Supporting information for Calderwood et al. (2003) Proc. Natl. Acad. Sci. USA, 10.1073/pnas.262791999
Table 3. A summary of PTB domain-binding to integrin b cytoplasmic tails
PTB domain | Binding by cytoplasmic tail | ||||
β1A | β2 | β3 | β5 | β7 | |
mShc | 0 | 0 | 3 | ND | 1 |
mNumb | 0 | 0 | 3 | 3 | 1 |
mDab1 | 3 | 1 | 3 | 1 | 1 |
mDab2 | 0 | 0 | 3 | 3 | 1 |
rX11α | 1 | 0 | 3 | ND | 2 |
rX11γ | 0 | 0 | 3 | ND | 1 |
CeLin10 | 0 | 0 | 3 | ND | 0 |
HJIP | 0 | 0 | 3 | ND | 1 |
HEPS8 | 2 | 0 | 3 | 3 | 0 |
HRGS12 | 0 | 0 | 3 | ND | 0 |
HCED6 | 0 | 0 | 3 | ND | 1 |
hEB-1 | 1 | 0 | 3 | ND | 1 |
HGAPCenA | 1 | 0 | 3 | ND | 1 |
Htensin2 | 1 | 0 | 3 | 3 | 2 |
rIRS-1 | 0 | 0 | 3 | ND | 0 |
Hdok-1 | 0 | 2 | 3 | 3 | 3 |
Mtalin | 2 | 3 | 3 | 3 | 3 |
The binding of GST fusion proteins of PTB domains to recombinant β integrin cytoplasmic tails was assessed as described in the legend to Fig. 2 in the main text. Results are summarized as follows: 0, no binding; 1, very weak binding; 2, weak binding; 3, strong binding; ND, not determined.