Supplementary Table 4a Representative Significant GO terms and the associated genes in our candidate genes by GOTM.
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AspectaHierarchyObEcRdP-valueeGO TermLocus Link, Gene Symbol
P550.935.380.002084regulation of cell cycle1118645158166988518915¡¡¡¡¡¡¡¡¡¡¡¡
RASSF1MTCP1CCNL2CDK5R1BCL10
P720.08250.002714brain development2388851¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
ALKCDK5R1
P461.533.920.003472cell cycle102741118645158166988518915¡¡¡¡¡¡¡¡¡¡
STAG1RASSF1MTCP1CCNL2CDK5R1BCL10
P710.011000.011077phosphoenolpyruvate-dependent sugar phosphotransferase system23005¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
MAPKBP1(NoLink)
P610.011000.011077phosphoenolpyruvate-dependent sugar phosphotransferase system23005¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
MAPKBP1(NoLink)
P910.011000.011077detection of visible light5158¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
PDE6B
P810.011000.011077detection of visible light5158¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
PDE6B
P920.1811.110.013553positive regulation of I-kappaB kinase/NF-kappaB cascade545038915¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
ZDHHC13BCL10
P720.1811.110.013553positive regulation of I-kappaB kinase/NF-kappaB cascade545038915¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
ZDHHC13BCL10
P620.1811.110.013553positive regulation of I-kappaB kinase/NF-kappaB cascade545038915¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
ZDHHC13BCL10
P820.1811.110.014536regulation of I-kappaB kinase/NF-kappaB cascade545038915¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
ZDHHC13BCL10
P620.1811.110.014536regulation of I-kappaB kinase/NF-kappaB cascade545038915¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
ZDHHC13BCL10
P520.1811.110.014536regulation of I-kappaB kinase/NF-kappaB cascade545038915¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
ZDHHC13BCL10
P910.02500.015474negative regulation of translation3658¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
IREB2
P810.02500.015474negative regulation of translation3658¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
IREB2
P1010.02500.015474negative regulation of translation3658¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
IREB2
P910.02500.015474L-glutamate transport10550¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
ARL6IP5
P810.02500.015474L-glutamate transport10550¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
ARL6IP5
P1010.02500.015474L-glutamate transport10550¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
ARL6IP5
P910.02500.015474acidic amino acid transport10550¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
ARL6IP5
P810.02500.015474acidic amino acid transport10550¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
ARL6IP5
P710.02500.015474acidic amino acid transport10550¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
ARL6IP5
P620.2100.017302negative regulation of cell cycle111868915¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
RASSF1BCL10
P620.2100.017662positive regulation of signal transduction545038915¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
ZDHHC13BCL10
P520.2100.017662positive regulation of signal transduction545038915¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
ZDHHC13BCL10
P810.02500.017666purine ribonucleoside metabolism1716¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
DGUOK
P710.02500.017666purine nucleoside metabolism1716¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
DGUOK
P710.02500.022035ribonucleoside metabolism1716¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
DGUOK
P510.02500.022035regulation of neuron differentiation8851¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
CDK5R1
P910.02500.022035phospholipid catabolism9588¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
PRDX6
P810.02500.022035phospholipid catabolism9588¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
PRDX6
P720.248.330.024682I-kappaB kinase/NF-kappaB cascade545038915¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
ZDHHC13BCL10
P620.248.330.024682central nervous system development2388851¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
ALKCDK5R1
P910.0333.330.028554L-amino acid transport10550¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
ARL6IP5
P810.0333.330.028554L-amino acid transport10550¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
ARL6IP5
P710.0333.330.028554L-amino acid transport10550¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
ARL6IP5
P820.287.140.032656induction of programmed cell death87428915¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
TNFSF12BCL10
P720.287.140.032656induction of programmed cell death87428915¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
TNFSF12BCL10
P920.287.140.032656induction of apoptosis87428915¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
TNFSF12BCL10
P820.287.140.032656induction of apoptosis87428915¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
TNFSF12BCL10
P810.0333.330.032875membrane lipid catabolism9588¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
PRDX6
P710.0333.330.032875membrane lipid catabolism9588¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
PRDX6
P410.0333.330.032875circadian rhythm1960¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
EGR3
P820.36.670.035995positive regulation of apoptosis87428915¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
TNFSF12BCL10
P720.36.670.035995positive regulation of apoptosis87428915¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
TNFSF12BCL10
P720.36.670.036483positive regulation of programmed cell death87428915¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
TNFSF12BCL10
P620.36.670.036483positive regulation of programmed cell death87428915¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
TNFSF12BCL10
P410.04250.03718neuron differentiation8851¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
CDK5R1
P910.04250.043601phototransduction5158¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
PDE6B
P810.04250.043601phototransduction5158¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
PDE6B
P810.05200.045732detection of light5158¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
PDE6B
P710.05200.045732detection of light5158¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
PDE6B
P520.345.880.046227cytokinesis1027481669¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
STAG1CCNL2
P420.345.880.046227cell division1027481669¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
STAG1CCNL2
P3116.661.650.049091regulation of cellular process11186181019603658451554503629481669874288518915
RASSF1DR1EGR3IREB2MTCP1ZDHHC13SAFBCCNL2TNFSF12CDK5R1BCL10
P710.05200.049982acute-phase response325¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
APCS
P610.05200.049982acute-phase response325¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
APCS
P510.05200.049982acute-phase response325¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
APCS
F910NA0.002566deoxyguanosine kinase activity1716¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
DGUOK
F710NA0.002566alpha-N-acetylglucosaminidase activity4669¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
NAGLU
F810.011000.010214deoxynucleoside kinase activity1716¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
DGUOK
F910.02500.015283cGMP-specific phosphodiesterase activity5158¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
PDE6B
F510.02500.017809protein kinase activator activity8851¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
CDK5R1
F510.02500.020328oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor55753¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
OGDHL
F410.02500.020328kinase activator activity8851¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
CDK5R1
F810.0333.330.027846receptor signaling protein tyrosine kinase activity238¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
ALK
F410.0333.330.027846receptor signaling protein tyrosine kinase activity238¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
ALK
F710.0333.330.03034nucleoside kinase activity1716¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
DGUOK
F610.0333.330.03034hexosaminidase activity4669¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
NAGLU
F510.05200.045173non-G-protein coupled 7TM receptor activity7855¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
FZD5
F510.05200.047623double-stranded DNA binding6294¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
SAFB
C720.36.670.035278lytic vacuole46699588¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
NAGLUPRDX6
C620.36.670.035278lytic vacuole46699588¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
NAGLUPRDX6
C820.36.670.035278lysosome46699588¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
NAGLUPRDX6
C720.36.670.035278lysosome46699588¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
NAGLUPRDX6
C620.316.450.038398vacuole46699588¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
NAGLUPRDX6
C520.316.450.038398vacuole46699588¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡¡
NAGLUPRDX6
a) P, F, C indicate "Biological Process", "Molecular Function" and "Cellular Component"¡¡
b) The number of genes assigned to the GO term. ¡¡
c) The expected value of the number of genes assingned to the GO term.¡¡
d) Ratio of number of b) and c).¡¡
e) Significant probability of hyper-geometric tests..
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