASAAEGKSGSSGSGSGSSK--- Schizosaccharomyces_pombe -------------------------------------------------- Homo_sapiens -------------------------------------------------- Rhizobium_meliloti -------------------------------------------------- Mesorhizobium_loti -------------------------------------------------- Bartonella_henselae_ -------------------------------------------------- Pseudomonas_aeruginosa -------------------------------------------------- Helicobacter_pylori -------------------------------------------------- Thermotoga_maritima -------------------------------------------------- Treponema_pallidum -------------------------------------------------- Caenorhabditis_elegans -------------------------------------------------- Borrelia_burgdorferi -------------------------------------------------- Mycobacterium_leprae ---RERALIVLTGGSSGIGLLRDLATR--G-QQIDWSRVHLFWGDERYVP Mycobacterium_tuberculosis ---RGQALIVLTGGGNGIALLRYLSAQ--A-QQIEWSKVHLFWGDERYVP Streptomyces_coelicolor ---RGSASVVLTGGRNGNGLLAALAGSPAR-DAIDWSRLDLWWGDERFLP Chlamydophila_pneumoniae ---RGAFYVALSGGKTPLEIYKDIVINK--DKLIDPSKIFLFWGDERLAP Chlamydia_trachomatis ---RGAFYVALSGGKTPLQIFQEIVKKR--AAISDCSKIVVFWGDERANE Anabaena_sp. ---QGRFTIALSGGSTPKPLYEAIAAQK-----LPWDKIHVFWGDERYVS Synechocystis_sp. ---RGQGTIALSGGNTPKPLYEALARQA-----LPWEKIHVFWGDERYVS 1Saccharomyces_cerevisiae KEKERRFKIALSGGSLIQVLHEGLLKRDD----VQWGKWDIYFADERLVP 2Saccharomyces_cerevisiae PKKEKRFKIALSGGSLIEVLHEGLLKRDD----VRWGDWDIYFADERLVP Schizosaccharomyces_pombe ---HGVFTLALSGGSLPKVLAEGLAQQRG----IEFSKWEVFFADERIVP Homo_sapiens --ARARFALGLSGGSLVSMLARELPAAVAPAGPASLARWTLGFCDERLVP Rhizobium_meliloti ---RGTASLAVSGGSTPKAFFRSLSRRE-----LDWSKVTVTLVDERFVP Mesorhizobium_loti ---RGTAVLAVSGGTTPTKFFAALSAMP-----IAWDKVIVTLVDERFVP Bartonella_henselae_ ---RKRAILAVSGGKTPELFFHYLSKAD-----IDWENIIITLVDERFVP Pseudomonas_aeruginosa ---QGQALLVVSGGRSPVAFLEALSEEP-----LDWSRITVSLADERWVP Helicobacter_pylori ---HHQVSVAFSGGRSPISLLQKLSVLD-----LKWHECLISLVDERIIE Thermotoga_maritima ---KDKIFVVLAGGRTPLPVYEKLAEQK-----FPWNRIHFFLSDERYVP Treponema_pallidum ---QEILWLALSGGSTPREIFRTWAHEFR--HHLDWKRLRFFWSDERCVP Caenorhabditis_elegans ---NGTVSIGVSGGSMPRVFSKAILSLPQ--EQLNWKRIRIFMVDERNVD Borrelia_burgdorferi ---DKYTSIGICGGRSIVNFLSVFLKQN-----FSFRRSHFFLVDERCVP : . ** . . *** Mycobacterium_leprae KDDDERNEKQARVALLDHIDIPPSQVHPMPAGDGEFGN----DLEAAALA Mycobacterium_tuberculosis EDDDERNLKQARRALLNHVDIPSNQVHPMAASDGDFGG----DLDAAALA Streptomyces_coelicolor EGDPERNVTQAQQALLDSVPLDPKRVHAMAASDGPYGS----DVEAAAAA Chlamydophila_pneumoniae ITSSESN-YGQAMSILRDLNIPDEQIFRMETENPD-------GAKKYQEL Chlamydia_trachomatis DVEAGSN-YLKAMDILKGLRIPEDQIFRMDTADPK-------GDEAYEAL Anabaena_sp. PDHPDSNELMARTAWLDRVDIPAEDIHAVPTLDNNPAV----SAAKYEQH Synechocystis_sp. VDHPDSNQRMARLAWLDQVDIPEANIHPMPTAAADPEQ----DAQTYENE 1Saccharomyces_cerevisiae FSSSESNYGLAKRKIFDLIDTEKYGTPKIYHIDESLIN----DPQECADN 2Saccharomyces_cerevisiae FSSNESNYGCAKRKILDLIDTAKYGTPKVYHIDESLID----DPQECADN Schizosaccharomyces_pombe LDDENSNYALCKKLIFDKFEG--FDPKKIHTINPELLKENPIDPQNVADE Homo_sapiens FDHAESTYGLYRTHLLSRLPIP---ESQVITINPELPV------EEAAED Rhizobium_meliloti PENDRSNHRLVADNLLKDGAAEARFVPLYQAAETAEAA------AAIASG Mesorhizobium_loti ASSPRSNAGLVAANLLQNAAKAARFVPLYHEASGIEDA------AASDDA Bartonella_henselae_ VHHERSNEHVVRRYLLQNFAAKARFVGLYQKAITVELA------AFSAAS Pseudomonas_aeruginosa ESHADSNAGLVRRHLLRGEAAKARFIGLYQPAASLEEA------AELADH Helicobacter_pylori ASHEDSNAKLLHDYLLQNNALKASFTPLLPEKISGDTN-------ELLDF Thermotoga_maritima LDSDQSNFRNINEVLFSRAKIPSGNVHYVDTSLPIEKA---------CEK Treponema_pallidum PTDAQSNFNMTHSALLEPLEINPDAVFRVRGEDAPESA-----CAAYSQE Caenorhabditis_elegans LDSEESNQGEYLRLFPNELRDVFVPMQIFKDPCLTAQH--------YEIS Borrelia_burgdorferi LNDENSNYNLLNKNFFSKMVDKNLISISKFHAFVYSEID----EATAIHD . Mycobacterium_leprae YEQLLAAYAAPG--YPTPNFDVHLMGMGPEGHINSLFPN----TVAVRET Mycobacterium_tuberculosis YEQVLAASAAPG--DPAPNFDVHLLGMGPEGHINSLFPH----SPAVLES Streptomyces_coelicolor YAQELATASVPENHAAVPSFDVLLLGVGPDTHVASLFPE----HPGVRET Chlamydophila_pneumoniae IENKIPDAS----------FDMIMLGLGEDGHTLSLFSN----TSALEEE Chlamydia_trachomatis IQKYVPDAI----------FDMVMLGVGEDGHTLSLFPE----THALEEK Anabaena_sp. LQTFFNSAPGEF-----PALDVVLLGMGDDAHTASLFPH----TEALQVR Synechocystis_sp. LATFFQVEAGHF-----PAFDLILLGLGDDGHTASLFPH----TPALTVG 1Saccharomyces_cerevisiae YEKILIKGFAGRDSVKLPMFDLFLLGCAPDGHIASLFPNF---QENLREN 2Saccharomyces_cerevisiae YEKVLIRGFAGRDSVKLPMFDLFLLGCAPDGHIASLFPNF---QDNLREK Schizosaccharomyces_pombe YEKQLVHVFANSSTVKVPVFDLLLLGCGPDGHTCSLFPD----HEVLQED Homo_sapiens YAKKLRQAFQGDS---IPVFDLLILGVGPDGHTCSLFPD----HPLLQER Rhizobium_meliloti RTASLGAP-----------LDVVVLGMGTDGHTASFFPGGTRLEEALDPT Mesorhizobium_loti ALRSLPWP-----------LDVVVLGMGPDGHTASFFPDADDLAELLDPA Bartonella_henselae_ RVNTLPRP-----------FDVVVLGMGVDGHTASFFPDADRLKQALDLQ Pseudomonas_aeruginosa HLHELPLP-----------IDVLVLGMGDDGHTASLFPNSPGLDLAMDPQ Helicobacter_pylori ANQHFKQP------------HLAILGMGTDGHTASLFPET----SAFLNE Thermotoga_maritima YEREIRSAT--------DQFDLAILGMGPDGHVASIFDL------ETGNK Treponema_pallidum IEARLPRQRG------VPCFDIILLGMGADGHTASIFPH-----EIELWD Caenorhabditis_elegans LRKYLLPEQLNN----TARFDILFLGVGPDGHTASIFPGKE--RLEKITE Borrelia_burgdorferi YNIEFNSRFN--------IFDFIIVSVGEDGHIASLFPS----RKLLFSD . .. .:. . : * *:* Mycobacterium_leprae SRMVVGVRNSPKPPPERITLTLNAIQRSREVWLMVSGTAKADAVAAAMGG Mycobacterium_tuberculosis TRMVVAVDDSPKPPPRRITLTLPAIQRSREVWLLVSGPGKADAVAAAIGG Streptomyces_coelicolor ERTVIGVHGSPKPPPIRISLTLPAIRAAREVWLLAAGEDKANAVAMALSG Chlamydophila_pneumoniae NDLVV-FNSVPHLETERMTLTFPCVHKGKHVVVYVQGENKKPILKSVFFS Chlamydia_trachomatis ERFVV-FNEVPQLHTRRMTLTFPIVRQARHLVAYVQGENKQDLFHKLVHP Anabaena_sp. DRLIT-VGNK--DGNPRITFTYPFINAASSVIFVVAGANKRPALAQVFAP Synechocystis_sp. DRLIT-VGNK--DGQPRLTFTIPLINRARSVVFLVAGASKQHALGEIFAP 1Saccharomyces_cerevisiae LAWVIPVENAPSGPSNRISLTIPVICHSHRVTFVVEGATKAPVIKTIMER 2Saccharomyces_cerevisiae LAWVVPVENAPSGPSTRISLTIPVICHSHRVTFVVEGATKAPIIKTIMER Schizosaccharomyces_pombe VAWVAPVTDSPKPPKDRITLTLPVVTHAQAIAFVTTGAGKKDILPIVIED Homo_sapiens EKIVAPISDSPKPPPQRVTLTLPVLNAARTVIFVATGEGKAAVLKRILED Rhizobium_meliloti TPRGVITMEAEGAGEPRLTFTFS--------------------------- Mesorhizobium_loti SDRIILPVHAASAGEPRLTLTLARIIDAGFIALHIEGEDKRTAFDGAVAP Bartonella_henselae_ TQALVLPLYAKSALEPRLTLTLPVIMQSRCIILHFEGFQKRDCFEVVCQN Pseudomonas_aeruginosa GTRRCLPMWAPSVPHQRLTLPRAVLAAAKVQLLAIQGQSKLATLNAALAV Helicobacter_pylori EKENIVLTKPTNAPYERLSMSINALENCEKLFLSISGVEKRGVLEKALKE Thermotoga_maritima DNLVTFTDPSGDPKVPRVTLTFRALNTSLYVLFLIRGKEKINRLTEILKD Treponema_pallidum HSGCCVVATHPDTGQKRVSFTGHLINNAHEIYVVVTGREKQDMLASVASD Caenorhabditis_elegans LNWVSVITDSPKPPPSRITLTLQTLQHAKNVAFIICGKQKAEIVRGICDR Borrelia_burgdorferi VEGYQYEYNSPKFPSKRISLTPKSLFGSKAVVLLFMGVDKKCALENFLAS *:::. . . Mycobacterium_leprae APSAS----IPAAGAVGLETTLWLLDEEAAAKIPG--------------- Mycobacterium_tuberculosis ADPVS----VPAAGAVGRQNTLWLLDRDAAAKLPS--------------- Streptomyces_coelicolor AGEIQ----APAAGARGRARTLWLLDSAAASQLPRSLYPPASA------- Chlamydophila_pneumoniae EGREEK-LYPIERVGRDRSPLFWIISPESYDIADFDNISSIYKMDIL--- Chlamydia_trachomatis LGRDT---FPIERVGTPLNPVQWVLSSDSCRKTDLADIPADCKLEMF--- Anabaena_sp. SADDL---AYPSRFIQPQGELLWLLDAAARRTLSV--------------- Synechocystis_sp. EADPQ---QYPARFIQPQGELIWLLDQQAGENLRP--------------- 1Saccharomyces_cerevisiae PEKGL---PSSIVNEGAAGRVSWFVDDDALKDVFVIKKKYKFYDDENLTE 2Saccharomyces_cerevisiae PEKGL---PSSIVNEGAAGRVSWFVDDDALTDVLVTKKKYKFHQGLSI-- Schizosaccharomyces_pombe FTSKL---PSALITRNNLTRTSWFVDDEASAN--LERSSLKVFPQ----- Homo_sapiens QEENP---LPAALVQPHTGKLCWFLDEAAARLLTVPFEKHSTL------- Rhizobium_meliloti -----------------SLQIYWAP------------------------- Mesorhizobium_loti GP--RKPIRAVLDAAPRPVEVFWAP------------------------- Bartonella_henselae_ GSEMEMPVRAVLRNAHHLVQVYWSPKENEISEAEHKTSKVDT-------- Pseudomonas_aeruginosa EDERRMPVRAFLR---APLTIHWYP------------------------- Helicobacter_pylori NAPYSLPIARILHSKKVTTEVFYAKN------------------------ Thermotoga_maritima TP-------LPAYFVRGKEKTVWFVGK----------------------- Treponema_pallidum PHASVP----LHAWTLPKRSGCWIPLLRGLYPRKQCKPTV---------- Caenorhabditis_elegans DQKYP-----AAQARPFNDKLTLFLDEDAATGVPDRDSSDSDSPPPFDG- Borrelia_burgdorferi NSSIN---ECPARLLKEHPNLLVLTNIKRDESYAGS--------------