Hitchhiking mapping: A population-based fine-mapping strategy for adaptive mutations in Drosophilamelanogaster -- Data Supplement - Supporting Information -- Proceedings of the National Academy of Sciences

Supporting information for Harr et al. (2002) Proc. Natl. Acad. Sci. USA, 10.1073/pnas.202336899

Table 7. Results of likelihood ratio test [Kim, Y. & Stephan, W. (2002) Genetics 160, 765–777]

Simulation	C = 4Nr	q	Option 1 (derived alleles/non-derived alleles distinguished)				Option 2 (derived alleles/non-derived alleles not distinguished)
Simulation	C = 4Nr	q	LR^†	2Ns	X	s^‡	LR^†	2Ns	X	s^‡
Sweep region 1
1*	0.0185	0.0087	84.2	9035.1	2491474	0.0045	85.8	10728.7	2491442	0.0054
2	0.0185	0.0043	36.0	5604.9	2487488	0.0028	35.0	6626.9	2487344	0.0033
3	0.0185	0.0173	195.0	13422.0	2491535	0.0067	200.4	15789.9	2491480	0.0079
4	0.0093	0.0087	84.2	4071.8	2491449	0.0020	85.7	4940.4	2491437	0.0025
5	0.037	0.0087	84.2	19468.2	2491405	0.0097	85.7	23149.7	2491526	0.0116
Sweep region 2
1*	0.0185	0.0087	23.6	1083.0	2661027	0.0005	22.3	957.3	2661004	0.0005
2	0.0185	0.0043	9.19	291.9	2661024	0.0001	8.44	281.5	2661053	0.0001
3	0.0185	0.0173	64.8	3426.9	2662380	0.0017	61.2	2550.9	2661132	0.0013
4	0.0093	0.0087	23.5	447.6	2661012	0.0002	22.3	422.3	2661104	0.0002
5	0.037	0.0087	23.5	2914.2	2660930	0.0015	22.3	2131.4	2661118	0.0011

X
, position of selected mutation on the chromosome (according to release 2 of the complete Drosophila genome); s, selection coefficient; LR, likelihood ratio.

*Standard parameter, estimated from non-African polymorphism in frag.1, frag.4, and frag.7.

^†All simulations fitted the hitchhiking model significantly better than the neutral model [P (LR) < 0.05]. ^‡Based on an effective population size (N_e) of 10⁶.