Supporting information for Lee et al. (2002) Proc. Natl. Acad. Sci. USA, 10.1073/pnas.232308999
Table 3. List of selected genes altered in the expression level by CR
Identifier | FC (CR) | Gene | P value | pp |
Apoptosis | ||||
U88909 | 2.9 | Baculoviral IAP repeat-containing 3 (Birc3) | 0.0069 | 0.93 |
M83649 | 2.8 | Tumor necrosis factor receptor superfamily, member 6 (Tnfrsf6) (Fas) | 0.0110 | 0.92 |
X67914 | 2.8 | Programmed cell death 1 (Pdcd1) | 0.0326 | 0.89 |
AF067395 | 1.8 | Bcl2/adenovirus E1B 19 kDa-interacting protein 3-like (Bnip3l) (Nix) | 0.0218 | 0.90 |
L35049 | 1.6 | Bcl2-like (Bcl2l) | 0.0005 | 0.97 |
AB009376 | -4.3 | DNA fragmentation factor, alpha subunit (Dffa) | 0.0090 | 0.93 |
L37296 | -3.4 | Bcl-associated death promoter (Bad) | 0.0326 | 0.89 |
Y13089 | -2.1 | Caspase 11 | 0.0469 | 0.87 |
L22472 | -1.8 | Bcl2-associated X protein (Bax) | 0.0186 | 0.91 |
AI837308 | -1.8 | Fas-activated serine/threonine kinase (Fastk) | 0.0003 | 0.98 |
AB019601 | -1.5 | Caspase 9 (Casp9) | 0.0292 | 0.89 |
D86344 | -1.5 | Programmed cell death 4 (Pdcd4) | 0.0152 | 0.91 |
AI852470 | -1.5 | Expressed in non-metastatic cells 3 (Nme3) | 0.0037 | 0.95 |
| DNA repair | ||||
U27398 | 2.6 | Xeroderma pigmentosum, complementation group C (Xpc) | 0.0354 | 0.88 |
X70956 | 1.8 | Topoisomerase (DNA) I (Top1) | 0.0238 | 0.90 |
U66887 | 1.6 | Rad50 homolog (S. cerevisiae) (Rad50) | 0.0061 | 0.94 |
D37790 | 1.5 | RAD21 homolog (S.pombe) (Rad21) | 0.0074 | 0.93 |
X67083 | -3.6 | DNA-damage inducible transcript 3 (Ddit3) (CHOP-10) | 0.0085 | 0.93 |
U00937 | -3.0 | Growth arrest and DNA-damage-inducible 45 alpha (Gadd45a) | 0.0175 | 0.91 |
AW060552 | -1.8 | Homologous to rat DNA polymerase beta | 0.0423 | 0.88 |
AI850881 | -1.8 | General transcription factor IIH, polypeptide 4 (Gtf2h4) | 0.0011 | 0.97 |
| Immune response | ||||
X58609 | -11.1 | Histocompatibility 2, Q region locus 2 (H2-Q2) | 0.0214 | 0.90 |
M22531 | -9.8 | Complement component 1, q subcomponent, beta polypeptide (C1qb) | 0.0080 | 0.93 |
M58156 | -8.3 | MHC class I antigen H-2Kf | 0.0132 | 0.92 |
M18837 | -5.9 | MHC class I histocompatibility antigen H-2 Q4 alpha chain | 0.0401 | 0.88 |
X66295 | -5.9 | Complement component 1, q subcomponent, c polypeptide (C1qc) | 0.0278 | 0.89 |
AI117211 | -4.2 | H-2 class I histocompatibility antigen K2 | 0.0366 | 0.88 |
X52490 | -3.4 | H-2 class I histocompatibility antigen, D-B alpha chain | 0.0131 | 0.92 |
X58861 | -2.9 | Complement component 1, q subcomponent, alpha polypeptide (C1qa) | 0.0003 | 0.98 |
U21906 | -2.3 | Histocompatibility 2, blastocyst (H2-B1) | 0.0177 | 0.91 |
X12905 | -1.9 | Properdin | 0.0081 | 0.93 |
AJ001101 | 1.7 | Complement component 1, q subcomponent binding protein (C1qbp) | 0.0032 | 0.95 |
| Protein catabolism | ||||
AW050342 | -5.0 | Ubiquitin specific protease 23 (Usp23) | 0.0035 | 0.95 |
AJ242663 | -4.3 | Cathepsin Z (ctsz) | 0.0011 | 0.97 |
M25149 | -2.7 | 26S proteosome regulatory subunit S3 | 0.0006 | 0.97 |
AW120683 | -2.2 | Homologous to human ubiquitin conjugating enzyme | 0.0190 | 0.91 |
AB003304 | -2.1 | Proteasome (prosome, macropain) subunit, beta type 5 (Psmb5) | 0.0060 | 0.94 |
AJ131851 | -2.1 | Cathepsin F (Ctsf) | 0.0116 | 0.92 |
AI836676 | 1.5 | Proteasome (prosome, macropain) subunit, alpha type 7 (Psma7) | 0.0052 | 0.94 |
| Oxidative metabolism of xenobiotics | ||||
X78445 | 6.1 | Cytochrome P450, 1b1, benz[a]anthracene inducible (Cyp1b1) | 0.0038 | 0.95 |
L06047 | 4.4 | Glutathione S-transferase, alpha 4 (Gsta4) | 0.0032 | 0.95 |
AB017482 | 3.0 | Aldehyde oxidase 1 (Aox1) | 0.0006 | 0.97 |
X65021 | 3.0 | Glutathione S-transferase, alpha 2 (Yc2) (Gsta2) | 0.0010 | 0.97 |
M21856 | 2.6 | Cytochrome P450, 2b10, phenobarbitol inducible, type b (Cyp2b10) | 0.0032 | 0.95 |
D50834 | 1.7 | Cytochrome P450, subfamily IV B, polypeptide 1 (Cyp4b1) | 0.0044 | 0.94 |
D16215 | 1.7 | Flavin containing monooxygenase 1 (Fmo1) | 0.0003 | 0.98 |
AI647493 | -11.4 | Aldehyde dehydrogenase 2, mitochondrial (Aldh2) | 0.0048 | 0.94 |
This table lists the genes, of selected classes, that were significantly (P value < 0.05) altered in expression and displayed a fold change greater than 1.5 when comparing 30-month-old CR mice with 30-month-old control mice. The last two columns display P values computed by the bootstrap method and their posterior probabilities (pp).