Appendix Figure 1
The pilot studies were originally designed by H.Kitchener, J.Patnick & M.Vessey.
The Steering group for the pilot studies comprised H. Kitchener (chair), H. Cubie, D. Hicks, E. McGoogan, J. Richards, J. Rimmer, L. Turnbull, N. Wald, P. Walker, P. Wilkie,
The lead clinicians at the three pilot sites were, K. Denton (Bristol), S. Johnson proceeded by S. Needham (Newcastle), R. Lonsdale (Norfolk & Norwich).
Executive group: K. Denton, Gwyneth Mercer (Bristol), S. Johnson/S. Needham, Dave Evans (Newcastle), R. Lonsdale, Richard Wood (Norfolk & Norwich).J. Richards, J. Rimmer, L. Turnbull, J Patnick, RJ Winder, Mina Desai and Jean Mather (Manchester), Maggie Cooper (Marie Curie)
DH set up an advisory group to advise on the conduct of the evaluation : its independent members were : R. Lilford (chair), K. Boyd, M. Buxton, J. Cuzick, K.Sutherland, C. Wilkinson).
Appendix Figure 1: Cost effectiveness acceptability frontier
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Appendix [As supplied by authors]
Appendix Table 1 Key parameters identified in one-way sensitivity analysis
| Minimum parameter estimate* | Maximum parameter estimate* | |||||||
| †Cost Effective Strategy | Incre-mental cost | Incre-mental effect | ICER | †Cost Effective Strategy | Incre-mental Cost | Incre-mental Effect | ICER | |
Cost of HPV | D | £11.5 | 0.0034 | £3,376 | D | £12.9 | 0.0034 | £3,851 | |
E | £5.8 | 0.0015 | £3,932 | E | £6.5 | 0.0014 | £4,520 | ||
B | £0.3 | 0.0000 | £7,373 | B | £1.0 | 0.0000 | £22,558 | ||
Cost of LBC | A | -£0.2 | 0.0019 | Dominates | D | £24.1 | 0.0034 | £7,100 | |
D | £3.1 | 0.0015 | £2,020 | E | £6.3 | 0.0015 | £4,264 | ||
E | £6.5 | 0.0015 | £4,420 | B | £0.7 | 0.0000 | £15,207 | ||
B | £1.0 | 0.0000 | £23,733 |
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Cost of colposcopy with CIN | D | £9.7 | 0.0034 | £2,858 | D | £15.7 | 0.0034 | £4,621 | |
E | £3.8 | 0.0015 | £2,594 | E | £9.0 | 0.0015 | £6,098 | ||
B | £0.9 | 0.0000 | £20,046 | B | £0.9 | 0.0000 | £19,816 | ||
Discount rate costs | D | £20.9 | 0.0034 | £6,155 | D | £8.4 | 0.0034 | £2,481 | |
E | £7.4 | 0.0015 | £5,004 | E | £5.4 | 0.0015 | £3,640 | ||
B | £1.7 | 0.0000 | £39,401 | B | £0.5 | 0.0000 | £12,212 | ||
Discount rate Effects | D | £12.7 | 0.0160 | £792 | D | £12.7 | 0.0009 | £14,305 | |
E | £6.4 | 0.0056 | £1,145 | E | £6.4 | 0.0005 | £12,303 | ||
B | £0.9 | 0.0002 | £4,589 | B | £0.9 | 0.0000 | £67,969 | ||
Effectiveness of colposcopy | D | £13.4 | 0.0033 | £4,061 | D | £12.2 | 0.0034 | £3,588 | |
E | £6.9 | 0.0014 | £4,929 | E | £5.9 | 0.0014 | £4,214 | ||
B | £0.9 | 0.0001 | £9,000 | ||||||
LBC sensitivity change CIN2/3 | D | £14.7 | 0.0026 | £5,678 | D | £12.1 | 0.0037 | £3,266 | |
E | £7.1 | 0.0011 | £6,358 | E | £6.5 | 0.0014 | £4,507 | ||
B | £0.9 | 0.0000 | £11,743 | B | £0.9 | 0.0000 | £21,078 | ||
Progression of CIN 2/3 to invasive | D | £14.7 | 0.0026 | £5,678 | D | £12.5 | 0.0035 | £3,595 | |
E | £7.1 | 0.0011 | £6,358 | E | £6.3 | 0.0015 | £4,248 | ||
B | £0.9 | 0.0000 | £27,190 | B | £0.9 | 0.0000 | £19,865 | ||
*Minimum and maximum estimates as defined in Table 1
† Eliminating dominated and extended dominated options where: in dominated options the next more effective strategy costs less and with extended dominance once dominated options have been excluded if the next more effective strategy has a lower cost effective ratio then this strategy is also excluded.