Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: The role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza -- Data Supplement - Supporting Information -- Proceedings of the National Academy of Sciences

Supporting information for Geiss et al. (2002) Proc. Natl. Acad. Sci. USA, 10.1073/pnas.112338099

Fig. 13.
Hierarchical clustering results for genes known to be associated with IFN. A set of genes known to be IFN-induced or associated with IFN signaling was created in RESOLVER gene expression data analysis software. Genes were clustered with agglomerative algorithm, complete link heuristic criteria, and correlation without mean subtraction metric. Experiments were not clustered. Only genes that were significantly regulated in at least one experiment were clustered. The fold change in mRNA levels in influenza virus-infected cells relative to mock-infected cells is represented by red (increased in influenza virus-infected cells) or green (decreased in influenza virus-infected cells) squares. Each square is the result of four measurements per gene per experiment. The color scale indicates the magnitude of increase or decrease in log10 scale. Each vertical column represents an independent infection. From left to right, A549 cells infected with delNS1 virus, cells infected with NS1(1-126) virus, cells infected with wt A/PR/8/34 virus, cells infected with wt A/WSN/33 virus, and cells infected with 1918 NS recombinant virus. Characterized genes are indicated by their HUGO names, and more information and aliases for these genes can be found at GeneCards database (http://bioinfo.weizmann.ac.il/cards/index.html).