Increase in TNF-{alpha} and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a) -- Lowes et al. 102 (52): 19057 Data Supplement - HTML Page - index.htslp -- Proceedings of the National Academy of Sciences

Lowes et al. 10.1073/pnas.0509736102.

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Fig. 5. Photomicrographs of psoriasis lesions showing dendritic nature of CD11c⁺ and inducible nitric oxide synthase (NOS)⁺ cells. (A-C) Images at ´10 magnification. (D and Insets) Images at ´40 magnification. (A) iNOS+ cells in the dermis and epidermis of psoriasis lesions. (Inset) Dendritic nature. (B) There are few CD14⁺ cells in psoriasis lesions. (C) CD11c⁺ cells in the dermis and epidermis of psoriasis lesions. (Inset) Dendritic nature. (D) Worsening psoriasis after discontinuation of efalizumab. Higher power magnification showing a DC that appears to be crossing the dermoepidermal junction (arrow), and others which have invaded the epidermis.