Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors -- Data Supplement - Supporting Information -- Proceedings of the National Academy of Sciences

Supporting information for Pollack et al. (2002) Proc. Natl. Acad. Sci. USA, 10.1073/pnas.162471999.

Supporting Figure 8 Fig. 8.
DNA copy number profiles are provided for a representative set of breast cancer cell lines and tumors (listed below). For each cell line/tumor included, two representations are shown. The first representation displays moving average (symmetric 5-nearest neighbors) ratios on a log₁₀ scale, with genes mapped by nucleotide position. Green indicates fluorescence ratios <0, and red indicates fluorescence ratios >0. The second representation displays the graphical output of the statistical method (described above) used to identify chromosomal gains/losses. Here, ratios are plotted on a log₂ scale, and black tick marks indicate fluorescence ratios estimated to be significantly different from baseline normal vs. normal hybridizations (see Estimating the Significance of Altered Fluorescence Ratios), specifying a false discovery rate of 1%. 1, 46,XX; 2, 47,XXX; 3, BT474; 4, MCF7; 5, T47D; 6, Norway 12; 7, Norway 39; 8, Norway 48; 9, Norway 57; 10, Norway 109; 11, Norway 111; 12, Stanford 31.