Initiating oncogenic event determines gene-expression patterns of human breast cancer models -- Data Supplement - Supporting Figure 5 -- Proceedings of the National Academy of Sciences

Supporting information for Desai et al. (2002) Proc. Natl. Acad. Sci. USA 99 (10), 6967–6972. (10.1073/pnas.102172399)

Supporting Figure 5

Fig. 5.
Representative cluster of mammary fat-specific genes. As the tumor samples are principally composed of epithelial cells, the genes that appear suppressed in our comparisons with normal mammary gland may be so because of lack of adipose tissue RNA in the tumors. In order to identify this sub-set of genes, fat pads of 3-week old FVB female mice were surgically cleared of epithelial cells. The animals were killed at 11 weeks of age, and the cleared fat pad RNA (fvb-clear) was compared to that from the reference normal mammary gland by using the NCI 2.7K set of genes. Genes induced in the fvb-clear sample would represent genes potentially specific to the adipose tissue and are shown in this cluster. Selection of genes was as described in Methods. Tumor labels are shown at the top of the figure; gene names are shown on the right-hand side.