CLUSTAL W (1.83) multiple sequence alignment Ag_ENSANGP00000000768 ------------------------GVPGAMETLSNFGQVALKWDPKNLEI Dm_CG17947 -----------------------MLKPDKMGTLTDFGQIALKWDPKNLEI Human_CTNNA2 -------------------------------MTSATSPIILKWDPKSLEI Md8i18_5 MVHIYSESNVLGQFCTNNERITVTKIIIIEITVTITVTVTAITNKFNINR Ag_ENSANGP00000022276 -------------------------------------------------- Dm_CG2987_RA -------------------------------------------------- Dm_CG2987_RB -------------------------------------------------- Human_CTNNAL1 ------------------MAASPGPAGVGGAGAVYGSGSSGFALDSGLEI Ag_white -------------------------------------------------- Ag_ENSANGP00000000768 RTMSVEKTLEPLVLQVTTLVST--KGPSKKKKGKSKRAS-ALVAAVEKAT Dm_CG17947 RTMSVEKTLEPLVLQVTTLVNT--KGPSKKKKGKSKRAS-ALVAAVEKAT Human_CTNNA2 RTLTVERLLEPLVTQVTTLVNTSNKGPSGKKKGRSKKAH-VLAASVEQAT Md8i18_5 QLNKTKTMATAYDRQVSSIGPHRSDRPHTMSGERTLRVIGHIGQSVNLSV Ag_ENSANGP00000022276 ---------LSPTSQISTLVQHRSEQQHHTS-EQKMRAIGRVGQAVNLAV Dm_CG2987_RA -----------MYGITQSTVNNQRFRVRDMDNEQIMSTFGNIGHLLNIAV Dm_CG2987_RB -----------------------------MDNEQIMSTFGNIGHLLNIAV Human_CTNNAL1 KTRSVEQTLLPLVSQITTLINH---KDNTKKSDKTLQAIQRVGQAVNLAV Ag_white -------------------------------------------------- Ag_ENSANGP00000000768 DIFIERGEQIAYENPDITQEMLSAVEEVRKTGSAMSIAAREFSEDP---- Dm_CG17947 ENFIQKGEQIAYENPDITQEMLTAVDEVKKTGDAMSIAAREFSEDP---- Human_CTNNA2 QNFLEKGEQIAKESQDLKEELVAAVEDVRKQGETMRIASSEFADDP---- Md8i18_5 ERFVTVGERIADDNTEIKQDMYDACKEARSAGSSLERLCEIVANN----R Ag_ENSANGP00000022276 ERFVTVGETIADDNPEIKQDMYDACKEARAAGSSIERLCDIAATDPTVGY Dm_CG2987_RA ERFITIGEIIAEENIDIKGDMYEAAKEARDAGKSIERLCDISPLSG-MEL Dm_CG2987_RB ERFITIGEIIAEENIDIKGDMYEAAKEARDAGKSIERLCDISPLSG-MEL Human_CTNNAL1 GRFVKVGEAIANENWDLKEEINIACIEAKQAGETIAALTDITNLNH-LES Ag_white --------------MTINTDDQYGDAESKTTISSSRRYSSSSYQDQ---- :. : . : : .: . Ag_ENSANGP00000000768 ----CSSLKRGNMVRAARNLLSAVTRLLILADMVDVHLLLKSLHVVEDDL Dm_CG17947 ----CSSLKRGNMVRAARNLLSAVTRLLILADMVDVHLLLKSLHIVEDDL Human_CTNNA2 ----CSSVKRGTMVRAARALLSAVTRLLILADMADVMRLLSHLKIVEEAL Md8i18_5 LDHDDALCERTAMIRAARTLLNSVTRVLLLADIVVVKQLLLDKDKIPKAF Ag_ENSANGP00000022276 SPRPNPIDDRGPMIRAARTLLSSVTRVLLLADIVVVKQLLLAKDRVARTL Dm_CG2987_RA RHHIEPLKDYGAIILAARSLLSSVTRILLLVDIIVVKKLLTAKKRASESL Dm_CG2987_RB RHHIEPLKDYGAIILAARSLLSSVTRILLLVDIIVVKKLLTAKKRASESL Human_CTNNAL1 DGQITIFTDKTGVIKAARLLLSSVTKVLLLADRVVIKQIITSRNKVLATM Ag_white -------------------SMDDALNTTLTNDKATLIQVWKPKS-YGSVK :. . . : * : : Ag_ENSANGP00000000768 DKLRNASSQDELMNNMRQFGRNANELIKQAAKRQQELKDPQLRDDLAAAR Dm_CG17947 NKLKNASSQDELMDNMRQFGRNAGELIKQAAKRQQELKDPQLRDDLAAAR Human_CTNNA2 EAVKNATNEQDLANRFKEFGKEMVKLNYVAARRQQELKDPHCRDEMAAAR Md8i18_5 SRLESVAHFTEFVKAFSVFGAEMVELAHLTYNRQNDPKDERRRSQMISAR Ag_ENSANGP00000022276 GRLESVANFTEFVKAFSVFGAEMVELAHVTGNRQNDLKDERRRAQMSSAR Dm_CG2987_RA EKLESVMNFTEFVRAFSVFGTEMIELAYLTGHHRNSFKEERRRAQMFSAR Dm_CG2987_RB EKLESVMNFTEFVRAFSVFGTEMIELAYLTGHHRNSFKEERRRAQMFSAR Human_CTNNAL1 ERLEKVNSFQEFVQIFSQFGNEMVEFAHLSGDRQNDLKDEKKKAKMAAAR Ag_white GQIPQCERLTYTWKEIDVFGEAPTDGKPREPLCTRLRNCCTRQRKDFNPR : . : ** . . : : . .* Ag_ENSANGP00000000768 AVLKKHSTMLLTASKVYVRHPELDLAKVNRDHILKQVCEAVNTISDVAQG Dm_CG17947 AMLKKHSTMLLTASKVYVRHPELDLAKVNRDFILKQVCDAVNTISDVAQG Human_CTNNA2 GALKKNATMLYTASQAFLRHPDVAATRANRDYVFKQVQEAIAGISNAAQA Md8i18_5 KVLERSTLMLLISSKTSLRNPNCVHSKENRDTVFCQMRRAMDLIHYVIKD Ag_ENSANGP00000022276 QVLERSTMMLLTSSKTCLRHSECAHSKENRDTVFCQMRRAMDLIHYVVKD Dm_CG2987_RA QILEKSIAILLTSSKNSLIHSDCVIVKENRDTVFCQIRRAMDLIHFVVKD Dm_CG2987_RB QILEKSIAILLTSSKNSLIHSDCVIVKENRDTVFCQIRRAMDLIHFVVKD Human_CTNNAL1 AVLEKCTMMLLTASKTCLRHPNCESAHKNKEGVFDRMKVALDKVIEIVTD Ag_white KHLLKNVTGVAKSGELLAVMGSSGAG------------------------ * : : :.: . Ag_ENSANGP00000000768 KS-SQPQDVYVGAGELAAALDDFDEGIIMDPRAYNEVRSRPSLEERLES- Dm_CG17947 KS-SQPTDIYSGAGELAAALDDFDEGIVMDPMTYSEKRSRQLLEERLES- Human_CTNNA2 TSPTDEAKGHTGIGELAAALNEFDNKIILDPMTFSEARFRPSLEERLESS Md8i18_5 AIISAAAHDRRGRSQQQSMDWDTDRGTASSCLRIFARLMESSRPRFSASN Ag_ENSANGP00000022276 GILESASDR---NALRQVPEWDSERATAFTCLRHFSRLIEISRPSYERNA Dm_CG2987_RA SIFDTAKHMP---FEKQASNPNYENESIYTTIKRIVNLIKRYKYQMSYYE Dm_CG2987_RB SIFDTAKHMP---FEKQASNPNYENESIYTTIKRIVNLIKRYKYQMSYYE Human_CTNNAL1 CKPNGETDISSISIFTGIKEFKMNIEALRENLYFQSK------------- Ag_white -------------------------------------------------- Ag_ENSANGP00000000768 IISAAALMADADCTRDERRERIVGECNAVRQALQDLLSEYMSN------- Dm_CG17947 IISAAALMADADCTRDERRERIVAECNAVRQALQDLLSEYMSN------- Human_CTNNA2 IISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMNN------- Md8i18_5 TSIIGTSKTGLKDISSNNRTTIDTLHTTSHAAGRELMRSNSERDRHVTNH Ag_ENSANGP00000022276 GPGGGGTAGRYLRQCSRTATERQGPHTDDGTS------------------ Dm_CG2987_RA GSGEGNNNSDAYFSFLDDDLWKSEKNLPSAAGG----------------- Dm_CG2987_RB GSGEGNNNSDAYFSFLDDDLWKSEKNLPSAAGG----------------- Human_CTNNAL1 -------------------------------------------------- Ag_white -------------------------------------------------- Ag_ENSANGP00000000768 ----MGTKDRTPELERAIGHMYRKTKDLRRQLRKAVVDHVSDSFLETNMP Dm_CG17947 ----MSQKDNSPGLSRAIDQMCRKTRDLRRQLRKAVVDHVSDSFLETTTP Human_CTNNA2 ----TGRKEKGDPLNIAIDKMTKKTRDLRRQLRKAVMDHISDSFLETNVP Md8i18_5 HTSTVSLRKAMHRDPYENSQSSNGIKGSYSELTGYGGTGSFDSFHGITIL Ag_ENSANGP00000022276 ----------------------------------APVQGVHLADPGISIF Dm_CG2987_RA ----------------------------------GRMVNNTNFRKHLSSE Dm_CG2987_RB ----------------------------------GRMVNNTNFRKHLSSE Human_CTNNAL1 -------------------------------------------------- Ag_white -------------------------------------------------- Ag_ENSANGP00000000768 LLDLIDAARGGNEKLVRERADIFTKHAEKLVEVANLVCSMSNNEDGVKMV Dm_CG17947 LLDLIEAAKSGNEKKVREKSEIFTKHAEKLVEVANLVCSMSNNEDGVKMV Human_CTNNA2 LLVLIEAAKSGNEKEVKEYAQVFREHANKLVEVANLACSISNNEEGVKLV Md8i18_5 SPQTREEMTYALNKCVEKTQDFTDSAYTTHEHRENILLLCDRMRLELNQC Ag_ENSANGP00000022276 STDTREQLLAALDKVCEKTQDFTDSAYTSHEHRENILLLCDRAKLELNQL Dm_CG2987_RA SLDLREELSLAFEKLFEKAHDFTDSPYISHNHRKNILSYCDNCKLEFDLY Dm_CG2987_RB SLDLREELSLAFEKLFEKAHDFTDSPYISHNHRKNILSYCDNCKLEFDLY Human_CTNNAL1 -----ENLSVTLEVILERMEDFTDSAYTSHEHRERILELSTQARMELQQL Ag_white -------------------------------------------------- Ag_ENSANGP00000000768 RYAADQIETLCPQVINAALILAARPNSKVAQENMEAYRQAWENQVRILTE Dm_CG17947 RYAAAQIESLCPQVINAASILTVRPNSKVAQENMTTYRQAWEVQVRILTE Human_CTNNA2 RMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDVFKDQWEKQVRVLTE Md8i18_5 LRMAVNMEQFPNSRYDIDGAVDS------------VLGAAQDLSQQLSMA Ag_ENSANGP00000022276 MRIAVSMEQYPNSSFDIDGAIES------------VLAAAHDLTTQLTLT Dm_CG2987_RA LNTIMKDQHEGGGGAGGVGGVGGGQVKGRSDPELGMLSSLEELCKQLVVS Dm_CG2987_RB LNTIMKDQHEGGGGAGGVGGVGGGQVKGRSDPELGMLSSLEELCKQLVVS Human_CTNNAL1 ISVWIQAQSKKTKSIAEELELSILKIS----------HSLNELKKELHST Ag_white -------------------------------------------------- Ag_ENSANGP00000000768 AVDDITTIDDFLAVSENHILEDVNKCVLALQEGDAQDLRNTAGAIQGRSA Dm_CG17947 AVDDITTIDDFLAVSENHILEDVNKCVMALQVGDARDLRATAGAIQGRSS Human_CTNNA2 AVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAA Md8i18_5 VADQL--------PELNHILNTGIELVNSLRNIALNQELERLQECADRFH Ag_ENSANGP00000022276 AQDQS--------AELSHIIKSGIDIANSLRNIALNQELDRLQECADRFH Dm_CG2987_RA VSSQI--------EDFNESLKICSKLVKSFHVLATNYDIDNLNQRSSKFH Dm_CG2987_RB VSSQI--------EDFNESLKICSKLVKSFHVLATNYDIDNLNQRSSKFH Human_CTNNAL1 ATQLA---------ADLLKYHADHVVLKALKLTGVEGNLEALAEYACKLS Ag_white --------------------KTTLLNALAFRSPPGVKISPNAVRALNGVP . ::: Ag_ENSANGP00000000768 RVCNVVEAEMDNYEPCIYTKRVLEAVKVLREQVMSKFAQRVDVAVDALSS Dm_CG17947 RVCNVVEAEMDNYEPCIYTKRVLEAVKVLRDQVMMKFDQRVGAAVGALSN Human_CTNNA2 RVIHIINAEMENYEAGVYTEKVLEATKLLSETVMPRFAEQVEVAIEALSA Md8i18_5 DNIDHILEVCKLLRHIALTEPHQIEAKFTEINLR-IYGPQVITAARALSS Ag_ENSANGP00000022276 EHIDHMLEVCKLLRQIALTETLQVQAKFTEINVR-IYGPQVITAARALTS Dm_CG2987_RA DCCDHIFDICKLLQHIAPTERLQVQAKCLAINLR-IYGPQVFIAAKILWK Dm_CG2987_RB DCCDHIFDICKLLQHIAPTERLQVQAKCLAINLR-IYGPQVFIAAKILWK Human_CTNNAL1 EQKEQLVETCRLLRHISGTEPLEITCIHAEETFQ-VTGQQIISAAETLTL Ag_white VNAEQLRARCAYVQQDDLFIPSLTTREHLLFQAMLRMGRDVPASVKQHR- . : . : : Ag_ENSANGP00000000768 NSPKDVDENDFIDASRLVYDGVREIRRAVLMNRSSDELDTDTEFEPVEDM Dm_CG17947 NSNKDVDENDFIDASRLVYDGVREIRRAVLMNRSSEDLDTDTEFEPVEDL Human_CTNNA2 NVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFE---QE Md8i18_5 HPNSKIAKDNFDVFSDMWQWLSRDVTLFSKEIIEMAQCISKPDRTEYSSL Ag_ENSANGP00000022276 HPQSKIAKENLEVFVDMWQWLSTDVTTITKEVIDLAHLLLG-------CF Dm_CG2987_RA YSNSSAANENFESFSDMWKWLTNEISMIAKKILVSINTTKGDR-----DA Dm_CG2987_RB YSNSSAANENFESFSDMWKWLTNEISMIAKKILVSINTTKGDR-----DA Human_CTNNAL1 HPSSKIAKENLDVFCEAWESQISDMSTLLREINDVFEGRRGEKYG-YLSL Ag_white -VQEVLQELSLVKCADTIIGAPGRIKGLSGG------------------- . : .: : Ag_ENSANGP00000000768 TIETRSRSSAHTGDQTIDEYPEISGITTAREAMRKMNEEDKQKIMQQVEL Dm_CG17947 TLETRSRSSAHTGDQTVDEYPDISGICTAREAMRKMTEEDKQKIAQQVEL Human_CTNNA2 DYDVRSRTSVQTEDDQLIAG------QSARAIMAQLPQEEKAKIAEQVEI Md8i18_5 PRPGKHGTTSKPLKA---------------VRLDQDEQEKIAKAGLEMKE Ag_ENSANGP00000022276 DVLQKHGTTSKPLKP---------------TRLDSEEQEKIAKTGLEMKM Dm_CG2987_RA DAEKCESSSDKLTKS---------------GVPATEDGEMVEYSGLEGKN Dm_CG2987_RB DAEKCESSSDKLTKS---------------GVPATEDGEMVEYSGLEGKN Human_CTNNAL1 PKPMKNNANLKSLKP------------------DKPDSEEQAKIAKLGLK Ag_white ---------------------------------------ERKRLAFASET Ag_ENSANGP00000000768 FRREKLTFDSEVAKWDDTGNDIIYLAKHMCMIMMEMTDFTRGRGPLKTTM Dm_CG17947 FRREKLTFDSEVAKWDDTGNDIIFLAKHMCMIMMEMTDFTRGRGPLKTTM Human_CTNNA2 FHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTS Md8i18_5 SANEMDAETEKWNGASEENNDIVKRAKSMSTMALSMYQFTKGEGTLRTTQ Ag_ENSANGP00000022276 VTNEMDAETDKWNGASEENNDIVKRAKNMSAMAFSMYQFTKGEGTLRTTQ Dm_CG2987_RA NG-DLNTYQSKWSEDLSDDNDILKRAKNMSAMAFLMYQFTKGNGSLRTTQ Dm_CG2987_RB NG-DLNTYQSKWSEDLSDDNDILKRAKNMSAMAFLMYQFTKGNGSLRTTQ Human_CTNNAL1 LGLLTSDADCEIEKWEDQENEIVQYGRNMSSMAYSLYLFTRGEGPLKTSQ Ag_white LTDPHLLLCDEPTSGLDSFMAHSVLQVLKGMAMKGKTIILTIHQPSSELY : . : . . Ag_ENSANGP00000000768 DVINAAKKISEAGTKLDKLTREIADQCPESSTKKDLLAYLQRIALYCHQI Dm_CG17947 DVINAAKKISEAGTKLDKLTREIAEQCPESSTKKDLLAYLQRIALYCHQI Human_CTNNA2 DVINAAKKIAEAGSRMDKLARAVADQCPDSACKQDLLAYLQRIALYCHQL Md8i18_5 DLFTQAEYFAEEANCLYKLVRMFSYQVPAGDPKKGLLDQLDVVPTYVQAL Ag_ENSANGP00000022276 DLFTQAEYFAEEANRLYKVVRQFSYQVPAGPPKKELLEHLDKVPTYVQTL Dm_CG2987_RA DLFTQAEYFAEEANRLYKVLRHFSYQVPASDNKKDLLNILDRVPTFVQAL Dm_CG2987_RB DLFTQAEYFAEEANRLYKVLRHFSYQVPASDNKKDLLNILDRVPTFVQAL Human_CTNNAL1 DLIHQLEVFAAEGLKLTSSVQAFSKQLKDDD-KLMLLLEINKLIPLCHQL Ag_white CLFDKILLVAEGRVAFLGSPYQSAEFFSQ--------------------- :: .: : : Ag_ENSANGP00000000768 QITSKV---KADVQNISGELIVSG-------------------------- Dm_CG17947 QITSKV---KADVQNISGELIVSG-------------------------- Human_CTNNA2 NICSKV---KAEVQNLGGELIVSGTGVQSTFTTFYEVDCDVIDGGRASQL Md8i18_5 QFTVKD---PTVGKAAT--------------------------------- Ag_ENSANGP00000022276 QFTVKD---PTVGKAAT--------------------------------- Dm_CG2987_RA QFTVKD---HTVGKAAT--------------------------------- Dm_CG2987_RB QFTVKD---HTVGKAAT--------------------------------- Human_CTNNAL1 QTVTKTSLQNKVFL------------------------------------ Ag_white -------------------------------------------------- Ag_ENSANGP00000000768 ----------------------LDSATSLIQAAKNLMNAVVYTVKYSYVA Dm_CG17947 ----------------------LDSATSLIQAAKNLMNAVVLTVKYSYVA Human_CTNNA2 STHLPTCAEGAPIGSGSSDSSMLDSATSLIQAAKNLMNAVVLTVKASYVA Md8i18_5 ----------------------FNKVDHVVRETKNLMTAINKVVTTCFDC Ag_ENSANGP00000022276 ----------------------FVKVDHVIQETKNLMNVISKVVSTCFVC Dm_CG2987_RA ----------------------FVKVDHVIRETKNLMNVINKVVSKCFEC Dm_CG2987_RB ----------------------FVKVDHVIRETKNLMNVINKVVSKCFEC Human_CTNNAL1 ------------------------KVDKCITKTRSMMALLVQLLSLCYKL Ag_white -------------------------------------------------- Ag_ENSANGP00000000768 STKYTRQG---TVSSPIVVWKMKAPEKKPLVRPEKPEEVRAKVRRASQKK Dm_CG17947 STKYTRQG---TVSSPIVVWKMKAPEKKPLVRPEKPEEVRAKVRKGSQKK Human_CTNNA2 STKYQKVYGTAAVNSPVVSWKMKAPEKKPLVKREKPEEFQTRVRRGSQKK Md8i18_5 ANKYKLDFSG-----------LSGRATSGGLRDDEGGSGAAGDSKGSSTS Ag_ENSANGP00000022276 A------------------------------------------------- Dm_CG2987_RA ATKYKLNLTG-----------ITGGLTS--ERSNENMAGGMCDSKGTTSS Dm_CG2987_RB ATKYKLNLTG-----------ITGGLTS--ERSNENMAGGMCDSKGTTSS Human_CTNNAL1 LKKLQMENNG-------------------------WVSVTNKDTMDSKT- Ag_white -------------------------------------------------- Ag_ENSANGP00000000768 TQNPVHALSEFQSPTDAV Dm_CG17947 VQNPIHALSEFQSPADAV Human_CTNNA2 HISPVQALSEFKAMDSF- Md8i18_5 TEASM------------- Ag_ENSANGP00000022276 ------------------ Dm_CG2987_RA SDIP-------------- Dm_CG2987_RB SDIP-------------- Human_CTNNAL1 ------------------ Ag_white ------------------