Supporting information for Zhang et al. (2003) Proc. Natl. Acad. Sci. USA, 10.1073/pnas.2627983100

 

Table 19. Chromosomal clustering analysis of genes whose expression was altered specifically during senescence (M1) in two individual HMEC lines (48R and 184)

No. of genes

Chr.

distances

No. of clusters

P

value

No. of clustered genes

P

value

Observed

Expected

Observed

Expected

Senescence

down-regulation

in 48R

349

1 kb

0

0.14

0.125

0

0.28

0.125

2 kb

1

0.38

0.065

2

0.76

0.065

5 kb

1

0.96

0.248

2

1.92

0.25

10 kb

3

1.57

0.062

6

3.15

0.062

20 kb

3

2.63

0.285

6

5.28

0.288

50 kb

4

5.18

0.586

8

10.4

0.595

100 kb

8

8.85

0.524

17

17.9

0.524

200 kb

17

15.2

0.257

35

31

0.271

500 kb

34

29.9

0.155

71

62.4

0.166

1 Mb

48

46.2

0.313

104

99.1

0.298

2 Mb

67

66.1

0.387

150

149.2

0.461

5 Mb

86

88.2

0.66

218

224.8

0.761

Senescence

down-regulation

in 184

218

1 kb

1

0.07

0.004

2

0.14

0.004

2 kb

2

0.14

<0.001

4

0.27

<0.001

5 kb

2

0.34

0.006

4

0.68

0.006

10 kb

2

0.63

0.025

4

1.26

0.026

20 kb

4

1.05

0.003

8

2.1

0.003

50 kb

5

1.98

0.012

10

3.99

0.012

100 kb

9

3.56

0.003

18

7.17

0.003

200 kb

10

6.18

0.047

20

12.5

0.054

500 kb

18

12.6

0.037

36

25.8

0.051

1 Mb

27

20.5

0.03

55

42.7

0.051

2 Mb

37

31.4

0.069

76

68

0.161

5 Mb

51

47.9

0.177

118

112

0.229

The occurrence of perturbed gene expression in two or more genes located within the distance shown defined a chromosomal cluster.