Supporting Information for Jiménez et al. (2002) Proc. Natl. Acad. Sci. USA, 10.1073/pnas.142459399
Fig. 7. The average and variance of the six independent protofilaments found in the insulin amyloid fibril cross sections. The average insulin protofilament (black contours) has dimensions ~30 ´ 40 Å (a and c). The low variance within the protofilament profile (b) supports the idea that there is a common protofilament structure in the different insulin fibrils. Density variations outside the protofilament show that binding to other protofilaments occurs around the lower part of the protofilament density plotted in (a). Comparing the SH3 amyloid protofilament (red; ref. 1) with the insulin protofilament (black) shows that the SH3 protofilament, although similar in overall dimension of the core region, is more extended laterally. The insulin protofilament is more compact and lacks the flanking, lower density regions.
1. Jiménez, J. L., Guijarro, J. I., Orlova, E., Zurdo, J., Dobson, C. M., Sunde, M. & Saibil, H. R. (1999) EMBO J.18, 815–821.
