Supporting Figures

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Supporting Figure 8
Supporting Figure 9

Fig. 8. The intracellular calcium chelator BAPTA/AM inhibited the activity-dependent release of endogenous plasminogen (A), neuroserpin (C), inactive matrix metalloproteinase (proMMP-9) (E) and tissue inhibitor metalloproteinase (TIMP-1) (G) after the second carbachol stimulation, whereas the release of these neuroactive proteins was not affected by the presence of the extracellular calcium chelator BAPTA (B, D, F and H, respectively). Every condition was repeated six times, and data were presented as the mean ± SEM.

Fig. 9. Activity-dependent release of Substance P. Substance P released by cerebral cortical tissue upon stimulation with KCl (50 mM) (A) and glutamate (60 mM) (D). The absence of the extracellular calcium (calcium-free superfusion medium) (B and E) or the presence of the extracellular calcium chelator, BAPTA (10 mM) (C and F) abolished the stimulus-coupled substance P release. Data represents the mean ± SEM.