GO ID Dmel Bany Term Table 5 2 2 0 mitochondrial genome maintenance 0 3 854 79 reproduction 0 9 1 0 "alpha-1,6-mannosyltransferase activity" 0 10 2 0 trans-hexaprenyltranstransferase activity 0 12 2 0 single strand break repair 0 14 4 0 single-stranded DNA specific endodeoxyribonuclease activity 0 15 1 1 phosphopyruvate hydratase complex 0 22 2 0 mitotic spindle elongation 0 26 1 0 "alpha-1,2-mannosyltransferase activity" 0 30 10 0 mannosyltransferase activity 0 36 1 1 acyl carrier activity 0 38 5 0 very-long-chain fatty acid metabolism 0 41 11 2 transition metal ion transport 0 42 4 0 protein targeting to Golgi 0 45 1 1 autophagic vacuole formation 0 49 5 3 tRNA binding 0 50 1 0 urea cycle 0 51 5 1 urea cycle intermediate metabolism 0 53 1 0 argininosuccinate metabolism 0 54 1 0 ribosome export from nucleus 0 55 1 0 ribosomal large subunit export from nucleus 0 59 18 0 "protein import into nucleus, docking" 0 60 2 0 "protein import into nucleus, translocation" 0 62 8 1 acyl-CoA binding 0 64 1 0 L-ornithine transporter activity 0 66 1 0 mitochondrial ornithine transport 0 67 1 0 DNA replication and chromosome cycle 0 70 38 5 mitotic sister chromatid segregation 0 72 1 0 M phase specific microtubule process 0 73 1 0 spindle pole body separation 0 74 209 38 regulation of progression through cell cycle 0 75 19 4 cell cycle checkpoint 0 76 1 0 DNA replication checkpoint 0 77 5 1 DNA damage checkpoint 0 79 5 0 regulation of cyclin dependent protein kinase activity 0 80 1 1 G1 phase of mitotic cell cycle 0 82 12 3 G1/S transition of mitotic cell cycle 0 83 1 1 G1/S-specific transcription in mitotic cell cycle 0 84 3 2 S phase of mitotic cell cycle 0 85 1 0 G2 phase of mitotic cell cycle 0 86 8 1 G2/M transition of mitotic cell cycle 0 87 290 44 M phase of mitotic cell cycle 0 89 1 1 mitotic metaphase 0 90 10 2 mitotic anaphase 0 92 1 1 mitotic anaphase B 0 96 9 1 sulfur amino acid metabolism 0 97 4 1 sulfur amino acid biosynthesis 0 98 1 0 sulfur amino acid catabolism 0 99 1 0 sulfur amino acid transporter activity 0 101 1 0 sulfur amino acid transport 0 103 1 1 sulfate assimilation 0 104 5 0 succinate dehydrogenase activity 0 109 3 1 nucleotide-excision repair complex 0 118 7 2 histone deacetylase complex 0 119 32 7 mediator complex 0 122 55 7 negative regulation of transcription from RNA polymerase II promoter 0 123 13 8 histone acetyltransferase complex 0 124 7 3 SAGA complex 0 126 4 1 transcription factor TFIIIB complex 0 132 1 0 establishment of mitotic spindle orientation 0 137 1 0 Golgi cis cisterna 0 138 2 0 Golgi trans cisterna 0 139 20 1 Golgi membrane 0 145 12 1 exocyst 0 146 3 0 microfilament motor activity 0 149 6 0 SNARE binding 0 150 4 1 recombinase activity 0 151 126 11 ubiquitin ligase complex 0 152 16 1 nuclear ubiquitin ligase complex 0 153 1 0 cytoplasmic ubiquitin ligase complex 0 154 4 1 rRNA modification 0 155 4 0 two-component sensor molecule activity 0 158 3 1 protein phosphatase type 2A activity 0 159 8 1 protein phosphatase type 2A complex 0 160 20 4 two-component signal transduction system (phosphorelay) 0 163 9 0 protein phosphatase type 1 activity 0 164 5 0 protein phosphatase type 1 complex 0 165 116 14 MAPKKK cascade 0 166 916 147 nucleotide binding 0 175 14 3 3'-5'-exoribonuclease activity 0 176 13 3 nuclear exosome (RNase complex) 0 177 8 2 cytoplasmic exosome (RNase complex) 0 178 14 3 exosome (RNase complex) 0 179 3 1 "rRNA (adenine-N6,N6-)-dimethyltransferase activity" 0 184 8 1 "mRNA catabolism, nonsense-mediated decay" 0 185 1 1 activation of MAPKKK activity 0 186 2 0 activation of MAPKK activity 0 187 6 2 activation of MAPK activity 0 188 1 0 inactivation of MAPK activity 0 212 17 1 meiotic spindle organization and biogenesis 0 213 2 0 tRNA-intron endonuclease activity 0 214 2 0 tRNA-intron endonuclease complex 0 217 1 0 DNA secondary structure binding 0 220 18 3 hydrogen-transporting ATPase V0 domain 0 221 15 4 hydrogen-transporting ATPase V1 domain 0 224 1 0 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity 0 226 102 19 microtubule cytoskeleton organization and biogenesis 0 228 56 9 nuclear chromosome 0 235 1 1 astral microtubule 0 242 6 1 pericentriolar material 0 245 14 6 spliceosome assembly 0 254 2 0 C-4 methylsterol oxidase activity 0 255 1 0 allantoin metabolism 0 257 3 0 nitrilase activity 0 262 1 0 mitochondrial chromosome 0 267 96 10 cell fraction 0 268 3 0 peroxisome targeting sequence binding 0 270 12 0 peptidoglycan metabolism 0 271 10 0 polysaccharide biosynthesis 0 272 7 1 polysaccharide catabolism 0 273 3 0 lipoic acid metabolism 0 275 10 7 "proton-transporting ATP synthase complex, catalytic core F(1) (sensu Eukaryota)" 0 276 9 7 "proton-transporting ATP synthase complex, coupling factor F(o) (sensu Eukaryota)" 0 278 326 51 mitotic cell cycle 0 279 476 49 M phase 0 280 8 1 nuclear division 0 281 5 2 cytokinesis after mitosis 0 287 5 1 magnesium ion binding 0 288 2 0 "mRNA catabolism, deadenylylation-dependent decay" 0 289 1 0 poly(A) tail shortening 0 300 1 0 peripheral to membrane of membrane fraction 0 301 4 0 "retrograde transport, vesicle recycling within Golgi" 0 302 1 1 response to reactive oxygen species 0 307 5 3 cyclin-dependent protein kinase holoenzyme complex 0 313 77 28 organellar ribosome 0 314 30 10 organellar small ribosomal subunit 0 315 48 18 organellar large ribosomal subunit 0 318 1 0 protein-methionine-R-oxide reductase activity 0 323 30 3 lytic vacuole 0 338 2 1 protein deneddylation 0 339 11 1 RNA cap binding 0 375 191 39 "RNA splicing, via transesterification reactions" 0 377 191 39 "RNA splicing, via transesterification reactions with bulged adenosine as nucleophile" 0 380 52 15 "alternative nuclear mRNA splicing, via spliceosome" 0 381 51 15 "regulation of alternative nuclear mRNA splicing, via spliceosome" 0 390 1 1 spliceosome disassembly 0 391 1 1 U2-type spliceosome disassembly 0 394 5 0 "RNA splicing, via endonucleolytic cleavage and ligation" 0 398 191 39 "nuclear mRNA splicing, via spliceosome" 0 502 58 27 proteasome complex (sensu Eukaryota) 0 578 83 13 embryonic axis specification 0 700 1 0 mismatch base pair DNA N-glycosylase activity 0 702 3 1 oxidized base lesion DNA N-glycosylase activity 0 703 1 0 pyrimidine-specific oxidized base lesion DNA N-glycosylase activity 0 705 1 1 achiasmate meiosis I 0 707 1 0 meiotic DNA recombinase assembly 0 712 3 0 resolution of meiotic joint molecules as recombinants 0 715 1 0 "nucleotide-excision repair, DNA damage recognition" 0 722 1 0 telomerase-independent telomere maintenance 0 723 8 1 telomere maintenance 0 724 3 1 double-strand break repair via homologous recombination 0 725 3 1 recombinational repair 0 726 3 0 non-recombinational repair 0 730 1 0 DNA recombinase assembly 0 731 1 0 DNA synthesis during DNA repair 0 737 5 1 "DNA catabolism, endonucleolytic" 0 738 1 0 "DNA catabolism, exonucleolytic" 0 739 3 1 DNA strand annealing activity 0 741 10 2 karyogamy 0 774 1 0 adenyl-nucleotide exchange factor activity 0 775 27 6 "chromosome, pericentric region" 0 776 9 2 kinetochore 0 777 6 0 condensed chromosome kinetochore 0 778 1 0 condensed nuclear chromosome kinetochore 0 779 6 0 "condensed chromosome, pericentric region" 0 780 1 0 "condensed nuclear chromosome, pericentric region" 0 781 4 1 "chromosome, telomeric region" 0 784 2 0 "nuclear chromosome, telomeric region" 0 785 89 23 chromatin 0 786 20 9 nucleosome 0 790 23 3 nuclear chromatin 0 791 3 1 euchromatin 0 792 15 2 heterochromatin 0 793 16 1 condensed chromosome 0 794 4 0 condensed nuclear chromosome 0 795 3 0 synaptonemal complex 0 796 6 1 condensin complex 0 803 7 1 sex chromosome 0 805 6 0 X chromosome 0 806 1 1 Y chromosome 0 808 7 0 origin recognition complex 0 819 38 5 sister chromatid segregation 0 900 4 0 "translation repressor activity, nucleic acid binding" 0 902 439 61 cellular morphogenesis 0 904 249 39 cellular morphogenesis during differentiation 0 910 96 17 cytokinesis 0 912 12 2 "cytokinesis, formation of actomyosin apparatus" 0 915 12 2 "cytokinesis, contractile ring formation" 0 916 8 0 "cytokinesis, contractile ring contraction" 0 920 1 0 cell separation during cytokinesis 0 922 7 2 spindle pole 0 930 8 0 gamma-tubulin complex 0 939 1 0 inner kinetochore of condensed chromosome 0 940 5 0 outer kinetochore of condensed chromosome 0 941 1 0 inner kinetochore of condensed nuclear chromosome 0 1501 28 1 skeletal development 0 1505 143 10 regulation of neurotransmitter levels 0 1507 1 0 acetylcholine catabolism in synaptic cleft 0 1509 1 0 legumain activity 0 1510 1 0 RNA methylation 0 1518 3 0 voltage-gated sodium channel complex 0 1519 1 0 peptide amidation 0 1522 1 1 pseudouridine synthesis 0 1525 1 0 angiogenesis 0 1527 1 0 microfibril 0 1530 1 1 lipopolysaccharide binding 0 1539 9 0 ciliary or flagellar motility 0 1540 1 0 beta-amyloid binding 0 1555 2 0 oocyte growth 0 1556 3 0 oocyte maturation 0 1558 22 3 regulation of cell growth 0 1565 6 0 phorbol ester receptor activity 0 1568 1 0 blood vessel development 0 1584 226 2 rhodopsin-like receptor activity 0 1586 2 0 5-HT1 receptor activity 0 1587 1 0 5-HT2 receptor activity 0 1588 2 0 dopamine D1 receptor-like receptor activity 0 1590 1 0 dopamine D1 receptor activity 0 1591 1 0 dopamine D2 receptor-like receptor activity 0 1603 1 0 vasopressin-like receptor activity 0 1607 1 0 neuromedin U receptor activity 0 1608 1 0 "nucleotide receptor activity, G-protein coupled" 0 1609 1 0 "adenosine receptor activity, G-protein coupled" 0 1614 1 0 purinergic nucleotide receptor activity 0 1633 8 0 secretin-like receptor activity 0 1651 1 0 dense fibrillar component 0 1653 48 0 peptide receptor activity 0 1654 361 26 eye development 0 1659 3 2 thermoregulation 0 1664 3 0 G-protein-coupled receptor binding 0 1666 7 1 response to hypoxia 0 1669 1 0 acrosome 0 1672 4 2 regulation of chromatin assembly or disassembly 0 1673 1 0 male germ cell nucleus 0 1674 1 0 female germ cell nucleus 0 1676 1 0 long-chain fatty acid metabolism 0 1677 2 2 formation of translation initiation ternary complex 0 1678 2 0 cell glucose homeostasis 0 1692 2 0 histamine metabolism 0 1700 202 19 embryonic development (sensu Insecta) 0 1703 33 2 gastrulation (sensu Protostomia) 0 1704 33 2 formation of primary germ layer 0 1706 5 1 endoderm formation 0 1707 31 2 mesoderm formation 0 1708 58 2 cell fate specification 0 1709 125 12 cell fate determination 0 1710 17 1 mesodermal cell fate commitment 0 1711 1 1 endodermal cell fate commitment 0 1712 3 0 ectodermal cell fate commitment 0 1715 3 0 ectodermal cell fate specification 0 1726 1 0 ruffle 0 1727 12 1 lipid kinase activity 0 1736 52 10 establishment of planar polarity 0 1737 14 4 establishment of wing hair orientation 0 1738 61 12 morphogenesis of a polarized epithelium 0 1742 8 0 oenocyte differentiation 0 1743 2 0 optic placode formation 0 1744 2 0 optic placode formation (sensu Endopterygota) 0 1745 290 21 compound eye morphogenesis (sensu Endopterygota) 0 1746 16 0 Bolwig's organ morphogenesis 0 1748 3 0 optic placode development (sensu Endopterygota) 0 1751 85 12 eye photoreceptor cell differentiation (sensu Endopterygota) 0 1752 38 7 eye photoreceptor fate commitment (sensu Endopterygota) 0 1754 96 12 eye photoreceptor cell differentiation 0 1763 40 6 morphogenesis of a branching structure 0 1764 2 0 neuron migration 0 1775 24 1 cell activation 0 1846 1 0 opsonin binding 0 1847 1 0 opsonin receptor activity 0 1864 1 0 pentraxin binding 0 1871 79 16 pattern binding 0 1888 1 0 glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity 0 1932 2 0 regulation of protein amino acid phosphorylation 0 1934 1 0 positive regulation of protein amino acid phosphorylation 0 1944 1 0 vasculature development 0 2009 173 23 morphogenesis of an epithelium 0 2164 54 6 larval development 0 2165 575 57 larval or pupal development (sensu Insecta) 1 2168 33 5 larval development (sensu Insecta) 0 3674 8303 1077 molecular_function 1 3676 1870 357 nucleic acid binding 0 3677 896 106 DNA binding 0 3678 53 11 DNA helicase activity 0 3680 3 1 AT DNA binding 0 3682 96 13 chromatin binding 0 3684 29 4 damaged DNA binding 0 3688 14 0 DNA replication origin binding 0 3689 2 1 DNA clamp loader activity 0 3690 6 1 double-stranded DNA binding 0 3696 3 0 satellite DNA binding 0 3697 31 3 single-stranded DNA binding 0 3700 414 28 transcription factor activity 1 3701 2 0 RNA polymerase I transcription factor activity 0 3702 296 36 RNA polymerase II transcription factor activity 0 3704 88 9 specific RNA polymerase II transcription factor activity 0 3705 2 0 "RNA polymerase II transcription factor activity, enhancer binding" 0 3707 20 0 steroid hormone receptor activity 0 3709 6 1 RNA polymerase III transcription factor activity 0 3711 14 3 transcriptional elongation regulator activity 0 3712 80 15 transcription cofactor activity 0 3713 24 4 transcription coactivator activity 0 3714 20 2 transcription corepressor activity 0 3715 4 1 transcription termination factor activity 0 3717 2 0 RNA polymerase II transcription termination factor activity 0 3718 1 1 RNA polymerase III transcription termination factor activity 0 3723 417 106 RNA binding 0 3724 61 15 RNA helicase activity 0 3725 20 1 double-stranded RNA binding 0 3726 1 0 double-stranded RNA adenosine deaminase activity 0 3727 24 7 single-stranded RNA binding 0 3729 345 91 mRNA binding 0 3730 15 2 mRNA 3'-UTR binding 0 3735 192 110 structural constituent of ribosome 1 3743 57 19 translation initiation factor activity 0 3746 21 5 translation elongation factor activity 0 3747 9 4 translation release factor activity 0 3755 22 13 peptidyl-prolyl cis-trans isomerase activity 0 3756 11 1 protein disulfide isomerase activity 0 3774 94 15 motor activity 1 3777 54 7 microtubule motor activity 0 3779 132 24 actin binding 0 3785 1 1 actin monomer binding 0 3796 14 0 lysozyme activity 0 3810 2 0 protein-glutamine gamma-glutamyltransferase activity 0 3823 1 0 antigen binding 0 3824 4103 568 catalytic activity 1 3825 1 0 "alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity" 0 3827 1 0 "alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity" 0 3832 2 0 beta-alanyl-dopamine hydrolase activity 0 3833 1 0 beta-alanyl-dopamine synthase activity 0 3834 1 0 "beta-carotene 15,15'-monooxygenase activity" 0 3835 1 0 "beta-galactoside alpha-2,6-sialyltransferase activity" 0 3837 1 0 beta-ureidopropionase activity 0 3840 4 0 gamma-glutamyltransferase activity 0 3841 7 0 1-acylglycerol-3-phosphate O-acyltransferase activity 0 3842 3 0 1-pyrroline-5-carboxylate dehydrogenase activity 0 3843 1 0 "1,3-beta-glucan synthase activity" 0 3844 1 0 "1,4-alpha-glucan branching enzyme activity" 0 3847 1 0 1-alkyl-2-acetylglycerophosphocholine esterase activity 0 3848 1 0 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity 0 3851 5 0 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity 0 3854 1 0 3-beta-hydroxy-delta5-steroid dehydrogenase activity 0 3857 1 0 3-hydroxyacyl-CoA dehydrogenase activity 0 3858 2 0 3-hydroxybutyrate dehydrogenase activity 0 3860 1 0 3-hydroxyisobutyryl-CoA hydrolase activity 0 3863 2 0 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity 0 3865 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase activity 0 3867 1 1 4-aminobutyrate transaminase activity 0 3868 1 0 4-hydroxyphenylpyruvate dioxygenase activity 0 3869 9 0 4-nitrophenylphosphatase activity 0 3870 1 0 5-aminolevulinate synthase activity 0 3872 1 0 6-phosphofructokinase activity 0 3873 1 1 6-phosphofructo-2-kinase activity 0 3874 1 0 6-pyruvoyltetrahydropterin synthase activity 0 3876 1 0 AMP deaminase activity 0 3878 1 0 ATP citrate synthase activity 0 3881 1 0 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity 0 3882 1 0 CDP-diacylglycerol-serine O-phosphatidyltransferase activity 0 3883 1 1 CTP synthase activity 0 3884 2 0 D-amino-acid oxidase activity 0 3886 2 1 DNA (cytosine-5-)-methyltransferase activity 0 3887 29 4 DNA-directed DNA polymerase activity 0 3889 5 0 alpha DNA polymerase activity 0 3891 2 1 delta DNA polymerase activity 0 3893 3 1 epsilon DNA polymerase activity 0 3894 1 0 zeta DNA polymerase activity 0 3895 2 0 gamma DNA-directed DNA polymerase activity 0 3896 2 1 DNA primase activity 0 3899 33 10 DNA-directed RNA polymerase activity 0 3904 2 0 deoxyribodipyrimidine photo-lyase activity 0 3906 7 2 DNA-(apurinic or apyrimidinic site) lyase activity 0 3908 1 0 methylated-DNA-[protein]-cysteine S-methyltransferase activity 0 3909 9 2 DNA ligase activity 0 3910 8 2 DNA ligase (ATP) activity 0 3913 4 0 DNA photolyase activity 0 3914 1 0 DNA (6-4) photolyase activity 0 3916 11 3 DNA topoisomerase activity 0 3917 4 2 DNA topoisomerase type I activity 0 3918 4 1 DNA topoisomerase (ATP-hydrolyzing) activity 0 3919 2 0 FMN adenylyltransferase activity 0 3921 1 0 GMP synthase activity 0 3922 1 0 GMP synthase (glutamine-hydrolyzing) activity 0 3923 1 0 GPI-anchor transamidase activity 0 3924 142 26 GTPase activity 0 3933 1 0 GTP cyclohydrolase activity 0 3934 1 0 GTP cyclohydrolase I activity 0 3937 1 0 IMP cyclohydrolase activity 0 3938 1 1 IMP dehydrogenase activity 0 3939 4 0 L-iditol 2-dehydrogenase activity 0 3940 1 0 L-iduronidase activity 0 3943 4 0 N-acetylgalactosamine-4-sulfatase activity 0 3948 3 1 N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity 0 3950 1 1 NAD+ ADP-ribosyltransferase activity 0 3952 1 0 NAD+ synthase (glutamine-hydrolyzing) activity 0 3954 44 23 NADH dehydrogenase activity 0 3956 2 0 NAD(P)+-protein-arginine ADP-ribosyltransferase activity 0 3958 1 1 NADPH-hemoprotein reductase activity 0 3959 1 0 NADPH dehydrogenase activity 0 3963 2 0 RNA-3'-phosphate cyclase activity 0 3964 1 0 RNA-directed DNA polymerase activity 0 3969 2 0 RNA editase activity 0 3973 2 0 (S)-2-hydroxy-acid oxidase activity 0 3975 1 0 UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity 0 3977 1 0 UDP-N-acetylglucosamine diphosphorylase activity 0 3978 3 0 UDP-glucose 4-epimerase activity 0 3979 2 0 UDP-glucose 6-dehydrogenase activity 0 3980 1 0 UDP-glucose:glycoprotein glucosyltransferase activity 0 3983 1 0 UTP:glucose-1-phosphate uridylyltransferase activity 0 3985 2 1 acetyl-CoA C-acetyltransferase activity 0 3987 3 0 acetate-CoA ligase activity 0 3988 4 1 acetyl-CoA C-acyltransferase activity 0 3989 2 0 acetyl-CoA carboxylase activity 0 3990 1 0 acetylcholinesterase activity 0 3993 11 1 acid phosphatase activity 0 3994 4 1 aconitate hydratase activity 0 3995 10 0 acyl-CoA dehydrogenase activity 0 3997 6 0 acyl-CoA oxidase activity 0 3998 6 0 acylphosphatase activity 0 3999 1 0 adenine phosphoribosyltransferase activity 0 4000 8 0 adenosine deaminase activity 0 4001 3 0 adenosine kinase activity 0 4003 22 6 ATP-dependent DNA helicase activity 0 4004 40 12 ATP-dependent RNA helicase activity 0 4008 1 0 copper-exporting ATPase activity 0 4012 1 0 phospholipid-translocating ATPase activity 0 4013 3 1 adenosylhomocysteinase activity 0 4014 1 0 adenosylmethionine decarboxylase activity 0 4016 16 0 adenylate cyclase activity 0 4017 7 0 adenylate kinase activity 0 4018 1 1 adenylosuccinate lyase activity 0 4019 1 0 adenylosuccinate synthase activity 0 4020 1 1 adenylylsulfate kinase activity 0 4021 2 0 alanine transaminase activity 0 4022 16 3 alcohol dehydrogenase activity 0 4024 10 3 "alcohol dehydrogenase activity, zinc-dependent" 0 4028 4 2 aldehyde dehydrogenase activity 0 4029 3 1 aldehyde dehydrogenase (NAD) activity 0 4031 1 0 aldehyde oxidase activity 0 4032 7 4 aldehyde reductase activity 0 4033 9 5 aldo-keto reductase activity 0 4034 6 0 aldose 1-epimerase activity 0 4035 17 0 alkaline phosphatase activity 0 4038 1 0 allantoinase activity 0 4040 6 0 amidase activity 0 4044 2 0 amidophosphoribosyltransferase activity 0 4045 1 0 aminoacyl-tRNA hydrolase activity 0 4046 7 0 aminoacylase activity 0 4047 4 0 aminomethyltransferase activity 0 4049 3 1 anthranilate synthase activity 0 4053 2 0 arginase activity 0 4054 4 1 arginine kinase activity 0 4055 1 0 argininosuccinate synthase activity 0 4056 1 0 argininosuccinate lyase activity 0 4057 1 1 arginyltransferase activity 0 4058 5 0 aromatic-L-amino-acid decarboxylase activity 0 4059 2 0 aralkylamine N-acetyltransferase activity 0 4060 2 0 arylamine N-acetyltransferase activity 0 4061 2 0 arylformamidase activity 0 4062 1 0 aryl sulfotransferase activity 0 4063 1 0 aryldialkylphosphatase activity 0 4065 1 0 arylsulfatase activity 0 4066 2 0 asparagine synthase (glutamine-hydrolyzing) activity 0 4067 8 1 asparaginase activity 0 4068 2 0 aspartate 1-decarboxylase activity 0 4069 2 0 aspartate transaminase activity 0 4070 2 1 aspartate carbamoyltransferase activity 0 4071 1 0 aspartate-ammonia ligase activity 0 4074 1 0 biliverdin reductase activity 0 4075 2 0 biotin carboxylase activity 0 4077 1 0 biotin-[acetyl-CoA-carboxylase] ligase activity 0 4080 1 0 biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity 0 4081 2 1 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity 0 4084 1 0 branched-chain-amino-acid transaminase activity 0 4085 1 0 butyryl-CoA dehydrogenase activity 0 4086 2 1 carbamoyl-phosphate synthase activity 0 4087 2 1 carbamoyl-phosphate synthase (ammonia) activity 0 4089 19 1 carbonate dehydratase activity 0 4090 3 2 carbonyl reductase (NADPH) activity 0 4091 49 0 carboxylesterase activity 0 4092 3 0 carnitine O-acetyltransferase activity 0 4095 2 0 carnitine O-palmitoyltransferase activity 0 4096 2 1 catalase activity 0 4100 2 0 chitin synthase activity 0 4102 1 0 choline O-acetyltransferase activity 0 4103 2 1 choline kinase activity 0 4104 3 0 cholinesterase activity 0 4105 2 0 choline-phosphate cytidylyltransferase activity 0 4108 3 0 citrate (Si)-synthase activity 0 4109 1 0 coproporphyrinogen oxidase activity 0 4112 8 0 cyclic-nucleotide phosphodiesterase activity 0 4114 8 0 "3',5'-cyclic-nucleotide phosphodiesterase activity" 0 4115 4 0 cAMP-specific phosphodiesterase activity 0 4116 5 0 cGMP-specific phosphodiesterase activity 0 4117 1 0 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity 0 4122 1 0 cystathionine beta-synthase activity 0 4123 2 0 cystathionine gamma-lyase activity 0 4126 3 0 cytidine deaminase activity 0 4127 1 0 cytidylate kinase activity 0 4128 1 0 cytochrome-b5 reductase activity 0 4129 19 8 cytochrome-c oxidase activity 0 4131 1 1 cytosine deaminase activity 0 4132 1 0 dCMP deaminase activity 0 4133 1 0 glycogen debranching enzyme activity 0 4134 1 0 4-alpha-glucanotransferase activity 0 4135 1 0 "amylo-alpha-1,6-glucosidase activity" 0 4139 2 0 deoxyribose-phosphate aldolase activity 0 4142 1 0 diacylglycerol cholinephosphotransferase activity 0 4143 8 0 diacylglycerol kinase activity 0 4144 1 0 diacylglycerol O-acyltransferase activity 0 4146 1 0 dihydrofolate reductase activity 0 4147 2 0 dihydrolipoamide branched chain acyltransferase activity 0 4148 5 0 dihydrolipoyl dehydrogenase activity 0 4149 1 0 dihydrolipoyllysine-residue succinyltransferase activity 0 4151 2 1 dihydroorotase activity 0 4152 2 0 dihydroorotate dehydrogenase activity 0 4153 1 0 dihydropterin deaminase activity 0 4154 2 0 dihydropterin oxidase activity 0 4155 1 0 "6,7-dihydropteridine reductase activity" 0 4157 1 0 dihydropyrimidinase activity 0 4158 2 0 dihydroorotate oxidase activity 0 4159 1 0 dihydrouracil dehydrogenase (NAD+) activity 0 4161 2 2 dimethylallyltranstransferase activity 0 4162 1 0 dimethylnitrosamine demethylase activity 0 4163 1 0 diphosphomevalonate decarboxylase activity 0 4164 1 0 diphthine synthase activity 0 4165 5 0 dodecenoyl-CoA delta-isomerase activity 0 4167 3 0 dopachrome isomerase activity 0 4168 1 0 dolichol kinase activity 0 4169 2 0 dolichyl-phosphate-mannose-protein mannosyltransferase activity 0 4170 1 1 dUTP diphosphatase activity 0 4174 1 0 electron-transferring-flavoprotein dehydrogenase activity 0 4175 504 57 endopeptidase activity 0 4176 6 0 ATP-dependent peptidase activity 0 4177 49 4 aminopeptidase activity 0 4178 16 0 leucyl aminopeptidase activity 0 4179 23 2 membrane alanyl aminopeptidase activity 0 4180 46 6 carboxypeptidase activity 0 4181 32 4 metallocarboxypeptidase activity 0 4182 32 4 carboxypeptidase A activity 0 4183 1 0 carboxypeptidase E activity 0 4184 1 0 lysine carboxypeptidase activity 0 4185 15 2 serine carboxypeptidase activity 0 4187 1 0 carboxypeptidase D activity 0 4188 3 1 serine-type Pro-X carboxypeptidase activity 0 4190 19 0 aspartic-type endopeptidase activity 0 4192 6 0 cathepsin D activity 0 4193 2 0 cathepsin E activity 0 4194 13 0 pepsin A activity 0 4197 91 12 cysteine-type endopeptidase activity 0 4198 7 2 calpain activity 0 4213 2 0 cathepsin B activity 0 4216 2 0 cathepsin K activity 0 4217 7 0 cathepsin L activity 0 4219 1 0 pyroglutamyl-peptidase I activity 0 4221 28 7 ubiquitin thiolesterase activity 0 4222 77 3 metalloendopeptidase activity 0 4228 1 0 gelatinase A activity 0 4230 4 0 glutamyl aminopeptidase activity 0 4231 2 0 insulysin activity 0 4237 4 0 membrane dipeptidase activity 0 4238 4 0 meprin A activity 0 4239 5 1 methionyl aminopeptidase activity 0 4240 2 1 mitochondrial processing peptidase activity 0 4243 1 0 mitochondrial intermediate peptidase activity 0 4245 23 0 neprilysin activity 0 4246 8 0 peptidyl-dipeptidase A activity 0 4249 1 0 stromelysin 3 activity 0 4251 1 0 X-Pro dipeptidase activity 0 4252 271 18 serine-type endopeptidase activity 0 4263 212 13 chymotrypsin activity 0 4274 5 0 dipeptidyl-peptidase IV activity 0 4275 2 1 enteropeptidase activity 0 4276 3 0 furin activity 0 4286 1 0 proprotein convertase 2 activity 0 4287 3 1 prolyl oligopeptidase activity 0 4289 9 0 subtilase activity 0 4290 1 0 kexin activity 0 4291 2 0 subtilisin activity 0 4294 1 0 tripeptidyl-peptidase II activity 0 4295 242 14 trypsin activity 0 4300 3 1 enoyl-CoA hydratase activity 0 4301 4 0 epoxide hydrolase activity 0 4303 3 0 estradiol 17-beta-dehydrogenase activity 0 4305 2 1 ethanolamine kinase activity 0 4306 1 0 ethanolamine-phosphate cytidylyltransferase activity 0 4307 1 0 ethanolaminephosphotransferase activity 0 4311 2 1 farnesyltranstransferase activity 0 4312 8 1 fatty-acid synthase activity 0 4313 1 1 [acyl-carrier protein] S-acetyltransferase activity 0 4314 2 1 [acyl-carrier protein] S-malonyltransferase activity 0 4315 2 1 3-oxoacyl-[acyl-carrier protein] synthase activity 0 4321 1 0 fatty-acyl-CoA synthase activity 0 4322 2 1 ferroxidase activity 0 4324 1 0 ferredoxin-NADP+ reductase activity 0 4325 1 0 ferrochelatase activity 0 4326 2 0 tetrahydrofolylpolyglutamate synthase activity 0 4327 1 1 formaldehyde dehydrogenase (glutathione) activity 0 4329 1 0 formate-tetrahydrofolate ligase activity 0 4331 1 1 "fructose-2,6-bisphosphate 2-phosphatase activity" 0 4332 2 1 fructose-bisphosphate aldolase activity 0 4333 5 0 fumarate hydratase activity 0 4334 1 1 fumarylacetoacetase activity 0 4335 1 0 galactokinase activity 0 4337 2 2 geranyltranstransferase activity 0 4342 1 0 glucosamine-6-phosphate deaminase activity 0 4343 1 0 glucosamine 6-phosphate N-acetyltransferase activity 0 4344 3 0 glucose dehydrogenase (acceptor) activity 0 4345 2 0 glucose-6-phosphate 1-dehydrogenase activity 0 4346 1 0 glucose-6-phosphatase activity 0 4347 1 1 glucose-6-phosphate isomerase activity 0 4348 2 0 glucosylceramidase activity 0 4349 1 0 glutamate 5-kinase activity 0 4350 1 0 glutamate-5-semialdehyde dehydrogenase activity 0 4351 3 0 glutamate decarboxylase activity 0 4353 2 1 glutamate dehydrogenase [NAD(P)+] activity 0 4355 1 0 glutamate synthase (NADPH) activity 0 4356 3 2 glutamate-ammonia ligase activity 0 4357 3 0 glutamate-cysteine ligase activity 0 4359 1 0 glutaminase activity 0 4360 2 0 glutamine-fructose-6-phosphate transaminase (isomerizing) activity 0 4361 1 0 glutaryl-CoA dehydrogenase activity 0 4362 1 0 glutathione-disulfide reductase activity 0 4363 2 0 glutathione synthase activity 0 4364 38 7 glutathione transferase activity 0 4365 8 1 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity 0 4366 2 0 glycerol-3-phosphate O-acyltransferase activity 0 4367 3 0 glycerol-3-phosphate dehydrogenase (NAD+) activity 0 4368 6 0 glycerol-3-phosphate dehydrogenase activity 0 4370 5 0 glycerol kinase activity 0 4372 5 2 glycine hydroxymethyltransferase activity 0 4373 2 0 glycogen (starch) synthase activity 0 4375 1 0 glycine dehydrogenase (decarboxylating) activity 0 4376 1 0 glycolipid mannosyltransferase activity 0 4379 2 2 glycylpeptide N-tetradecanoyltransferase activity 0 4382 1 0 guanosine-diphosphatase activity 0 4383 28 0 guanylate cyclase activity 0 4385 9 1 guanylate kinase activity 0 4386 120 28 helicase activity 0 4392 1 0 heme oxygenase (decyclizing) activity 0 4394 2 0 heparan sulfate 2-O-sulfotransferase activity 0 4395 1 1 hexaprenyldihydroxybenzoate methyltransferase activity 0 4396 7 0 hexokinase activity 0 4398 1 0 histidine decarboxylase activity 0 4402 12 3 histone acetyltransferase activity 0 4406 2 0 H3/H4 histone acetyltransferase activity 0 4407 7 0 histone deacetylase activity 0 4408 2 1 holocytochrome-c synthase activity 0 4411 1 0 "homogentisate 1,2-dioxygenase activity" 0 4415 1 0 hyalurononglucosaminidase activity 0 4416 1 0 hydroxyacylglutathione hydrolase activity 0 4418 1 0 hydroxymethylbilane synthase activity 0 4419 1 0 hydroxymethylglutaryl-CoA lyase activity 0 4420 1 0 hydroxymethylglutaryl-CoA reductase (NADPH) activity 0 4421 1 1 hydroxymethylglutaryl-CoA synthase activity 0 4423 1 0 iduronate-2-sulfatase activity 0 4427 1 0 inorganic diphosphatase activity 0 4428 18 1 inositol or phosphatidylinositol kinase activity 0 4430 3 1 1-phosphatidylinositol 4-kinase activity 0 4434 3 0 inositol or phosphatidylinositol phosphodiesterase activity 0 4435 3 0 phosphoinositide phospholipase C activity 0 4437 21 0 inositol or phosphatidylinositol phosphatase activity 0 4441 1 0 "inositol-1,4-bisphosphate 1-phosphatase activity" 0 4445 3 0 inositol-polyphosphate 5-phosphatase activity 0 4448 8 1 isocitrate dehydrogenase activity 0 4449 7 0 isocitrate dehydrogenase (NAD+) activity 0 4450 1 1 isocitrate dehydrogenase (NADP+) activity 0 4452 1 0 isopentenyl-diphosphate delta-isomerase activity 0 4453 1 0 juvenile-hormone esterase activity 0 4454 4 0 ketohexokinase activity 0 4457 2 0 lactate dehydrogenase activity 0 4459 2 0 L-lactate dehydrogenase activity 0 4462 2 1 lactoylglutathione lyase activity 0 4463 5 1 leukotriene-A4 hydrolase activity 0 4465 4 0 lipoprotein lipase activity 0 4466 1 0 long-chain-acyl-CoA dehydrogenase activity 0 4467 7 1 long-chain-fatty-acid-CoA ligase activity 0 4468 12 3 lysine N-acetyltransferase activity 0 4470 5 0 malic enzyme activity 0 4473 5 0 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity 0 4475 2 0 mannose-1-phosphate guanylyltransferase activity 0 4476 3 0 mannose-6-phosphate isomerase activity 0 4477 2 0 methenyltetrahydrofolate cyclohydrolase activity 0 4478 1 0 methionine adenosyltransferase activity 0 4479 1 1 methionyl-tRNA formyltransferase activity 0 4482 1 0 mRNA (guanine-N7-)-methyltransferase activity 0 4484 1 1 mRNA guanylyltransferase activity 0 4485 2 0 methylcrotonoyl-CoA carboxylase activity 0 4486 3 0 methylenetetrahydrofolate dehydrogenase activity 0 4487 1 0 methylenetetrahydrofolate dehydrogenase (NAD+) activity 0 4488 2 0 methylenetetrahydrofolate dehydrogenase (NADP+) activity 0 4489 1 0 methylenetetrahydrofolate reductase (NADPH) activity 0 4491 1 0 methylmalonate-semialdehyde dehydrogenase (acylating) activity 0 4496 1 1 mevalonate kinase activity 0 4497 113 9 monooxygenase activity 0 4498 1 0 calcidiol 1-monooxygenase activity 0 4499 2 1 dimethylaniline monooxygenase (N-oxide-forming) activity 0 4500 6 3 dopamine beta-monooxygenase activity 0 4501 1 0 ecdysone 20-monooxygenase activity 0 4502 1 0 kynurenine 3-monooxygenase activity 0 4503 4 0 monophenol monooxygenase activity 0 4504 3 0 peptidylglycine monooxygenase activity 0 4505 3 1 phenylalanine 4-monooxygenase activity 0 4510 2 1 tryptophan 5-monooxygenase activity 0 4511 2 0 tyrosine 3-monooxygenase activity 0 4512 1 0 inositol-3-phosphate synthase activity 0 4516 1 0 nicotinate phosphoribosyltransferase activity 0 4517 1 0 nitric-oxide synthase activity 0 4518 102 16 nuclease activity 0 4519 56 9 endonuclease activity 0 4520 31 4 endodeoxyribonuclease activity 0 4521 23 5 endoribonuclease activity 0 4522 1 0 pancreatic ribonuclease activity 0 4523 2 1 ribonuclease H activity 0 4524 2 1 ribonuclease H1 activity 0 4525 4 0 ribonuclease III activity 0 4526 2 1 ribonuclease P activity 0 4527 42 5 exonuclease activity 0 4529 13 1 exodeoxyribonuclease activity 0 4530 2 0 deoxyribonuclease I activity 0 4531 1 0 deoxyribonuclease II activity 0 4532 23 4 exoribonuclease activity 0 4534 2 0 5'-3' exoribonuclease activity 0 4535 1 0 poly(A)-specific ribonuclease activity 0 4536 44 5 deoxyribonuclease activity 0 4537 1 0 caspase-activated deoxyribonuclease activity 0 4540 49 9 ribonuclease activity 0 4549 4 1 tRNA-specific ribonuclease activity 0 4550 4 0 nucleoside diphosphate kinase activity 0 4551 3 1 nucleotide diphosphatase activity 0 4552 1 1 octanol dehydrogenase activity 0 4553 115 14 "hydrolase activity, hydrolyzing O-glycosyl compounds" 0 4555 3 0 "alpha,alpha-trehalase activity" 0 4556 14 0 alpha-amylase activity 0 4557 1 1 alpha-galactosidase activity 0 4558 17 1 alpha-glucosidase activity 0 4559 10 2 alpha-mannosidase activity 0 4560 2 0 alpha-L-fucosidase activity 0 4561 1 0 alpha-N-acetylglucosaminidase activity 0 4563 7 2 beta-N-acetylhexosaminidase activity 0 4565 2 0 beta-galactosidase activity 0 4566 3 0 beta-glucuronidase activity 0 4567 1 0 beta-mannosidase activity 0 4568 18 4 chitinase activity 0 4571 5 0 "mannosyl-oligosaccharide 1,2-alpha-mannosidase activity" 0 4572 2 0 "mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity" 0 4573 1 0 mannosyl-oligosaccharide glucosidase activity 0 4574 1 0 "oligo-1,6-glucosidase activity" 0 4575 1 0 sucrose alpha-glucosidase activity 0 4576 8 4 oligosaccharyl transferase activity 0 4579 3 1 dolichyl-diphosphooligosaccharide-protein glycotransferase activity 0 4581 1 1 dolichyl-phosphate beta-glucosyltransferase activity 0 4582 1 0 dolichyl-phosphate beta-D-mannosyltransferase activity 0 4584 1 0 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity 0 4586 2 0 ornithine decarboxylase activity 0 4587 2 0 ornithine-oxo-acid transaminase activity 0 4588 1 0 orotate phosphoribosyltransferase activity 0 4590 1 0 orotidine-5'-phosphate decarboxylase activity 0 4591 3 1 oxoglutarate dehydrogenase (succinyl-transferring) activity 0 4594 1 0 pantothenate kinase activity 0 4596 2 1 peptide alpha-N-acetyltransferase activity 0 4597 1 0 peptide-aspartate beta-dioxygenase activity 0 4598 1 0 peptidylamidoglycolate lyase activity 0 4601 33 11 peroxidase activity 0 4602 9 3 glutathione peroxidase activity 0 4605 2 0 phosphatidate cytidylyltransferase activity 0 4607 3 0 phosphatidylcholine-sterol O-acyltransferase activity 0 4609 1 1 phosphatidylserine decarboxylase activity 0 4610 1 0 phosphoacetylglucosamine mutase activity 0 4611 2 0 phosphoenolpyruvate carboxykinase activity 0 4613 2 0 phosphoenolpyruvate carboxykinase (GTP) activity 0 4614 1 0 phosphoglucomutase activity 0 4615 3 0 phosphomannomutase activity 0 4616 4 2 phosphogluconate dehydrogenase (decarboxylating) activity 0 4617 2 1 phosphoglycerate dehydrogenase activity 0 4618 2 1 phosphoglycerate kinase activity 0 4619 3 1 phosphoglycerate mutase activity 0 4620 49 3 phospholipase activity 0 4622 4 1 lysophospholipase activity 0 4623 21 0 phospholipase A2 activity 0 4629 4 0 phospholipase C activity 0 4630 2 0 phospholipase D activity 0 4631 1 0 phosphomevalonate kinase activity 0 4634 1 1 phosphopyruvate hydratase activity 0 4637 1 0 phosphoribosylamine-glycine ligase activity 0 4638 2 0 phosphoribosylaminoimidazole carboxylase activity 0 4639 2 0 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity 0 4641 1 0 phosphoribosylformylglycinamidine cyclo-ligase activity 0 4642 1 0 phosphoribosylformylglycinamidine synthase activity 0 4643 1 0 phosphoribosylaminoimidazolecarboxamide formyltransferase activity 0 4644 1 0 phosphoribosylglycinamide formyltransferase activity 0 4645 2 0 phosphorylase activity 0 4647 1 0 phosphoserine phosphatase activity 0 4648 1 1 phosphoserine transaminase activity 0 4649 1 0 poly(ADP-ribose) glycohydrolase activity 0 4652 3 0 polynucleotide adenylyltransferase activity 0 4653 14 0 polypeptide N-acetylgalactosaminyltransferase activity 0 4654 2 0 polyribonucleotide nucleotidyltransferase activity 0 4655 1 0 porphobilinogen synthase activity 0 4656 19 0 procollagen-proline 4-dioxygenase activity 0 4657 1 0 proline dehydrogenase activity 0 4658 1 0 propionyl-CoA carboxylase activity 0 4659 19 4 prenyltransferase activity 0 4660 3 1 protein farnesyltransferase activity 0 4661 7 1 protein geranylgeranyltransferase activity 0 4662 2 0 CAAX-protein geranylgeranyltransferase activity 0 4663 5 1 Rab-protein geranylgeranyltransferase activity 0 4664 1 0 prephenate dehydratase activity 0 4671 1 0 protein-S-isoprenylcysteine O-methyltransferase activity 0 4672 332 31 protein kinase activity 0 4673 4 0 protein histidine kinase activity 0 4674 232 17 protein serine/threonine kinase activity 0 4675 20 0 transmembrane receptor protein serine/threonine kinase activity 0 4677 1 0 DNA-dependent protein kinase activity 0 4679 3 1 AMP-activated protein kinase activity 0 4680 11 1 casein kinase activity 0 4681 8 0 casein kinase I activity 0 4682 3 1 protein kinase CK2 activity 0 4683 11 0 calmodulin regulated protein kinase activity 0 4684 1 0 calmodulin-dependent protein kinase I activity 0 4685 4 0 calcium- and calmodulin-dependent protein kinase activity 0 4686 2 0 eukaryotic elongation factor-2 kinase activity 0 4687 4 0 myosin light chain kinase activity 0 4689 1 0 phosphorylase kinase activity 0 4690 7 0 cyclic nucleotide-dependent protein kinase activity 0 4691 4 0 cAMP-dependent protein kinase activity 0 4692 3 0 cGMP-dependent protein kinase activity 0 4693 16 0 cyclin-dependent protein kinase activity 0 4696 1 0 glycogen synthase kinase 3 activity 0 4697 6 0 protein kinase C activity 0 4698 3 0 calcium-dependent protein kinase C activity 0 4700 1 0 atypical protein kinase C activity 0 4701 3 0 diacylglycerol-activated phospholipid-dependent protein kinase C activity 0 4702 185 13 receptor signaling protein serine/threonine kinase activity 0 4703 5 0 G-protein coupled receptor kinase activity 0 4705 2 0 JUN kinase activity 0 4706 2 0 JUN kinase kinase kinase activity 0 4707 11 0 MAP kinase activity 0 4708 5 2 MAP kinase kinase activity 0 4709 5 1 MAP kinase kinase kinase activity 0 4710 1 0 MAP/ERK kinase kinase activity 0 4711 2 1 ribosomal protein S6 kinase activity 0 4712 9 3 protein threonine/tyrosine kinase activity 0 4713 99 12 protein-tyrosine kinase activity 0 4714 34 9 transmembrane receptor protein tyrosine kinase activity 0 4715 16 1 non-membrane spanning protein tyrosine kinase activity 0 4716 5 0 receptor signaling protein tyrosine kinase activity 0 4718 2 0 Janus kinase activity 0 4719 2 0 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity 0 4720 2 0 protein-lysine 6-oxidase activity 0 4721 100 8 phosphoprotein phosphatase activity 0 4722 42 2 protein serine/threonine phosphatase activity 0 4723 6 0 calcium-dependent protein serine/threonine phosphatase activity 0 4725 38 2 protein tyrosine phosphatase activity 0 4726 6 2 non-membrane spanning protein tyrosine phosphatase activity 0 4727 1 0 prenylated protein tyrosine phosphatase activity 0 4728 4 1 receptor signaling protein tyrosine phosphatase activity 0 4729 2 0 protoporphyrinogen oxidase activity 0 4730 6 2 pseudouridylate synthase activity 0 4731 2 0 purine-nucleoside phosphorylase activity 0 4732 1 0 pyridoxal oxidase activity 0 4733 3 1 pyridoxamine-phosphate oxidase activity 0 4734 1 0 pyrimidodiazepine synthase activity 0 4735 2 0 pyrroline-5-carboxylate reductase activity 0 4736 1 0 pyruvate carboxylase activity 0 4738 3 1 pyruvate dehydrogenase activity 0 4739 3 1 pyruvate dehydrogenase (acetyl-transferring) activity 0 4740 1 0 [pyruvate dehydrogenase (lipoamide)] kinase activity 0 4741 1 0 [pyruvate dehydrogenase (lipoamide)] phosphatase activity 0 4742 1 0 dihydrolipoyllysine-residue acetyltransferase activity 0 4743 6 2 pyruvate kinase activity 0 4747 2 0 ribokinase activity 0 4748 2 2 ribonucleoside-diphosphate reductase activity 0 4749 2 0 ribose phosphate diphosphokinase activity 0 4750 1 1 ribulose-phosphate 3-epimerase activity 0 4751 1 0 ribose-5-phosphate isomerase activity 0 4753 1 0 saccharopine dehydrogenase activity 0 4754 1 0 "saccharopine dehydrogenase (NAD+, L-lysine-forming) activity" 0 4756 2 1 "selenide, water dikinase activity" 0 4757 3 0 sepiapterin reductase activity 0 4758 2 0 serine C-palmitoyltransferase activity 0 4759 1 0 serine esterase activity 0 4760 1 0 serine-pyruvate transaminase activity 0 4766 2 1 spermidine synthase activity 0 4767 5 0 sphingomyelin phosphodiesterase activity 0 4768 9 0 stearoyl-CoA 9-desaturase activity 0 4770 2 1 sterol carrier protein X-related thiolase activity 0 4772 3 0 sterol O-acyltransferase activity 0 4774 5 0 succinate-CoA ligase activity 0 4775 1 0 succinate-CoA ligase (ADP-forming) activity 0 4776 4 0 succinate-CoA ligase (GDP-forming) activity 0 4777 1 0 succinate-semialdehyde dehydrogenase activity 0 4779 1 1 sulfate adenylyltransferase activity 0 4781 1 1 sulfate adenylyltransferase (ATP) activity 0 4782 1 0 sulfinoalanine decarboxylase activity 0 4784 9 4 superoxide dismutase activity 0 4785 8 3 "copper, zinc superoxide dismutase activity" 0 4788 2 0 thiamin diphosphokinase activity 0 4791 2 0 thioredoxin-disulfide reductase activity 0 4792 1 0 thiosulfate sulfurtransferase activity 0 4793 1 0 threonine aldolase activity 0 4794 1 0 threonine ammonia-lyase activity 0 4797 1 0 thymidine kinase activity 0 4798 1 0 thymidylate kinase activity 0 4799 1 0 thymidylate synthase activity 0 4801 1 0 transaldolase activity 0 4802 2 0 transketolase activity 0 4803 3 1 transposase activity 0 4805 3 0 trehalose-phosphatase activity 0 4806 37 4 triacylglycerol lipase activity 0 4807 1 1 triose-phosphate isomerase activity 0 4808 1 0 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity 0 4809 1 1 tRNA (guanine-N2-)-methyltransferase activity 0 4811 1 0 tRNA isopentenyltransferase activity 0 4812 67 10 tRNA ligase activity 0 4813 4 0 alanine-tRNA ligase activity 0 4814 3 2 arginine-tRNA ligase activity 0 4815 7 0 aspartate-tRNA ligase activity 0 4816 2 0 asparagine-tRNA ligase activity 0 4817 2 0 cysteine-tRNA ligase activity 0 4818 4 0 glutamate-tRNA ligase activity 0 4819 1 0 glutamine-tRNA ligase activity 0 4820 1 0 glycine-tRNA ligase activity 0 4821 2 0 histidine-tRNA ligase activity 0 4822 3 0 isoleucine-tRNA ligase activity 0 4823 2 1 leucine-tRNA ligase activity 0 4824 3 0 lysine-tRNA ligase activity 0 4825 3 0 methionine-tRNA ligase activity 0 4826 5 0 phenylalanine-tRNA ligase activity 0 4827 2 0 proline-tRNA ligase activity 0 4828 4 1 serine-tRNA ligase activity 0 4829 2 2 threonine-tRNA ligase activity 0 4830 2 1 tryptophan-tRNA ligase activity 0 4831 2 0 tyrosine-tRNA ligase activity 0 4832 2 0 valine-tRNA ligase activity 0 4833 1 1 "tryptophan 2,3-dioxygenase activity" 0 4835 10 0 tubulin-tyrosine ligase activity 0 4836 1 0 tyramine-beta hydroxylase activity 0 4837 2 0 tyrosine decarboxylase activity 0 4838 1 0 tyrosine transaminase activity 0 4839 5 2 ubiquitin activating enzyme activity 0 4840 36 10 ubiquitin conjugating enzyme activity 0 4842 139 14 ubiquitin-protein ligase activity 0 4843 30 7 ubiquitin-specific protease activity 0 4844 2 0 uracil DNA N-glycosylase activity 0 4845 1 0 uracil phosphoribosyltransferase activity 0 4846 1 0 urate oxidase activity 0 4849 4 0 uridine kinase activity 0 4850 3 0 uridine phosphorylase activity 0 4852 2 0 uroporphyrinogen-III synthase activity 0 4853 2 1 uroporphyrinogen decarboxylase activity 0 4854 2 0 xanthine dehydrogenase activity 0 4856 2 0 xylulokinase activity 0 4857 131 16 enzyme inhibitor activity 0 4858 1 0 dUTP pyrophosphatase inhibitor activity 0 4860 5 2 protein kinase inhibitor activity 0 4861 1 0 cyclin-dependent protein kinase inhibitor activity 0 4863 2 2 diacylglycerol-activated phospholipid-dependent protein kinase C inhibitor activity 0 4864 7 0 protein phosphatase inhibitor activity 0 4865 1 0 type 1 serine/threonine specific protein phosphatase inhibitor activity 0 4866 88 10 endopeptidase inhibitor activity 0 4867 73 10 serine-type endopeptidase inhibitor activity 0 4869 9 0 cysteine protease inhibitor activity 0 4871 1113 72 signal transducer activity 1 4872 590 32 receptor activity 0 4879 26 0 ligand-dependent nuclear receptor activity 0 4884 2 0 ecdysteroid hormone receptor activity 0 4887 1 0 thyroid hormone receptor activity 0 4888 455 18 transmembrane receptor activity 0 4889 16 0 nicotinic acetylcholine-activated cation-selective channel activity 0 4890 12 0 GABA-A receptor activity 0 4896 9 0 hematopoietin/interferon-class (D200-domain) cytokine receptor activity 0 4907 1 0 interleukin receptor activity 0 4930 272 6 G-protein coupled receptor activity 0 4935 3 0 adrenoceptor activity 0 4946 2 0 bombesin receptor activity 0 4948 3 0 calcitonin receptor activity 0 4951 2 0 cholecystokinin receptor activity 0 4952 5 0 dopamine receptor activity 0 4965 6 0 GABA-B receptor activity 0 4966 3 0 galanin receptor activity 0 4968 2 0 gonadotropin-releasing hormone receptor activity 0 4970 27 0 ionotropic glutamate receptor activity 0 4971 3 0 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity 0 4972 5 0 N-methyl-D-aspartate selective glutamate receptor activity 0 4981 2 0 muscarinic acetylcholine receptor activity 0 4983 6 0 neuropeptide Y receptor activity 0 4984 61 0 olfactory receptor activity 0 4985 2 0 opioid receptor activity 0 4988 1 0 mu-opioid receptor activity 0 4989 5 0 octopamine receptor activity 0 4993 5 0 serotonin receptor activity 0 4994 2 0 somatostatin receptor activity 0 4995 6 0 tachykinin receptor activity 0 5000 1 0 vasopressin receptor activity 0 5001 8 0 transmembrane receptor protein tyrosine phosphatase activity 0 5003 1 0 ephrin receptor activity 0 5006 5 0 epidermal growth factor receptor activity 0 5007 3 1 fibroblast growth factor receptor activity 0 5009 2 0 insulin receptor activity 0 5010 2 0 insulin-like growth factor receptor activity 0 5017 2 0 platelet-derived growth factor receptor activity 0 5021 3 0 vascular endothelial growth factor receptor activity 0 5024 5 0 transforming growth factor beta receptor activity 0 5025 3 0 "transforming growth factor beta receptor activity, type I" 0 5026 2 0 "transforming growth factor beta receptor activity, type II" 0 5030 1 0 neurotrophin receptor activity 0 5031 1 0 tumor necrosis factor receptor activity 0 5035 1 0 death receptor activity 0 5041 13 1 low-density lipoprotein receptor activity 0 5042 2 0 netrin receptor activity 0 5043 1 0 repulsive netrin receptor activity 0 5044 23 2 scavenger receptor activity 0 5046 1 0 KDEL sequence binding 0 5047 3 2 signal recognition particle binding 0 5048 11 2 signal sequence binding 0 5049 2 0 nuclear export signal receptor activity 0 5053 2 0 peroxisome targeting signal-2 binding 0 5055 1 0 laminin receptor activity 0 5057 252 18 receptor signaling protein activity 0 5070 10 0 SH3/SH2 adaptor activity 0 5071 5 0 transmembrane receptor protein serine/threonine kinase signaling protein activity 0 5072 4 0 "transforming growth factor beta receptor, cytoplasmic mediator activity" 0 5080 3 1 protein kinase C binding 0 5083 129 21 small GTPase regulator activity 0 5084 1 1 Rab escort protein activity 0 5085 62 7 guanyl-nucleotide exchange factor activity 0 5086 3 0 ARF guanyl-nucleotide exchange factor activity 0 5087 2 0 Ran guanyl-nucleotide exchange factor activity 0 5088 4 0 Ras guanyl-nucleotide exchange factor activity 0 5089 9 0 Rho guanyl-nucleotide exchange factor activity 0 5092 2 1 GDP-dissociation inhibitor activity 0 5093 1 1 Rab GDP-dissociation inhibitor activity 0 5094 1 0 Rho GDP-dissociation inhibitor activity 0 5096 46 7 GTPase activator activity 0 5097 5 2 Rab GTPase activator activity 0 5098 2 0 Ran GTPase activator activity 0 5099 7 1 Ras GTPase activator activity 0 5100 7 1 Rho GTPase activator activity 0 5102 294 23 receptor binding 0 5104 3 0 fibroblast growth factor receptor binding 0 5109 1 0 frizzled binding 0 5110 1 0 frizzled-2 binding 0 5112 8 1 Notch binding 0 5113 3 0 patched binding 0 5118 2 0 sevenless binding 0 5119 1 0 smoothened binding 0 5121 1 0 Toll binding 0 5122 2 0 torso binding 0 5123 1 0 death receptor binding 0 5125 15 0 cytokine activity 0 5154 8 0 epidermal growth factor receptor binding 0 5155 1 0 epidermal growth factor receptor activating ligand activity 0 5158 12 0 insulin receptor binding 0 5159 1 0 insulin-like growth factor receptor binding 0 5160 10 0 transforming growth factor beta receptor binding 0 5164 2 0 tumor necrosis factor receptor binding 0 5165 1 0 neurotrophin receptor binding 0 5172 3 0 vascular endothelial growth factor receptor binding 0 5178 1 1 integrin binding 0 5179 61 0 hormone activity 0 5184 40 0 neuropeptide hormone activity 0 5198 775 195 structural molecule activity 1 5200 313 46 structural constituent of cytoskeleton 0 5201 6 1 extracellular matrix structural constituent 0 5212 1 0 structural constituent of eye lens 0 5213 11 0 structural constituent of chorion (sensu Insecta) 0 5214 85 23 structural constituent of cuticle (sensu Insecta) 0 5215 1244 151 transporter activity 1 5216 181 8 ion channel activity 0 5217 10 0 intracellular ligand-gated ion channel activity 0 5218 2 0 intracellular ligand-gated calcium channel activity 0 5219 1 0 ryanodine-sensitive calcium-release channel activity 0 5220 1 0 "inositol 1,4,5-triphosphate-sensitive calcium-release channel activity" 0 5221 7 0 intracellular cyclic nucleotide activated cation channel activity 0 5223 1 0 intracellular cGMP activated cation channel activity 0 5225 1 0 volume-sensitive anion channel activity 0 5230 57 0 extracellular ligand-gated ion channel activity 0 5231 52 0 excitatory extracellular ligand-gated ion channel activity 0 5234 28 0 glutamate-gated ion channel activity 0 5242 4 0 inward rectifier potassium channel activity 0 5243 8 3 gap-junction forming channel activity 0 5244 55 4 voltage-gated ion channel activity 0 5245 13 0 voltage-gated calcium channel activity 0 5246 1 0 calcium channel regulator activity 0 5247 3 0 voltage-gated chloride channel activity 0 5248 4 0 voltage-gated sodium channel activity 0 5249 35 3 voltage-gated potassium channel activity 0 5250 1 0 A-type (transient outward) potassium channel activity 0 5252 4 0 open rectifier potassium channel activity 0 5253 24 4 anion channel activity 0 5254 13 0 chloride channel activity 0 5261 131 4 cation channel activity 0 5262 27 1 calcium channel activity 0 5267 55 3 potassium channel activity 0 5272 30 0 sodium channel activity 0 5275 53 1 amine transporter activity 0 5276 1 0 hydrogen:vesicular amine antiporter activity 0 5277 1 0 acetylcholine transporter activity 0 5278 1 0 acetylcholine:hydrogen antiporter activity 0 5279 39 0 amino acid-polyamine transporter activity 0 5280 2 0 hydrogen:amino acid symporter activity 0 5283 5 0 sodium:amino acid symporter activity 0 5294 1 0 neutral L-amino acid porter activity 0 5298 1 0 proline:sodium symporter activity 0 5302 2 1 L-tyrosine transporter activity 0 5310 8 1 dicarboxylic acid transporter activity 0 5313 2 0 L-glutamate transporter activity 0 5315 1 0 inorganic phosphate transporter activity 0 5316 18 0 high affinity inorganic phosphate:sodium symporter activity 0 5319 24 3 lipid transporter activity 0 5324 8 0 long-chain fatty acid transporter activity 0 5326 22 1 neurotransmitter transporter activity 0 5328 19 0 neurotransmitter:sodium symporter activity 0 5329 2 0 dopamine transporter activity 0 5330 2 0 dopamine:sodium symporter activity 0 5332 1 0 gamma-aminobutyric acid:sodium symporter activity 0 5337 6 0 nucleoside transporter activity 0 5338 9 0 nucleotide-sugar transporter activity 0 5342 74 2 organic acid transporter activity 0 5343 8 0 organic acid:sodium symporter activity 0 5344 10 1 oxygen transporter activity 0 5351 41 4 sugar porter activity 0 5353 3 0 fructose transporter activity 0 5355 15 3 glucose transporter activity 0 5368 1 0 taurine transporter activity 0 5369 1 0 taurine:sodium symporter activity 0 5371 3 1 tricarboxylate carrier activity 0 5372 8 0 water transporter activity 0 5375 7 2 copper ion transporter activity 0 5381 5 1 iron ion transporter activity 0 5385 7 1 zinc ion transporter activity 0 5386 536 89 carrier activity 0 5388 5 1 calcium-transporting ATPase activity 0 5391 9 0 sodium:potassium-exchanging ATPase activity 0 5395 3 0 eye pigment precursor transporter activity 0 5402 1 0 cation:sugar symporter activity 0 5403 1 0 hydrogen:sugar symporter activity 0 5415 2 0 nucleoside:sodium symporter activity 0 5416 13 0 cation:amino acid symporter activity 0 5427 3 0 proton-dependent oligopeptide transporter activity 0 5432 3 0 calcium:sodium antiporter activity 0 5436 21 0 sodium:phosphate symporter activity 0 5451 5 1 monovalent cation:proton antiporter activity 0 5452 2 0 inorganic anion exchanger activity 0 5456 2 0 CMP-sialic acid transporter activity 0 5457 2 0 GDP-fucose transporter activity 0 5458 1 0 GDP-mannose transporter activity 0 5459 6 0 UDP-galactose transporter activity 0 5460 1 0 UDP-glucose transporter activity 0 5461 3 0 UDP-glucuronic acid transporter activity 0 5462 2 0 UDP-N-acetylglucosamine transporter activity 0 5463 2 0 UDP-N-acetylgalactosamine transporter activity 0 5464 3 0 UDP-xylose transporter activity 0 5471 2 1 ATP:ADP antiporter activity 0 5476 2 1 carnitine:acyl carnitine antiporter activity 0 5478 37 3 intracellular transporter activity 0 5483 7 0 soluble NSF attachment protein activity 0 5484 27 1 SNAP receptor activity 0 5485 7 0 v-SNARE activity 0 5486 14 1 t-SNARE activity 0 5487 3 1 nucleocytoplasmic transporter activity 0 5488 4346 651 binding 1 5489 230 42 electron transporter activity 0 5496 12 3 steroid binding 0 5498 3 1 sterol carrier activity 0 5500 2 0 juvenile hormone binding 0 5501 8 1 retinoid binding 0 5504 11 1 fatty acid binding 0 5506 49 4 iron ion binding 0 5507 28 4 copper ion binding 0 5509 228 26 calcium ion binding 0 5513 3 1 detection of calcium ion 0 5515 1309 180 protein binding 0 5516 75 6 calmodulin binding 0 5517 2 0 calmodulin inhibitor activity 0 5520 3 0 insulin-like growth factor binding 0 5521 1 0 lamin binding 0 5523 3 2 tropomyosin binding 0 5524 702 107 ATP binding 0 5525 171 35 GTP binding 0 5527 6 2 macrolide binding 0 5528 6 2 FK506 binding 0 5529 53 3 sugar binding 0 5534 17 0 galactose binding 0 5537 6 0 mannose binding 0 5539 3 1 glycosaminoglycan binding 0 5542 3 0 folic acid binding 0 5543 33 5 phospholipid binding 0 5544 17 1 calcium-dependent phospholipid binding 0 5545 1 0 phosphatidylinositol binding 0 5546 1 1 "phosphatidylinositol-4,5-bisphosphate binding" 0 5548 10 3 phospholipid transporter activity 0 5549 115 2 odorant binding 0 5550 8 1 pheromone binding 0 5575 5611 787 cellular_component 0 5576 468 41 extracellular region 0 5577 3 0 fibrinogen complex 0 5578 88 6 extracellular matrix (sensu Metazoa) 0 5581 4 1 collagen 0 5587 3 1 collagen type IV 0 5604 21 4 basement membrane 0 5605 13 3 basal lamina 0 5606 2 1 laminin-1 0 5614 1 0 interstitial matrix 0 5615 25 2 extracellular space 0 5616 6 1 larval serum protein complex 0 5618 1 0 cell wall 0 5622 3831 677 intracellular 0 5623 5197 755 cell 0 5624 95 9 membrane fraction 0 5625 2 1 soluble fraction 0 5626 1 1 insoluble fraction 0 5634 1737 244 nucleus 0 5635 68 5 nuclear envelope 0 5637 5 0 nuclear inner membrane 0 5638 2 0 lamin filament 0 5640 1 0 nuclear outer membrane 0 5641 2 0 nuclear envelope lumen 0 5643 44 4 nuclear pore 0 5652 4 0 nuclear lamina 0 5654 258 60 nucleoplasm 0 5656 9 0 pre-replicative complex 0 5657 27 5 replication fork 0 5658 5 1 alpha DNA polymerase:primase complex 0 5659 4 2 delta DNA polymerase complex 0 5660 2 1 delta-DNA polymerase cofactor complex 0 5662 5 0 DNA replication factor A complex 0 5663 8 1 DNA replication factor C complex 0 5664 7 0 nuclear origin of replication recognition complex 0 5665 12 4 "DNA-directed RNA polymerase II, core complex" 0 5666 9 2 DNA-directed RNA polymerase III complex 0 5667 102 25 transcription factor complex 0 5669 29 7 transcription factor TFIID complex 0 5671 2 2 Ada2/Gcn5/Ada3 transcription activator complex 0 5672 3 1 transcription factor TFIIA complex 0 5673 2 0 transcription factor TFIIE complex 0 5674 3 1 transcription factor TFIIF complex 0 5675 14 2 transcription factor TFIIH complex 0 5677 5 1 chromatin silencing complex 0 5678 9 4 chromatin assembly complex 0 5680 8 0 anaphase-promoting complex 0 5681 126 27 spliceosome complex 0 5682 16 3 snRNP U5 0 5683 1 0 snRNP U7 0 5684 65 9 major (U2-dependent) spliceosome 0 5685 15 0 snRNP U1 0 5686 20 4 snRNP U2 0 5687 5 0 snRNP U4 0 5688 12 2 snRNP U6 0 5689 23 3 minor (U12-dependent) spliceosome complex 0 5690 1 0 snRNP U4atac 0 5691 1 0 snRNP U6atac 0 5692 3 0 snRNP U11 0 5693 2 0 snRNP U12 0 5694 220 44 chromosome 0 5700 59 10 polytene chromosome 0 5701 6 1 polytene chromosome chromocenter 0 5703 18 4 polytene chromosome puff 0 5704 3 0 polytene chromosome band 0 5705 4 1 polytene chromosome interband 0 5719 1 1 nuclear euchromatin 0 5720 9 1 nuclear heterochromatin 0 5721 3 1 centric heterochromatin 0 5724 1 0 nuclear telomeric heterochromatin 0 5725 7 0 intercalary heterochromatin 0 5727 1 0 extrachromosomal circular DNA 0 5730 99 25 nucleolus 0 5732 18 9 small nucleolar ribonucleoprotein complex 0 5736 6 1 DNA-directed RNA polymerase I complex 0 5737 1817 378 cytoplasm 0 5739 515 128 mitochondrion 0 5740 220 70 mitochondrial envelope 0 5741 19 4 mitochondrial outer membrane 0 5742 8 2 mitochondrial outer membrane translocase complex 0 5743 185 64 mitochondrial inner membrane 0 5744 13 2 mitochondrial inner membrane presequence translocase complex 0 5746 82 40 mitochondrial electron transport chain 0 5747 45 23 respiratory chain complex I (sensu Eukaryota) 0 5749 7 0 respiratory chain complex II (sensu Eukaryota) 0 5750 13 9 respiratory chain complex III (sensu Eukaryota) 0 5751 17 8 respiratory chain complex IV (sensu Eukaryota) 0 5753 22 14 proton-transporting ATP synthase complex (sensu Eukaryota) 0 5756 2 1 "proton-transporting ATP synthase, central stalk (sensu Eukaryota)" 0 5758 4 0 mitochondrial intermembrane space 0 5759 152 40 mitochondrial matrix 0 5760 2 0 gamma DNA polymerase complex 0 5761 77 28 mitochondrial ribosome 0 5762 48 18 mitochondrial large ribosomal subunit 0 5763 30 10 mitochondrial small ribosomal subunit 0 5764 30 3 lysosome 0 5765 3 0 lysosomal membrane 0 5767 1 0 secondary lysosome 0 5768 11 0 endosome 0 5769 2 0 early endosome 0 5770 4 0 late endosome 0 5771 2 0 multivesicular body 0 5773 62 10 vacuole 0 5774 32 7 vacuolar membrane 0 5777 35 4 peroxisome 0 5778 14 0 peroxisomal membrane 0 5779 5 0 integral to peroxisomal membrane 0 5783 121 23 endoplasmic reticulum 0 5784 8 6 translocon complex 0 5785 4 2 signal recognition particle receptor complex 0 5786 12 6 signal recognition particle (sensu Eukaryota) 0 5787 4 3 signal peptidase complex 0 5788 7 4 endoplasmic reticulum lumen 0 5789 42 15 endoplasmic reticulum membrane 0 5790 1 0 smooth endoplasmic reticulum 0 5791 14 8 rough endoplasmic reticulum 0 5792 85 8 microsome 0 5794 100 11 Golgi apparatus 0 5795 29 1 Golgi stack 0 5798 23 4 Golgi vesicle 0 5801 8 1 Golgi cis-face 0 5802 1 1 Golgi trans face 0 5811 2 0 lipid particle 0 5813 34 6 centrosome 0 5814 1 0 centriole 0 5815 40 6 microtubule organizing center 0 5816 1 0 spindle pole body 0 5818 3 2 aster 0 5819 29 12 spindle 0 5821 1 0 intermediate layer of spindle pole body 0 5823 1 0 central plaque of spindle pole body 0 5826 4 0 contractile ring 0 5827 1 0 polar microtubule 0 5828 4 0 kinetochore microtubule 0 5829 389 109 cytosol 0 5830 97 79 cytosolic ribosome (sensu Eukaryota) 0 5832 8 2 chaperonin-containing T-complex 0 5834 23 4 heterotrimeric G-protein complex 0 5835 1 0 fatty acid synthase complex 0 5838 24 13 proteasome regulatory particle (sensu Eukaryota) 0 5839 28 12 proteasome core complex (sensu Eukaryota) 0 5840 200 110 ribosome 0 5842 57 46 cytosolic large ribosomal subunit (sensu Eukaryota) 0 5843 42 33 cytosolic small ribosomal subunit (sensu Eukaryota) 0 5844 1 0 polysome 0 5845 2 0 mRNA cap complex 0 5846 2 0 snRNA cap binding complex 0 5847 8 5 mRNA cleavage and polyadenylation specificity factor complex 0 5848 4 1 mRNA cleavage stimulating factor complex 0 5849 14 5 mRNA cleavage factor complex 0 5850 5 2 eukaryotic translation initiation factor 2 complex 0 5851 7 2 eukaryotic translation initiation factor 2B complex 0 5852 15 8 eukaryotic translation initiation factor 3 complex 0 5853 5 4 eukaryotic translation elongation factor 1 complex 0 5854 3 2 nascent polypeptide-associated complex 0 5856 305 60 cytoskeleton 0 5858 11 1 axonemal dynein complex 0 5859 3 0 muscle myosin 0 5861 2 1 troponin complex 0 5862 2 2 muscle thin filament tropomyosin 0 5863 3 0 striated muscle thick filament 0 5865 5 3 striated muscle thin filament 0 5868 14 2 cytoplasmic dynein complex 0 5869 13 3 dynactin complex 0 5871 31 4 kinesin complex 0 5872 1 1 minus-end kinesin complex 0 5873 3 0 plus-end kinesin complex 0 5874 46 11 microtubule 0 5875 126 19 microtubule associated complex 0 5876 11 5 spindle microtubule 0 5881 1 0 cytoplasmic microtubule 0 5882 2 0 intermediate filament 0 5884 21 6 actin filament 0 5885 6 3 Arp2/3 protein complex 0 5886 581 57 plasma membrane 0 5887 209 17 integral to plasma membrane 0 5889 2 0 hydrogen:potassium-exchanging ATPase complex 0 5890 8 0 sodium:potassium-exchanging ATPase complex 0 5891 8 0 voltage-gated calcium channel complex 0 5892 17 0 nicotinic acetylcholine-gated receptor-channel complex 0 5899 2 0 insulin receptor complex 0 5901 2 0 caveola 0 5902 1 0 microvillus 0 5905 5 1 coated pit 0 5911 49 8 intercellular junction 0 5912 56 7 adherens junction 0 5913 27 4 cell-cell adherens junction 0 5914 3 0 spot adherens junction 0 5915 9 1 zonula adherens 0 5918 17 3 septate junction 0 5919 3 1 pleated septate junction 0 5921 8 3 gap junction 0 5923 4 0 tight junction 0 5924 17 2 cell-substrate adherens junction 0 5925 16 2 focal adhesion 0 5927 1 0 muscle tendon junction 0 5929 1 0 cilium 0 5930 11 1 axoneme 0 5932 1 0 basal body 0 5938 52 7 cell cortex 0 5940 5 2 septin ring 0 5941 96 7 unlocalized protein complex 0 5942 5 0 phosphoinositide 3-kinase complex 0 5945 1 0 6-phosphofructokinase complex 0 5947 1 0 alpha-ketoglutarate dehydrogenase complex (sensu Eukaryota) 0 5952 9 0 cAMP-dependent protein kinase complex 0 5954 2 0 calcium- and calmodulin-dependent protein kinase complex 0 5955 5 0 calcineurin complex 0 5956 18 1 protein kinase CK2 complex 0 5958 2 0 DNA-dependent protein kinase complex 0 5960 4 1 glycine cleavage complex 0 5961 1 0 glycine dehydrogenase complex (decarboxylating) 0 5962 1 0 isocitrate dehydrogenase complex (NAD+) (sensu Eukaryota) 0 5964 3 0 phosphorylase kinase complex 0 5965 2 1 protein farnesyltransferase complex 0 5967 2 0 pyruvate dehydrogenase complex (sensu Eukaryota) 0 5968 5 1 Rab-protein geranylgeranyltransferase complex 0 5971 2 2 ribonucleoside-diphosphate reductase complex 0 5975 496 61 carbohydrate metabolism 0 5976 167 24 polysaccharide metabolism 0 5977 9 1 glycogen metabolism 0 5978 3 0 glycogen biosynthesis 0 5984 6 0 disaccharide metabolism 0 5991 5 0 trehalose metabolism 0 5992 3 0 trehalose biosynthesis 0 5996 102 15 monosaccharide metabolism 0 6000 1 1 fructose metabolism 0 6003 1 1 "fructose 2,6-bisphosphate metabolism" 0 6004 4 0 fucose metabolism 0 6005 2 0 L-fucose biosynthesis 0 6006 61 15 glucose metabolism 0 6007 52 15 glucose catabolism 0 6012 9 0 galactose metabolism 0 6013 1 0 mannose metabolism 0 6014 2 0 D-ribose metabolism 0 6020 7 0 myo-inositol metabolism 0 6021 1 0 myo-inositol biosynthesis 0 6022 13 1 aminoglycan metabolism 0 6023 13 1 aminoglycan biosynthesis 0 6024 13 1 glycosaminoglycan biosynthesis 0 6029 18 1 proteoglycan metabolism 0 6030 66 16 chitin metabolism 0 6032 7 1 chitin catabolism 0 6034 7 1 cuticle chitin metabolism 0 6036 7 1 cuticle chitin catabolism 0 6040 76 17 amino sugar metabolism 0 6041 75 17 glucosamine metabolism 0 6043 7 1 glucosamine catabolism 0 6044 75 17 N-acetylglucosamine metabolism 0 6046 7 1 N-acetylglucosamine catabolism 0 6054 1 0 N-acetylneuraminate metabolism 0 6055 1 0 CMP-N-acetylneuraminate biosynthesis 0 6066 166 25 alcohol metabolism 0 6067 1 0 ethanol metabolism 0 6069 1 0 ethanol oxidation 0 6071 10 0 glycerol metabolism 0 6072 9 0 glycerol-3-phosphate metabolism 0 6073 9 1 glucan metabolism 0 6081 2 2 aldehyde metabolism 0 6082 408 46 organic acid metabolism 0 6084 49 5 acetyl-CoA metabolism 0 6085 2 0 acetyl-CoA biosynthesis 0 6086 1 0 acetyl-CoA biosynthesis from pyruvate 0 6090 15 5 pyruvate metabolism 0 6091 529 113 generation of precursor metabolites and energy 0 6092 107 21 main pathways of carbohydrate metabolism 0 6094 6 2 gluconeogenesis 0 6096 40 12 glycolysis 0 6097 1 1 glyoxylate cycle 0 6098 12 4 pentose-phosphate shunt 0 6099 48 5 tricarboxylic acid cycle 0 6100 22 2 tricarboxylic acid cycle intermediate metabolism 0 6101 2 0 citrate metabolism 0 6103 2 1 2-oxoglutarate metabolism 0 6105 2 0 succinate metabolism 0 6106 6 1 fumarate metabolism 0 6108 10 1 malate metabolism 0 6112 14 1 energy reserve metabolism 0 6118 353 75 electron transport 0 6119 152 61 oxidative phosphorylation 0 6120 41 23 "mitochondrial electron transport, NADH to ubiquinone" 0 6121 2 0 "mitochondrial electron transport, succinate to ubiquinone" 0 6122 13 9 "mitochondrial electron transport, ubiquinol to cytochrome c" 0 6123 14 7 "mitochondrial electron transport, cytochrome c to oxygen" 0 6124 6 0 ferredoxin metabolism 0 6125 2 0 thioredoxin pathway 0 6127 2 0 glycerophosphate shuttle 0 6139 1981 306 "nucleobase, nucleoside, nucleotide and nucleic acid metabolism" 0 6144 57 12 purine base metabolism 0 6163 94 20 purine nucleotide metabolism 0 6164 92 20 purine nucleotide biosynthesis 0 6165 2 0 nucleoside diphosphate phosphorylation 0 6166 3 0 purine ribonucleoside salvage 0 6171 6 0 cAMP biosynthesis 0 6172 2 0 ADP biosynthesis 0 6177 2 1 GMP biosynthesis 0 6182 3 0 cGMP biosynthesis 0 6183 4 0 GTP biosynthesis 0 6188 7 0 IMP biosynthesis 0 6189 7 0 'de novo' IMP biosynthesis 0 6206 34 5 pyrimidine base metabolism 0 6207 5 1 'de novo' pyrimidine base biosynthesis 0 6208 2 0 pyrimidine base catabolism 0 6212 2 0 uracil catabolism 0 6213 4 1 pyrimidine nucleoside metabolism 0 6220 10 2 pyrimidine nucleotide metabolism 0 6221 9 1 pyrimidine nucleotide biosynthesis 0 6228 4 0 UTP biosynthesis 0 6230 1 0 TMP biosynthesis 0 6231 1 0 dTMP biosynthesis 0 6233 1 0 dTDP biosynthesis 0 6235 1 0 dTTP biosynthesis 0 6241 4 0 CTP biosynthesis 0 6259 477 86 DNA metabolism 0 6260 132 31 DNA replication 0 6261 66 15 DNA-dependent DNA replication 0 6264 4 1 mitochondrial DNA replication 0 6265 8 3 DNA topological change 0 6267 7 0 pre-replicative complex formation and maintenance 0 6268 8 5 DNA unwinding during replication 0 6269 2 1 "DNA replication, synthesis of RNA primer" 0 6270 13 0 DNA replication initiation 0 6271 7 3 DNA strand elongation 0 6272 2 1 leading strand elongation 0 6273 3 1 lagging strand elongation 0 6275 10 3 regulation of DNA replication 0 6277 17 7 DNA amplification 0 6281 115 21 DNA repair 0 6284 5 0 base-excision repair 0 6289 19 5 nucleotide-excision repair 0 6295 1 0 "nucleotide-excision repair, DNA incision, 3'-to lesion" 0 6296 1 0 "nucleotide-excision repair, DNA incision, 5'-to lesion" 0 6298 9 1 mismatch repair 0 6301 2 0 postreplication repair 0 6302 10 1 double-strand break repair 0 6303 3 0 double-strand break repair via nonhomologous end-joining 0 6304 24 3 DNA modification 0 6305 19 1 DNA alkylation 0 6306 19 1 DNA methylation 0 6307 1 0 DNA dealkylation 0 6308 12 2 DNA catabolism 0 6309 3 0 DNA fragmentation during apoptosis 0 6310 45 9 DNA recombination 0 6311 2 0 meiotic gene conversion 0 6312 2 0 mitotic recombination 0 6313 2 1 DNA transposition 0 6323 223 36 DNA packaging 0 6325 223 36 establishment and/or maintenance of chromatin architecture 0 6333 176 27 chromatin assembly or disassembly 0 6334 27 10 nucleosome assembly 0 6335 1 0 DNA replication-dependent nucleosome assembly 0 6338 112 6 chromatin remodeling 0 6342 92 2 chromatin silencing 0 6343 1 1 establishment of chromatin silencing 0 6348 2 0 chromatin silencing at telomere 0 6350 1075 127 transcription 0 6351 1018 121 "transcription, DNA-dependent" 0 6352 91 19 transcription initiation 0 6353 2 0 transcription termination 0 6354 23 6 RNA elongation 0 6355 896 96 "regulation of transcription, DNA-dependent" 0 6356 1 0 regulation of transcription from RNA polymerase I promoter 0 6357 576 60 regulation of transcription from RNA polymerase II promoter 0 6359 6 2 regulation of transcription from RNA polymerase III promoter 0 6360 7 1 transcription from RNA polymerase I promoter 0 6364 19 7 rRNA processing 0 6365 2 0 35S primary transcript processing 0 6366 720 88 transcription from RNA polymerase II promoter 0 6367 89 19 transcription initiation from RNA polymerase II promoter 0 6368 18 4 RNA elongation from RNA polymerase II promoter 0 6369 1 0 transcription termination from RNA polymerase II promoter 0 6370 2 1 mRNA capping 0 6374 26 1 nuclear mRNA splicing via U2-type spliceosome 0 6375 3 0 nuclear mRNA splicing via U12-type spliceosome 0 6376 8 4 mRNA splice site selection 0 6378 21 7 mRNA polyadenylylation 0 6379 14 5 mRNA cleavage 0 6381 1 0 mRNA editing 0 6382 1 0 adenosine to inosine editing 0 6383 20 3 transcription from RNA polymerase III promoter 0 6384 1 0 transcription initiation from RNA polymerase III promoter 0 6388 5 0 tRNA splicing 0 6390 1 0 transcription from mitochondrial promoter 0 6393 1 0 RNA transcription termination from mitochondrial promoter 0 6396 301 64 RNA processing 0 6397 245 52 mRNA processing 0 6398 17 5 histone mRNA 3'-end processing 0 6399 96 17 tRNA metabolism 0 6400 7 1 tRNA modification 0 6401 24 5 RNA catabolism 0 6402 10 1 mRNA catabolism 0 6403 124 19 RNA localization 0 6404 1 1 RNA import into nucleus 0 6405 21 4 RNA export from nucleus 0 6406 17 3 mRNA export from nucleus 0 6408 2 0 snRNA export from nucleus 0 6409 1 0 tRNA export from nucleus 0 6410 7 1 "transcription, RNA-dependent" 0 6412 745 162 protein biosynthesis 0 6413 61 20 translational initiation 0 6414 23 9 translational elongation 0 6415 5 1 translational termination 0 6417 86 18 regulation of protein biosynthesis 0 6418 68 11 tRNA aminoacylation for protein translation 0 6419 4 0 alanyl-tRNA aminoacylation 0 6420 3 2 arginyl-tRNA aminoacylation 0 6421 2 0 asparaginyl-tRNA aminoacylation 0 6422 7 0 aspartyl-tRNA aminoacylation 0 6423 2 0 cysteinyl-tRNA aminoacylation 0 6424 3 0 glutamyl-tRNA aminoacylation 0 6425 2 1 glutaminyl-tRNA aminoacylation 0 6426 1 0 glycyl-tRNA aminoacylation 0 6427 2 0 histidyl-tRNA aminoacylation 0 6428 3 0 isoleucyl-tRNA aminoacylation 0 6429 1 0 leucyl-tRNA aminoacylation 0 6430 3 0 lysyl-tRNA aminoacylation 0 6431 3 0 methionyl-tRNA aminoacylation 0 6432 5 0 phenylalanyl-tRNA aminoacylation 0 6433 2 0 prolyl-tRNA aminoacylation 0 6434 4 1 seryl-tRNA aminoacylation 0 6435 2 2 threonyl-tRNA aminoacylation 0 6436 2 1 tryptophanyl-tRNA aminoacylation 0 6437 2 0 tyrosyl-tRNA aminoacylation 0 6438 2 0 valyl-tRNA aminoacylation 0 6445 83 18 regulation of translation 0 6446 13 1 regulation of translational initiation 0 6447 3 0 regulation of translational initiation by iron 0 6448 1 1 regulation of translational elongation 0 6457 138 39 protein folding 0 6458 11 3 'de novo' protein folding 0 6461 128 33 protein complex assembly 0 6464 892 108 protein modification 0 6465 4 3 signal peptide processing 0 6468 316 32 protein amino acid phosphorylation 0 6469 2 0 negative regulation of protein kinase activity 0 6470 96 8 protein amino acid dephosphorylation 0 6471 18 4 protein amino acid ADP-ribosylation 0 6473 14 2 protein amino acid acetylation 0 6476 5 0 protein amino acid deacetylation 0 6479 24 2 protein amino acid methylation 0 6481 1 0 C-terminal protein amino acid methylation 0 6486 83 9 protein amino acid glycosylation 0 6487 14 1 protein amino acid N-linked glycosylation 0 6488 1 0 dolichol-linked oligosaccharide biosynthesis 0 6493 3 1 protein amino acid O-linked glycosylation 0 6494 1 0 protein amino acid terminal glycosylation 0 6496 1 0 protein amino acid terminal N-glycosylation 0 6497 30 5 protein amino acid lipidation 0 6499 2 2 N-terminal protein myristoylation 0 6500 1 0 N-terminal protein palmitoylation 0 6505 7 1 GPI anchor metabolism 0 6506 7 1 GPI anchor biosynthesis 0 6508 775 105 proteolysis 0 6509 2 0 membrane protein ectodomain proteolysis 0 6510 19 10 ATP-dependent proteolysis 0 6511 76 30 ubiquitin-dependent protein catabolism 0 6512 193 29 ubiquitin cycle 0 6513 1 0 protein monoubiquitination 0 6515 1 0 misfolded or incompletely synthesized protein catabolism 0 6516 5 1 glycoprotein catabolism 0 6518 8 3 peptide metabolism 0 6519 311 39 amino acid and derivative metabolism 0 6520 276 33 amino acid metabolism 0 6521 14 0 regulation of amino acid metabolism 0 6522 1 0 alanine metabolism 0 6523 1 0 alanine biosynthesis 0 6525 4 1 arginine metabolism 0 6526 3 1 arginine biosynthesis 0 6527 1 0 arginine catabolism 0 6528 2 0 asparagine metabolism 0 6529 2 0 asparagine biosynthesis 0 6531 2 0 aspartate metabolism 0 6534 1 0 cysteine metabolism 0 6535 1 0 cysteine biosynthesis from serine 0 6536 9 2 glutamate metabolism 0 6537 5 0 glutamate biosynthesis 0 6538 4 2 glutamate catabolism 0 6541 3 1 glutamine metabolism 0 6542 1 1 glutamine biosynthesis 0 6544 6 1 glycine metabolism 0 6545 1 0 glycine biosynthesis 0 6546 3 1 glycine catabolism 0 6549 1 0 isoleucine metabolism 0 6550 1 0 isoleucine catabolism 0 6551 4 0 leucine metabolism 0 6552 1 0 leucine catabolism 0 6553 1 0 lysine metabolism 0 6554 1 0 lysine catabolism 0 6555 3 0 methionine metabolism 0 6556 1 0 S-adenosylmethionine biosynthesis 0 6558 6 1 L-phenylalanine metabolism 0 6559 5 1 L-phenylalanine catabolism 0 6560 7 0 proline metabolism 0 6561 4 0 proline biosynthesis 0 6562 2 0 proline catabolism 0 6563 11 3 L-serine metabolism 0 6564 10 3 L-serine biosynthesis 0 6566 1 0 threonine metabolism 0 6567 1 0 threonine catabolism 0 6568 6 2 tryptophan metabolism 0 6569 2 1 tryptophan catabolism 0 6570 8 0 tyrosine metabolism 0 6572 3 0 tyrosine catabolism 0 6573 3 1 valine metabolism 0 6574 1 0 valine catabolism 0 6575 53 9 amino acid derivative metabolism 0 6576 33 8 biogenic amine metabolism 0 6580 1 1 ethanolamine metabolism 0 6581 1 0 acetylcholine catabolism 0 6582 9 0 melanin metabolism 0 6583 4 0 melanin biosynthesis from tyrosine 0 6584 16 4 catecholamine metabolism 0 6585 1 0 dopamine biosynthesis from tyrosine 0 6586 8 2 indolalkylamine metabolism 0 6587 2 1 serotonin biosynthesis from tryptophan 0 6588 1 1 tryptophan hydroxylase activation 0 6589 1 0 octopamine biosynthesis 0 6591 2 0 ornithine metabolism 0 6595 6 1 polyamine metabolism 0 6596 5 1 polyamine biosynthesis 0 6597 1 0 spermine biosynthesis 0 6598 1 0 polyamine catabolism 0 6605 241 46 protein targeting 0 6606 52 3 protein import into nucleus 0 6607 3 0 NLS-bearing substrate import into nucleus 0 6608 1 0 snRNP protein import into nucleus 0 6611 6 0 protein export from nucleus 0 6612 20 11 protein targeting to membrane 0 6613 18 10 cotranslational protein targeting to membrane 0 6614 17 9 SRP-dependent cotranslational protein targeting to membrane 0 6616 5 3 "SRP-dependent cotranslational protein targeting to membrane, translocation" 0 6617 1 1 "SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition" 0 6621 3 1 protein retention in ER 0 6622 2 0 protein targeting to lysosome 0 6623 1 1 protein targeting to vacuole 0 6625 10 0 protein targeting to peroxisome 0 6626 36 6 protein targeting to mitochondrion 0 6627 2 1 mitochondrial protein processing 0 6629 495 34 lipid metabolism 0 6631 103 8 fatty acid metabolism 0 6633 30 4 fatty acid biosynthesis 0 6635 22 2 fatty acid beta-oxidation 0 6636 1 0 fatty acid desaturation 0 6637 20 0 acyl-CoA metabolism 0 6638 5 0 neutral lipid metabolism 0 6639 5 0 acylglycerol metabolism 0 6641 2 0 triacylglycerol metabolism 0 6643 89 4 membrane lipid metabolism 0 6644 78 4 phospholipid metabolism 0 6646 1 1 phosphatidylethanolamine biosynthesis 0 6650 19 2 glycerophospholipid metabolism 0 6651 3 0 diacylglycerol biosynthesis 0 6654 1 0 phosphatidic acid biosynthesis 0 6658 1 0 phosphatidylserine metabolism 0 6659 1 0 phosphatidylserine biosynthesis 0 6661 2 0 phosphatidylinositol biosynthesis 0 6662 6 0 glycerol ether metabolism 0 6664 5 0 glycolipid metabolism 0 6665 15 0 sphingolipid metabolism 0 6670 2 0 sphingosine metabolism 0 6672 1 0 ceramide metabolism 0 6684 5 0 sphingomyelin metabolism 0 6685 3 0 sphingomyelin catabolism 0 6686 1 0 sphingomyelin biosynthesis 0 6687 3 0 glycosphingolipid metabolism 0 6688 3 0 glycosphingolipid biosynthesis 0 6694 12 1 steroid biosynthesis 0 6695 1 0 cholesterol biosynthesis 0 6697 5 0 ecdysone biosynthesis 0 6706 1 0 steroid catabolism 0 6707 1 0 cholesterol catabolism 0 6714 7 0 sesquiterpenoid metabolism 0 6716 7 0 juvenile hormone metabolism 0 6718 3 0 juvenile hormone biosynthesis 0 6719 4 0 juvenile hormone catabolism 0 6720 14 2 isoprenoid metabolism 0 6721 8 0 terpenoid metabolism 0 6723 1 0 cuticle hydrocarbon biosynthesis 0 6725 160 27 aromatic compound metabolism 0 6726 31 4 eye pigment biosynthesis 0 6727 21 2 ommochrome biosynthesis 0 6728 3 0 pteridine biosynthesis 0 6729 4 1 tetrahydrobiopterin biosynthesis 0 6730 20 3 one-carbon compound metabolism 0 6732 242 36 coenzyme metabolism 0 6733 20 5 oxidoreduction coenzyme metabolism 0 6739 12 4 NADP metabolism 0 6740 12 4 NADPH regeneration 0 6743 5 1 ubiquinone metabolism 0 6744 3 0 ubiquinone biosynthesis 0 6748 1 0 lipoamide metabolism 0 6749 4 0 glutathione metabolism 0 6750 4 0 glutathione biosynthesis 0 6752 73 19 group transfer coenzyme metabolism 0 6753 65 18 nucleoside phosphate metabolism 0 6754 65 18 ATP biosynthesis 0 6760 7 1 folic acid and derivative metabolism 0 6766 37 7 vitamin metabolism 0 6767 23 6 water-soluble vitamin metabolism 0 6769 14 4 nicotinamide metabolism 0 6771 2 0 riboflavin metabolism 0 6772 1 0 thiamin metabolism 0 6775 2 0 fat-soluble vitamin metabolism 0 6776 1 0 vitamin A metabolism 0 6777 7 0 Mo-molybdopterin cofactor biosynthesis 0 6778 14 1 porphyrin metabolism 0 6779 12 1 porphyrin biosynthesis 0 6782 1 0 protoporphyrinogen IX biosynthesis 0 6783 11 1 heme biosynthesis 0 6787 1 0 porphyrin catabolism 0 6788 1 0 heme oxidation 0 6790 63 9 sulfur metabolism 0 6791 1 1 sulfur utilization 0 6793 661 107 phosphorus metabolism 0 6796 661 107 phosphate metabolism 0 6797 1 0 polyphosphate metabolism 0 6798 1 0 polyphosphate catabolism 0 6800 69 22 oxygen and reactive oxygen species metabolism 0 6801 9 4 superoxide metabolism 0 6805 9 0 xenobiotic metabolism 0 6807 415 57 nitrogen compound metabolism 0 6809 1 0 nitric oxide biosynthesis 0 6810 1906 256 transport 0 6811 476 45 ion transport 0 6812 396 40 cation transport 0 6813 61 3 potassium ion transport 0 6814 47 1 sodium ion transport 0 6816 29 1 calcium ion transport 0 6817 43 1 phosphate transport 0 6818 80 24 hydrogen transport 0 6820 100 6 anion transport 0 6821 8 0 chloride transport 0 6825 6 2 copper ion transport 0 6826 4 0 iron ion transport 0 6829 1 0 zinc ion transport 0 6833 2 0 water transport 0 6835 5 0 dicarboxylic acid transport 0 6836 24 1 neurotransmitter transport 0 6839 17 2 mitochondrial transport 0 6842 5 1 tricarboxylic acid transport 0 6844 2 1 acyl carnitine transport 0 6855 2 0 multidrug transport 0 6856 5 0 eye pigment precursor transport 0 6857 3 0 oligopeptide transport 0 6858 126 2 extracellular transport 0 6862 2 1 nucleotide transport 0 6865 46 0 amino acid transport 0 6869 59 8 lipid transport 0 6873 23 1 cell ion homeostasis 0 6874 14 0 calcium ion homeostasis 0 6875 23 1 metal ion homeostasis 0 6879 7 1 iron ion homeostasis 0 6884 1 0 regulation of cell volume 0 6885 5 1 regulation of pH 0 6886 536 97 intracellular protein transport 0 6887 143 16 exocytosis 0 6888 16 3 ER to Golgi transport 0 6890 8 3 "retrograde transport, Golgi to ER" 0 6891 13 1 intra-Golgi transport 0 6892 6 1 post-Golgi transport 0 6893 2 0 Golgi to plasma membrane transport 0 6895 1 0 Golgi to endosome transport 0 6897 128 20 endocytosis 0 6898 41 6 receptor mediated endocytosis 0 6900 4 3 vesicle budding 0 6901 15 3 vesicle coating 0 6903 15 2 vesicle targeting 0 6904 33 3 vesicle docking during exocytosis 0 6907 6 1 pinocytosis 0 6909 19 3 phagocytosis 0 6910 1 0 "phagocytosis, recognition" 0 6911 2 0 "phagocytosis, engulfment" 0 6913 78 9 nucleocytoplasmic transport 0 6914 20 4 autophagy 0 6915 192 25 apoptosis 0 6916 43 6 anti-apoptosis 0 6917 65 10 induction of apoptosis 0 6919 2 0 caspase activation 0 6921 4 0 disassembly of cell structures during apoptosis 0 6922 1 0 cleavage of lamin 0 6923 1 0 cleavage of cytoskeletal proteins 0 6928 332 41 cell motility 0 6935 9 0 chemotaxis 0 6936 93 7 muscle contraction 0 6937 3 0 regulation of muscle contraction 0 6939 3 0 smooth muscle contraction 0 6941 1 0 striated muscle contraction 0 6944 2 0 membrane fusion 0 6950 371 56 response to stress 0 6952 541 65 defense response 0 6954 10 1 inflammatory response 0 6955 136 7 immune response 0 6959 91 3 humoral immune response 0 6960 46 1 antimicrobial humoral response (sensu Protostomia) 0 6961 24 1 antibacterial humoral response (sensu Protostomia) 0 6962 1 0 male-specific antibacterial humoral response 0 6963 20 2 antibacterial polypeptide induction 0 6964 1 0 anti-Gram-negative bacterial polypeptide induction 0 6965 4 0 anti-Gram-positive bacterial polypeptide induction 0 6966 9 0 antifungal humoral response (sensu Protostomia) 0 6967 8 0 antifungal polypeptide induction 0 6968 13 0 cellular defense response 0 6970 3 0 response to osmotic stress 0 6974 123 22 response to DNA damage stimulus 0 6979 18 7 response to oxidative stress 0 6980 1 0 redox signal response 0 6982 1 1 response to lipid hydroperoxide 0 6983 1 0 ER overload response 0 6984 1 0 ER-nuclear signaling pathway 0 6986 2 0 response to unfolded protein 0 6996 940 152 organelle organization and biogenesis 0 6997 24 5 nuclear organization and biogenesis 0 6998 5 0 nuclear membrane organization and biogenesis 0 7000 2 2 nucleolus organization and biogenesis 0 7001 249 41 chromosome organization and biogenesis (sensu Eukaryota) 0 7005 21 4 mitochondrion organization and biogenesis 0 7006 7 2 mitochondrial membrane organization and biogenesis 0 7007 6 2 inner mitochondrial membrane organization and biogenesis 0 7009 8 2 plasma membrane organization and biogenesis 0 7010 557 85 cytoskeleton organization and biogenesis 0 7015 70 9 actin filament organization 0 7016 19 2 cytoskeletal anchoring 0 7017 219 34 microtubule-based process 0 7018 114 15 microtubule-based movement 0 7019 11 2 microtubule depolymerization 0 7020 5 0 microtubule nucleation 0 7021 3 0 tubulin folding 0 7022 1 0 chaperonin-mediated tubulin folding 0 7026 10 2 negative regulation of microtubule depolymerization 0 7028 55 16 cytoplasm organization and biogenesis 0 7029 1 0 endoplasmic reticulum organization and biogenesis 0 7030 7 1 Golgi organization and biogenesis 0 7031 14 1 peroxisome organization and biogenesis 0 7032 14 1 endosome organization and biogenesis 0 7033 30 4 vacuole organization and biogenesis 0 7034 22 3 vacuolar transport 0 7040 30 4 lysosome organization and biogenesis 0 7041 22 3 lysosomal transport 0 7043 23 2 intercellular junction assembly 0 7046 28 12 ribosome biogenesis 0 7047 1 0 cell wall organization and biogenesis 0 7049 661 88 cell cycle 0 7050 5 1 cell cycle arrest 0 7051 36 7 spindle organization and biogenesis 0 7052 18 5 mitotic spindle organization and biogenesis 0 7053 2 0 male meiotic spindle assembly (sensu Metazoa) 0 7054 1 0 male meiosis I spindle assembly (sensu Metazoa) 0 7056 5 1 female meiotic spindle assembly (sensu Metazoa) 0 7058 1 0 female meiosis II spindle assembly (sensu Metazoa) 0 7059 178 25 chromosome segregation 0 7060 13 0 male meiosis chromosome segregation 0 7062 16 2 sister chromatid cohesion 0 7064 4 1 mitotic sister chromatid cohesion 0 7065 1 0 male meiosis sister chromatid cohesion 0 7066 1 0 female meiosis sister chromatid cohesion 0 7067 288 44 mitosis 0 7068 4 2 "negative regulation of transcription, mitotic" 0 7070 4 2 "negative regulation of transcription from RNA polymerase II promoter, mitotic" 0 7076 18 2 mitotic chromosome condensation 0 7079 1 1 mitotic chromosome movement towards spindle pole 0 7080 2 0 mitotic metaphase plate congression 0 7084 2 0 mitotic nuclear envelope reassembly 0 7088 36 7 regulation of mitosis 0 7091 5 0 mitotic metaphase/anaphase transition 0 7093 15 3 mitotic checkpoint 0 7094 10 2 mitotic spindle checkpoint 0 7096 5 2 regulation of exit from mitosis 0 7097 26 4 nuclear migration 0 7098 17 5 centrosome cycle 0 7099 1 0 centriole replication 0 7100 5 2 mitotic centrosome separation 0 7109 1 0 "cytokinesis, completion of separation" 0 7110 10 0 cytokinesis after meiosis I 0 7111 9 0 cytokinesis after meiosis II 0 7112 1 0 male meiosis cytokinesis 0 7113 3 2 endomitotic cell cycle 0 7126 226 12 meiosis 0 7127 35 1 meiosis I 0 7129 1 0 synapsis 0 7131 18 0 meiotic recombination 0 7132 1 0 meiotic metaphase I 0 7133 2 0 meiotic anaphase I 0 7140 102 1 male meiosis 0 7141 10 0 male meiosis I 0 7143 80 10 female meiosis 0 7146 1 0 meiotic recombination nodule assembly 0 7147 1 0 female meiosis II 0 7154 1640 144 cell communication 0 7155 313 38 cell adhesion 0 7156 29 8 homophilic cell adhesion 0 7157 12 4 heterophilic cell adhesion 0 7158 2 1 neuron adhesion 0 7160 30 6 cell-matrix adhesion 0 7163 80 12 establishment and/or maintenance of cell polarity 0 7164 52 10 establishment of tissue polarity 0 7165 1366 128 signal transduction 0 7166 715 63 cell surface receptor linked signal transduction 0 7167 194 24 enzyme linked receptor protein signaling pathway 0 7169 138 23 transmembrane receptor protein tyrosine kinase signaling pathway 0 7173 44 5 epidermal growth factor receptor signaling pathway 0 7174 2 0 epidermal growth factor ligand processing 0 7175 2 0 negative regulation of epidermal growth factor receptor activity 0 7176 4 0 regulation of epidermal growth factor receptor activity 0 7178 59 1 transmembrane receptor protein serine/threonine kinase signaling pathway 0 7179 36 1 transforming growth factor beta receptor signaling pathway 0 7181 1 0 transforming growth factor beta receptor complex assembly 0 7185 1 1 transmembrane receptor protein tyrosine phosphatase signaling pathway 0 7186 321 16 G-protein coupled receptor protein signaling pathway 0 7187 8 1 "G-protein signaling, coupled to cyclic nucleotide second messenger" 0 7188 8 1 "G-protein signaling, coupled to cAMP nucleotide second messenger" 0 7189 3 0 "G-protein signaling, adenylate cyclase activating pathway" 0 7190 2 0 adenylate cyclase activation 0 7192 1 0 "serotonin receptor, adenylate cyclase activating pathway" 0 7193 2 0 "G-protein signaling, adenylate cyclase inhibiting pathway" 0 7198 2 0 "serotonin receptor, adenylate cyclase inhibiting pathway" 0 7200 16 1 "G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" 0 7202 2 1 phospholipase C activation 0 7204 3 0 elevation of cytosolic calcium ion concentration 0 7205 8 0 protein kinase C activation 0 7208 2 0 "serotonin receptor, phospholipase C activating pathway" 0 7210 5 0 serotonin receptor signaling pathway 0 7211 2 0 octopamine/tyramine signaling pathway 0 7212 3 0 dopamine receptor signaling pathway 0 7213 2 0 "acetylcholine receptor signaling, muscarinic pathway" 0 7214 1 0 gamma-aminobutyric acid signaling pathway 0 7215 5 0 glutamate signaling pathway 0 7216 3 0 metabotropic glutamate receptor signaling pathway 0 7217 5 0 tachykinin signaling pathway 0 7218 36 1 neuropeptide signaling pathway 0 7219 44 3 Notch signaling pathway 1 7220 4 0 Notch receptor processing 0 7222 21 6 frizzled signaling pathway 1 7223 10 1 frizzled-2 signaling pathway 0 7224 37 3 smoothened signaling pathway 0 7225 1 0 patched ligand processing 0 7227 5 0 signal transduction downstream of smoothened 0 7228 5 0 activation of hh target transcription factor 0 7229 3 0 integrin-mediated signaling pathway 0 7231 1 0 osmosensory signaling pathway 0 7242 553 48 intracellular signaling cascade 0 7243 143 16 protein kinase cascade 0 7249 10 1 I-kappaB kinase/NF-kappaB cascade 0 7254 54 8 JNK cascade 0 7256 2 0 activation of JNKK activity 0 7257 2 1 activation of JNK activity 0 7258 1 0 JUN phosphorylation 0 7259 20 0 JAK-STAT cascade 0 7260 2 0 tyrosine phosphorylation of STAT protein 0 7262 2 0 STAT protein nuclear translocation 0 7263 14 0 nitric oxide mediated signal transduction 0 7264 121 17 small GTPase mediated signal transduction 0 7265 25 5 Ras protein signal transduction 0 7266 5 0 Rho protein signal transduction 0 7267 501 33 cell-cell signaling 0 7268 273 15 synaptic transmission 0 7269 128 9 neurotransmitter secretion 0 7270 59 0 nerve-nerve synaptic transmission 0 7271 1 0 "synaptic transmission, cholinergic" 0 7274 32 1 neuromuscular synaptic transmission 0 7275 2278 190 development 1 7276 746 70 gametogenesis 0 7277 24 1 pole cell development 0 7278 4 1 pole cell fate determination 0 7279 20 0 pole cell formation 0 7280 21 3 pole cell migration 0 7281 169 16 germ cell development 0 7282 13 1 cystoblast division 0 7283 168 14 spermatogenesis 0 7284 4 0 spermatogonial cell division 0 7285 2 0 primary spermatocyte growth 0 7286 73 7 spermatid development 0 7287 3 0 Nebenkern formation 0 7288 6 0 sperm axoneme assembly 0 7289 4 0 spermatid nuclear differentiation 0 7291 20 2 sperm individualization 0 7292 541 52 female gamete generation 0 7293 58 4 egg chamber formation (sensu Insecta) 0 7294 19 2 oocyte fate determination (sensu Insecta) 0 7295 2 0 egg chamber growth (sensu Insecta) 0 7296 9 0 vitellogenesis 0 7297 56 2 follicle cell migration (sensu Insecta) 0 7298 44 1 border follicle cell migration (sensu Insecta) 0 7299 3 0 follicle cell adhesion (sensu Insecta) 0 7300 50 6 nurse cell to oocyte transport (sensu Insecta) 0 7301 15 1 ovarian ring canal formation 0 7303 12 1 "cytoplasmic transport, nurse cell to oocyte" 0 7304 86 10 eggshell formation (sensu Insecta) 0 7305 8 0 vitelline membrane formation (sensu Insecta) 0 7306 60 8 insect chorion formation 0 7307 16 7 chorion gene amplification 0 7308 122 15 oocyte construction 0 7309 119 15 oocyte axis determination 0 7310 37 4 oocyte dorsal/ventral axis determination 0 7311 10 2 "maternal determination of dorsal/ventral axis, oocyte, germ-line encoded" 0 7312 7 1 oocyte nucleus migration during oocyte axis determination 0 7313 3 0 "maternal determination of dorsal/ventral axis, oocyte, soma encoded" 0 7314 88 10 oocyte anterior/posterior axis determination 0 7315 69 6 pole plasm assembly 0 7316 61 5 pole plasm RNA localization 0 7317 22 2 regulation of pole plasm oskar mRNA localization 0 7318 7 1 pole plasm protein localization 0 7319 9 1 negative regulation of oskar mRNA translation 0 7320 13 3 insemination 0 7321 5 0 sperm displacement 0 7338 32 2 fertilization (sensu Metazoa) 0 7343 14 0 egg activation 0 7344 10 2 pronuclear fusion 0 7346 28 1 regulation of progression through mitotic cell cycle 0 7347 3 0 regulation of progression through preblastoderm mitotic cell cycle 0 7348 6 0 regulation of progression through syncytial blastoderm mitotic cell cycle 0 7349 56 5 cellularization 0 7350 141 15 blastoderm segmentation 0 7351 74 11 regional subdivision 0 7352 7 1 zygotic determination of dorsal/ventral axis 0 7354 32 8 "zygotic determination of anterior/posterior axis, embryo" 0 7355 5 1 anterior region determination 0 7362 23 7 terminal region determination 0 7365 36 1 periodic partitioning 0 7366 6 0 periodic partitioning by pair rule gene 0 7367 23 1 segment polarity determination 0 7368 2 0 determination of left/right symmetry 0 7369 74 7 gastrulation 0 7370 9 1 ventral furrow formation 0 7374 5 1 posterior midgut invagination 0 7375 4 0 anterior midgut invagination 0 7376 2 0 cephalic furrow formation 0 7377 9 1 germ-band extension 0 7378 7 1 amnioserosa formation 0 7379 51 2 segment specification 0 7380 9 0 "specification of segmental identity, head" 0 7381 2 0 "specification of segmental identity, labial segment" 0 7382 2 0 "specification of segmental identity, maxillary segment" 0 7383 1 0 "specification of segmental identity, antennal segment" 0 7384 2 0 "specification of segmental identity, thorax" 0 7385 5 0 "specification of segmental identity, abdomen" 0 7386 5 0 compartment specification 0 7388 1 0 posterior compartment specification 0 7389 381 37 pattern specification 1 7390 13 1 germ-band shortening 0 7391 92 12 dorsal closure 0 7392 13 4 initiation of dorsal closure 0 7393 4 1 "dorsal closure, leading edge cell fate determination" 0 7394 6 1 "dorsal closure, elongation of leading edge cells" 0 7395 3 2 "dorsal closure, spreading of leading edge cells" 0 7396 2 0 suture of dorsal opening 0 7398 253 26 ectoderm development 0 7399 649 62 nervous system development 0 7400 37 2 neuroblast fate determination 0 7402 7 1 ganglion mother cell fate determination 0 7403 3 1 glial cell fate determination 0 7405 6 2 neuroblast proliferation 0 7406 2 0 negative regulation of neuroblast proliferation 0 7409 160 26 axonogenesis 0 7411 110 17 axon guidance 0 7412 6 2 axon target recognition 0 7413 13 3 axonal fasciculation 0 7414 6 0 axonal defasciculation 0 7415 6 0 defasciculation of motor neuron 0 7416 29 3 synaptogenesis 0 7417 169 18 central nervous system development 0 7418 1 1 ventral midline development 0 7419 29 2 ventral cord development 0 7420 73 11 brain development 0 7421 1 0 stomatogastric nervous system development 0 7422 169 13 peripheral nervous system development 0 7423 91 5 sensory organ development 0 7424 127 13 tracheal system development (sensu Insecta) 1 7425 9 0 tracheal epithelial cell fate determination (sensu Insecta) 0 7426 16 2 tracheal outgrowth (sensu Insecta) 0 7427 27 2 tracheal epithelial cell migration (sensu Insecta) 0 7428 15 3 primary tracheal branching (sensu Insecta) 0 7429 4 1 secondary tracheal branching (sensu Insecta) 0 7430 12 0 "terminal branching of trachea, cytoplasmic projection extension (sensu Insecta)" 0 7431 114 9 salivary gland development 0 7432 16 0 salivary gland determination 0 7435 16 1 salivary gland morphogenesis 0 7436 2 0 larval salivary gland morphogenesis 0 7438 7 0 oenocyte development 0 7439 51 4 ectodermal gut development 0 7440 14 1 foregut morphogenesis 0 7442 47 3 hindgut morphogenesis 0 7443 30 3 Malpighian tubule morphogenesis 0 7444 523 45 imaginal disc development 0 7446 30 3 imaginal disc growth 0 7447 51 4 imaginal disc pattern formation 0 7448 18 1 "anterior/posterior pattern formation, imaginal disc" 0 7449 20 1 "proximal/distal pattern formation, imaginal disc" 0 7450 20 2 "dorsal/ventral pattern formation, imaginal disc" 0 7451 7 1 "dorsal/ventral lineage restriction, imaginal disc" 0 7455 316 23 eye-antennal disc morphogenesis 0 7456 343 25 eye development (sensu Endopterygota) 0 7458 10 0 progression of morphogenetic furrow (sensu Endopterygota) 0 7459 52 9 photoreceptor fate commitment (sensu Endopterygota) 0 7460 11 0 R8 cell fate commitment 0 7461 6 0 restriction of R8 fate 0 7462 3 0 R1/R6 cell fate commitment 0 7464 9 2 R3/R4 cell fate commitment 0 7465 21 5 R7 cell fate commitment 0 7466 10 0 cone cell fate commitment (sensu Endopterygota) 0 7467 102 16 photoreceptor cell differentiation (sensu Endopterygota) 0 7469 24 3 antennal morphogenesis 0 7472 168 19 wing disc morphogenesis 0 7473 7 0 wing disc proximal/distal pattern formation 0 7474 19 1 wing vein specification 0 7475 36 4 apposition of dorsal and ventral wing surfaces 0 7476 165 18 wing morphogenesis 0 7477 3 0 notum morphogenesis 0 7478 26 0 leg disc morphogenesis 0 7479 15 1 leg disc proximal/distal pattern formation 0 7480 23 0 leg morphogenesis (sensu Endopterygota) 0 7481 1 1 haltere disc morphogenesis 0 7482 1 0 haltere development 0 7483 12 1 genital disc morphogenesis 0 7484 7 1 genitalia morphogenesis (sensu Endopterygota) 0 7485 5 1 male genitalia morphogenesis (sensu Endopterygota) 0 7486 3 1 female genitalia morphogenesis (sensu Endopterygota) 0 7487 8 1 analia morphogenesis (sensu Endopterygota) 0 7488 1 0 histoblast morphogenesis 0 7489 1 0 maintenance of imaginal histoblast diploidy 0 7492 16 1 endoderm development 0 7493 1 1 endodermal cell fate determination 0 7494 29 1 midgut development 0 7496 1 0 anterior midgut development 0 7497 1 0 posterior midgut development 0 7498 215 22 mesoderm development 0 7499 3 0 ectoderm and mesoderm interaction 0 7500 5 1 mesodermal cell fate determination 0 7501 12 0 mesodermal cell fate specification 0 7502 3 0 gut mesoderm development 0 7503 2 0 fat body development 0 7506 10 1 gonadal mesoderm development 0 7507 69 6 heart development 0 7508 1 0 larval heart development 0 7509 12 1 mesoderm migration 0 7510 4 0 cardioblast cell fate determination 0 7513 7 2 pericardial cell differentiation 0 7516 2 0 hemocyte development 0 7517 131 14 muscle development 0 7518 1 0 myoblast cell fate determination 0 7519 54 4 striated muscle development 0 7520 19 0 myoblast fusion 0 7521 3 1 muscle cell fate determination 0 7522 9 1 visceral muscle development 0 7523 5 1 larval visceral muscle development 0 7525 11 3 somatic muscle development 0 7526 2 0 larval somatic muscle development 0 7528 20 1 neuromuscular junction development 0 7530 50 5 sex determination 0 7531 1 0 mating type determination 0 7533 1 0 mating type switching 0 7534 1 0 gene conversion at mating-type locus 0 7538 17 1 primary sex determination 0 7539 14 1 "primary sex determination, soma" 0 7540 5 1 "sex determination, establishment of X:A ratio" 0 7541 6 0 "sex determination, primary response to X:A ratio" 0 7542 1 0 "primary sex determination, germ-line" 0 7544 1 0 "sex determination, female germ-line determination" 0 7548 57 6 sex differentiation 0 7549 14 1 dosage compensation 0 7552 479 43 metamorphosis 1 7553 1 0 regulation of ecdysteroid metabolism 0 7555 1 0 regulation of ecdysteroid secretion 0 7556 2 0 regulation of juvenile hormone metabolism 0 7557 2 0 regulation of juvenile hormone biosynthesis 0 7559 74 9 histolysis 0 7560 464 39 imaginal disc morphogenesis 0 7561 4 0 imaginal disc eversion 0 7562 19 1 eclosion 0 7563 3 0 regulation of eclosion 0 7564 2 0 regulation of cuticle tanning 0 7568 52 5 aging 1 7582 7848 1013 physiological process 1 7584 12 1 response to nutrient 0 7586 4 0 digestion 0 7588 5 0 excretion 0 7589 5 0 fluid secretion 0 7591 34 2 molting cycle (sensu Insecta) 0 7592 26 4 cuticle biosynthesis (sensu Protostomia and Nematoda) 0 7593 3 0 cuticle tanning 0 7594 14 0 puparial adhesion 0 7599 2 0 hemostasis 0 7600 286 14 sensory perception 0 7601 77 8 visual perception 0 7602 35 6 phototransduction 0 7603 5 1 "phototransduction, visible light" 0 7604 5 1 "phototransduction, UV" 0 7605 29 3 sensory perception of sound 0 7606 177 5 sensory perception of chemical stimulus 0 7608 73 1 sensory perception of smell 0 7610 391 31 behavior 1 7611 96 10 learning and/or memory 0 7612 78 8 learning 0 7613 27 4 memory 0 7614 3 1 short-term memory 0 7615 4 0 anesthesia-resistant memory 0 7616 13 2 long-term memory 0 7617 93 8 mating behavior 0 7618 15 2 mating 0 7619 61 3 courtship behavior 0 7620 12 2 copulation 0 7621 8 1 negative regulation of female receptivity 0 7622 33 5 rhythmic behavior 0 7623 45 7 circadian rhythm 0 7624 1 0 ultradian rhythm 0 7625 10 0 grooming behavior 0 7626 148 10 locomotory behavior 0 7628 13 0 adult walking behavior 0 7629 44 3 flight behavior 0 7630 11 0 jump response 0 7631 13 0 feeding behavior 0 7632 11 2 visual behavior 0 7635 117 8 chemosensory behavior 0 7636 8 0 chemosensory jump behavior 0 7637 3 0 proboscis extension reflex 0 7638 26 1 mechanosensory behavior 0 8010 43 11 structural constituent of larval cuticle (sensu Insecta) 0 8011 7 1 structural constituent of pupal cuticle (sensu Insecta) 0 8012 4 1 structural constituent of adult cuticle (sensu Insecta) 0 8013 6 2 beta-catenin binding 0 8015 11 0 circulation 0 8016 11 0 regulation of heart contraction 0 8017 78 15 microtubule binding 0 8020 8 0 G-protein coupled photoreceptor activity 0 8021 64 5 synaptic vesicle 0 8022 1 0 protein C-terminus binding 0 8023 6 2 transcription elongation factor complex 0 8024 3 1 transcription elongation factor complex b 0 8026 88 23 ATP-dependent helicase activity 0 8028 17 0 monocarboxylic acid transporter activity 0 8029 1 0 pentraxin receptor activity 0 8030 1 0 neuronal pentraxin receptor activity 0 8031 1 0 eclosion hormone activity 0 8033 14 3 tRNA processing 0 8034 15 1 lipoprotein binding 0 8035 1 0 high-density lipoprotein binding 0 8036 3 0 diuretic hormone receptor activity 0 8037 23 3 cell recognition 0 8038 23 3 neuron recognition 0 8039 5 1 synaptic target recognition 0 8043 3 1 ferritin complex 0 8045 12 1 motor axon guidance 0 8046 6 0 axon guidance receptor activity 0 8047 97 17 enzyme activator activity 0 8048 1 0 calcium sensitive guanylate cyclase activator activity 0 8049 41 1 male courtship behavior 0 8050 3 1 female courtship behavior 0 8052 18 0 sensory organ determination 0 8053 5 0 mitochondrial fusion 0 8054 3 2 cyclin catabolism 0 8055 21 2 ocellus pigment biosynthesis 0 8056 2 0 ocellus morphogenesis 0 8057 8 1 eye pigment granule organization and biogenesis 0 8060 8 1 ARF GTPase activator activity 0 8061 63 15 chitin binding 0 8062 12 0 eclosion rhythm 0 8063 30 2 Toll signaling pathway 0 8064 14 5 regulation of actin polymerization and/or depolymerization 0 8065 3 0 establishment of blood-nerve barrier 0 8066 39 0 glutamate receptor activity 0 8067 11 0 "metabotropic glutamate, GABA-B-like receptor activity" 0 8068 1 0 glutamate-gated chloride channel activity 0 8069 10 2 "dorsal/ventral axis determination, follicular epithelium (sensu Insecta)" 0 8070 1 0 "maternal determination of dorsal/ventral axis, follicular epithelium, germ-line encoded" 0 8071 1 0 "maternal determination of dorsal/ventral axis, follicular epithelium, soma encoded (sensu Insecta)" 0 8073 1 0 ornithine decarboxylase inhibitor activity 0 8074 5 0 "guanylate cyclase complex, soluble" 0 8076 23 3 voltage-gated potassium channel complex 0 8078 4 1 mesodermal cell migration 0 8079 9 4 translation termination factor activity 0 8080 30 4 N-acetyltransferase activity 0 8081 24 0 phosphoric diester hydrolase activity 0 8083 34 4 growth factor activity 0 8084 5 1 imaginal disc growth factor activity 0 8086 2 0 light-activated voltage-gated calcium channel activity 0 8087 1 0 light-activated voltage-gated calcium channel complex 0 8088 10 1 axon cargo transport 0 8089 1 0 anterograde axon cargo transport 0 8090 3 1 retrograde axon cargo transport 0 8091 3 1 spectrin 0 8092 255 42 cytoskeletal protein binding 0 8093 1 0 cytoskeletal adaptor activity 0 8094 39 10 DNA-dependent ATPase activity 0 8095 1 0 "inositol-1,4,5-triphosphate receptor activity" 0 8096 3 0 juvenile hormone epoxide hydrolase activity 0 8097 2 2 5S rRNA binding 0 8098 1 1 5S rRNA primary transcript binding 0 8101 8 0 decapentaplegic receptor signaling pathway 0 8103 14 4 oocyte microtubule cytoskeleton polarization 0 8104 603 101 protein localization 0 8105 35 3 asymmetric protein localization 0 8106 1 1 alcohol dehydrogenase (NADP+) activity 0 8108 1 0 UDP-glucose:hexose-1-phosphate uridylyltransferase activity 0 8109 1 0 "N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity" 0 8111 1 0 alpha-methylacyl-CoA racemase activity 0 8113 1 0 protein-methionine-S-oxide reductase activity 0 8117 1 0 sphinganine-1-phosphate aldolase activity 0 8120 1 0 ceramide glucosyltransferase activity 0 8121 11 8 ubiquinol-cytochrome-c reductase activity 0 8124 1 1 4-alpha-hydroxytetrahydrobiopterin dehydratase activity 0 8131 1 0 amine oxidase activity 0 8132 3 2 pancreatic elastase activity 0 8134 98 18 transcription factor binding 0 8135 88 25 "translation factor activity, nucleic acid binding" 0 8137 36 15 NADH dehydrogenase (ubiquinone) activity 0 8138 22 3 protein tyrosine/serine/threonine phosphatase activity 0 8139 3 0 nuclear localization sequence binding 0 8140 1 1 cAMP response element binding protein binding 0 8142 4 1 oxysterol binding 0 8143 17 6 poly(A) binding 0 8144 23 2 drug binding 0 8145 7 0 phenylalkylamine binding 0 8146 17 2 sulfotransferase activity 0 8150 9156 1053 biological_process 1 8152 5620 835 metabolism 0 8154 24 6 actin polymerization and/or depolymerization 0 8156 7 2 negative regulation of DNA replication 0 8157 6 0 protein phosphatase 1 binding 0 8158 6 0 hedgehog receptor activity 0 8159 5 0 positive transcription elongation factor activity 0 8160 3 0 protein tyrosine phosphatase activator activity 0 8168 94 19 methyltransferase activity 0 8169 1 0 C-methyltransferase activity 0 8170 39 4 N-methyltransferase activity 0 8171 4 0 O-methyltransferase activity 0 8172 3 0 S-methyltransferase activity 0 8173 19 6 RNA methyltransferase activity 0 8174 3 1 mRNA methyltransferase activity 0 8175 5 1 tRNA methyltransferase activity 0 8176 2 0 tRNA (guanine-N7-)-methyltransferase activity 0 8177 5 0 succinate dehydrogenase (ubiquinone) activity 0 8179 1 0 adenylate cyclase binding 0 8180 9 3 signalosome complex 0 8184 1 0 glycogen phosphorylase activity 0 8186 40 12 RNA-dependent ATPase activity 0 8187 9 2 poly-pyrimidine tract binding 0 8188 45 0 neuropeptide receptor activity 0 8190 1 0 eukaryotic initiation factor 4E binding 0 8191 1 0 metalloendopeptidase inhibitor activity 0 8192 2 1 RNA guanylyltransferase activity 0 8193 1 0 tRNA guanylyltransferase activity 0 8194 95 4 UDP-glycosyltransferase activity 0 8195 10 1 phosphatidate phosphatase activity 0 8196 1 0 vitellogenin receptor activity 0 8198 3 1 ferrous iron binding 0 8199 7 1 ferric iron binding 0 8200 3 0 ion channel inhibitor activity 0 8201 3 1 heparin binding 0 8202 136 6 steroid metabolism 0 8203 26 4 cholesterol metabolism 0 8205 7 0 ecdysone metabolism 0 8209 1 0 androgen metabolism 0 8210 1 0 estrogen metabolism 0 8213 24 2 protein amino acid alkylation 0 8215 1 0 spermine metabolism 0 8216 4 1 spermidine metabolism 0 8219 268 34 cell death 0 8226 1 0 tyramine receptor activity 0 8227 23 0 amine receptor activity 0 8230 2 0 ecdysone receptor holocomplex 0 8233 709 82 peptidase activity 0 8234 105 14 cysteine-type peptidase activity 0 8235 85 9 metalloexopeptidase activity 0 8236 315 23 serine-type peptidase activity 0 8237 203 15 metallopeptidase activity 0 8238 124 12 exopeptidase activity 0 8239 15 1 dipeptidyl-peptidase activity 0 8240 1 0 tripeptidyl-peptidase activity 0 8241 8 0 peptidyl-dipeptidase activity 0 8242 4 0 omega peptidase activity 0 8250 4 2 oligosaccharyl transferase complex 0 8251 1 0 tRNA specific adenosine deaminase activity 0 8252 8 1 nucleotidase activity 0 8253 5 0 5'-nucleotidase activity 0 8255 2 0 ecdysis-triggering hormone activity 0 8258 33 3 head involution 0 8260 1 0 3-oxoacid CoA-transferase activity 0 8261 6 0 allatostatin receptor activity 0 8262 1 0 importin-alpha export receptor activity 0 8263 1 0 pyrimidine-specific mismatch base pair DNA N-glycosylase activity 0 8265 3 0 Mo-molybdopterin cofactor sulfurase activity 0 8266 2 0 poly(U) binding 0 8267 1 0 poly-glutamine tract binding 0 8268 2 0 receptor signaling protein tyrosine kinase signaling protein activity 0 8269 1 0 JAK pathway signal transduction adaptor activity 0 8270 617 60 zinc ion binding 0 8271 9 0 sulfate porter activity 0 8272 3 0 sulfate transport 0 8273 5 0 "calcium, potassium:sodium antiporter activity" 0 8274 4 0 gamma-tubulin ring complex 0 8275 4 0 gamma-tubulin small complex 0 8276 25 2 protein methyltransferase activity 0 8277 9 0 regulation of G-protein coupled receptor protein signaling pathway 0 8278 8 2 cohesin complex 0 8280 1 0 cohesin core heterodimer 0 8281 1 0 sulfonylurea receptor activity 0 8282 1 0 ATP-sensitive potassium channel complex 0 8283 302 43 cell proliferation 0 8284 4 1 positive regulation of cell proliferation 0 8285 18 2 negative regulation of cell proliferation 0 8286 18 1 insulin receptor signaling pathway 0 8287 27 2 protein serine/threonine phosphatase complex 0 8288 1 1 boss receptor activity 0 8289 74 9 lipid binding 0 8290 3 0 F-actin capping protein complex 0 8291 3 0 acetylcholine metabolism 0 8292 2 0 acetylcholine biosynthesis 0 8293 35 10 torso signaling pathway 0 8294 1 0 calcium- and calmodulin-responsive adenylate cyclase activity 0 8295 3 1 spermidine biosynthesis 0 8296 6 0 3'-5'-exodeoxyribonuclease activity 0 8297 2 0 single-stranded DNA specific exodeoxyribonuclease activity 0 8298 78 9 intracellular mRNA localization 0 8299 9 2 isoprenoid biosynthesis 0 8300 4 0 isoprenoid catabolism 0 8301 4 1 DNA bending activity 0 8302 5 0 "ring canal formation, actin assembly" 0 8303 2 0 caspase complex 0 8305 11 3 integrin complex 0 8306 5 2 associative learning 0 8307 12 1 structural constituent of muscle 0 8308 4 2 voltage-gated ion-selective channel activity 0 8309 2 0 double-stranded DNA specific exodeoxyribonuclease activity 0 8310 2 0 single-stranded DNA specific 3'-5' exodeoxyribonuclease activity 0 8311 2 0 double-stranded DNA specific 3'-5' exodeoxyribonuclease activity 0 8312 5 3 7S RNA binding 0 8313 1 0 gurken receptor activity 0 8314 4 0 gurken receptor signaling pathway 0 8315 6 0 meiotic G2/MI transition 0 8316 4 0 structural constituent of vitelline membrane (sensu Insecta) 0 8317 2 0 gurken receptor binding 0 8318 15 2 protein prenyltransferase activity 0 8319 1 0 prenyl protein specific endopeptidase activity 0 8320 21 4 protein carrier activity 0 8321 1 0 Ral guanyl-nucleotide exchange factor activity 0 8322 3 1 Pro-X carboxypeptidase activity 0 8324 467 71 cation transporter activity 0 8326 1 0 site-specific DNA-methyltransferase (cytosine-specific) activity 0 8327 2 0 methyl-CpG binding 0 8328 6 0 ionotropic glutamate receptor complex 0 8329 6 2 pattern recognition receptor activity 0 8330 1 0 protein tyrosine/threonine phosphatase activity 0 8332 2 0 low voltage-gated calcium channel activity 0 8333 4 0 endosome to lysosome transport 0 8334 17 5 histone mRNA metabolism 0 8335 5 1 ovarian ring canal stabilization 0 8336 4 0 gamma-butyrobetaine dioxygenase activity 0 8339 1 0 MP kinase activity 0 8340 52 5 determination of adult life span 0 8343 1 0 adult feeding behavior 0 8344 77 4 adult locomotory behavior 0 8345 12 2 larval locomotory behavior 0 8347 15 4 glial cell migration 0 8348 1 0 attenuation of antimicrobial humoral response 0 8349 1 1 MAP kinase kinase kinase kinase activity 0 8352 4 2 katanin 0 8353 3 0 RNA polymerase subunit kinase activity 0 8354 44 8 germ cell migration 0 8355 74 5 olfactory learning 0 8356 68 2 asymmetric cell division 0 8358 5 1 "maternal determination of anterior/posterior axis, embryo" 0 8359 4 0 regulation of bicoid mRNA localization 0 8360 91 11 regulation of cell shape 0 8361 41 6 regulation of cell size 0 8362 13 3 embryonic cuticle biosynthesis (sensu Insecta) 0 8363 5 1 larval cuticle biosynthesis (sensu Insecta) 0 8364 1 0 pupal cuticle biosynthesis (sensu Insecta) 0 8365 5 0 adult cuticle biosynthesis (sensu Insecta) 0 8366 1 0 nerve ensheathment 0 8367 5 2 bacterial binding 0 8368 5 2 Gram-negative bacterial binding 0 8373 1 0 sialyltransferase activity 0 8374 22 0 O-acyltransferase activity 0 8375 23 1 acetylglucosaminyltransferase activity 0 8376 18 0 acetylgalactosaminyltransferase activity 0 8377 2 0 light-induced release of internally sequestered calcium ion 0 8378 22 1 galactosyltransferase activity 0 8379 4 2 thioredoxin peroxidase activity 0 8380 197 40 RNA splicing 0 8381 1 0 mechanically-gated ion channel activity 0 8383 1 1 manganese superoxide dismutase activity 0 8384 3 0 IkappaB kinase activity 0 8385 3 0 IkappaB kinase complex 0 8393 1 0 fatty acid (omega-1)-hydroxylase activity 0 8395 4 0 steroid hydroxylase activity 0 8406 29 2 gonad development 0 8407 31 3 bristle morphogenesis 0 8408 28 4 3'-5' exonuclease activity 0 8409 3 0 5'-3' exonuclease activity 0 8410 2 0 CoA-transferase activity 0 8411 1 0 4-hydroxybutyrate CoA-transferase activity 0 8412 1 0 4-hydroxybenzoate octaprenyltransferase activity 0 8414 1 0 CDP-alcohol phosphotransferase activity 0 8415 123 17 acyltransferase activity 0 8416 2 0 "delta5-delta2,4-dienoyl-CoA isomerase activity" 0 8417 7 1 fucosyltransferase activity 0 8418 1 0 protein N-terminal asparagine amidohydrolase activity 0 8419 2 0 RNA lariat debranching enzyme activity 0 8420 1 1 CTD phosphatase activity 0 8424 1 0 glycoprotein 6-alpha-L-fucosyltransferase activity 0 8425 1 0 "2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity" 0 8426 2 2 protein kinase C inhibitor activity 0 8428 1 1 ribonuclease inhibitor activity 0 8429 8 1 phosphatidylethanolamine binding 0 8430 1 0 selenium binding 0 8431 9 2 vitamin E binding 0 8432 2 0 JUN kinase binding 0 8439 9 0 monophenol monooxygenase activator activity 0 8440 5 0 inositol trisphosphate 3-kinase activity 0 8441 2 0 "3'(2'),5'-bisphosphate nucleotidase activity" 0 8442 2 1 3-hydroxyisobutyrate dehydrogenase activity 0 8443 3 2 phosphofructokinase activity 0 8444 1 0 CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity 0 8445 2 0 D-aspartate oxidase activity 0 8446 1 0 "GDP-mannose 4,6-dehydratase activity" 0 8447 1 0 L-ascorbate oxidase activity 0 8448 1 0 N-acetylglucosamine-6-phosphate deacetylase activity 0 8449 3 1 N-acetylglucosamine-6-sulfatase activity 0 8450 2 1 O-sialoglycoprotein endopeptidase activity 0 8451 3 1 X-Pro aminopeptidase activity 0 8452 67 10 RNA ligase activity 0 8453 2 0 alanine-glyoxylate transaminase activity 0 8454 2 0 "alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity" 0 8455 1 0 "alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity" 0 8456 1 1 alpha-N-acetylgalactosaminidase activity 0 8458 1 0 carnitine O-octanoyltransferase activity 0 8459 1 0 chondroitin 6-sulfotransferase activity 0 8460 1 0 "dTDP-glucose 4,6-dehydratase activity" 0 8462 3 0 endopeptidase Clp activity 0 8463 3 0 formylmethionine deformylase activity 0 8464 2 0 gamma-glutamyl hydrolase activity 0 8466 1 0 glycogenin glucosyltransferase activity 0 8467 2 0 heparin-glucosamine 3-O-sulfotransferase activity 0 8469 1 0 histone-arginine N-methyltransferase activity 0 8470 1 0 isovaleryl-CoA dehydrogenase activity 0 8471 3 0 laccase activity 0 8472 1 0 metallocarboxypeptidase D activity 0 8474 2 0 palmitoyl-(protein) hydrolase activity 0 8475 2 0 procollagen-lysine 5-dioxygenase activity 0 8476 1 0 protein-tyrosine sulfotransferase activity 0 8478 1 0 pyridoxal kinase activity 0 8479 2 0 queuine tRNA-ribosyltransferase activity 0 8480 1 0 sarcosine dehydrogenase activity 0 8482 1 0 sulfite oxidase activity 0 8483 20 2 transaminase activity 0 8484 10 1 sulfuric ester hydrolase activity 0 8486 1 0 diphosphoinositol-polyphosphate diphosphatase activity 0 8487 3 0 prenyl-dependent CAAX protease activity 0 8488 1 0 gamma-glutamyl carboxylase activity 0 8490 1 0 arsenite porter activity 0 8493 5 0 tetracycline transporter activity 0 8494 1 0 translation activator activity 0 8495 1 0 protoheme IX farnesyltransferase activity 0 8496 1 0 "mannan endo-1,6-alpha-mannosidase activity" 0 8499 7 1 "UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity" 0 8502 1 0 melatonin receptor activity 0 8503 1 0 benzodiazepine receptor activity 0 8504 1 0 monoamine transporter activity 0 8506 1 0 sucrose:hydrogen symporter activity 0 8507 9 0 sodium:iodide symporter activity 0 8508 2 0 bile acid:sodium symporter activity 0 8509 94 5 anion transporter activity 0 8510 1 0 sodium:bicarbonate symporter activity 0 8511 3 0 sodium:potassium:chloride symporter activity 0 8513 24 1 organic cation porter activity 0 8514 9 0 organic anion transporter activity 0 8515 1 0 sucrose transporter activity 0 8517 1 0 folic acid transporter activity 0 8518 3 0 reduced folate carrier activity 0 8519 1 0 ammonium transporter activity 0 8520 1 0 L-ascorbate:sodium symporter activity 0 8521 1 0 acetyl-CoA transporter activity 0 8523 6 0 sodium-dependent multivitamin transporter activity 0 8524 1 0 glucose 6-phosphate:phosphate antiporter activity 0 8525 2 1 phosphatidylcholine transporter activity 0 8526 3 1 phosphatidylinositol transporter activity 0 8527 61 0 taste receptor activity 0 8528 48 0 "peptide receptor activity, G-protein coupled" 0 8531 1 0 riboflavin kinase activity 0 8532 3 0 "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity" 0 8533 13 0 astacin activity 0 8534 2 1 purine-specific oxidized base lesion DNA N-glycosylase activity 0 8535 8 3 cytochrome c oxidase complex assembly 0 8536 8 1 Ran GTPase binding 0 8537 1 0 proteasome activator complex 0 8538 1 0 proteasome activator activity 0 8539 1 1 proteasome inhibitor activity 0 8540 11 8 "proteasome regulatory particle, base subcomplex (sensu Eukaryota)" 0 8541 8 5 "proteasome regulatory particle, lid subcomplex (sensu Eukaryota)" 0 8542 1 0 visual learning 0 8543 13 2 fibroblast growth factor receptor signaling pathway 0 8544 30 7 epidermis development 0 8545 2 1 JUN kinase kinase activity 0 8553 54 21 "hydrogen-exporting ATPase activity, phosphorylative mechanism" 0 8559 8 1 xenobiotic-transporting ATPase activity 0 8565 76 15 protein transporter activity 0 8569 2 1 minus-end-directed microtubule motor activity 0 8574 7 1 plus-end-directed microtubule motor activity 0 8579 1 0 JUN kinase phosphatase activity 0 8581 1 0 ubiquitin-specific protease 5 activity 0 8582 13 1 regulation of synaptic growth at neuromuscular junction 0 8583 1 0 mystery cell fate differentiation (sensu Endopterygota) 0 8584 5 0 male gonad development 0 8585 11 0 female gonad development 0 8586 28 1 wing vein morphogenesis 0 8587 53 4 wing margin morphogenesis 0 8588 1 0 release of cytoplasmic sequestered NF-kappaB 0 8589 14 0 regulation of smoothened signaling pathway 0 8590 6 2 regulation of frizzled signaling pathway 0 8592 4 0 regulation of Toll signaling pathway 0 8593 10 1 regulation of Notch signaling pathway 0 8594 58 9 photoreceptor cell morphogenesis (sensu Endopterygota) 0 8595 74 11 "determination of anterior/posterior axis, embryo" 0 8597 4 0 calcium-dependent protein serine/threonine phosphatase regulator activity 0 8599 6 0 protein phosphatase type 1 regulator activity 0 8601 7 0 protein phosphatase type 2A regulator activity 0 8603 6 0 cAMP-dependent protein kinase regulator activity 0 8605 17 0 protein kinase CK2 regulator activity 0 8607 2 0 phosphorylase kinase regulator activity 0 8608 2 2 attachment of spindle microtubules to kinetochore 0 8609 1 0 alkylglycerone-phosphate synthase activity 0 8610 86 10 lipid biosynthesis 0 8611 1 0 ether lipid biosynthesis 0 8612 1 0 hypusine biosynthesis from peptidyl-lysine 0 8613 5 0 diuretic hormone activity 0 8614 4 2 pyridoxine metabolism 0 8615 4 2 pyridoxine biosynthesis 0 8616 2 0 queuosine biosynthesis 0 8617 2 0 guanosine metabolism 0 8618 2 0 7-methylguanosine metabolism 0 8622 3 1 epsilon DNA polymerase complex 0 8623 5 3 chromatin accessibility complex 0 8624 3 0 induction of apoptosis by extracellular signals 0 8627 2 0 induction of apoptosis by ionic changes 0 8628 1 0 induction of apoptosis by hormones 0 8629 4 0 induction of apoptosis by intracellular signals 0 8630 4 0 "DNA damage response, signal transduction resulting in induction of apoptosis" 0 8632 20 0 apoptotic program 0 8635 1 0 caspase activation via cytochrome c 0 8639 37 10 small protein conjugating enzyme activity 0 8640 3 1 ubiquitin-like conjugating enzyme activity 0 8641 7 3 small protein activating enzyme activity 0 8642 4 2 ubiquitin-like activating enzyme activity 0 8643 83 7 carbohydrate transport 0 8645 3 0 hexose transport 0 8649 8 3 rRNA methyltransferase activity 0 8650 3 1 rRNA (uridine-2'-O-)-methyltransferase activity 0 8652 73 10 amino acid biosynthesis 0 8653 1 0 lipopolysaccharide metabolism 0 8654 26 3 phospholipid biosynthesis 0 8656 1 0 caspase activator activity 0 8665 1 0 2'-phosphotransferase activity 0 8708 4 1 glucose dehydrogenase activity 0 8717 1 0 D-alanyl-D-alanine endopeptidase activity 0 8745 12 0 N-acetylmuramoyl-L-alanine amidase activity 0 8757 66 15 S-adenosylmethionine-dependent methyltransferase activity 0 8781 1 0 N-acylneuraminate cytidylyltransferase activity 0 8796 2 1 bis(5'-nucleosyl)-tetraphosphatase activity 0 8805 1 0 carbon-monoxide oxygenase activity 0 8812 7 2 choline dehydrogenase activity 0 8821 1 0 crossover junction endodeoxyribonuclease activity 0 8835 1 0 diaminohydroxyphosphoribosylaminopyrimidine deaminase activity 0 8846 1 0 endopeptidase La activity 0 8852 1 0 exodeoxyribonuclease I activity 0 8859 1 0 exoribonuclease II activity 0 8890 1 0 glycine C-acetyltransferase activity 0 8891 1 0 glycolate oxidase activity 0 8892 1 0 guanine deaminase activity 0 8897 1 0 phosphopantetheinyltransferase activity 0 8898 2 0 homocysteine S-methyltransferase activity 0 8900 2 0 hydrogen:potassium-exchanging ATPase activity 0 8901 1 0 ferredoxin hydrogenase activity 0 8905 2 0 mannose-phosphate guanylyltransferase activity 0 8934 7 0 inositol-1(or 4)-monophosphatase activity 0 8937 2 0 ferredoxin reductase activity 0 8943 8 1 glyceraldehyde-3-phosphate dehydrogenase activity 0 8944 1 0 oligopeptidase A activity 0 8946 1 1 oligonucleotidase activity 0 8949 1 0 oxalyl-CoA decarboxylase activity 0 8965 3 0 phosphoenolpyruvate-protein phosphotransferase activity 0 8970 10 1 phospholipase A1 activity 0 9003 4 3 signal peptidase activity 0 9007 1 1 site-specific DNA-methyltransferase (adenine-specific) activity 0 9008 5 2 DNA-methyltransferase activity 0 9041 1 0 uridylate kinase activity 0 9045 1 0 xylose isomerase activity 0 9047 8 0 "dosage compensation, by hyperactivation of X chromosome" 0 9052 2 0 "pentose-phosphate shunt, non-oxidative branch" 0 9055 5 1 electron carrier activity 0 9056 344 70 catabolism 0 9057 188 53 macromolecule catabolism 0 9058 1175 219 biosynthesis 0 9059 776 165 macromolecule biosynthesis 0 9060 48 5 aerobic respiration 0 9062 1 0 fatty acid catabolism 0 9063 51 9 amino acid catabolism 0 9064 20 3 glutamine family amino acid metabolism 0 9065 7 2 glutamine family amino acid catabolism 0 9066 8 0 aspartate family amino acid metabolism 0 9067 2 0 aspartate family amino acid biosynthesis 0 9068 2 0 aspartate family amino acid catabolism 0 9069 18 5 serine family amino acid metabolism 0 9070 14 4 serine family amino acid biosynthesis 0 9071 3 1 serine family amino acid catabolism 0 9072 22 4 aromatic amino acid family metabolism 0 9073 1 0 aromatic amino acid family biosynthesis 0 9074 7 2 aromatic amino acid family catabolism 0 9078 1 0 pyruvate family amino acid metabolism 0 9079 1 0 pyruvate family amino acid biosynthesis 0 9081 7 1 branched chain family amino acid metabolism 0 9082 1 0 branched chain family amino acid biosynthesis 0 9083 2 0 branched chain family amino acid catabolism 0 9084 9 2 glutamine family amino acid biosynthesis 0 9087 1 0 methionine catabolism 0 9094 1 0 L-phenylalanine biosynthesis 0 9100 88 10 glycoprotein metabolism 0 9101 85 9 glycoprotein biosynthesis 0 9103 1 0 lipopolysaccharide biosynthesis 0 9105 2 0 lipoic acid biosynthesis 0 9106 2 0 lipoate metabolism 0 9107 2 0 lipoate biosynthesis 0 9108 96 18 coenzyme biosynthesis 0 9109 49 6 coenzyme catabolism 0 9110 21 3 vitamin biosynthesis 0 9111 1 0 vitamin catabolism 0 9112 81 15 nucleobase metabolism 0 9113 3 0 purine base biosynthesis 0 9116 18 2 nucleoside metabolism 0 9117 163 28 nucleotide metabolism 0 9118 1 1 regulation of nucleoside metabolism 0 9119 7 0 ribonucleoside metabolism 0 9120 2 1 deoxyribonucleoside metabolism 0 9123 21 1 nucleoside monophosphate metabolism 0 9124 21 1 nucleoside monophosphate biosynthesis 0 9126 18 1 purine nucleoside monophosphate metabolism 0 9127 18 1 purine nucleoside monophosphate biosynthesis 0 9129 2 0 pyrimidine nucleoside monophosphate metabolism 0 9130 2 0 pyrimidine nucleoside monophosphate biosynthesis 0 9132 6 1 nucleoside diphosphate metabolism 0 9133 3 0 nucleoside diphosphate biosynthesis 0 9135 2 0 purine nucleoside diphosphate metabolism 0 9136 2 0 purine nucleoside diphosphate biosynthesis 0 9138 1 0 pyrimidine nucleoside diphosphate metabolism 0 9139 1 0 pyrimidine nucleoside diphosphate biosynthesis 0 9141 73 19 nucleoside triphosphate metabolism 0 9142 70 18 nucleoside triphosphate biosynthesis 0 9144 71 18 purine nucleoside triphosphate metabolism 0 9145 69 18 purine nucleoside triphosphate biosynthesis 0 9147 6 1 pyrimidine nucleoside triphosphate metabolism 0 9148 1 0 pyrimidine nucleoside triphosphate biosynthesis 0 9150 92 20 purine ribonucleotide metabolism 0 9152 90 20 purine ribonucleotide biosynthesis 0 9156 20 1 ribonucleoside monophosphate biosynthesis 0 9157 1 0 deoxyribonucleoside monophosphate biosynthesis 0 9161 20 1 ribonucleoside monophosphate metabolism 0 9162 1 0 deoxyribonucleoside monophosphate metabolism 0 9163 2 0 nucleoside biosynthesis 0 9165 112 21 nucleotide biosynthesis 0 9166 9 1 nucleotide catabolism 0 9167 18 1 purine ribonucleoside monophosphate metabolism 0 9168 18 1 purine ribonucleoside monophosphate biosynthesis 0 9173 1 0 pyrimidine ribonucleoside monophosphate metabolism 0 9174 1 0 pyrimidine ribonucleoside monophosphate biosynthesis 0 9176 1 0 pyrimidine deoxyribonucleoside monophosphate metabolism 0 9177 1 0 pyrimidine deoxyribonucleoside monophosphate biosynthesis 0 9179 2 0 purine ribonucleoside diphosphate metabolism 0 9180 2 0 purine ribonucleoside diphosphate biosynthesis 0 9185 2 0 ribonucleoside diphosphate metabolism 0 9186 2 1 deoxyribonucleoside diphosphate metabolism 0 9187 36 0 cyclic nucleotide metabolism 0 9188 2 0 ribonucleoside diphosphate biosynthesis 0 9189 1 0 deoxyribonucleoside diphosphate biosynthesis 0 9190 11 0 cyclic nucleotide biosynthesis 0 9196 1 0 pyrimidine deoxyribonucleoside diphosphate metabolism 0 9197 1 0 pyrimidine deoxyribonucleoside diphosphate biosynthesis 0 9199 71 18 ribonucleoside triphosphate metabolism 0 9200 2 1 deoxyribonucleoside triphosphate metabolism 0 9201 69 18 ribonucleoside triphosphate biosynthesis 0 9202 1 0 deoxyribonucleoside triphosphate biosynthesis 0 9205 71 18 purine ribonucleoside triphosphate metabolism 0 9206 69 18 purine ribonucleoside triphosphate biosynthesis 0 9208 4 0 pyrimidine ribonucleoside triphosphate metabolism 0 9209 4 0 pyrimidine ribonucleoside triphosphate biosynthesis 0 9211 2 1 pyrimidine deoxyribonucleoside triphosphate metabolism 0 9212 1 0 pyrimidine deoxyribonucleoside triphosphate biosynthesis 0 9218 5 0 pyrimidine ribonucleotide metabolism 0 9219 3 1 pyrimidine deoxyribonucleotide metabolism 0 9220 5 0 pyrimidine ribonucleotide biosynthesis 0 9221 2 0 pyrimidine deoxyribonucleotide biosynthesis 0 9225 6 0 nucleotide-sugar metabolism 0 9226 3 0 nucleotide-sugar biosynthesis 0 9229 1 0 thiamin diphosphate biosynthesis 0 9231 2 0 riboflavin biosynthesis 0 9233 1 0 menaquinone metabolism 0 9234 1 0 menaquinone biosynthesis 0 9241 3 0 polyisoprenoid biosynthesis 0 9247 5 0 glycolipid biosynthesis 0 9250 3 0 glucan biosynthesis 0 9253 12 0 peptidoglycan catabolism 0 9256 2 1 10-formyltetrahydrofolate metabolism 0 9258 1 1 10-formyltetrahydrofolate catabolism 0 9259 94 20 ribonucleotide metabolism 0 9260 92 20 ribonucleotide biosynthesis 0 9262 4 2 deoxyribonucleotide metabolism 0 9263 2 0 deoxyribonucleotide biosynthesis 0 9266 61 13 response to temperature stimulus 0 9269 1 0 response to desiccation 0 9288 9 0 flagellum (sensu Bacteria) 0 9295 1 0 nucleoid 0 9296 8 0 flagellum biogenesis 0 9298 1 0 GDP-mannose biosynthesis 0 9299 25 6 mRNA transcription 0 9301 1 0 snRNA transcription 0 9303 2 1 rRNA transcription 0 9304 1 0 tRNA transcription 0 9306 4 0 protein secretion 0 9307 3 1 DNA restriction-modification system 0 9308 400 57 amine metabolism 0 9309 87 13 amine biosynthesis 0 9310 55 9 amine catabolism 0 9311 15 0 oligosaccharide metabolism 0 9312 13 0 oligosaccharide biosynthesis 0 9314 77 9 response to radiation 0 9317 2 0 acetyl-CoA carboxylase complex 0 9320 2 0 phosphoribosylaminoimidazole carboxylase complex 0 9328 2 0 phenylalanine-tRNA ligase complex 0 9331 7 0 glycerol-3-phosphate dehydrogenase complex 0 9341 2 0 beta-galactosidase complex 0 9343 2 0 biotin carboxylase complex 0 9347 2 1 aspartate carbamoyltransferase complex 0 9353 4 1 oxoglutarate dehydrogenase complex (sensu Eukaryota) 0 9361 1 0 succinate-CoA ligase complex (ADP-forming) 0 9368 1 0 endopeptidase Clp complex 0 9374 3 0 biotin binding 0 9395 3 0 phospholipid catabolism 0 9396 5 0 folic acid and derivative biosynthesis 0 9397 1 1 folic acid and derivative catabolism 0 9399 3 1 nitrogen fixation 0 9401 22 2 phosphoenolpyruvate-dependent sugar phosphotransferase system 0 9404 9 0 toxin metabolism 0 9405 3 0 pathogenesis 0 9407 3 0 toxin catabolism 0 9408 53 11 response to heat 0 9409 4 2 response to cold 0 9410 9 0 response to xenobiotic stimulus 0 9411 5 1 response to UV 0 9414 1 0 response to water deprivation 0 9415 1 0 response to water 0 9416 73 8 response to light stimulus 0 9434 1 0 flagellum (sensu Eukaryota) 0 9435 2 0 NAD biosynthesis 0 9437 1 0 carnitine metabolism 0 9448 3 1 gamma-aminobutyric acid metabolism 0 9449 1 0 gamma-aminobutyric acid biosynthesis 0 9450 1 0 gamma-aminobutyric acid catabolism 0 9451 14 3 RNA modification 0 9452 2 1 RNA capping 0 9453 19 1 energy taxis 0 9507 4 0 chloroplast 0 9532 4 0 plastid stroma 0 9536 4 0 plastid 0 9566 33 3 fertilization 0 9570 4 0 chloroplast stroma 0 9573 4 0 ribulose bisphosphate carboxylase complex (sensu Magnoliophyta) 0 9581 48 6 detection of external stimulus 0 9582 48 7 detection of abiotic stimulus 0 9583 38 6 detection of light stimulus 0 9584 8 1 detection of visible light 0 9586 18 3 rhodopsin mediated phototransduction 0 9588 2 0 "UV-A, blue light phototransduction" 0 9589 5 1 detection of UV 0 9593 6 2 detection of chemical stimulus 0 9594 2 1 detection of nutrient 0 9595 5 0 detection of biotic stimulus 0 9605 163 12 response to external stimulus 0 9607 552 68 response to biotic stimulus 0 9611 35 2 response to wounding 0 9612 33 2 response to mechanical stimulus 0 9613 116 6 "response to pest, pathogen or parasite" 0 9615 1 1 response to virus 0 9617 82 5 response to bacteria 0 9618 1 0 response to pathogenic bacteria 0 9620 20 2 response to fungi 0 9628 512 53 response to abiotic stimulus 0 9629 8 0 response to gravity 0 9636 131 12 response to toxin 0 9637 1 0 response to blue light 0 9649 6 1 entrainment of circadian clock 0 9651 2 0 response to salt stress 0 9653 988 89 morphogenesis 1 9719 140 23 response to endogenous stimulus 0 9725 18 1 response to hormone stimulus 0 9755 1 0 hormone-mediated signaling 0 9790 528 46 embryonic development 1 9791 586 58 post-embryonic development 0 9792 292 26 embryonic development (sensu Metazoa) 0 9794 10 0 regulation of progression through embryonic mitotic cell cycle 0 9796 9 1 cellularization (sensu Metazoa) 0 9798 232 29 axis specification 0 9799 2 0 determination of symmetry 0 9826 6 1 unidimensional cell growth 0 9855 2 0 determination of bilateral symmetry 0 9880 189 18 embryonic pattern specification 0 9881 8 0 photoreceptor activity 0 9886 10 2 post-embryonic morphogenesis 0 9887 583 49 organ morphogenesis 0 9888 427 45 tissue development 0 9889 90 18 regulation of biosynthesis 0 9890 5 0 negative regulation of biosynthesis 0 9892 226 17 negative regulation of metabolism 0 9893 72 8 positive regulation of metabolism 0 9894 3 1 regulation of catabolism 0 9895 1 0 negative regulation of catabolism 0 9897 2 0 external side of plasma membrane 0 9913 24 7 epidermal cell differentiation 0 9922 2 0 fatty acid elongase activity 0 9948 176 22 anterior/posterior axis specification 0 9949 5 1 polarity specification of anterior/posterior axis 0 9950 77 9 dorsal/ventral axis specification 0 9951 5 1 polarity specification of dorsal/ventral axis 0 9952 193 23 anterior/posterior pattern formation 0 9953 99 11 dorsal/ventral pattern formation 0 9954 20 1 proximal/distal pattern formation 0 9966 115 8 regulation of signal transduction 0 9967 25 2 positive regulation of signal transduction 0 9968 52 4 negative regulation of signal transduction 0 9975 31 0 cyclase activity 0 9982 2 0 pseudouridine synthase activity 0 9986 4 1 cell surface 0 9987 7738 1000 cellular process 1 9991 17 1 response to extracellular stimulus 0 9993 493 48 oogenesis (sensu Insecta) 0 9994 131 16 oocyte differentiation 0 9996 13 1 negative regulation of cell fate specification 0 9997 4 1 negative regulation of cardioblast cell fate specification 0 10000 1 0 negative regulation of cone cell fate specification (sensu Endopterygota) 0 10001 5 0 glial cell differentiation 0 10002 18 2 cardioblast differentiation 0 10004 33 2 gastrulation (sensu Insecta) 0 10032 1 0 meiotic chromosome condensation 0 10033 30 3 response to organic substance 0 10035 1 1 response to inorganic substance 0 10092 3 0 specification of organ identity 0 10181 3 1 FMN binding 0 12501 266 34 programmed cell death 0 12502 75 11 induction of programmed cell death 0 12505 132 21 endomembrane system 0 12506 10 0 vesicle membrane 0 12507 3 0 ER to Golgi transport vesicle membrane 0 15002 19 8 heme-copper terminal oxidase activity 0 15012 12 1 heparan sulfate proteoglycan biosynthesis 0 15014 6 0 "heparan sulfate proteoglycan biosynthesis, polysaccharide chain biosynthesis" 0 15016 1 0 [heparan sulfate]-glucosamine N-sulfotransferase activity 0 15018 3 0 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity 0 15020 36 1 glucuronosyltransferase activity 0 15030 1 0 Cajal body 0 15031 547 98 protein transport 0 15032 1 0 storage protein import into fat body 0 15036 24 6 disulfide oxidoreductase activity 0 15037 1 0 peptide disulfide oxidoreductase activity 0 15038 1 0 glutathione disulfide oxidoreductase activity 0 15039 1 0 NADPH-adrenodoxin reductase activity 0 15071 1 0 protein phosphatase type 2C activity 0 15074 1 0 DNA integration 0 15075 554 76 ion transporter activity 0 15077 151 56 monovalent inorganic cation transporter activity 0 15078 149 56 hydrogen ion transporter activity 0 15081 36 15 sodium ion transporter activity 0 15082 24 5 "di-, tri-valent inorganic cation transporter activity" 0 15085 5 1 calcium ion transporter activity 0 15101 30 1 organic cation transporter activity 0 15103 40 1 inorganic anion transporter activity 0 15105 2 1 arsenite transporter activity 0 15106 3 0 bicarbonate transporter activity 0 15108 3 0 chloride transporter activity 0 15114 26 0 phosphate transporter activity 0 15116 9 0 sulfate transporter activity 0 15125 2 0 bile acid transporter activity 0 15137 6 2 citrate transporter activity 0 15141 1 1 succinate transporter activity 0 15142 7 2 tricarboxylic acid transporter activity 0 15143 2 0 urate transporter activity 0 15144 83 7 carbohydrate transporter activity 0 15145 21 4 monosaccharide transporter activity 0 15149 18 3 hexose transporter activity 0 15154 1 0 disaccharide transporter activity 0 15165 8 0 pyrimidine nucleotide sugar transporter activity 0 15166 1 0 polyol transporter activity 0 15168 1 0 glycerol transporter activity 0 15169 1 0 glycerol-3-phosphate transporter activity 0 15171 47 1 amino acid transporter activity 0 15172 2 0 acidic amino acid transporter activity 0 15173 2 1 aromatic amino acid transporter activity 0 15175 4 0 neutral amino acid transporter activity 0 15179 11 1 L-amino acid transporter activity 0 15183 1 0 L-aspartate transporter activity 0 15184 1 0 L-cystine transporter activity 0 15185 3 0 L-gamma-aminobutyric acid transporter activity 0 15187 3 0 glycine transporter activity 0 15193 1 0 L-proline transporter activity 0 15197 3 0 peptide transporter activity 0 15198 3 0 oligopeptide transporter activity 0 15203 39 0 polyamine transporter activity 0 15205 1 0 nucleobase transporter activity 0 15211 1 0 purine nucleoside transporter activity 0 15220 1 0 choline transporter activity 0 15222 1 0 serotonin transporter activity 0 15226 6 0 carnitine transporter activity 0 15227 2 0 acyl carnitine transporter activity 0 15232 4 2 heme transporter activity 0 15238 20 1 drug transporter activity 0 15239 12 1 multidrug transporter activity 0 15245 8 0 fatty acid transporter activity 0 15247 1 0 aminophospholipid transporter activity 0 15248 1 0 sterol transporter activity 0 15249 1 0 nonselective channel activity 0 15250 6 0 water channel activity 0 15267 199 11 channel or pore class transporter activity 0 15268 199 11 alpha-type channel activity 0 15269 3 0 calcium-activated potassium channel activity 0 15271 3 0 outward rectifier potassium channel activity 0 15272 1 0 ATP-activated inward rectifier potassium channel activity 0 15276 76 0 ligand-gated ion channel activity 0 15277 11 0 kainate selective glutamate receptor activity 0 15278 3 0 calcium-release channel activity 0 15279 2 0 store-operated calcium channel activity 0 15280 3 0 amiloride-sensitive sodium channel activity 0 15281 1 0 nonselective cation channel activity 0 15286 6 2 innexin channel activity 0 15288 1 0 porin activity 0 15290 221 9 electrochemical potential-driven transporter activity 0 15291 221 9 porter activity 0 15293 75 0 symporter activity 0 15294 65 0 solute:cation symporter activity 0 15295 3 0 solute:hydrogen symporter activity 0 15296 39 0 anion:cation symporter activity 0 15297 32 3 antiporter activity 0 15298 12 1 solute:cation antiporter activity 0 15299 12 1 solute:hydrogen antiporter activity 0 15300 21 3 solute:solute antiporter activity 0 15301 8 0 anion:anion antiporter activity 0 15307 5 0 drug:hydrogen antiporter activity 0 15315 1 0 organophosphate:inorganic phosphate antiporter activity 0 15321 1 0 sodium-dependent phosphate transporter activity 0 15326 5 0 cationic amino acid transporter activity 0 15347 3 0 sodium-independent organic anion transporter activity 0 15354 3 0 polyspecific organic cation transporter activity 0 15355 6 0 monocarboxylate porter activity 0 15367 4 0 oxoglutarate:malate antiporter activity 0 15368 7 0 calcium:cation antiporter activity 0 15370 64 0 solute:sodium symporter activity 0 15373 9 0 monovalent anion:sodium symporter activity 0 15375 1 0 glycine:sodium symporter activity 0 15377 5 0 cation:chloride symporter activity 0 15378 1 0 sodium:chloride symporter activity 0 15379 1 0 potassium:chloride symporter activity 0 15380 3 0 anion exchanger activity 0 15381 8 0 high affinity sulfate permease activity 0 15385 5 1 sodium:hydrogen antiporter activity 0 15395 3 0 "nucleoside transporter activity, down a concentration gradient" 0 15397 2 0 "equilibrative nucleoside transporter, nitrobenzyl-thioinosine-insensitive activity" 0 15399 192 63 primary active transporter activity 0 15405 126 32 P-P-bond-hydrolysis-driven transporter activity 0 15446 1 0 arsenite-transporting ATPase activity 0 15450 24 6 protein translocase activity 0 15457 8 0 auxiliary transport protein activity 0 15459 2 0 potassium channel regulator activity 0 15464 12 0 acetylcholine receptor activity 0 15467 1 0 G-protein activated inward rectifier potassium channel activity 0 15482 1 0 voltage-gated anion channel porin activity 0 15485 1 0 cholesterol binding 0 15491 12 1 cation:cation antiporter activity 0 15495 2 0 gamma-aminobutyric acid:hydrogen symporter activity 0 15501 2 0 glutamate:sodium symporter activity 0 15520 5 0 tetracycline:hydrogen antiporter activity 0 15629 79 21 actin cytoskeleton 0 15630 202 36 microtubule cytoskeleton 0 15631 97 19 tubulin binding 0 15645 7 1 fatty-acid ligase activity 0 15646 2 0 permease activity 0 15662 78 23 "ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism" 0 15665 1 0 alcohol transporter activity 0 15666 3 1 restriction endodeoxyribonuclease activity 0 15668 3 1 type III site-specific deoxyribonuclease activity 0 15669 2 0 gas transport 0 15671 2 0 oxygen transport 0 15672 183 28 monovalent inorganic cation transport 0 15674 40 3 "di-, tri-valent inorganic cation transport" 0 15680 1 0 intracellular copper ion transport 0 15695 3 0 organic cation transport 0 15698 54 1 inorganic anion transport 0 15701 1 0 bicarbonate transport 0 15711 8 0 organic anion transport 0 15718 1 0 monocarboxylic acid transport 0 15734 1 0 taurine transport 0 15742 3 0 alpha-ketoglutarate transport 0 15743 3 0 malate transport 0 15746 5 1 citrate transport 0 15749 6 1 monosaccharide transport 0 15757 2 0 galactose transport 0 15758 1 0 glucose transport 0 15780 4 0 nucleotide-sugar transport 0 15781 4 0 pyrimidine nucleotide-sugar transport 0 15782 2 0 CMP-sialic acid transport 0 15783 1 0 GDP-fucose transport 0 15785 3 0 UDP-galactose transport 0 15786 1 0 UDP-glucose transport 0 15787 1 0 UDP-glucuronic acid transport 0 15788 1 0 UDP-N-acetylglucosamine transport 0 15789 2 0 UDP-N-acetylgalactosamine transport 0 15790 1 0 UDP-xylose transport 0 15807 2 0 L-amino acid transport 0 15811 1 0 L-cystine transport 0 15822 1 0 L-ornithine transport 0 15833 3 0 peptide transport 0 15837 46 0 amine transport 0 15849 54 1 organic acid transport 0 15858 1 0 nucleoside transport 0 15860 1 0 purine nucleoside transport 0 15865 2 1 purine nucleotide transport 0 15866 2 1 ADP transport 0 15867 2 1 ATP transport 0 15879 2 1 carnitine transport 0 15884 1 0 folic acid transport 0 15886 2 0 heme transport 0 15893 10 0 drug transport 0 15904 5 0 tetracycline transport 0 15908 2 0 fatty acid transport 0 15909 2 0 long-chain fatty acid transport 0 15914 2 1 phospholipid transport 0 15918 1 0 sterol transport 0 15922 2 0 aspartate oxidase activity 0 15923 16 2 mannosidase activity 0 15924 7 0 mannosyl-oligosaccharide mannosidase activity 0 15925 3 1 galactosidase activity 0 15926 36 4 glucosidase activity 0 15927 3 0 trehalase activity 0 15928 2 0 fucosidase activity 0 15929 10 3 hexosaminidase activity 0 15930 2 0 glutamate synthase activity 0 15931 38 7 "nucleobase, nucleoside, nucleotide and nucleic acid transport" 0 15932 7 0 "nucleobase, nucleoside, nucleotide and nucleic acid transporter activity" 0 15934 103 62 large ribosomal subunit 0 15935 72 43 small ribosomal subunit 0 15936 1 0 coenzyme A metabolism 0 15937 1 0 coenzyme A biosynthesis 0 15949 1 0 "nucleobase, nucleoside and nucleotide interconversion" 0 15953 1 0 pyrimidine nucleotide interconversion 0 15955 1 0 pyrimidine deoxyribonucleotide interconversion 0 15976 5 0 carbon utilization 0 15977 4 0 carbon utilization by fixation of carbon dioxide 0 15980 121 22 energy derivation by oxidation of organic compounds 0 15985 65 18 "energy coupled proton transport, down electrochemical gradient" 0 15986 65 18 ATP synthesis coupled proton transport 0 15988 1 0 "energy coupled proton transport, against electrochemical gradient" 0 15992 80 24 proton transport 0 15997 1 0 ubiquinone biosynthesis monooxygenase activity 0 15999 1 0 eta DNA polymerase activity 0 16000 1 0 iota DNA polymerase activity 0 16004 1 0 phospholipase activator activity 0 16005 1 0 phospholipase A2 activator activity 0 16006 2 1 Nebenkern 0 16007 3 0 mitochondrial derivative 0 16010 8 1 dystrophin-associated glycoprotein complex 0 16011 5 1 dystroglycan complex 0 16012 3 0 sarcoglycan complex 0 16013 2 0 syntrophin complex 0 16014 1 0 dystrobrevin complex 0 16015 10 1 morphogen activity 0 16018 1 0 cyclosporin A binding 0 16019 3 0 peptidoglycan receptor activity 0 16020 1969 201 membrane 0 16021 981 84 integral to membrane 0 16022 1 0 endoplasmic reticulum cisterna 0 16023 99 10 cytoplasmic membrane-bound vesicle 0 16024 1 0 CDP-diacylglycerol biosynthesis 0 16027 9 1 inaD signaling complex 0 16028 23 4 rhabdomere 0 16029 2 1 subrhabdomeral cisterna 0 16030 3 0 metarhodopsin binding 0 16032 1 0 viral life cycle 0 16034 2 0 maleylacetoacetate isomerase activity 0 16035 1 0 zeta DNA polymerase complex 0 16037 2 0 absorption of light 0 16038 1 0 absorption of visible light 0 16039 1 0 absorption of UV light 0 16042 22 0 lipid catabolism 0 16043 1635 258 cell organization and biogenesis 0 16044 34 4 membrane organization and biogenesis 0 16045 5 0 detection of bacteria 0 16049 34 6 cell growth 0 16050 3 1 vesicle organization and biogenesis 0 16051 52 4 carbohydrate biosynthesis 0 16052 72 16 carbohydrate catabolism 0 16053 32 4 organic acid biosynthesis 0 16054 2 0 organic acid catabolism 0 16055 71 11 Wnt receptor signaling pathway 1 16056 7 3 rhodopsin mediated signaling 0 16058 1 0 maintenance of rhodopsin mediated signaling 0 16059 12 2 deactivation of rhodopsin mediated signaling 0 16060 5 1 metarhodopsin inactivation 0 16061 1 1 regulation of light-activated channel activity 0 16062 4 1 adaptation of rhodopsin mediated signaling 0 16063 9 1 rhodopsin biosynthesis 0 16064 3 0 humoral defense mechanism (sensu Vertebrata) 0 16065 54 1 humoral defense mechanism (sensu Protostomia) 0 16066 1 0 cellular defense response (sensu Vertebrata) 0 16070 423 90 RNA metabolism 0 16071 257 54 mRNA metabolism 0 16072 42 15 rRNA metabolism 0 16079 61 2 synaptic vesicle exocytosis 0 16080 12 1 synaptic vesicle targeting 0 16081 25 2 synaptic vesicle docking during exocytosis 0 16082 16 0 synaptic vesicle priming 0 16084 2 0 myostimulatory hormone activity 0 16085 1 0 myoinhibitory hormone activity 0 16087 1 0 ecdysiostatic hormone activity 0 16096 8 0 polyisoprenoid metabolism 0 16097 4 0 polyisoprenoid catabolism 0 16106 3 0 sesquiterpenoid biosynthesis 0 16107 4 0 sesquiterpenoid catabolism 0 16108 1 0 tetraterpenoid metabolism 0 16114 3 0 terpenoid biosynthesis 0 16115 4 0 terpenoid catabolism 0 16116 1 0 carotenoid metabolism 0 16119 1 0 carotene metabolism 0 16125 33 4 sterol metabolism 0 16126 6 0 sterol biosynthesis 0 16127 1 0 sterol catabolism 0 16137 1 0 glycoside metabolism 0 16139 1 0 glycoside catabolism 0 16140 1 0 O-glycoside metabolism 0 16142 1 0 O-glycoside catabolism 0 16149 2 0 "translation release factor activity, codon specific" 0 16155 1 1 formyltetrahydrofolate dehydrogenase activity 0 16160 14 0 amylase activity 0 16163 1 0 nitrogenase activity 0 16167 1 0 glial cell line-derived neurotrophic factor receptor activity 0 16175 1 0 superoxide-generating NADPH oxidase activity 0 16183 15 3 synaptic vesicle coating 0 16185 2 1 synaptic vesicle budding 0 16189 1 0 synaptic vesicle to endosome fusion 0 16191 3 0 synaptic vesicle uncoating 0 16192 344 53 vesicle-mediated transport 0 16197 14 1 endosome transport 0 16198 13 2 axon choice point recognition 0 16199 8 2 axon midline choice point recognition 0 16200 3 1 synaptic target attraction 0 16201 1 0 synaptic target inhibition 0 16202 7 1 regulation of striated muscle development 0 16203 19 7 muscle attachment 0 16204 3 1 determination of muscle attachment site 0 16205 2 0 selenocysteine methyltransferase activity 0 16207 5 0 4-coumarate-CoA ligase activity 0 16209 39 13 antioxidant activity 1 16211 4 2 ammonia ligase activity 0 16212 1 0 kynurenine-oxoglutarate transaminase activity 0 16215 9 0 CoA desaturase activity 0 16216 1 0 isopenicillin-N synthase activity 0 16219 1 0 GDP-dissociation stimulator activity 0 16220 1 0 RAL GDP-dissociation stimulator activity 0 16222 18 0 "procollagen-proline, 2-oxoglutarate-4-dioxygenase complex" 0 16226 2 0 iron-sulfur cluster assembly 0 16229 8 0 steroid dehydrogenase activity 0 16230 2 0 sphingomyelin phosphodiesterase activator activity 0 16231 2 0 beta-N-acetylglucosaminidase activity 0 16232 3 0 HNK-1 sulfotransferase activity 0 16233 1 0 telomere capping 0 16236 2 1 macroautophagy 0 16245 1 0 hyperphosphorylation of RNA polymerase II 0 16246 12 3 RNA interference 0 16247 6 0 channel regulator activity 0 16248 3 0 channel inhibitor activity 0 16250 1 0 N-sulfoglucosamine sulfohydrolase activity 0 16251 111 22 general RNA polymerase II transcription factor activity 0 16253 3 1 UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase activity 0 16255 2 1 attachment of GPI anchor to protein 0 16259 2 1 selenocysteine metabolism 0 16260 2 1 selenocysteine biosynthesis 0 16265 319 40 death 0 16271 74 9 tissue death 0 16272 7 1 prefoldin complex 0 16273 9 0 arginine N-methyltransferase activity 0 16274 9 0 protein-arginine N-methyltransferase activity 0 16278 17 2 lysine N-methyltransferase activity 0 16279 17 2 protein-lysine N-methyltransferase activity 0 16281 11 1 eukaryotic translation initiation factor 4F complex 0 16282 63 44 eukaryotic 43S preinitiation complex 0 16283 42 33 eukaryotic 48S initiation complex 0 16284 23 2 alanine aminopeptidase activity 0 16285 1 1 cytosol alanyl aminopeptidase activity 0 16286 1 0 small conductance calcium-activated potassium channel activity 0 16287 1 0 glycerone-phosphate O-acyltransferase activity 0 16289 3 0 CoA hydrolase activity 0 16291 2 0 acyl-CoA thioesterase activity 0 16298 96 6 lipase activity 0 16299 8 0 regulator of G-protein signaling activity 0 16301 447 44 kinase activity 0 16303 5 0 phosphatidylinositol 3-kinase activity 0 16307 7 0 phosphatidylinositol phosphate kinase activity 0 16308 4 0 1-phosphatidylinositol-4-phosphate 5-kinase activity 0 16310 504 99 phosphorylation 0 16311 122 8 dephosphorylation 0 16312 1 0 inositol bisphosphate phosphatase activity 0 16314 1 0 "phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity" 0 16316 1 0 "phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity" 0 16318 22 6 ommatidial rotation 0 16319 40 8 mushroom body development 0 16320 1 0 endoplasmic reticulum membrane fusion 0 16321 60 6 female meiosis chromosome segregation 0 16322 2 0 neuron remodeling 0 16323 27 4 basolateral plasma membrane 0 16324 17 2 apical plasma membrane 0 16325 23 6 oocyte microtubule cytoskeleton organization 0 16327 41 7 apicolateral plasma membrane 0 16328 6 3 lateral plasma membrane 0 16330 10 1 second mitotic wave (sensu Endopterygota) 0 16331 109 13 morphogenesis of embryonic epithelium 0 16332 10 1 establishment and/or maintenance of polarity of embryonic epithelium 0 16333 28 4 morphogenesis of follicular epithelium 0 16334 20 4 establishment and/or maintenance of polarity of follicular epithelium 0 16335 7 1 morphogenesis of larval imaginal disc epithelium 0 16336 4 1 establishment and/or maintenance of polarity of larval imaginal disc epithelium 0 16337 128 22 cell-cell adhesion 0 16338 1 0 calcium-independent cell-cell adhesion 0 16339 22 10 calcium-dependent cell-cell adhesion 0 16340 2 1 calcium-dependent cell-matrix adhesion 0 16342 2 0 catenin complex 0 16344 1 0 meiotic chromosome movement towards spindle pole 0 16346 1 0 male meiotic chromosome movement towards spindle pole 0 16348 7 0 leg joint morphogenesis (sensu Endopterygota) 0 16350 8 2 maintenance of oocyte identity (sensu Insecta) 0 16358 53 8 dendrite morphogenesis 0 16360 14 0 sensory organ precursor cell fate determination 0 16361 1 0 "activin receptor activity, type I" 0 16362 1 0 "activin receptor activity, type II" 0 16363 1 0 nuclear matrix 0 16401 3 0 palmitoyl-CoA oxidase activity 0 16402 2 0 pristanoyl-CoA oxidase activity 0 16403 1 0 dimethylargininase activity 0 16405 13 0 CoA-ligase activity 0 16406 6 0 carnitine O-acyltransferase activity 0 16407 49 9 acetyltransferase activity 0 16408 10 2 C-acyltransferase activity 0 16409 4 0 palmitoyltransferase activity 0 16410 33 6 N-acyltransferase activity 0 16411 8 0 acylglycerol O-acyltransferase activity 0 16413 5 0 O-acetyltransferase activity 0 16414 1 0 O-octanoyltransferase activity 0 16415 1 0 octanoyltransferase activity 0 16416 2 0 O-palmitoyltransferase activity 0 16417 6 1 S-acyltransferase activity 0 16418 2 1 S-acetyltransferase activity 0 16419 2 1 S-malonyltransferase activity 0 16420 2 1 malonyltransferase activity 0 16421 4 0 CoA carboxylase activity 0 16422 2 1 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity 0 16423 3 1 tRNA (guanine) methyltransferase activity 0 16433 3 1 rRNA (adenine) methyltransferase activity 0 16436 3 1 rRNA (uridine) methyltransferase activity 0 16441 15 3 posttranscriptional gene silencing 0 16442 6 2 RNA-induced silencing complex 0 16443 1 0 bidentate ribonuclease III activity 0 16452 2 0 theta DNA polymerase activity 0 16453 3 1 C-acetyltransferase activity 0 16454 2 0 C-palmitoyltransferase activity 0 16455 29 5 RNA polymerase II transcription mediator activity 0 16456 8 0 dosage compensation complex (sensu Insecta) 0 16457 6 0 dosage compensation complex assembly (sensu Insecta) 0 16458 112 5 gene silencing 0 16459 25 4 myosin 0 16460 4 0 myosin II 0 16461 7 3 unconventional myosin 0 16462 562 115 pyrophosphatase activity 0 16469 70 20 proton-transporting two-sector ATPase complex 0 16471 32 7 hydrogen-translocating V-type ATPase complex 0 16476 8 1 shape changes of embryonic cells 0 16477 239 29 cell migration 0 16478 25 3 negative regulation of translation 0 16480 1 0 negative regulation of transcription from RNA polymerase III promoter 0 16481 181 11 negative regulation of transcription 0 16482 12 1 cytoplasmic transport 0 16483 1 1 tryptophan hydroxylase activator activity 0 16484 1 0 proprotein convertase 2 activator activity 0 16485 32 8 protein processing 0 16486 2 0 peptide hormone processing 0 16490 24 5 structural constituent of peritrophic membrane (sensu Insecta) 0 16491 675 127 oxidoreductase activity 0 16500 6 0 protein-hormone receptor activity 0 16502 1 0 nucleotide receptor activity 0 16504 4 0 protease activator activity 0 16505 4 0 apoptotic protease activator activity 0 16507 2 0 fatty acid beta-oxidation multienzyme complex 0 16508 1 0 long-chain-enoyl-CoA hydratase activity 0 16509 2 0 long-chain-3-hydroxyacyl-CoA dehydrogenase activity 0 16511 11 0 endothelin-converting enzyme activity 0 16513 3 0 core-binding factor complex 0 16520 3 0 growth hormone-releasing hormone receptor activity 0 16524 1 0 latrotoxin receptor activity 0 16526 10 0 "G-protein coupled receptor activity, unknown ligand" 0 16528 4 0 sarcoplasm 0 16529 4 0 sarcoplasmic reticulum 0 16530 3 0 metallochaperone activity 0 16531 3 0 copper chaperone activity 0 16532 1 0 superoxide dismutase copper chaperone activity 0 16533 1 0 cyclin-dependent protein kinase 5 activator complex 0 16534 1 0 cyclin-dependent protein kinase 5 activator activity 0 16536 1 0 cyclin-dependent protein kinase 5 activator regulator activity 0 16538 16 5 cyclin-dependent protein kinase regulator activity 0 16539 2 0 intein-mediated protein splicing 0 16540 9 2 protein autoprocessing 0 16542 21 1 male courtship behavior (sensu Insecta) 0 16543 2 0 "male courtship behavior (sensu Insecta), orientation" 0 16545 12 1 "male courtship behavior (sensu Insecta), wing vibration" 0 16547 1 0 RNA editing 0 16553 1 0 base conversion or substitution editing 0 16556 1 0 mRNA modification 0 16558 1 0 protein import into peroxisome matrix 0 16559 1 0 peroxisome fission 0 16560 1 0 "protein import into peroxisome matrix, docking" 0 16563 59 10 transcriptional activator activity 0 16564 60 6 transcriptional repressor activity 0 16565 3 0 general transcriptional repressor activity 0 16566 13 0 specific transcriptional repressor activity 0 16567 113 9 protein ubiquitination 0 16568 134 9 chromatin modification 0 16569 27 4 covalent chromatin modification 0 16570 27 4 histone modification 0 16571 14 2 histone methylation 0 16572 6 2 histone phosphorylation 0 16573 5 0 histone acetylation 0 16575 5 0 histone deacetylation 0 16579 21 4 protein deubiquitination 0 16580 3 1 Sin3 complex 0 16581 3 1 NuRD complex 0 16582 1 0 non-covalent chromatin modification 0 16584 5 2 nucleosome spacing 0 16585 32 7 chromatin remodeling complex 0 16589 5 1 NURF complex 0 16590 6 3 ACF complex 0 16591 94 22 "DNA-directed RNA polymerase II, holoenzyme" 0 16592 2 1 Srb-mediator complex 0 16594 1 0 glycine binding 0 16595 3 0 glutamate binding 0 16596 1 0 thienylcyclohexylpiperidine binding 0 16597 8 2 amino acid binding 0 16598 1 1 protein arginylation 0 16599 2 0 caveolar membrane 0 16600 2 0 flotillin complex 0 16601 3 0 Rac protein signal transduction 0 16602 1 0 CCAAT-binding factor complex 0 16603 2 0 glutaminyl-peptide cyclotransferase activity 0 16604 10 3 nuclear body 0 16607 9 3 nuclear speck 0 16609 5 0 G-protein coupled serotonin receptor activity 0 16614 132 22 "oxidoreductase activity, acting on CH-OH group of donors" 0 16615 12 1 malate dehydrogenase activity 0 16616 94 17 "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor" 0 16620 16 4 "oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor" 0 16622 1 0 "oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor" 0 16623 2 0 "oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor" 0 16624 8 2 "oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor" 0 16627 32 1 "oxidoreductase activity, acting on the CH-CH group of donors" 0 16628 3 0 "oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor" 0 16634 11 0 "oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor" 0 16635 5 0 "oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor" 0 16638 13 2 "oxidoreductase activity, acting on the CH-NH2 group of donors" 0 16639 3 1 "oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor" 0 16641 8 1 "oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor" 0 16642 1 0 "oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor" 0 16645 17 1 "oxidoreductase activity, acting on the CH-NH group of donors" 0 16646 13 1 "oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor" 0 16648 1 0 "oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor" 0 16649 1 0 "oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor" 0 16651 51 25 "oxidoreductase activity, acting on NADH or NADPH" 0 16652 2 1 "oxidoreductase activity, acting on NADH or NADPH, NAD or NADP as acceptor" 0 16654 2 0 "oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor" 0 16655 36 15 "oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor" 0 16661 1 0 "oxidoreductase activity, acting on other nitrogenous compounds as donors" 0 16663 1 0 "oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor" 0 16667 13 0 "oxidoreductase activity, acting on sulfur group of donors" 0 16668 7 0 "oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor" 0 16670 4 0 "oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor" 0 16671 2 0 "oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor" 0 16675 19 8 "oxidoreductase activity, acting on heme group of donors" 0 16676 19 8 "oxidoreductase activity, acting on heme group of donors, oxygen as acceptor" 0 16679 15 8 "oxidoreductase activity, acting on diphenols and related substances as donors" 0 16681 11 8 "oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor" 0 16682 4 0 "oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor" 0 16684 33 11 "oxidoreductase activity, acting on peroxide as acceptor" 0 16695 1 0 "oxidoreductase activity, acting on hydrogen as donor" 0 16699 1 0 "oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor" 0 16701 5 1 "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen" 0 16702 5 1 "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen" 0 16705 72 5 "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" 0 16706 34 0 "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors" 0 16709 8 1 "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD or NADH as one donor, and incorporation of one atom of oxygen" 0 16714 5 1 "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen" 0 16715 9 3 "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen" 0 16716 4 0 "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen" 0 16721 9 4 "oxidoreductase activity, acting on superoxide radicals as acceptor" 0 16722 3 1 "oxidoreductase activity, oxidizing metal ions" 0 16723 1 0 "oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor" 0 16724 2 1 "oxidoreductase activity, oxidizing metal ions, oxygen as acceptor" 0 16725 4 2 "oxidoreductase activity, acting on CH2 groups" 0 16726 2 0 "oxidoreductase activity, acting on CH2 groups, NAD or NADP as acceptor" 0 16728 2 2 "oxidoreductase activity, acting on CH2 groups, disulfide as acceptor" 0 16730 3 0 "oxidoreductase activity, acting on iron-sulfur proteins as donors" 0 16731 2 0 "oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor" 0 16732 1 0 "oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor" 0 16740 1049 121 transferase activity 0 16741 96 20 "transferase activity, transferring one-carbon groups" 0 16742 4 2 "hydroxymethyl-, formyl- and related transferase activity" 0 16743 2 1 carboxyl- and carbamoyltransferase activity 0 16744 3 0 "transferase activity, transferring aldehyde or ketonic groups" 0 16746 137 19 "transferase activity, transferring acyl groups" 0 16747 129 17 "transferase activity, transferring groups other than amino-acyl groups" 0 16748 2 0 succinyltransferase activity 0 16749 1 0 N-succinyltransferase activity 0 16751 1 0 S-succinyltransferase activity 0 16755 8 1 "transferase activity, transferring amino-acyl groups" 0 16757 164 10 "transferase activity, transferring glycosyl groups" 0 16758 134 9 "transferase activity, transferring hexosyl groups" 0 16763 19 1 "transferase activity, transferring pentosyl groups" 0 16765 65 12 "transferase activity, transferring alkyl or aryl (other than methyl) groups" 0 16769 20 2 "transferase activity, transferring nitrogenous groups" 0 16772 552 62 "transferase activity, transferring phosphorus-containing groups" 0 16773 398 40 "phosphotransferase activity, alcohol group as acceptor" 0 16774 3 1 "phosphotransferase activity, carboxyl group as acceptor" 0 16775 11 1 "phosphotransferase activity, nitrogenous group as acceptor" 0 16776 23 1 "phosphotransferase activity, phosphate group as acceptor" 0 16778 5 0 diphosphotransferase activity 0 16779 97 18 nucleotidyltransferase activity 0 16780 8 0 "phosphotransferase activity, for other substituted phosphate groups" 0 16781 2 1 "phosphotransferase activity, paired acceptors" 0 16782 20 2 "transferase activity, transferring sulfur-containing groups" 0 16783 1 0 sulfurtransferase activity 0 16787 1959 258 hydrolase activity 0 16788 520 49 "hydrolase activity, acting on ester bonds" 0 16789 149 7 carboxylic ester hydrolase activity 0 16790 34 7 thiolester hydrolase activity 0 16791 201 15 phosphoric monoester hydrolase activity 0 16796 25 3 "exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters" 0 16798 122 15 "hydrolase activity, acting on glycosyl bonds" 0 16799 43 10 "hydrolase activity, hydrolyzing N-glycosyl compounds" 0 16801 8 2 "hydrolase activity, acting on ether bonds" 0 16802 3 1 trialkylsulfonium hydrolase activity 0 16803 5 1 ether hydrolase activity 0 16804 1 0 prolyl aminopeptidase activity 0 16805 6 0 dipeptidase activity 0 16806 17 1 dipeptidyl-peptidase and tripeptidyl-peptidase activity 0 16808 1 0 proprotein convertase activity 0 16810 95 6 "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds" 0 16811 56 1 "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides" 0 16812 6 1 "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides" 0 16813 3 0 "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines" 0 16814 20 1 "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines" 0 16815 3 0 "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles" 0 16817 579 117 "hydrolase activity, acting on acid anhydrides" 0 16818 579 117 "hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides" 0 16820 161 30 "hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances" 0 16822 1 1 "hydrolase activity, acting on acid carbon-carbon bonds" 0 16823 1 1 "hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances" 0 16826 1 0 "hydrolase activity, acting on acid sulfur-nitrogen bonds" 0 16829 173 20 lyase activity 0 16830 51 4 carbon-carbon lyase activity 0 16831 38 2 carboxy-lyase activity 0 16832 6 1 aldehyde-lyase activity 0 16833 4 1 oxo-acid-lyase activity 0 16835 68 10 carbon-oxygen lyase activity 0 16836 60 8 hydro-lyase activity 0 16838 1 0 "carbon-oxygen lyase activity, acting on phosphates" 0 16840 6 2 carbon-nitrogen lyase activity 0 16841 1 0 ammonia-lyase activity 0 16842 3 1 amidine-lyase activity 0 16843 2 1 amine-lyase activity 0 16844 2 1 strictosidine synthase activity 0 16846 8 2 carbon-sulfur lyase activity 0 16847 2 0 1-aminocyclopropane-1-carboxylate synthase activity 0 16849 32 0 phosphorus-oxygen lyase activity 0 16853 97 22 isomerase activity 0 16854 14 1 racemase and epimerase activity 0 16857 10 1 "racemase and epimerase activity, acting on carbohydrates and derivatives" 0 16859 24 13 cis-trans isomerase activity 0 16860 30 3 intramolecular oxidoreductase activity 0 16861 8 2 "intramolecular oxidoreductase activity, interconverting aldoses and ketoses" 0 16862 11 1 "intramolecular oxidoreductase activity, interconverting keto- and enol-groups" 0 16863 11 0 "intramolecular oxidoreductase activity, transposing C=C bonds" 0 16864 11 1 "intramolecular oxidoreductase activity, transposing S-S bonds" 0 16866 11 2 intramolecular transferase activity 0 16868 8 1 "intramolecular transferase activity, phosphotransferases" 0 16872 1 0 intramolecular lyase activity 0 16874 331 43 ligase activity 0 16875 67 10 "ligase activity, forming carbon-oxygen bonds" 0 16876 67 10 "ligase activity, forming aminoacyl-tRNA and related compounds" 0 16877 20 1 "ligase activity, forming carbon-sulfur bonds" 0 16878 13 0 acid-thiol ligase activity 0 16879 184 20 "ligase activity, forming carbon-nitrogen bonds" 0 16880 4 2 acid-ammonia (or amide) ligase activity 0 16881 158 14 acid-amino acid ligase activity 0 16882 3 1 cyclo-ligase activity 0 16884 8 1 "carbon-nitrogen ligase activity, with glutamine as amido-N-donor" 0 16885 5 0 "ligase activity, forming carbon-carbon bonds" 0 16886 78 12 "ligase activity, forming phosphoric ester bonds" 0 16887 389 82 ATPase activity 0 16888 5 1 "endodeoxyribonuclease activity, producing 5'-phosphomonoesters" 0 16889 2 0 "endodeoxyribonuclease activity, producing 3'-phosphomonoesters" 0 16891 11 2 "endoribonuclease activity, producing 5'-phosphomonoesters" 0 16892 3 0 "endoribonuclease activity, producing 3'-phosphomonoesters" 0 16893 16 3 "endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters" 0 16894 5 0 "endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters" 0 16895 8 1 "exodeoxyribonuclease activity, producing 5'-phosphomonoesters" 0 16896 18 3 "exoribonuclease activity, producing 5'-phosphomonoesters" 0 16899 3 0 "oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor" 0 16900 1 0 "oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor" 0 16903 27 6 "oxidoreductase activity, acting on the aldehyde or oxo group of donors" 0 16909 5 0 SAP kinase activity 0 16917 18 0 GABA receptor activity 0 16918 6 1 retinal binding 0 16919 2 0 nardilysin activity 0 16920 2 0 pyroglutamyl-peptidase activity 0 16921 1 0 pyroglutamyl-peptidase II activity 0 16922 3 0 ligand-dependent nuclear receptor binding 0 16925 2 1 protein sumoylation 0 16929 1 0 SUMO-specific protease activity 0 16931 1 0 vasopressin activated calcium mobilizing receptor activity 0 16933 7 0 glycine-gated ion channel activity 0 16934 4 0 glycine-gated chloride channel activity 0 16935 4 0 glycine-gated chloride channel complex 0 16936 2 0 galactoside binding 0 16937 2 0 short-branched-chain-acyl-CoA dehydrogenase activity 0 16939 1 0 kinesin II complex 0 16941 1 0 natriuretic peptide receptor activity 0 16942 2 0 insulin-like growth factor binding protein complex 0 16944 3 0 RNA polymerase II transcription elongation factor activity 0 16971 3 0 flavin-linked sulfhydryl oxidase activity 0 16972 3 0 thiol oxidase activity 0 16973 4 0 poly(A)+ mRNA export from nucleus 0 16974 2 0 sodium channel auxiliary protein activity 0 16976 1 0 NEDD8 conjugating enzyme activity 0 16978 1 0 lipoate-protein ligase B activity 0 16979 3 0 lipoate-protein ligase activity 0 16984 4 0 ribulose-bisphosphate carboxylase activity 0 16986 6 1 transcription initiation factor activity 0 16992 1 0 lipoate synthase activity 0 16998 8 1 cell wall catabolism 0 16999 1 0 antibiotic metabolism 0 17000 1 0 antibiotic biosynthesis 0 17002 2 0 activin receptor activity 0 17003 1 1 protein-heme linkage 0 17004 2 1 cytochrome complex assembly 0 17005 2 0 tyrosyl-DNA phosophodiesterase activity 0 17006 1 1 protein-tetrapyrrole linkage 0 17015 6 1 regulation of transforming growth factor beta receptor signaling pathway 0 17016 4 0 Ras GTPase binding 0 17017 4 0 MAP kinase phosphatase activity 0 17018 3 0 myosin phosphatase activity 0 17020 1 0 myosin phosphatase regulator activity 0 17022 5 0 myosin binding 0 17023 1 0 myosin phosphatase complex 0 17024 1 0 myosin I binding 0 17025 2 1 TATA-binding protein binding 0 17026 5 0 procollagen C-endopeptidase activity 0 17032 5 0 potassium:amino acid symporter activity 0 17033 1 0 DNA topoisomerase I binding 0 17034 1 0 Rap guanyl-nucleotide exchange factor activity 0 17038 60 5 protein import 0 17039 2 1 dipeptidyl-peptidase III activity 0 17040 4 0 ceramidase activity 0 17046 1 0 peptide hormone binding 0 17047 1 0 adrenocorticotropin-releasing hormone binding 0 17048 6 1 Rho GTPase binding 0 17049 1 0 GTP-Rho binding 0 17050 3 0 D-erythro-sphingosine kinase activity 0 17051 2 1 retinol dehydratase activity 0 17053 6 2 transcriptional repressor complex 0 17054 2 0 negative cofactor 2 complex 0 17055 2 0 negative regulation of transcriptional preinitiation complex formation 0 17056 3 0 structural constituent of nuclear pore 0 17057 1 1 6-phosphogluconolactonase activity 0 17058 2 1 FH1 domain binding 0 17059 1 0 serine C-palmitoyltransferase complex 0 17061 2 0 S-methyl-5-thioadenosine phosphorylase activity 0 17063 1 0 phosphatidylserine-specific phospholipase A1 activity 0 17064 4 0 fatty acid amide hydrolase activity 0 17065 1 0 single-strand selective uracil DNA N-glycosylase activity 0 17067 1 0 tyrosine-ester sulfotransferase activity 0 17068 3 1 glutamyl-tRNA(Gln) amidotransferase activity 0 17069 3 1 snRNA binding 0 17070 1 1 U6 snRNA binding 0 17071 2 0 intracellular cyclic nucleotide activated cation channel complex 0 17074 1 0 procollagen N-endopeptidase activity 0 17075 1 0 syntaxin-1 binding 0 17076 886 144 purine nucleotide binding 0 17077 5 0 oxidative phosphorylation uncoupler activity 0 17078 1 0 Hsc70 protein regulator activity 0 17084 1 0 delta1-pyrroline-5-carboxylate synthetase activity 0 17085 16 0 response to insecticide 0 17086 2 0 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex 0 17087 1 1 mitochondrial processing peptidase complex 0 17088 1 0 X-Pro dipeptidyl-peptidase activity 0 17090 4 0 meprin A complex 0 17091 1 0 AU-specific RNA binding 0 17092 1 0 sterol regulatory element-binding protein site 2 protease activity 0 17093 1 0 sterol regulatory element-binding protein protease activity 0 17095 1 0 heparan sulfate 6-O-sulfotransferase activity 0 17098 1 0 sulfonylurea receptor binding 0 17099 1 0 very-long-chain-acyl-CoA dehydrogenase activity 0 17100 1 1 aminoacyl-tRNA synthetase auxiliary protein activity 0 17101 3 1 aminoacyl-tRNA synthetase multienzyme complex 0 17105 1 0 acyl-CoA delta11-desaturase activity 0 17106 1 0 activin inhibitor activity 0 17107 1 0 anion exchanger adaptor activity 0 17109 3 0 glutamate-cysteine ligase complex 0 17110 2 0 nucleoside-diphosphatase activity 0 17111 553 112 nucleoside-triphosphatase activity 0 17112 2 0 Rab guanyl-nucleotide exchange factor activity 0 17113 1 0 dihydropyrimidine dehydrogenase (NADP+) activity 0 17114 1 0 wide-spectrum protease inhibitor activity 0 17116 3 2 single-stranded DNA-dependent ATP-dependent DNA helicase activity 0 17117 1 0 single-stranded DNA-dependent ATP-dependent DNA helicase complex 0 17118 1 0 lipoyltransferase activity 0 17119 1 0 Golgi transport complex 0 17120 1 0 polyphosphoinositide phosphatase activity 0 17121 3 0 phospholipid scrambling 0 17122 2 1 UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase complex 0 17123 1 1 Ral GTPase activator activity 0 17124 5 0 SH3 domain binding 0 17125 1 1 deoxycytidyl transferase activity 0 17126 1 1 nucleologenesis 0 17127 1 0 cholesterol transporter activity 0 17128 3 0 phospholipid scramblase activity 0 17129 1 0 triglyceride binding 0 17130 1 1 poly(rC) binding 0 17131 1 0 uridine-rich cytoplasmic polyadenylylation element binding 0 17132 2 1 cyclic nucleotide-dependent guanyl-nucleotide exchange factor activity 0 17133 2 1 electron transfer flavoprotein complex (sensu Eukaryota) 0 17134 2 0 fibroblast growth factor binding 0 17136 2 0 NAD-dependent histone deacetylase activity 0 17137 2 0 Rab GTPase binding 0 17140 1 0 lipoic acid synthase activity 0 17143 9 0 insecticide metabolism 0 17144 1 0 drug metabolism 0 17145 50 1 stem cell division 0 17146 3 0 N-methyl-D-aspartate selective glutamate receptor complex 0 17147 8 1 Wnt-protein binding 0 17148 4 0 negative regulation of protein biosynthesis 0 17150 1 0 tRNA dihydrouridine synthase activity 0 17151 2 1 DEAD/H-box RNA helicase binding 0 17153 3 0 sodium:dicarboxylate symporter activity 0 17154 2 0 semaphorin receptor activity 0 17155 1 0 sodium:hydrogen antiporter regulator activity 0 17156 1 0 calcium ion-dependent exocytosis 0 17157 45 5 regulation of exocytosis 0 17158 1 0 regulation of calcium ion-dependent exocytosis 0 17159 3 0 pantetheinase activity 0 17160 1 0 Ral GTPase binding 0 17162 1 0 aryl hydrocarbon receptor binding 0 17163 1 0 negative regulator of basal transcription activity 0 17165 1 0 dipeptidase E activity 0 17166 1 0 vinculin binding 0 17168 1 0 5-oxoprolinase (ATP-hydrolyzing) activity 0 17169 6 0 CDP-alcohol phosphatidyltransferase activity 0 17170 1 0 KU70 binding 0 17171 2 0 serine hydrolase activity 0 17172 1 0 cysteine dioxygenase activity 0 17173 1 0 DRAP deaminase activity 0 17174 1 0 glycine N-methyltransferase activity 0 17176 3 0 phosphatidylinositol N-acetylglucosaminyltransferase activity 0 17177 5 1 alpha-glucosidase II complex 0 17182 2 0 peptidyl-diphthamide metabolism 0 17183 2 0 peptidyl-diphthamide biosynthesis from peptidyl-histidine 0 17187 1 0 peptidyl-glutamic acid carboxylation 0 18009 1 0 N-terminal peptidyl-L-cysteine N-palmitoylation 0 18024 17 2 histone-lysine N-methyltransferase activity 0 18063 1 1 cytochrome c-heme linkage 0 18105 1 0 peptidyl-serine phosphorylation 0 18107 1 1 peptidyl-threonine phosphorylation 0 18108 5 0 peptidyl-tyrosine phosphorylation 0 18130 1 0 heterocycle biosynthesis 0 18149 3 2 peptide cross-linking 0 18166 1 0 C-terminal protein-tyrosinylation 0 18193 37 2 peptidyl-amino acid modification 0 18195 3 0 peptidyl-arginine modification 0 18196 2 1 peptidyl-asparagine modification 0 18198 1 0 peptidyl-cysteine modification 0 18200 1 0 peptidyl-glutamic acid modification 0 18202 2 0 peptidyl-histidine modification 0 18205 2 0 peptidyl-lysine modification 0 18206 1 0 peptidyl-methionine modification 0 18208 16 0 peptidyl-proline modification 0 18209 1 0 peptidyl-serine modification 0 18210 1 1 peptidyl-threonine modification 0 18212 6 0 peptidyl-tyrosine modification 0 18214 1 0 protein amino acid carboxylation 0 18215 1 0 protein amino acid phosphopantetheinylation 0 18216 3 0 peptidyl-arginine methylation 0 18271 1 0 biotin-protein ligase activity 0 18279 2 1 protein amino acid N-linked glycosylation via asparagine 0 18318 1 0 protein amino acid palmitoylation 0 18319 2 2 protein amino acid myristoylation 0 18322 1 0 protein amino acid tyrosinylation 0 18342 10 2 protein prenylation 0 18343 1 0 protein farnesylation 0 18344 1 1 protein geranylgeranylation 0 18345 1 0 protein palmitoylation 0 18346 9 2 protein amino acid prenylation 0 18348 1 1 protein amino acid geranylgeranylation 0 18377 2 2 protein myristoylation 0 18392 1 0 glycoprotein 3-alpha-L-fucosyltransferase activity 0 18394 1 0 peptidyl-lysine acetylation 0 18401 16 0 peptidyl-proline hydroxylation to 4-hydroxy-L-proline 0 18410 2 0 peptide or protein carboxyl-terminal blocking 0 18444 1 0 translation release factor complex 0 18445 1 0 prothoracicotrophic hormone activity 0 18454 1 0 acetoacetyl-CoA reductase activity 0 18741 1 0 alkyl sulfatase activity 0 18958 17 5 phenol metabolism 0 18987 1 0 osmoregulation 0 18988 37 2 molting cycle (sensu Protostomia and Nematoda) 0 18990 6 0 ecdysis (sensu Insecta) 0 18991 14 1 oviposition 0 18992 6 0 germ-line sex determination 0 18993 18 2 somatic sex determination 0 18994 9 1 polar granule 0 18995 2 1 host 0 19001 172 35 guanyl nucleotide binding 0 19003 4 2 GDP binding 0 19005 11 5 SCF ubiquitin ligase complex 0 19007 1 1 N-acetylneuraminic acid phosphate synthase activity 0 19008 2 0 molybdopterin synthase complex 0 19009 1 0 molybdopterin converting factor 0 19010 1 0 farnesoic acid O-methyltransferase activity 0 19012 1 0 virion 0 19028 1 0 viral capsid 0 19058 1 0 viral infectious cycle 0 19090 1 1 mitochondrial rRNA export from mitochondrion 0 19093 1 1 mitochondrial RNA localization 0 19094 60 5 pole plasm mRNA localization 0 19098 97 8 reproductive behavior 0 19099 5 0 female germ-line sex determination 0 19101 6 1 female somatic sex determination 0 19102 2 1 male somatic sex determination 0 19104 6 1 DNA N-glycosylase activity 0 19107 2 2 myristoyltransferase activity 0 19136 1 0 deoxynucleoside kinase activity 0 19182 2 0 histamine-gated chloride channel activity 0 19183 2 0 histamine-gated chloride channel complex 0 19184 1 0 nonribosomal peptide biosynthesis 0 19185 1 0 snRNA-activating protein complex 0 19186 1 0 acyl-CoA N-acyltransferase activity 0 19187 2 0 "beta-1,4-mannosyltransferase activity" 0 19198 8 0 transmembrane receptor protein phosphatase activity 0 19199 54 9 transmembrane receptor protein kinase activity 0 19200 36 4 carbohydrate kinase activity 0 19201 32 2 nucleotide kinase activity 0 19202 5 1 amino acid kinase activity 0 19203 6 1 carbohydrate phosphatase activity 0 19204 36 4 nucleotide phosphatase activity 0 19205 34 2 "nucleobase, nucleoside, nucleotide kinase activity" 0 19206 8 0 nucleoside kinase activity 0 19207 81 13 kinase regulator activity 0 19208 33 2 phosphatase regulator activity 0 19209 19 6 kinase activator activity 0 19210 21 3 kinase inhibitor activity 0 19211 4 1 phosphatase activator activity 0 19212 9 0 phosphatase inhibitor activity 0 19213 12 1 deacetylase activity 0 19215 2 2 intermediate filament binding 0 19216 5 0 regulation of lipid metabolism 0 19217 1 0 regulation of fatty acid metabolism 0 19218 1 0 regulation of steroid metabolism 0 19219 1006 124 "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" 0 19220 13 3 regulation of phosphate metabolism 0 19221 33 4 cytokine and chemokine mediated signaling pathway 0 19222 1156 157 regulation of metabolism 0 19226 414 26 transmission of nerve impulse 0 19227 1 0 action potential propagation 0 19233 3 0 sensory perception of pain 0 19236 13 0 response to pheromone 0 19237 12 4 centromeric DNA binding 0 19238 4 0 cyclohydrolase activity 0 19239 24 2 deaminase activity 0 19307 1 0 mannose biosynthesis 0 19318 82 15 hexose metabolism 0 19319 10 2 hexose biosynthesis 0 19320 52 15 hexose catabolism 0 19321 3 0 pentose metabolism 0 19343 1 0 cysteine biosynthesis via cystathione 0 19344 1 0 cysteine biosynthesis 0 19362 15 4 pyridine nucleotide metabolism 0 19363 3 0 pyridine nucleotide biosynthesis 0 19368 1 0 "fatty acid elongation, unsaturated fatty acid" 0 19395 23 2 fatty acid oxidation 0 19428 1 0 allantoin biosynthesis 0 19430 3 1 removal of superoxide radicals 0 19432 1 0 triacylglycerol biosynthesis 0 19438 15 1 aromatic compound biosynthesis 0 19439 10 2 aromatic compound catabolism 0 19471 16 0 4-hydroxyproline metabolism 0 19482 2 0 beta-alanine metabolism 0 19483 2 0 beta-alanine biosynthesis 0 19511 16 0 peptidyl-proline hydroxylation 0 19538 2524 411 protein metabolism 0 19547 1 0 arginine catabolism to ornithine 0 19551 2 1 glutamate catabolism to 2-oxoglutarate 0 19605 3 1 butyrate metabolism 0 19627 1 0 urea metabolism 0 19673 1 0 GDP-mannose metabolism 0 19674 2 0 NAD metabolism 0 19720 7 0 Mo-molybdopterin cofactor metabolism 0 19722 63 1 calcium-mediated signaling 0 19724 3 0 B cell mediated immunity 0 19725 68 4 cell homeostasis 0 19730 69 3 antimicrobial humoral response 0 19731 44 3 antibacterial humoral response 0 19732 14 0 antifungal humoral response 0 19740 2 0 nitrogen utilization 0 19747 2 0 regulation of isoprenoid metabolism 0 19748 79 5 secondary metabolism 0 19751 10 0 polyol metabolism 0 19752 408 46 carboxylic acid metabolism 0 19781 2 1 NEDD8 activating enzyme activity 0 19783 1 0 ubiquitin-like-protein-specific protease activity 0 19794 4 0 nonprotein amino acid metabolism 0 19795 2 0 nonprotein amino acid biosynthesis 0 19798 19 0 procollagen-proline dioxygenase activity 0 19811 2 0 cocaine binding 0 19827 19 0 stem cell maintenance 0 19829 71 19 cation-transporting ATPase activity 0 19835 1 0 cytolysis 0 19838 8 0 growth factor binding 0 19840 8 1 isoprenoid binding 0 19841 1 0 retinol binding 0 19842 24 4 vitamin binding 0 19843 7 1 rRNA binding 0 19856 5 1 pyrimidine base biosynthesis 0 19860 2 0 uracil metabolism 0 19861 11 0 flagellum 0 19866 190 64 organelle inner membrane 0 19867 20 4 outer membrane 0 19887 48 8 protein kinase regulator activity 0 19888 33 2 protein phosphatase regulator activity 0 19889 3 0 pteridine metabolism 0 19894 8 1 kinesin binding 0 19895 1 0 kinesin-associated mitochondrial adaptor activity 0 19896 1 0 axon transport of mitochondrion 0 19897 40 5 extrinsic to plasma membrane 0 19898 49 5 extrinsic to membrane 0 19899 54 5 enzyme binding 0 19900 14 2 kinase binding 0 19901 11 2 protein kinase binding 0 19902 6 0 phosphatase binding 0 19903 6 0 protein phosphatase binding 0 19904 13 3 protein domain specific binding 0 19905 3 0 syntaxin binding 0 19908 5 3 nuclear cyclin-dependent protein kinase holoenzyme complex 0 19909 1 0 [pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity 0 19910 1 0 pyruvate dehydrogenase (lipoamide) phosphatase complex (sensu Eukaryota) 0 19911 1 0 structural constituent of myelin sheath 0 19915 3 0 sequestering of lipid 0 19919 3 0 "peptidyl-arginine methylation, to asymmetrical-dimethyl arginine" 0 19932 88 3 second-messenger-mediated signaling 0 19933 13 1 cAMP-mediated signaling 0 19934 1 0 cGMP-mediated signaling 0 19935 14 1 cyclic-nucleotide-mediated signaling 0 19941 78 31 modification-dependent protein catabolism 0 19948 2 1 SUMO activating enzyme activity 0 19949 1 1 SUMO conjugating enzyme activity 0 19950 2 1 SMT3-dependent protein catabolism 0 19953 774 72 sexual reproduction 0 19955 4 0 cytokine binding 0 19965 1 0 interleukin binding 0 19984 2 0 sigma DNA polymerase activity 0 19985 4 1 bypass DNA synthesis 0 19991 13 1 septate junction assembly 0 19992 27 2 diacylglycerol binding 0 20037 5 2 heme binding 0 30001 153 10 metal ion transport 0 30003 23 1 cation homeostasis 0 30005 21 1 "di-, tri-valent inorganic cation homeostasis" 0 30008 6 0 TRAPP complex 0 30010 10 3 establishment of cell polarity 0 30011 1 0 maintenance of cell polarity 0 30014 1 0 CCR4-NOT complex 0 30016 10 4 myofibril 0 30017 10 4 sarcomere 0 30018 1 1 Z disc 0 30029 112 18 actin filament-based process 0 30030 60 8 cell projection organization and biogenesis 0 30031 38 1 cell projection biogenesis 0 30032 3 0 lamellipodium biogenesis 0 30035 6 0 microspike biogenesis 0 30036 112 18 actin cytoskeleton organization and biogenesis 0 30037 5 1 actin filament reorganization during cell cycle 0 30041 10 5 actin filament polymerization 0 30042 6 0 actin filament depolymerization 0 30046 1 0 parallel actin filament bundle formation 0 30047 1 0 actin modification 0 30054 75 11 cell junction 0 30055 18 2 cell-matrix junction 0 30057 1 1 desmosome 0 30060 6 1 L-malate dehydrogenase activity 0 30062 5 0 tricarboxylic acid cycle enzyme complex (sensu Eukaryota) 0 30071 5 0 regulation of mitotic metaphase/anaphase transition 0 30091 1 0 protein repair 0 30097 72 9 hemopoiesis 0 30100 2 0 regulation of endocytosis 0 30104 1 0 water homeostasis 0 30111 17 2 regulation of Wnt receptor signaling pathway 0 30117 28 6 membrane coat 0 30118 18 3 clathrin coat 0 30119 6 0 membrane coat adaptor complex 0 30120 26 6 vesicle coat 0 30121 1 0 AP-1 adaptor complex 0 30122 2 0 AP-2 adaptor complex 0 30123 1 0 AP-3 adaptor complex 0 30125 16 3 clathrin vesicle coat 0 30126 9 4 COPI vesicle coat 0 30127 3 0 COPII vesicle coat 0 30128 2 0 clathrin coat of endocytic vesicle 0 30129 1 0 clathrin coat of synaptic vesicle 0 30130 5 0 clathrin coat of trans-Golgi network vesicle 0 30131 6 0 clathrin adaptor complex 0 30132 4 1 clathrin coat of coated pit 0 30133 16 1 transport vesicle 0 30134 3 0 ER to Golgi transport vesicle 0 30135 81 10 coated vesicle 0 30136 69 6 clathrin-coated vesicle 0 30137 10 4 COPI-coated vesicle 0 30139 5 0 endocytic vesicle 0 30140 7 0 trans-Golgi network transport vesicle 0 30141 2 0 secretory granule 0 30142 1 0 Golgi to ER transport vesicle 0 30145 7 0 manganese ion binding 0 30146 1 0 diuresis 0 30148 4 0 sphingolipid biosynthesis 0 30149 4 0 sphingolipid catabolism 0 30154 705 77 cell differentiation 0 30155 3 1 regulation of cell adhesion 0 30158 1 0 protein xylosyltransferase activity 0 30159 2 0 receptor signaling complex scaffold activity 0 30162 33 6 regulation of proteolysis 0 30163 92 32 protein catabolism 0 30166 17 1 proteoglycan biosynthesis 0 30169 13 1 low-density lipoprotein binding 0 30170 4 1 pyridoxal phosphate binding 0 30173 4 1 integral to Golgi membrane 0 30176 11 4 integral to endoplasmic reticulum membrane 0 30177 3 1 positive regulation of Wnt receptor signaling pathway 0 30178 13 2 negative regulation of Wnt receptor signaling pathway 0 30182 202 31 neuron differentiation 0 30188 1 0 chaperone regulator activity 0 30192 1 0 Hsp70/Hsc70 protein regulator activity 0 30198 34 3 extracellular matrix organization and biogenesis 0 30201 12 1 heparan sulfate proteoglycan metabolism 0 30202 2 0 heparin metabolism 0 30203 13 1 glycosaminoglycan metabolism 0 30204 10 1 chondroitin sulfate metabolism 0 30206 10 1 chondroitin sulfate biosynthesis 0 30210 2 0 heparin biosynthesis 0 30215 2 2 semaphorin receptor binding 0 30228 14 1 lipoprotein receptor activity 0 30234 383 52 enzyme regulator activity 1 30237 11 1 female sex determination 0 30238 2 1 male sex determination 0 30239 8 2 myofibril assembly 0 30241 2 0 muscle thick filament assembly 0 30246 119 19 carbohydrate binding 0 30247 67 16 polysaccharide binding 0 30249 1 0 guanylate cyclase regulator activity 0 30250 1 0 guanylate cyclase activator activity 0 30258 8 0 lipid modification 0 30261 30 3 chromosome condensation 0 30262 3 0 apoptotic nuclear changes 0 30267 2 1 glyoxylate reductase (NADP) activity 0 30272 2 1 5-formyltetrahydrofolate cyclo-ligase activity 0 30276 1 0 clathrin binding 0 30285 2 0 integral to synaptic vesicle membrane 0 30286 42 4 dynein complex 0 30289 1 1 protein phosphatase 4 complex 0 30292 1 0 protein tyrosine kinase inhibitor activity 0 30295 2 1 protein kinase activator activity 0 30296 1 1 protein tyrosine kinase activator activity 0 30301 1 0 cholesterol transport 0 30307 14 3 positive regulation of cell growth 0 30308 3 0 negative regulation of cell growth 0 30312 10 1 external encapsulating structure 0 30317 4 1 sperm motility 0 30330 1 0 "DNA damage response, signal transduction by p53 class mediator" 0 30332 6 1 cyclin binding 0 30334 2 1 regulation of cell migration 0 30337 4 1 DNA polymerase processivity factor activity 0 30371 5 0 translation repressor activity 0 30374 1 0 ligand-dependent nuclear receptor transcription coactivator activity 0 30381 8 2 eggshell pattern formation (sensu Insecta) 0 30384 18 2 phosphoinositide metabolism 0 30397 2 0 membrane disassembly 0 30414 89 10 protease inhibitor activity 0 30422 4 0 "RNA interference, production of siRNA" 0 30423 6 0 "RNA interference, targeting of mRNA for destruction" 0 30424 7 0 axon 0 30425 2 0 dendrite 0 30431 14 2 sleep 0 30432 1 1 peristalsis 0 30433 1 0 ER-associated protein catabolism 0 30471 1 0 spindle pole body and microtubule cycle (sensu Fungi) 0 30489 1 1 processing of 27S pre-rRNA 0 30496 6 1 midbody 0 30497 3 0 fatty acid elongation 0 30503 1 0 regulation of cell redox homeostasis 0 30506 1 0 ankyrin binding 0 30507 2 0 spectrin binding 0 30508 11 5 thiol-disulfide exchange intermediate activity 0 30509 13 1 BMP signaling pathway 0 30510 6 1 regulation of BMP signaling pathway 0 30511 1 1 positive regulation of transforming growth factor beta receptor signaling pathway 0 30512 4 1 negative regulation of transforming growth factor beta receptor signaling pathway 0 30513 1 0 positive regulation of BMP signaling pathway 0 30514 1 0 negative regulation of BMP signaling pathway 0 30516 4 1 regulation of axon extension 0 30517 2 0 negative regulation of axon extension 0 30518 2 0 steroid hormone receptor signaling pathway 0 30522 2 0 intracellular receptor-mediated signaling pathway 0 30523 3 0 dihydrolipoamide S-acyltransferase activity 0 30528 865 103 transcription regulator activity 1 30529 384 152 ribonucleoprotein complex 0 30530 7 2 heterogeneous nuclear ribonucleoprotein complex 0 30532 103 19 small nuclear ribonucleoprotein complex 0 30533 221 0 triplet codon-amino acid adaptor activity 0 30534 100 5 adult behavior 0 30536 10 0 larval feeding behavior 0 30537 24 3 larval behavior 0 30539 5 1 male genitalia morphogenesis 0 30540 3 1 female genitalia morphogenesis 0 30544 1 0 Hsp70 protein binding 0 30545 2 0 receptor regulator activity 0 30547 2 0 receptor inhibitor activity 0 30551 2 0 cyclic nucleotide binding 0 30554 719 111 adenyl nucleotide binding 0 30555 12 0 RNA modification guide activity 0 30556 5 0 rRNA modification guide activity 0 30575 1 0 nuclear body organization and biogenesis 0 30580 1 0 quinone cofactor methyltransferase activity 0 30586 1 0 [methionine synthase] reductase activity 0 30588 4 1 pseudocleavage 0 30589 4 1 pseudocleavage (sensu Insecta) 0 30594 66 0 neurotransmitter receptor activity 0 30599 1 0 pectinesterase activity 0 30616 1 0 "transforming growth factor beta receptor, common-partner cytoplasmic mediator activity" 0 30617 1 0 "transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity" 0 30618 1 0 "transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity" 0 30619 2 0 U1 snRNA binding 0 30658 3 0 transport vesicle membrane 0 30659 3 0 cytoplasmic vesicle membrane 0 30660 3 0 Golgi vesicle membrane 0 30662 3 0 coated vesicle membrane 0 30672 3 0 synaptic vesicle membrane 0 30674 10 0 "protein binding, bridging" 0 30677 4 2 ribonuclease P complex 0 30678 1 1 mitochondrial ribonuclease P complex 0 30693 10 1 caspase activity 0 30695 137 21 GTPase regulator activity 0 30702 39 1 chromatin silencing at centromere 0 30703 87 10 eggshell formation 0 30704 8 0 vitelline membrane formation 0 30705 115 15 cytoskeleton-dependent intracellular transport 0 30706 20 2 oocyte differentiation (sensu Insecta) 0 30707 184 17 ovarian follicle cell development (sensu Insecta) 0 30708 7 0 female germ-line cyst encapsulation (sensu Insecta) 0 30709 1 0 border follicle cell delamination 0 30710 1 0 regulation of border follicle cell delamination 0 30713 14 1 stalk formation (sensu Insecta) 0 30714 1 0 "anterior/posterior axis determination, follicular epithelium" 0 30716 21 3 oocyte fate determination 0 30717 15 2 karyosome formation 0 30718 14 0 germ-line stem cell maintenance 0 30719 1 0 polar granule organization and biogenesis 0 30720 11 0 oocyte localization during oogenesis 0 30721 5 1 spectrosome organization and biogenesis 0 30722 8 1 establishment of oocyte nucleus localization during oocyte axis determination 0 30723 5 1 ovarian fusome organization and biogenesis 0 30725 16 1 ring canal formation 0 30726 1 0 testicular ring canal formation 0 30727 6 0 female germ-line cyst formation (sensu Insecta) 0 30728 4 0 ovulation 0 30730 2 0 sequestering of triacylglycerol 0 30832 14 5 regulation of actin filament length 0 30833 4 4 regulation of actin filament polymerization 0 30834 3 0 regulation of actin filament depolymerization 0 30835 3 0 negative regulation of actin filament depolymerization 0 30849 1 0 autosome 0 30855 12 5 epithelial cell differentiation 0 30859 6 2 polarized epithelial cell differentiation 0 30863 3 1 cortical cytoskeleton 0 30864 3 1 cortical actin cytoskeleton 0 30865 7 1 cortical cytoskeleton organization and biogenesis 0 30866 7 1 cortical actin cytoskeleton organization and biogenesis 0 30867 12 8 rough endoplasmic reticulum membrane 0 30870 1 0 Mre11 complex 0 30880 26 7 RNA polymerase complex 0 30891 1 0 VCB complex 0 30894 17 4 replisome 0 30908 2 0 protein splicing 0 30935 3 1 sheet-forming collagen 0 30951 23 6 establishment and/or maintenance of microtubule cytoskeleton polarity 0 30952 23 6 establishment and/or maintenance of cytoskeleton polarity 0 31010 5 1 ISWI complex 0 31012 88 6 extracellular matrix 0 31023 18 5 microtubule organizing center organization and biogenesis 0 31032 12 2 actomyosin structure organization and biogenesis 0 31033 2 0 myosin filament assembly or disassembly 0 31034 2 0 myosin filament assembly 0 31047 15 3 RNA-mediated gene silencing 0 31050 6 0 dsRNA fragmentation 0 31053 2 0 primary microRNA processing 0 31054 1 0 pre-microRNA processing 0 31055 39 1 chromatin remodeling at centromere 0 31056 2 0 regulation of histone modification 0 31057 1 0 negative regulation of histone modification 0 31058 1 0 positive regulation of histone modification 0 31072 1 0 heat shock protein binding 0 31090 320 91 organelle membrane 0 31098 54 8 stress-activated protein kinase signaling pathway 0 31099 2 0 regeneration 0 31109 27 5 microtubule polymerization or depolymerization 0 31110 11 2 regulation of microtubule polymerization or depolymerization 0 31111 10 2 negative regulation of microtubule polymerization or depolymerization 0 31112 1 0 positive regulation of microtubule polymerization or depolymerization 0 31114 11 2 regulation of microtubule depolymerization 0 31117 1 0 positive regulation of microtubule depolymerization 0 31122 2 1 cytoplasmic microtubule organization and biogenesis 0 31123 32 8 RNA 3'-end processing 0 31124 32 8 mRNA 3'-end processing 0 31134 1 0 sister chromatid biorientation 0 31151 2 0 histone lysine N-methyltransferase activity (H3-K79 specific) 0 31163 2 0 metallo-sulfur cluster assembly 0 31175 195 30 neurite morphogenesis 0 31179 1 0 peptide modification 0 31202 24 9 "RNA splicing factor activity, transesterification mechanism" 0 31223 14 0 auditory behavior 0 31224 985 84 intrinsic to membrane 0 31225 2 0 anchored to membrane 0 31226 211 17 intrinsic to plasma membrane 0 31227 11 4 intrinsic to endoplasmic reticulum membrane 0 31228 4 1 intrinsic to Golgi membrane 0 31231 5 0 intrinsic to peroxisomal membrane 0 31248 1 0 protein acetyltransferase complex 0 31252 2 0 leading edge 0 31267 21 2 small GTPase binding 0 31279 3 1 regulation of cyclase activity 0 31281 3 1 positive regulation of cyclase activity 0 31300 19 5 intrinsic to organelle membrane 0 31301 19 5 integral to organelle membrane 0 31323 1111 144 regulation of cellular metabolism 0 31324 211 15 negative regulation of cellular metabolism 0 31325 72 8 positive regulation of cellular metabolism 0 31326 90 18 regulation of cellular biosynthesis 0 31327 5 0 negative regulation of cellular biosynthesis 0 31332 6 2 RNAi effector complex 0 31344 1 0 regulation of cell projection organization and biogenesis 0 31347 2 0 regulation of defense response 0 31348 1 0 negative regulation of defense response 0 31369 1 0 translation initiation factor binding 0 31395 2 0 bursicon neuropeptide hormone complex 0 31410 99 10 cytoplasmic vesicle 0 31461 11 5 cullin-RING ubiquitin ligase complex 0 31468 4 0 nuclear envelope reassembly 0 31490 2 0 chromatin DNA binding 0 31497 120 13 chromatin assembly 0 31507 92 2 heterochromatin formation 0 31508 39 1 centric heterochromatin formation 0 31509 2 0 telomeric heterochromatin formation 0 31510 2 1 SUMO activating enzyme complex 0 31519 14 0 PcG protein complex 0 31523 13 4 Myb complex 0 31532 7 2 actin cytoskeleton reorganization 0 31543 20 0 peptidyl-proline dioxygenase activity 0 31545 20 0 peptidyl-proline 4-dioxygenase activity 0 31570 6 1 DNA integrity checkpoint 0 31577 10 2 spindle checkpoint 0 31588 1 0 AMP-activated protein kinase complex 0 31589 30 6 cell-substrate adhesion 0 31647 1 0 regulation of protein stability 0 31667 17 1 response to nutrient levels 0 31672 3 0 A band 0 31887 1 0 lipid particle transport along microtubule 0 31903 14 0 microbody membrane 0 31933 1 0 telomeric heterochromatin 0 31965 6 0 nuclear membrane 0 31966 204 68 mitochondrial membrane 0 31967 288 75 organelle envelope 0 31968 20 4 organelle outer membrane 0 31970 2 0 organelle envelope lumen 0 31974 513 127 membrane-enclosed lumen 0 31975 288 75 envelope 0 31980 152 40 mitochondrial lumen 0 31981 353 84 nuclear lumen 0 31982 103 10 vesicle 0 31984 3 0 organelle subcompartment 0 31985 3 0 Golgi cisterna 0 31988 103 10 membrane-bound vesicle 0 35001 1 0 dorsal trunk growth 0 35002 3 0 tracheal liquid clearance 0 35003 9 1 subapical complex 0 35004 8 1 phosphoinositide 3-kinase activity 0 35005 3 0 phosphatidylinositol-4-phosphate 3-kinase activity 0 35006 4 0 melanization defense response 0 35007 2 0 regulation of melanization defense response 0 35009 1 0 negative regulation of melanization defense response 0 35010 4 0 encapsulation of foreign target 0 35011 1 0 melanotic encapsulation of foreign target 0 35012 2 1 "polytene chromosome, telomeric region" 0 35013 2 0 myosuppressin receptor activity 0 35014 1 0 phosphoinositide 3-kinase regulator activity 0 35015 2 0 elongation of arista core 0 35017 5 0 cuticle pattern formation 0 35018 1 0 adult cuticle pattern formation (sensu Insecta) 0 35019 2 0 somatic stem cell maintenance 0 35020 1 0 regulation of Rac protein signal transduction 0 35021 1 0 negative regulation of Rac protein signal transduction 0 35023 1 0 regulation of Rho protein signal transduction 0 35025 1 0 positive regulation of Rho protein signal transduction 0 35026 6 3 leading edge cell differentiation 0 35027 4 1 leading edge cell fate commitment 0 35028 4 1 leading edge cell fate determination 0 35029 4 1 "dorsal closure, leading edge cell fate commitment" 0 35030 2 0 "phosphoinositide 3-kinase complex, class IA" 0 35032 1 0 "phosphoinositide 3-kinase complex, class III" 0 35035 1 0 histone acetyltransferase binding 0 35037 1 0 sperm entry 0 35038 3 0 female pronucleus formation 0 35039 4 0 male pronucleus formation 0 35041 3 0 sperm chromatin decondensation 0 35042 2 0 "fertilization, exchange of chromosomal proteins" 0 35044 5 0 sperm aster formation 0 35045 1 0 sperm plasma membrane disassembly 0 35046 6 1 pronuclear migration 0 35048 1 0 splicing factor protein import into nucleus 0 35049 1 0 juvenile hormone acid methyltransferase activity 0 35050 18 2 embryonic heart tube development 0 35051 18 2 cardiac cell differentiation 0 35052 1 0 aortic cell fate commitment (sensu Insecta) 0 35053 2 0 heart proper cell fate commitment (sensu Insecta) 0 35054 3 0 embryonic heart tube anterior/posterior pattern formation 0 35055 1 0 regulation of nuclear mRNA splicing via U2-type spliceosome 0 35056 1 0 negative regulation of nuclear mRNA splicing via U2-type spliceosome 0 35058 10 0 sensory cilium biogenesis 0 35059 3 0 RCAF complex 0 35060 12 2 brahma complex 0 35062 7 3 omega speckle 0 35063 1 0 nuclear speck organization and biogenesis 0 35064 2 1 methylated histone residue binding 0 35065 2 0 regulation of histone acetylation 0 35066 1 0 positive regulation of histone acetylation 0 35067 1 0 negative regulation of histone acetylation 0 35068 1 0 micro-ribonucleoprotein complex 0 35069 3 0 larval midgut histolysis 0 35070 73 8 salivary gland histolysis 0 35071 73 8 salivary gland cell autophagic cell death 0 35072 11 1 ecdysone-mediated induction of salivary gland cell autophagic cell death 0 35073 5 1 pupariation 0 35074 2 1 pupation 0 35075 17 1 response to ecdysone 0 35076 1 0 ecdysone receptor-mediated signaling pathway 0 35078 12 1 induction of programmed cell death by ecdysone 0 35079 1 1 polytene chromosome puffing 0 35080 1 1 heat shock-mediated polytene chromosome puffing 0 35081 13 1 induction of programmed cell death by hormones 0 35082 7 0 axoneme biogenesis 0 35084 7 0 flagellum axoneme biogenesis 0 35087 4 0 "RNA interference, siRNA loading onto RISC" 0 35088 21 4 establishment and/or maintenance of apical/basal cell polarity 0 35089 7 2 establishment of apical/basal cell polarity 0 35090 1 0 maintenance of apical/basal cell polarity 0 35091 6 3 phosphoinositide binding 0 35092 1 0 sperm chromatin condensation 0 35094 1 0 response to nicotine 0 35095 1 0 behavioral response to nicotine 0 35096 2 0 larval midgut cell programmed cell death 0 35097 8 1 histone methyltransferase complex 0 35098 6 0 ESC/E(Z) complex 0 35099 7 0 hemocyte migration (sensu Arthropoda) 0 35101 2 1 FACT complex 0 35102 8 0 PRC1 complex 0 35103 3 0 sterol regulatory element binding-protein cleavage 0 35106 1 1 operant conditioning 0 35107 200 21 appendage morphogenesis 0 35108 35 2 limb morphogenesis 0 35109 25 0 limb morphogenesis (sensu Endopterygota) 0 35110 34 2 leg morphogenesis 0 35111 11 0 leg joint morphogenesis 0 35112 7 1 genitalia morphogenesis 0 35114 195 20 appendage morphogenesis (sensu Endopterygota) 0 35120 1 0 post-embryonic appendage morphogenesis 0 35145 1 1 exon-exon junction complex 0 35146 12 2 tube fusion 0 35147 12 2 tracheal branch fusion 0 35148 4 2 lumen formation 0 35149 4 2 tracheal lumen formation 0 35150 22 2 regulation of tube size 0 35151 20 2 regulation of tracheal tube size 0 35152 26 5 regulation of tracheal tube architecture 0 35153 7 0 tracheal epithelial cell type specification 0 35154 6 0 terminal cell fate specification 0 35155 4 0 negative regulation of terminal cell fate specification 0 35156 3 0 fusion cell fate specification 0 35157 2 0 negative regulation of fusion cell fate specification 0 35158 5 0 regulation of tracheal tube diameter 0 35159 5 1 regulation of tracheal tube length 0 35160 2 1 maintenance of tracheal epithelial integrity 0 35161 12 1 imaginal disc lineage restriction 0 35162 12 0 embryonic hemopoiesis 0 35163 4 0 embryonic hemocyte differentiation (sensu Arthropoda) 0 35164 2 0 embryonic plasmatocyte differentiation 0 35165 2 0 embryonic crystal cell differentiation 0 35166 13 0 post-embryonic hemopoiesis 0 35167 13 0 lymph gland hemopoiesis (sensu Arthropoda) 0 35168 12 0 lymph gland hemocyte differentiation (sensu Arthropoda) 0 35169 1 0 lymph gland plasmatocyte differentiation 0 35170 3 0 lymph gland crystal cell differentiation 0 35171 9 0 lamellocyte differentiation 0 35172 14 2 hemocyte proliferation (sensu Arthropoda) 0 35173 3 1 histone kinase activity 0 35174 2 0 histone serine kinase activity 0 35175 2 0 histone serine kinase activity (H3-S10 specific) 0 35177 2 0 larval foraging behavior 0 35182 2 0 ring canal outer rim 0 35183 4 0 ring canal inner rim 0 35184 1 1 histone threonine kinase activity 0 35185 3 0 preblastoderm mitotic cell cycle 0 35186 7 0 syncytial blastoderm mitotic cell cycle 0 35187 1 0 hatching behavior 0 35188 2 0 hatching 0 35189 4 3 Rb-E2F complex 0 35190 5 0 syncytial nuclear migration 0 35191 3 0 nuclear axial expansion 0 35192 1 0 nuclear cortical migration 0 35193 9 2 central nervous system remodeling (sensu Insecta) 0 35194 15 3 RNA-mediated posttranscriptional gene silencing 0 35195 5 0 miRNA-mediated gene silencing 0 35196 4 0 "miRNA-mediated gene silencing, production of miRNAs" 0 35199 1 0 salt aversion 0 35202 2 0 tracheal sac formation (sensu Insecta) 0 35203 2 0 regulation of lamellocyte differentiation 0 35204 1 0 negative regulation of lamellocyte differentiation 0 35206 1 0 regulation of hemocyte proliferation (sensu Arthropoda) 0 35207 1 0 negative regulation of hemocyte proliferation (sensu Arthropoda) 0 35209 3 1 pupal development (sensu Insecta) 0 35210 5 1 prepupal development (sensu Insecta) 0 35211 3 0 spermathecum morphogenesis 0 35212 2 0 cell competition (sensu Metazoa) 0 35213 2 1 clypeo-labral disc development 0 35214 324 23 eye-antennal disc development 0 35215 19 1 genital disc development 0 35216 2 1 haltere disc development 0 35218 46 2 leg disc development 0 35220 184 21 wing disc development 1 35221 3 0 genital disc pattern formation 0 35222 26 4 wing disc pattern formation 0 35223 15 1 leg disc pattern formation 0 35224 3 0 genital disc anterior/posterior pattern formation 0 35226 1 0 glutamate-cysteine ligase catalytic subunit binding 0 35227 1 0 regulation of glutamate-cysteine ligase activity 0 35229 1 0 positive regulation of glutamate-cysteine ligase activity 0 35231 3 0 cytoneme biogenesis 0 35232 3 0 germ cell attraction 0 35233 2 0 germ cell repulsion 0 35234 4 0 germ cell programmed cell death 0 35235 2 0 ionotropic glutamate receptor signaling pathway 0 35236 1 0 proctolin receptor activity 0 35237 1 0 corazonin receptor activity 0 35238 1 0 vitamin A biosynthesis 0 35239 83 10 tube morphogenesis 0 35240 5 0 dopamine binding 0 35241 2 0 protein-arginine omega-N monomethyltransferase activity 0 35242 2 0 protein-arginine omega-N asymmetric methyltransferase activity 0 35246 3 0 peptidyl-arginine N-methylation 0 35247 3 0 peptidyl-arginine omega-N-methylation 0 35248 1 0 "alpha-1,4-N-acetylgalactosaminyltransferase activity" 0 35250 13 1 UDP-galactosyltransferase activity 0 35251 10 1 UDP-glucosyltransferase activity 0 35252 1 0 UDP-xylosyltransferase activity 0 35253 1 0 ciliary rootlet 0 35254 1 0 glutamate receptor binding 0 35257 1 0 nuclear hormone receptor binding 0 35262 1 0 gonad morphogenesis 0 35263 5 0 genital disc sexually dimorphic development 0 35264 18 2 body growth 0 35265 29 3 organ growth 0 35267 2 2 TIP60 histone acetyltransferase complex 0 35268 2 0 protein amino acid mannosylation 0 35269 2 0 protein amino acid O-linked mannosylation 0 35270 7 2 endocrine system development 0 35271 7 2 ring gland development 0 35272 114 9 exocrine system development 0 35273 1 0 phthalate binding 0 35274 1 0 diphenyl phthalate binding 0 35275 1 0 dibutyl phthalate binding 0 35276 1 0 ethanol binding 0 35277 5 0 spiracle morphogenesis 0 35278 1 0 "miRNA-mediated gene silencing, negative regulation of translation" 0 35279 1 0 "miRNA-mediated gene silencing, mRNA cleavage" 0 35282 190 18 segmentation 0 35283 3 0 central nervous system segmentation 0 35284 3 0 brain segmentation 0 35285 17 2 appendage segmentation 0 35286 17 2 leg segmentation 0 35287 20 0 head segmentation 0 35288 9 0 anterior head segmentation 0 35289 16 0 posterior head segmentation 0 35290 16 0 trunk segmentation 0 35291 1 0 "specification of segmental identity, intercalary segment" 0 35292 5 0 "specification of segmental identity, trunk" 0 35293 2 0 larval cuticle pattern formation (sensu Insecta) 0 35295 97 11 tube development 0 35296 7 0 regulation of tube diameter 0 35297 2 0 regulation of Malpighian tubule diameter 0 35298 2 0 regulation of Malpighian tubule size 0 35299 1 0 inositol pentakisphosphate 2-kinase activity 0 35301 5 0 Hedgehog signaling complex 0 35302 1 0 ecdysteroid 25-hydroxylase activity 0 35303 6 2 regulation of dephosphorylation 0 35304 6 2 regulation of protein amino acid dephosphorylation 0 35305 4 0 negative regulation of dephosphorylation 0 35308 4 0 negative regulation of protein amino acid dephosphorylation 0 35309 6 0 wing and notum subfield formation 0 35310 3 0 notum cell fate specification 0 35311 1 0 wing cell fate specification 0 35312 1 0 5'-3' exodeoxyribonuclease activity 0 35313 1 0 "wound healing, spreading of epidermal cells" 0 35314 3 0 scab formation 0 35315 24 7 hair cell differentiation 0 35316 24 7 trichome organization and biogenesis (sensu Insecta) 0 35317 20 5 wing hair organization and biogenesis 0 35318 1 0 wing hair outgrowth 0 35320 4 0 wing hair site selection 0 40001 11 1 establishment of mitotic spindle localization 0 40003 26 4 cuticle biosynthesis (sensu Insecta) 0 40006 3 0 cuticular attachment to epithelium (sensu Protostomia and Nematoda) 0 40007 108 15 growth 0 40008 68 9 regulation of growth 0 40011 337 41 locomotion 0 40012 3 1 regulation of locomotion 0 40014 18 2 regulation of body size 0 40015 2 0 negative regulation of body size 0 40016 10 0 embryonic cleavage 0 40018 14 1 positive regulation of body size 0 40020 4 0 regulation of meiosis 0 40023 29 4 establishment of nucleus localization 0 40029 144 10 "regulation of gene expression, epigenetic" 0 40033 1 0 "negative regulation of mRNA translation, snRNA-mediated" 0 40034 14 1 "regulation of development, heterochronic" 0 40036 1 0 regulation of fibroblast growth factor receptor signaling pathway 0 40037 1 0 negative regulation of fibroblast growth factor receptor signaling pathway 0 40040 2 0 thermosensory behavior 0 42023 9 4 DNA endoreduplication 0 42025 2 1 host cell nucleus 0 42026 6 3 protein refolding 0 42043 4 0 neurexin binding 0 42044 7 0 fluid transport 0 42045 5 0 epithelial fluid transport 0 42048 101 8 olfactory behavior 0 42049 7 0 cell acyl-CoA homeostasis 0 42051 53 7 eye photoreceptor development (sensu Endopterygota) 0 42052 21 2 rhabdomere development 0 42053 2 0 regulation of dopamine metabolism 0 42054 20 2 histone methyltransferase activity 0 42055 3 1 neuron lineage restriction 0 42058 18 0 regulation of epidermal growth factor receptor signaling pathway 0 42059 12 0 negative regulation of epidermal growth factor receptor signaling pathway 0 42060 12 1 wound healing 0 42063 26 5 gliogenesis 0 42065 1 1 glial growth 0 42066 1 1 perineurial glial growth 0 42067 39 7 establishment of ommatidial polarity (sensu Endopterygota) 0 42069 3 1 regulation of catecholamine metabolism 0 42070 1 0 maintenance of oocyte nucleus localization during oocyte axis determination 0 42071 1 0 leucokinin receptor activity 0 42073 1 0 intraflagellar transport 0 42078 29 0 germ-line stem cell division 0 42083 1 0 "5,10-methylenetetrahydrofolate-dependent methyltransferase activity" 0 42087 1 0 cell-mediated immune response 0 42116 10 1 macrophage activation 0 42127 34 4 regulation of cell proliferation 0 42132 1 0 fructose-bisphosphatase activity 0 42133 16 1 neurotransmitter metabolism 0 42135 3 0 neurotransmitter catabolism 0 42136 9 1 neurotransmitter biosynthesis 0 42138 2 0 meiotic DNA double-strand break formation 0 42139 1 0 early meiotic recombination nodule assembly 0 42140 1 0 late meiotic recombination nodule assembly 0 42147 1 0 "retrograde transport, endosome to Golgi" 0 42157 30 5 lipoprotein metabolism 0 42158 30 5 lipoprotein biosynthesis 0 42165 66 0 neurotransmitter binding 0 42166 12 0 acetylcholine binding 0 42168 12 1 heme metabolism 0 42169 5 0 SH2 domain binding 0 42171 1 0 lysophosphatidic acid acyltransferase activity 0 42175 43 15 nuclear envelope-endoplasmic reticulum network 0 42176 3 1 regulation of protein catabolism 0 42177 1 0 negative regulation of protein catabolism 0 42178 3 0 xenobiotic catabolism 0 42180 8 1 ketone metabolism 0 42181 6 0 ketone biosynthesis 0 42214 8 0 terpene metabolism 0 42219 7 1 amino acid derivative catabolism 0 42220 11 1 response to cocaine 0 42221 345 31 response to chemical stimulus 0 42246 2 0 tissue regeneration 0 42248 2 0 maintenance of polarity of follicular epithelium 0 42250 1 0 maintenance of polarity of embryonic epithelium 0 42254 30 14 ribosome biogenesis and assembly 0 42263 1 0 neuropeptide F receptor activity 0 42273 1 1 ribosomal large subunit biogenesis 0 42274 1 0 ribosomal small subunit biogenesis 0 42277 62 2 peptide binding 0 42278 5 0 purine nucleoside metabolism 0 42281 1 0 "dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity" 0 42283 1 0 "dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity" 0 42284 1 0 sphingolipid delta-4 desaturase activity 0 42285 1 0 xylosyltransferase activity 0 42302 103 24 structural constituent of cuticle 0 42303 37 2 molting cycle 0 42304 1 0 regulation of fatty acid biosynthesis 0 42305 2 0 "specification of segmental identity, mandibular segment" 0 42306 13 0 regulation of protein import into nucleus 0 42307 1 0 positive regulation of protein import into nucleus 0 42308 5 0 negative regulation of protein import into nucleus 0 42309 3 2 homoiothermy 0 42313 1 0 protein kinase C deactivation 0 42325 5 0 regulation of phosphorylation 0 42326 2 0 negative regulation of phosphorylation 0 42328 1 0 heparan sulfate N-acetylglucosaminyltransferase activity 0 42330 38 1 taxis 0 42331 19 1 phototaxis 0 42332 8 0 gravitaxis 0 42335 33 4 cuticle biosynthesis 0 42336 6 1 cuticle biosynthesis during molting (sensu Protostomia and Nematoda) 0 42337 6 1 cuticle biosynthesis during molting (sensu Insecta) 0 42345 1 0 regulation of NF-kappaB import into nucleus 0 42346 1 0 positive regulation of NF-kappaB import into nucleus 0 42348 1 0 NF-kappaB import into nucleus 0 42350 2 0 GDP-L-fucose biosynthesis 0 42351 2 0 'de novo' GDP-L-fucose biosynthesis 0 42353 2 0 fucose biosynthesis 0 42354 2 0 L-fucose metabolism 0 42356 1 0 GDP-4-dehydro-D-rhamnose reductase activity 0 42357 1 0 thiamin diphosphate metabolism 0 42362 2 0 fat-soluble vitamin biosynthesis 0 42364 9 2 water-soluble vitamin biosynthesis 0 42371 1 0 vitamin K biosynthesis 0 42373 1 0 vitamin K metabolism 0 42375 4 0 quinone cofactor metabolism 0 42381 1 0 hemolymph coagulation 0 42384 12 0 cilium biogenesis 0 42385 1 0 myosin III 0 42386 34 2 hemocyte differentiation (sensu Arthropoda) 0 42387 5 0 plasmatocyte differentiation 0 42391 1 0 regulation of membrane potential 0 42393 8 3 histone binding 0 42394 6 0 ecdysis (sensu Protostomia and Nematoda) 0 42398 18 3 amino acid derivative biosynthesis 0 42401 16 3 biogenic amine biosynthesis 0 42402 6 1 biogenic amine catabolism 0 42416 3 0 dopamine biosynthesis 0 42417 9 0 dopamine metabolism 0 42420 2 0 dopamine catabolism 0 42423 5 0 catecholamine biosynthesis 0 42424 2 0 catecholamine catabolism 0 42427 3 1 serotonin biosynthesis 0 42428 5 1 serotonin metabolism 0 42429 2 0 serotonin catabolism 0 42430 10 2 indole and derivative metabolism 0 42434 10 2 indole derivative metabolism 0 42435 5 1 indole derivative biosynthesis 0 42436 4 1 indole derivative catabolism 0 42438 5 0 melanin biosynthesis 0 42439 5 1 ethanolamine and derivative metabolism 0 42440 54 5 pigment metabolism 0 42441 31 4 eye pigment metabolism 1 42445 24 1 hormone metabolism 0 42446 12 1 hormone biosynthesis 0 42447 6 0 hormone catabolism 0 42451 2 0 purine nucleoside biosynthesis 0 42455 2 0 ribonucleoside biosynthesis 0 42461 61 9 photoreceptor cell development 0 42462 54 7 eye photoreceptor cell development 0 42478 4 0 regulation of eye photoreceptor cell development 0 42479 1 0 positive regulation of eye photoreceptor cell development 0 42480 1 0 negative regulation of eye photoreceptor cell development 0 42493 23 1 response to drug 0 42499 1 0 signal peptide peptidase activity 0 42500 1 0 "aspartic endopeptidase activity, intramembrane cleaving" 0 42542 1 1 response to hydrogen peroxide 0 42545 1 0 cell wall modification 0 42551 3 0 neuron maturation 0 42558 16 1 pteridine and derivative metabolism 0 42559 13 1 pteridine and derivative biosynthesis 0 42562 8 1 hormone binding 0 42575 8 3 DNA polymerase complex 0 42577 3 0 lipid phosphatase activity 0 42578 220 15 phosphoric ester hydrolase activity 0 42579 35 4 microbody 0 42586 3 0 peptide deformylase activity 0 42592 78 8 homeostasis 0 42593 2 0 glucose homeostasis 0 42594 5 0 response to starvation 0 42595 1 0 behavioral response to starvation 0 42598 85 8 vesicular fraction 0 42600 9 1 chorion 0 42623 348 70 "ATPase activity, coupled" 0 42625 102 26 "ATPase activity, coupled to transmembrane movement of ions" 0 42626 160 30 "ATPase activity, coupled to transmembrane movement of substances" 0 42628 2 1 mating plug formation 0 42632 1 1 cholesterol homeostasis 0 42645 1 0 mitochondrial nucleoid 0 42654 1 0 ecdysis-triggering hormone receptor activity 0 42656 1 1 JUN kinase kinase kinase kinase activity 0 42659 18 1 regulation of cell fate specification 0 42674 13 0 cone cell differentiation (sensu Endopterygota) 0 42675 13 0 cone cell differentiation 0 42676 10 0 cone cell fate commitment 0 42678 1 0 cone cell fate specification (sensu Endopterygota) 0 42679 1 0 cone cell fate specification 0 42681 1 0 regulation of cone cell fate specification (sensu Endopterygota) 0 42682 1 0 regulation of cone cell fate specification 0 42683 1 0 negative regulation of cone cell fate specification 0 42684 11 1 cardioblast cell fate commitment 0 42685 5 1 cardioblast cell fate specification 0 42686 5 1 regulation of cardioblast cell fate specification 0 42688 8 0 crystal cell differentiation 0 42689 4 0 regulation of crystal cell differentiation 0 42690 2 0 negative regulation of crystal cell differentiation 0 42692 33 3 muscle cell differentiation 0 42693 4 1 muscle cell fate commitment 0 42694 1 0 muscle cell fate specification 0 42706 38 7 eye photoreceptor cell fate commitment 0 42708 12 3 elastase activity 0 42709 4 0 succinate-CoA ligase complex 0 42714 6 0 dosage compensation complex assembly 0 42721 5 2 mitochondrial inner membrane protein insertion complex 0 42723 1 0 thiamin and derivative metabolism 0 42724 1 0 thiamin and derivative biosynthesis 0 42726 2 0 riboflavin and derivative metabolism 0 42727 2 0 riboflavin and derivative biosynthesis 0 42732 1 0 D-xylose metabolism 0 42734 3 0 presynaptic membrane 0 42742 75 4 defense response to bacteria 0 42745 9 1 circadian sleep/wake cycle 0 42749 9 1 regulation of circadian sleep/wake cycle 0 42752 9 1 regulation of circadian rhythm 0 42756 1 0 drinking behavior 0 42761 1 0 very-long-chain fatty acid biosynthesis 0 42765 2 1 GPI-anchor transamidase complex 0 42766 7 3 nucleosome mobilization 0 42767 1 0 ecdysteroid 22-hydroxylase activity 0 42768 1 0 ecdysteroid 2-hydroxylase activity 0 42770 8 1 "DNA damage response, signal transduction" 0 42771 1 0 "DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" 0 42773 72 39 ATP synthesis coupled electron transport 0 42775 70 39 ATP synthesis coupled electron transport (sensu Eukaryota) 0 42787 2 1 protein ubiquitination during ubiquitin-dependent protein catabolism 0 42796 1 0 snRNA transcription from RNA polymerase III promoter 0 42797 1 0 tRNA transcription from RNA polymerase III promoter 0 42799 3 1 histone lysine N-methyltransferase activity (H4-K20 specific) 0 42800 3 1 histone lysine N-methyltransferase activity (H3-K4 specific) 0 42801 1 0 polo kinase kinase activity 0 42802 17 1 protein self binding 0 42803 17 1 protein homodimerization activity 0 42806 1 0 fucose binding 0 42810 9 0 pheromone metabolism 0 42811 3 0 pheromone biosynthesis 0 42813 4 0 Wnt receptor activity 0 42816 4 2 vitamin B6 metabolism 0 42819 4 2 vitamin B6 biosynthesis 0 42826 3 0 histone deacetylase binding 0 42828 1 0 response to pathogen 0 42834 12 0 peptidoglycan binding 0 42895 5 0 antibiotic transporter activity 0 42910 8 1 xenobiotic transporter activity 0 42923 45 0 neuropeptide binding 0 42924 1 0 neuromedin U binding 0 42953 1 0 lipoprotein transport 0 42979 1 0 ornithine decarboxylase regulator activity 0 42981 117 19 regulation of apoptosis 0 42990 4 0 regulation of transcription factor import into nucleus 0 42991 4 0 transcription factor import into nucleus 0 42992 3 0 negative regulation of transcription factor import into nucleus 0 42993 1 0 positive regulation of transcription factor import into nucleus 0 42994 2 0 cytoplasmic sequestering of transcription factor 0 42995 35 1 cell projection 0 43005 9 0 neuron projection 0 43015 5 0 gamma-tubulin binding 0 43021 4 2 ribonucleoprotein binding 0 43028 1 0 caspase regulator activity 0 43035 2 0 chromatin insulator sequence binding 0 43037 209 49 translation 0 43038 69 11 amino acid activation 0 43039 68 11 tRNA aminoacylation 0 43041 1 0 nonribosomal amino acid activation 0 43042 1 0 amino acid adenylylation by nonribosomal peptide synthase 0 43043 1 0 peptide biosynthesis 0 43044 2 0 ATP-dependent chromatin remodeling 0 43045 1 0 DNA methylation during embryonic development 0 43052 3 0 thermotaxis 0 43062 50 4 extracellular structure organization and biogenesis 0 43063 16 1 intercellular bridge organization and biogenesis 0 43064 8 0 flagellum organization and biogenesis 0 43065 67 12 positive regulation of apoptosis 0 43066 48 7 negative regulation of apoptosis 0 43067 130 20 regulation of programmed cell death 0 43068 80 13 positive regulation of programmed cell death 0 43069 49 7 negative regulation of programmed cell death 0 43073 1 0 germ cell nucleus 0 43085 16 4 positive regulation of enzyme activity 0 43086 2 0 negative regulation of enzyme activity 0 43087 10 3 regulation of GTPase activity 0 43094 3 0 metabolic compound salvage 0 43101 3 0 purine salvage 0 43109 1 0 regulation of smoothened activity 0 43112 3 1 receptor metabolism 0 43118 312 26 negative regulation of physiological process 0 43119 173 24 positive regulation of physiological process 0 43120 1 0 tumor necrosis factor binding 0 43121 1 0 neurotrophin binding 0 43122 1 0 regulation of I-kappaB kinase/NF-kappaB cascade 0 43124 1 0 negative regulation of I-kappaB kinase/NF-kappaB cascade 0 43142 3 2 single-stranded DNA-dependent ATPase activity 0 43146 7 0 spindle stabilization 0 43147 6 0 meiotic spindle stabilization 0 43148 1 0 mitotic spindle stabilization 0 43154 1 0 negative regulation of caspase activity 0 43161 4 2 proteasomal ubiquitin-dependent protein catabolism 0 43167 963 100 ion binding 0 43169 917 92 cation binding 0 43170 3602 577 macromolecule metabolism 0 43174 3 0 nucleoside salvage 0 43176 20 2 amine binding 0 43178 1 0 alcohol binding 0 43179 1 0 rhythmic excitation 0 43190 44 4 ATP-binding cassette (ABC) transporter complex 0 43195 5 0 terminal button 0 43205 1 0 fibril 0 43226 3006 554 organelle 0 43227 2594 418 membrane-bound organelle 0 43228 816 234 non-membrane-bound organelle 0 43229 3004 554 intracellular organelle 0 43231 2591 418 intracellular membrane-bound organelle 0 43232 816 234 intracellular non-membrane-bound organelle 0 43233 513 127 organelle lumen 0 43234 1781 441 protein complex 0 43235 44 5 receptor complex 0 43241 1 1 protein complex disassembly 0 43245 2 1 extraorganismal space 0 43256 2 1 laminin complex 0 43279 11 1 response to alkaloid 0 43280 2 0 positive regulation of caspase activity 0 43281 4 0 regulation of caspase activity 0 43283 1899 304 biopolymer metabolism 0 43284 10 0 biopolymer biosynthesis 0 43285 99 33 biopolymer catabolism 0 43292 15 4 contractile fiber 0 43295 1 0 glutathione binding 0 43296 36 5 apical junction complex 0 43297 22 2 apical junction assembly 0 43331 6 0 response to dsRNA 0 43405 7 2 regulation of MAPK activity 0 43406 6 2 positive regulation of MAPK activity 0 43407 1 0 negative regulation of MAPK activity 0 43412 932 114 biopolymer modification 0 43413 83 9 biopolymer glycosylation 0 43414 42 3 biopolymer methylation 0 43449 8 0 alkene metabolism 0 43450 3 0 alkene biosynthesis 0 43451 4 0 alkene catabolism 0 43473 56 4 pigmentation 0 43486 2 0 histone exchange 0 43487 2 0 regulation of RNA stability 0 43488 2 0 regulation of mRNA stability 0 43492 160 30 "ATPase activity, coupled to movement of substances" 0 43506 2 1 regulation of JNK activity 0 43507 2 1 positive regulation of JNK activity 0 43543 17 4 protein amino acid acylation 0 43545 7 0 molybdopterin cofactor metabolism 0 43549 27 3 regulation of kinase activity 0 43565 33 5 sequence-specific DNA binding 0 43566 36 3 structure-specific DNA binding 0 43596 17 4 replication fork (sensu Eukaryota) 0 43601 17 4 replisome (sensu Eukaryota) 0 44237 5228 796 cellular metabolism 0 44238 5093 742 primary metabolism 0 44242 10 0 cellular lipid catabolism 0 44247 7 1 cellular polysaccharide catabolism 0 44248 319 70 cellular catabolism 0 44249 1103 209 cellular biosynthesis 0 44255 338 19 cellular lipid metabolism 0 44257 83 32 cellular protein catabolism 0 44260 2582 425 cellular macromolecule metabolism 0 44262 285 41 cellular carbohydrate metabolism 0 44264 82 17 cellular polysaccharide metabolism 0 44265 179 53 cellular macromolecule catabolism 0 44267 2505 409 cellular protein metabolism 0 44270 55 9 nitrogen compound catabolism 0 44271 87 13 nitrogen compound biosynthesis 0 44272 22 2 sulfur compound biosynthesis 0 44273 1 0 sulfur compound catabolism 0 44274 33 4 organismal biosynthesis 0 44275 72 16 cellular carbohydrate catabolism 0 44403 3 0 "symbiosis, encompassing mutualism through parasitism" 0 44419 3 0 interspecies interaction between organisms 0 45003 3 1 double-strand break repair via synthesis-dependent strand annealing 0 45005 9 1 maintenance of fidelity during DNA-dependent DNA replication 0 45011 3 1 actin cable formation 0 45017 5 0 glycerolipid biosynthesis 0 45028 1 0 "purinergic nucleotide receptor activity, G-protein coupled" 0 45034 19 1 neuroblast division 0 45039 6 2 protein import into mitochondrial inner membrane 0 45045 243 36 secretory pathway 0 45047 18 10 protein targeting to ER 0 45055 128 9 regulated secretory pathway 0 45087 23 2 innate immune response 0 45088 1 0 regulation of innate immune response 0 45111 2 0 intermediate filament cytoskeleton 0 45121 1 0 lipid raft 0 45132 82 6 meiotic chromosome segregation 0 45137 29 2 development of primary sexual characteristics 0 45143 5 0 homologous chromosome segregation 0 45153 2 1 "electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity" 0 45155 2 1 "electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity" 0 45159 1 0 myosin II binding 0 45165 215 24 cell fate commitment 0 45167 9 0 asymmetric protein localization during cell fate commitment 0 45168 4 0 cell-cell signaling during cell fate commitment 0 45169 19 4 fusome 0 45170 8 1 spectrosome 0 45171 19 6 intercellular bridge 0 45172 19 6 ring canal (sensu Insecta) 0 45175 6 0 basal protein localization 0 45176 8 0 apical protein localization 0 45177 29 4 apical part of cell 0 45178 6 0 basal part of cell 0 45179 12 1 apical cortex 0 45180 5 0 basal cortex 0 45181 1 0 "glutamate synthase activity, NADH or NADPH as acceptor" 0 45182 93 26 translation regulator activity 1 45184 551 98 establishment of protein localization 0 45185 10 1 maintenance of protein localization 0 45186 11 1 zonula adherens assembly 0 45187 9 1 "regulation of circadian sleep/wake cycle, sleep" 0 45196 8 1 establishment and/or maintenance of neuroblast polarity 0 45197 20 4 establishment and/or maintenance of epithelial cell polarity 0 45198 6 2 establishment of epithelial cell polarity 0 45199 1 0 maintenance of epithelial cell polarity 0 45200 2 1 establishment of neuroblast polarity 0 45202 43 0 synapse 0 45211 25 0 postsynaptic membrane 0 45213 3 1 neurotransmitter receptor metabolism 0 45214 2 1 sarcomere organization 0 45216 26 2 intercellular junction assembly and/or maintenance 0 45217 2 0 intercellular junction maintenance 0 45218 1 0 zonula adherens maintenance 0 45229 1 0 external encapsulating structure organization and biogenesis 0 45239 9 0 tricarboxylic acid cycle enzyme complex 0 45240 1 0 alpha-ketoglutarate dehydrogenase complex 0 45242 1 0 isocitrate dehydrogenase complex (NAD+) 0 45244 3 0 succinate-CoA ligase complex (GDP-forming) 0 45251 2 1 electron transfer flavoprotein complex 0 45252 4 1 oxoglutarate dehydrogenase complex 0 45253 1 0 pyruvate dehydrogenase (lipoamide) phosphatase complex 0 45254 5 1 pyruvate dehydrogenase complex 0 45255 22 14 hydrogen-translocating F-type ATPase complex 0 45257 7 0 succinate dehydrogenase complex (ubiquinone) 0 45259 22 14 proton-transporting ATP synthase complex 0 45261 10 7 "proton-transporting ATP synthase complex, catalytic core F(1)" 0 45263 9 7 "proton-transporting ATP synthase complex, coupling factor F(o)" 0 45269 2 1 "proton-transporting ATP synthase, central stalk" 0 45271 45 23 respiratory chain complex I 0 45273 7 0 respiratory chain complex II 0 45275 13 9 respiratory chain complex III 0 45277 17 8 respiratory chain complex IV 0 45281 7 0 succinate dehydrogenase complex 0 45283 7 0 fumarate reductase complex 0 45285 13 9 ubiquinol-cytochrome-c reductase complex 0 45289 1 0 luciferin monooxygenase activity 0 45294 1 0 alpha-catenin binding 0 45296 2 0 cadherin binding 0 45297 20 2 post-mating behavior 0 45298 16 4 tubulin 1 45313 2 0 rhabdomere membrane biogenesis 0 45314 3 0 regulation of eye photoreceptor development (sensu Endopterygota) 0 45315 1 0 positive regulation of eye photoreceptor development (sensu Endopterygota) 0 45316 1 0 negative regulation of eye photoreceptor development (sensu Endopterygota) 0 45317 7 2 equator specification 0 45321 10 1 immune cell activation 0 45333 48 5 cellular respiration 0 45334 2 0 clathrin-coated endocytic vesicle 0 45337 1 1 farnesyl diphosphate biosynthesis 0 45338 1 1 farnesyl diphosphate metabolism 0 45426 4 0 quinone cofactor biosynthesis 0 45433 12 1 "male courtship behavior (sensu Insecta), song production" 0 45434 6 0 "negative regulation of female receptivity, post-mating" 0 45445 28 2 myoblast differentiation 0 45448 21 1 "mitotic cell cycle, embryonic" 0 45449 947 103 regulation of transcription 0 45450 18 2 bicoid mRNA localization 0 45451 53 5 pole plasm oskar mRNA localization 0 45454 5 3 cell redox homeostasis 0 45456 6 0 ecdysteroid biosynthesis 0 45457 1 0 ecdysteroid secretion 0 45463 5 0 R8 development 0 45464 6 0 R8 cell fate specification 0 45465 14 0 R8 cell differentiation 0 45466 30 7 R7 cell differentiation 0 45467 8 2 R7 development 0 45468 5 0 regulation of R8 spacing 0 45470 2 0 R8-mediated photoreceptor organization 0 45471 16 1 response to ethanol 0 45472 4 1 response to ether 0 45475 23 4 locomotor rhythm 0 45476 11 2 nurse cell apoptosis 0 45477 4 2 regulation of nurse cell apoptosis 0 45478 11 2 fusome organization and biogenesis 0 45479 2 0 vesicle targeting to fusome 0 45494 6 2 photoreceptor maintenance 0 45495 13 2 pole plasm 0 45496 2 1 male analia morphogenesis (sensu Endopterygota) 0 45497 2 1 female analia morphogenesis (sensu Endopterygota) 0 45498 6 0 sex comb development 0 45500 9 2 sevenless signaling pathway 1 45502 6 1 dynein binding 0 45544 1 0 gibberellin 20-oxidase activity 0 45570 9 1 regulation of imaginal disc growth 0 45571 4 1 negative regulation of imaginal disc growth 0 45572 1 0 positive regulation of imaginal disc growth 0 45595 45 2 regulation of cell differentiation 0 45596 19 1 negative regulation of cell differentiation 0 45610 21 2 regulation of hemocyte differentiation 0 45611 3 0 negative regulation of hemocyte differentiation 0 45664 3 0 regulation of neuron differentiation 0 45673 7 0 regulation of photoreceptor differentiation (sensu Endopterygota) 0 45674 3 0 negative regulation of photoreceptor differentiation (sensu Endopterygota) 0 45676 2 0 regulation of R7 differentiation 0 45679 1 0 regulation of R8 differentiation 0 45680 1 0 negative regulation of R8 differentiation 0 45704 9 0 regulation of salivary gland determination 0 45705 9 0 negative regulation of salivary gland determination 0 45735 8 1 nutrient reservoir activity 0 45736 1 0 negative regulation of cyclin dependent protein kinase activity 0 45741 1 0 positive regulation of epidermal growth factor receptor activity 0 45742 3 0 positive regulation of epidermal growth factor receptor signaling pathway 0 45746 5 0 negative regulation of Notch signaling pathway 0 45747 6 0 positive regulation of Notch signaling pathway 0 45751 1 0 negative regulation of Toll signaling pathway 0 45761 3 1 regulation of adenylate cyclase activity 0 45762 3 1 positive regulation of adenylate cyclase activity 0 45764 1 0 positive regulation of amino acid metabolism 0 45786 12 1 negative regulation of progression through cell cycle 0 45787 2 1 positive regulation of progression through cell cycle 0 45792 7 0 negative regulation of cell size 0 45793 16 3 positive regulation of cell size 0 45804 1 0 negative regulation of eclosion 0 45807 1 0 positive regulation of endocytosis 0 45810 5 2 negative regulation of frizzled signaling pathway 0 45811 1 1 positive regulation of frizzled signaling pathway 0 45814 92 2 "negative regulation of gene expression, epigenetic" 0 45815 9 3 "positive regulation of gene expression, epigenetic" 0 45822 2 0 negative regulation of heart contraction 0 45823 1 0 positive regulation of heart contraction 0 45836 1 0 positive regulation of meiosis 0 45839 3 0 negative regulation of mitosis 0 45840 1 0 positive regulation of mitosis 0 45841 1 0 negative regulation of mitotic metaphase/anaphase transition 0 45842 1 0 positive regulation of mitotic metaphase/anaphase transition 0 45843 1 0 negative regulation of striated muscle development 0 45850 2 2 positive regulation of nurse cell apoptosis 0 45859 27 3 regulation of protein kinase activity 0 45860 9 3 positive regulation of protein kinase activity 0 45861 9 1 negative regulation of proteolysis 0 45862 1 0 positive regulation of proteolysis 0 45877 1 0 negative regulation of smoothened activity 0 45879 8 0 negative regulation of smoothened signaling pathway 0 45880 5 0 positive regulation of smoothened signaling pathway 0 45886 4 0 negative regulation of synaptic growth at neuromuscular junction 0 45887 5 0 positive regulation of synaptic growth at neuromuscular junction 0 45892 166 11 "negative regulation of transcription, DNA-dependent" 0 45893 52 5 "positive regulation of transcription, DNA-dependent" 0 45896 4 2 "regulation of transcription, mitotic" 0 45898 2 0 regulation of transcriptional preinitiation complex formation 0 45900 1 1 negative regulation of translational elongation 0 45924 16 1 regulation of female receptivity 0 45926 20 4 negative regulation of growth 0 45927 27 3 positive regulation of growth 0 45930 1 0 negative regulation of progression through mitotic cell cycle 0 45931 1 1 positive regulation of progression through mitotic cell cycle 0 45932 2 0 negative regulation of muscle contraction 0 45934 191 14 "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" 0 45935 70 8 "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" 0 45936 6 0 negative regulation of phosphate metabolism 0 45941 69 8 positive regulation of transcription 0 45944 22 0 positive regulation of transcription from RNA polymerase II promoter 0 45946 8 1 positive regulation of translation 0 45947 1 0 negative regulation of translational initiation 0 45974 1 0 "regulation of mRNA translation, snRNA-mediated" 0 45978 1 1 negative regulation of nucleoside metabolism 0 45995 3 1 regulation of embryonic development 0 46008 9 0 "regulation of female receptivity, post-mating" 0 46011 15 1 regulation of oskar mRNA translation 0 46012 5 0 positive regulation of oskar mRNA translation 0 46021 4 2 "regulation of transcription from RNA polymerase II promoter, mitotic" 0 46030 8 0 inositol trisphosphate phosphatase activity 0 46031 2 0 ADP metabolism 0 46034 67 18 ATP metabolism 0 46036 4 0 CTP metabolism 0 46037 2 1 GMP metabolism 0 46039 4 0 GTP metabolism 0 46040 7 0 IMP metabolism 0 46044 1 0 TMP metabolism 0 46051 4 0 UTP metabolism 0 46058 6 0 cAMP metabolism 0 46068 3 0 cGMP metabolism 0 46072 1 0 dTDP metabolism 0 46073 1 0 dTMP metabolism 0 46075 1 0 dTTP metabolism 0 46080 1 1 dUTP metabolism 0 46087 2 0 cytidine metabolism 0 46112 8 1 nucleobase biosynthesis 0 46113 2 0 nucleobase catabolism 0 46114 2 0 guanosine biosynthesis 0 46116 2 0 queuosine metabolism 0 46118 2 0 7-methylguanosine biosynthesis 0 46125 2 1 pyrimidine deoxyribonucleoside metabolism 0 46128 5 0 purine ribonucleoside metabolism 0 46129 2 0 purine ribonucleoside biosynthesis 0 46131 2 0 pyrimidine ribonucleoside metabolism 0 46146 4 1 tetrahydrobiopterin metabolism 0 46148 47 5 pigment biosynthesis 0 46152 21 2 ommochrome metabolism 0 46154 9 1 rhodopsin metabolism 0 46158 21 2 ocellus pigment metabolism 0 46164 52 15 alcohol catabolism 0 46165 10 2 alcohol biosynthesis 0 46203 1 0 spermidine catabolism 0 46209 1 0 nitric oxide metabolism 0 46218 4 1 indolalkylamine catabolism 0 46219 3 1 indolalkylamine biosynthesis 0 46246 3 0 terpene biosynthesis 0 46247 4 0 terpene catabolism 0 46328 18 3 regulation of JNK cascade 0 46329 5 1 negative regulation of JNK cascade 0 46330 5 0 positive regulation of JNK cascade 0 46331 4 0 lateral inhibition 0 46333 3 0 octopamine metabolism 0 46334 2 0 octopamine catabolism 0 46335 1 1 ethanolamine biosynthesis 0 46337 1 1 phosphatidylethanolamine metabolism 0 46339 3 0 diacylglycerol metabolism 0 46341 1 0 CDP-diacylglycerol metabolism 0 46348 7 1 amino sugar catabolism 0 46349 1 0 amino sugar biosynthesis 0 46351 3 0 disaccharide biosynthesis 0 46356 48 5 acetyl-CoA catabolism 0 46358 1 0 butyrate biosynthesis 0 46359 1 0 butyrate catabolism 0 46364 10 2 monosaccharide biosynthesis 0 46365 52 15 monosaccharide catabolism 0 46368 2 0 GDP-L-fucose metabolism 0 46380 1 0 N-acetylneuraminate biosynthesis 0 46381 1 0 CMP-N-acetylneuraminate metabolism 0 46394 32 4 carboxylic acid biosynthesis 0 46395 2 0 carboxylic acid catabolism 0 46425 5 0 regulation of JAK-STAT cascade 0 46426 1 0 negative regulation of JAK-STAT cascade 0 46460 4 0 neutral lipid biosynthesis 0 46463 4 0 acylglycerol biosynthesis 0 46466 4 0 membrane lipid catabolism 0 46467 31 3 membrane lipid biosynthesis 0 46473 1 0 phosphatidic acid metabolism 0 46474 11 1 glycerophospholipid biosynthesis 0 46483 151 20 heterocycle metabolism 0 46485 1 0 ether lipid metabolism 0 46486 6 0 glycerolipid metabolism 0 46487 1 1 glyoxylate metabolism 0 46488 3 0 phosphatidylinositol metabolism 0 46489 10 1 phosphoinositide biosynthesis 0 46500 1 0 S-adenosylmethionine metabolism 0 46501 1 0 protoporphyrinogen IX metabolism 0 46504 5 0 glycerol ether biosynthesis 0 46515 1 0 hypusine biosynthesis 0 46516 1 0 hypusine metabolism 0 46519 3 0 sphingoid metabolism 0 46525 1 0 xylosylprotein 4-beta-galactosyltransferase activity 0 46527 13 1 glucosyltransferase activity 0 46528 4 0 imaginal disc fusion 0 46529 4 0 "imaginal disc fusion, thorax closure" 0 46530 128 17 photoreceptor cell differentiation 0 46532 7 0 regulation of photoreceptor cell differentiation 0 46533 3 0 negative regulation of photoreceptor cell differentiation 0 46536 8 0 dosage compensation complex 0 46545 11 0 development of primary female sexual characteristics 0 46546 5 0 development of primary male sexual characteristics 0 46552 53 9 photoreceptor cell fate commitment 0 46578 7 0 regulation of Ras protein signal transduction 0 46580 6 0 negative regulation of Ras protein signal transduction 0 46594 5 0 maintenance of pole plasm mRNA localization 0 46595 1 0 establishment of pole plasm mRNA localization 0 46602 1 0 regulation of mitotic centrosome separation 0 46605 1 0 regulation of centrosome cycle 0 46620 29 3 regulation of organ size 0 46621 10 1 negative regulation of organ size 0 46622 8 1 positive regulation of organ size 0 46626 4 0 regulation of insulin receptor signaling pathway 0 46627 4 0 negative regulation of insulin receptor signaling pathway 0 46658 2 0 anchored to plasma membrane 0 46660 16 1 female sex differentiation 0 46661 13 1 male sex differentiation 0 46662 5 1 regulation of oviposition 0 46663 6 3 "dorsal closure, leading edge cell differentiation" 0 46664 7 2 "dorsal closure, amnioserosa morphology change" 0 46665 5 1 amnioserosa maintenance 0 46666 17 2 retinal cell programmed cell death 0 46667 12 2 retinal cell programmed cell death (sensu Endopterygota) 0 46668 11 1 regulation of retinal programmed cell death 0 46669 7 1 regulation of retinal cell programmed cell death (sensu Endopterygota) 0 46670 4 0 positive regulation of retinal programmed cell death 0 46671 3 1 negative regulation of retinal programmed cell death 0 46672 4 0 positive regulation of retinal cell programmed cell death (sensu Endopterygota) 0 46673 3 1 negative regulation of retinal cell programmed cell death (sensu Endopterygota) 0 46674 1 0 induction of retinal programmed cell death 0 46675 1 0 induction of retinal cell programmed cell death (sensu Endopterygota) 0 46680 4 0 response to DDT 0 46681 1 0 response to carbamate 0 46682 1 0 response to cyclodiene 0 46683 3 0 response to organophosphorus 0 46684 1 0 response to pyrethroid 0 46685 1 1 response to arsenic 0 46692 10 1 sperm competition 0 46693 5 1 sperm storage 0 46698 477 43 morphogenesis (sensu Insecta) 0 46701 3 0 insecticide catabolism 0 46702 1 0 galactoside 6-L-fucosyltransferase activity 0 46716 2 0 muscle maintenance 0 46777 5 0 protein amino acid autophosphorylation 0 46785 16 3 microtubule polymerization 0 46821 1 0 extrachromosomal DNA 0 46822 16 0 regulation of nucleocytoplasmic transport 0 46823 6 0 negative regulation of nucleocytoplasmic transport 0 46824 1 0 positive regulation of nucleocytoplasmic transport 0 46825 1 0 regulation of protein export from nucleus 0 46826 1 0 negative regulation of protein export from nucleus 0 46834 6 0 lipid phosphorylation 0 46835 4 0 carbohydrate phosphorylation 0 46836 1 0 glycolipid transport 0 46838 2 0 phosphorylated carbohydrate dephosphorylation 0 46839 2 0 phospholipid dephosphorylation 0 46843 28 0 dorsal appendage formation 0 46844 4 0 micropyle formation 0 46845 10 0 branched duct epithelial cell fate determination (sensu Insecta) 0 46847 6 0 filopodium formation 0 46853 4 0 inositol and derivative phosphorylation 0 46854 5 0 phosphoinositide phosphorylation 0 46855 2 0 inositol phosphate dephosphorylation 0 46856 2 0 phosphoinositide dephosphorylation 0 46864 1 1 isoprenoid transport 0 46865 1 1 terpenoid transport 0 46866 1 1 tetraterpenoid transport 0 46867 1 1 carotenoid transport 0 46872 963 100 metal ion binding 0 46873 68 21 metal ion transporter activity 0 46875 1 0 ephrin receptor binding 0 46879 8 2 hormone secretion 0 46885 2 0 regulation of hormone biosynthesis 0 46890 3 0 regulation of lipid biosynthesis 0 46899 1 0 nucleoside triphosphate adenylate kinase activity 0 46900 1 0 tetrahydrofolylpolyglutamate metabolism 0 46901 1 0 tetrahydrofolylpolyglutamate biosynthesis 0 46902 1 0 regulation of mitochondrial membrane permeability 0 46903 260 38 secretion 0 46906 5 2 tetrapyrrole binding 0 46907 655 111 intracellular transport 0 46912 5 1 "transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer" 0 46914 697 68 transition metal ion binding 0 46915 19 4 transition metal ion transporter activity 0 46916 7 1 transition metal ion homeostasis 0 46920 4 0 "alpha(1,3)-fucosyltransferase activity" 0 46921 1 0 "alpha(1,6)-fucosyltransferase activity" 0 46923 1 0 ER retention sequence binding 0 46930 44 4 pore complex 0 46933 64 18 "hydrogen-transporting ATP synthase activity, rotational mechanism" 0 46934 3 0 "phosphatidylinositol-4,5-bisphosphate 3-kinase activity" 0 46939 2 0 nucleotide phosphorylation 0 46942 54 1 carboxylic acid transport 0 46943 72 2 carboxylic acid transporter activity 0 46946 1 0 hydroxylysine metabolism 0 46948 1 0 hydroxylysine catabolism 0 46949 3 0 acyl-CoA biosynthesis 0 46950 1 0 ketone body metabolism 0 46952 1 0 ketone body catabolism 0 46956 1 0 positive phototaxis 0 46958 3 2 nonassociative learning 0 46959 1 1 habituation 0 46961 64 18 "hydrogen-transporting ATPase activity, rotational mechanism" 0 46963 1 0 3'-phosphoadenosine 5'-phosphosulfate transport 0 46964 1 0 3'-phosphoadenosine 5'-phosphosulfate transporter activity 0 46966 1 0 thyroid hormone receptor binding 0 46972 1 0 histone acetyltransferase activity (H4-K16 specific) 0 46974 8 0 histone lysine N-methyltransferase activity (H3-K9 specific) 0 46976 6 0 histone lysine N-methyltransferase activity (H3-K27 specific) 0 46981 1 0 "beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity" 0 46982 24 3 protein heterodimerization activity 0 46983 50 4 protein dimerization activity 0 46987 2 0 "N-acetyllactosamine beta-1,3-glucuronosyltransferase activity" 0 46988 2 0 "asioloorosomucoid beta-1,3-glucuronosyltransferase activity" 0 46989 2 0 "galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity" 0 46992 1 0 "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond" 0 46993 1 0 "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor" 0 47022 1 0 7-beta-hydroxysteroid dehydrogenase (NADP+) activity 0 47035 1 0 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity 0 47057 1 0 vitamin-K-epoxide reductase (warfarin-sensitive) activity 0 47326 1 0 inositol tetrakisphosphate 5-kinase activity 0 47429 1 1 nucleoside-triphosphate diphosphatase activity 0 47498 1 0 calcium-dependent phospholipase A2 activity 0 47499 2 0 calcium-independent phospholipase A2 activity 0 47555 4 0 "3',5'-cyclic-GMP phosphodiesterase activity" 0 47710 1 0 bis(5'-adenosyl)-triphosphatase activity 0 47875 1 0 ecdysone oxidase activity 0 48015 16 1 phosphoinositide-mediated signaling 0 48019 2 0 receptor antagonist activity 0 48021 1 0 regulation of melanin biosynthesis 0 48022 1 0 negative regulation of melanin biosynthesis 0 48024 56 17 "regulation of nuclear mRNA splicing, via spliceosome" 0 48025 4 1 "negative regulation of nuclear mRNA splicing, via spliceosome" 0 48027 3 0 mRNA 5'-UTR binding 0 48029 24 0 monosaccharide binding 0 48033 1 0 heme o metabolism 0 48034 1 0 heme o biosynthesis 0 48036 4 1 central complex development 0 48037 39 11 cofactor binding 0 48038 1 1 quinone binding 0 48039 1 1 ubiquinone binding 0 48041 1 0 focal adhesion formation 0 48042 3 1 "regulation of oviposition, post-mating" 0 48047 3 0 "mating behavior, sex discrimination" 0 48048 3 1 embryonic eye morphogenesis 0 48049 3 1 embryonic eye morphogenesis (sensu Endopterygota) 0 48052 3 0 R1/R6 cell differentiation (sensu Endopterygota) 0 48054 1 0 R2/R5 cell differentiation (sensu Endopterygota) 0 48056 9 2 R3/R4 cell differentiation (sensu Endopterygota) 0 48057 1 1 R3/R4 development (sensu Endopterygota) 0 48065 13 1 "male courtship behavior (sensu Insecta), wing extension" 0 48066 56 4 pigmentation during development 1 48067 3 0 cuticle pigmentation 0 48069 34 4 eye pigmentation 0 48070 4 0 regulation of developmental pigmentation 0 48071 3 0 sex-specific pigmentation 0 48072 6 1 eye pigmentation (sensu Endopterygota) 0 48079 1 0 regulation of cuticle pigmentation 0 48082 1 0 regulation of adult cuticle pigmentation 0 48085 1 0 adult cuticle pigmentation 0 48086 2 0 negative regulation of pigmentation 0 48087 1 0 positive regulation of pigmentation 0 48088 1 0 regulation of male pigmentation 0 48092 1 0 negative regulation of male pigmentation 0 48094 1 0 male pigmentation 0 48096 9 3 chromatin-mediated maintenance of transcription 0 48098 3 0 antennal joint morphogenesis 0 48099 5 0 "anterior/posterior lineage restriction, imaginal disc" 0 48100 16 1 wing disc anterior/posterior pattern formation 0 48101 1 0 calcium- and calmodulin-regulated cGMP-specific phosphodiesterase activity 0 48102 73 8 autophagic cell death 0 48103 10 0 somatic stem cell division 0 48104 1 0 establishment of body hair or bristle orientation 0 48106 1 0 establishment of body bristle orientation 0 48110 88 11 oocyte construction (sensu Insecta) 0 48111 87 11 oocyte axis determination (sensu Insecta) 0 48112 73 7 oocyte anterior/posterior axis determination (sensu Insecta) 0 48113 66 6 pole plasm assembly (sensu Insecta) 0 48123 19 2 oocyte dorsal/ventral axis determination (sensu Insecta) 0 48124 6 1 "maternal determination of dorsal/ventral axis, oocyte, germ-line encoded (sensu Insecta)" 0 48126 8 1 establishment of oocyte nucleus localization during oocyte axis determination (sensu Insecta) 0 48128 7 1 oocyte nucleus migration during oocyte axis determination (sensu Insecta) 0 48129 2 2 oocyte microtubule cytoskeleton polarization (sensu Insecta) 0 48130 7 4 oocyte microtubule cytoskeleton organization (sensu Insecta) 0 48132 2 0 female germ-line stem cell division 0 48133 3 0 male germ-line stem cell division 0 48134 20 1 germ-line cyst formation 0 48135 9 0 female germ-line cyst formation 0 48136 6 0 male germ-line cyst formation 0 48137 2 0 spermatocyte division 0 48138 8 0 germ-line cyst encapsulation 0 48139 8 0 female germ-line cyst encapsulation 0 48140 1 0 male germ-line cyst encapsulation 0 48148 8 0 behavioral response to cocaine 0 48149 14 1 behavioral response to ethanol 0 48150 3 1 behavioral response to ether 0 48151 1 0 hyperphosphorylation 0 48167 1 0 regulation of synaptic plasticity 0 48179 2 0 activin receptor complex 0 48185 2 0 activin binding 0 48190 8 2 wing disc dorsal/ventral pattern formation 0 48193 37 7 Golgi vesicle transport 0 48194 1 1 Golgi vesicle budding 0 48232 168 14 male gamete generation 0 48252 1 0 lauric acid metabolism 0 48256 2 0 flap endonuclease activity 0 48278 33 3 vesicle docking 0 48284 15 2 organelle fusion 0 48285 1 0 organelle fission 0 48311 1 1 mitochondrion distribution 0 48312 1 1 intracellular distribution of mitochondria 0 48332 31 2 mesoderm morphogenesis 0 48333 17 1 mesodermal cell differentiation 0 48408 1 0 epidermal growth factor binding 0 48468 502 59 cell development 0 48469 33 2 cell maturation 0 48471 2 1 perinuclear region 0 48475 28 6 coated membrane 0 48477 517 51 oogenesis 0 48488 40 5 synaptic vesicle endocytosis 0 48489 102 9 synaptic vesicle transport 0 48492 4 0 ribulose bisphosphate carboxylase complex 0 48500 12 6 signal recognition particle 0 48505 1 0 regulation of timing of cell differentiation 0 48511 46 7 rhythmic process 0 48512 30 5 circadian behavior 0 48513 958 88 organ development 0 48514 1 0 blood vessel morphogenesis 0 48515 73 7 spermatid differentiation 0 48518 219 30 positive regulation of biological process 0 48519 383 34 negative regulation of biological process 0 48521 8 1 negative regulation of behavior 0 48522 195 26 positive regulation of cellular process 0 48523 352 29 negative regulation of cellular process 0 48526 1 0 wing expansion 0 48531 11 1 "beta-1,3-galactosyltransferase activity" 0 48534 88 12 hemopoietic or lymphoid organ development 0 48542 29 3 lymph gland development (sensu Arthropoda) 0 48545 17 1 response to steroid hormone stimulus 0 48546 52 4 digestive tract morphogenesis 0 48547 52 4 gut morphogenesis 0 48557 31 3 embryonic digestive tract morphogenesis 0 48558 31 3 embryonic gut morphogenesis 0 48562 34 4 embryonic organ morphogenesis 0 48565 77 5 gut development 0 48566 31 3 embryonic gut development 0 48567 51 4 ectodermal gut morphogenesis 0 48568 46 4 embryonic organ development 0 48569 13 0 post-embryonic organ development 0 48589 48 5 developmental growth 0 48592 319 22 eye morphogenesis 0 48598 146 17 embryonic morphogenesis 0 48599 124 15 oocyte development 0 48601 2 0 oocyte morphogenesis 0 48609 13 3 reproductive organismal physiological process 0 48611 30 3 embryonic ectodermal gut development 0 48613 30 3 embryonic ectodermal gut morphogenesis 0 48619 30 3 embryonic hindgut morphogenesis 0 48625 1 0 myoblast cell fate commitment 0 48627 27 2 myoblast development 0 48628 27 2 myoblast maturation 0 48637 47 3 skeletal muscle development 0 48646 35 2 anatomical structure formation 0 48663 3 1 neuron fate commitment 0 48666 195 30 neuron development 0 48667 195 30 neuron morphogenesis during differentiation 0 48675 4 1 axon extension 0 48699 240 33 neurogenesis 0 48728 2 1 proboscis development 0 48729 55 9 tissue morphogenesis 0 48730 24 7 epidermis morphogenesis 0 48731 781 74 system development 0 48732 120 11 gland development 0 48736 200 21 appendage development 0 48737 195 20 appendage development (sensu Endopterygota) 0 48741 47 3 skeletal muscle fiber development 0 48747 47 3 muscle fiber development 0 48748 303 22 eye morphogenesis (sensu Endopterygota) 0 48749 290 21 compound eye development (sensu Endopterygota) 0 48753 8 1 pigment granule organisation and biogenesis 0 48754 37 6 branching morphogenesis of a tube 0 50000 4 1 chromosome localization 0 50136 36 15 NADH dehydrogenase (quinone) activity 0 50321 1 0 tau-protein kinase activity 0 50327 1 0 testosterone 17-beta-dehydrogenase activity 0 50431 1 0 transforming growth factor beta binding 0 50488 2 0 ecdysteroid UDP-glucosyltransferase activity 0 50489 1 0 ecdysteroid UDP-glucuronosyltransferase activity 0 50508 2 0 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity 0 50509 2 0 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity 0 50516 1 0 inositol polyphosphate multikinase activity 0 50517 1 0 inositol hexakisphosphate kinase activity 0 50650 10 1 chondroitin sulfate proteoglycan biosynthesis 0 50654 10 1 chondroitin sulfate proteoglycan metabolism 0 50657 24 6 nucleic acid transport 0 50658 24 6 RNA transport 0 50660 16 4 FAD binding 0 50662 28 6 coenzyme binding 0 50664 1 0 "oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor" 0 50673 1 0 epithelial cell proliferation 0 50678 1 0 regulation of epithelial cell proliferation 0 50684 56 17 regulation of mRNA processing 0 50686 4 1 negative regulation of mRNA processing 0 50708 1 0 regulation of protein secretion 0 50764 1 0 regulation of phagocytosis 0 50767 31 3 regulation of neurogenesis 0 50768 7 0 negative regulation of neurogenesis 0 50770 20 2 regulation of axonogenesis 0 50771 2 0 negative regulation of axonogenesis 0 50773 8 1 regulation of dendrite morphogenesis 0 50774 2 0 negative regulation of dendrite morphogenesis 0 50776 1 0 regulation of immune response 0 50789 1685 217 regulation of biological process 1 50790 49 8 regulation of enzyme activity 0 50791 1488 197 regulation of physiological process 0 50793 90 7 regulation of development 1 50794 1530 197 regulation of cellular process 0 50795 18 2 regulation of behavior 0 50801 28 2 ion homeostasis 0 50802 9 1 "circadian sleep/wake cycle, sleep" 0 50803 17 1 regulation of synapse structure and function 0 50804 4 0 regulation of synaptic transmission 0 50805 1 0 negative regulation of synaptic transmission 0 50807 6 0 regulation of synapse structure 0 50808 34 3 synapse organization and biogenesis 0 50809 6 0 diazepam binding 0 50817 4 1 coagulation 0 50818 3 1 regulation of coagulation 0 50819 3 1 negative regulation of coagulation 0 50821 1 0 protein stabilization 0 50824 3 2 water binding 0 50825 3 2 ice binding 0 50826 3 2 response to freezing 0 50829 16 2 defense response to Gram-negative bacteria 0 50830 17 1 defense response to Gram-positive bacteria 0 50831 1 0 male-specific defense response to bacteria 0 50832 19 1 defense response to fungi 0 50839 19 6 cell adhesion molecule binding 0 50874 1021 65 organismal physiological process 0 50875 7146 968 cellular physiological process 0 50876 13 3 reproductive physiological process 0 50877 695 40 neurophysiological process 0 50878 9 0 regulation of body fluids 0 50879 1 1 organismal movement 0 50896 1439 143 response to stimulus 0 50906 9 0 detection of stimulus during sensory perception 0 50907 1 0 detection of chemical stimulus during sensory perception 0 50908 3 0 detection of light stimulus during visual perception 0 50909 69 2 sensory perception of taste 0 50910 4 0 detection of mechanical stimulus during sensory perception of sound 0 50912 1 0 detection of chemical stimulus during sensory perception of taste 0 50914 3 0 sensory perception of salty taste 0 50916 2 0 sensory perception of sweet taste 0 50918 1 0 positive chemotaxis 0 50919 2 0 negative chemotaxis 0 50931 1 0 pigment cell differentiation 0 50953 77 8 sensory perception of light stimulus 0 50954 35 3 sensory perception of mechanical stimulus 0 50962 3 0 detection of light stimulus during sensory perception 0 50974 5 0 detection of mechanical stimulus during sensory perception 0 50982 5 0 detection of mechanical stimulus 0 50983 1 0 "spermidine catabolism to deoxyhypusine, using deoxyhypusine synthase" 0 51013 4 2 microtubule severing 0 51015 4 2 actin filament binding 0 51016 3 0 barbed-end actin filament capping 0 51017 12 2 actin filament bundle formation 0 51018 4 0 protein kinase A binding 0 51020 24 2 GTPase binding 0 51028 17 3 mRNA transport 0 51030 2 0 snRNA transport 0 51031 1 0 tRNA transport 0 51046 2 0 regulation of secretion 0 51049 63 5 regulation of transport 0 51050 2 0 positive regulation of transport 0 51051 6 0 negative regulation of transport 0 51052 16 5 regulation of DNA metabolism 0 51053 8 2 negative regulation of DNA metabolism 0 51054 1 0 positive regulation of DNA metabolism 0 51056 8 0 regulation of small GTPase mediated signal transduction 0 51057 1 0 positive regulation of small GTPase mediated signal transduction 0 51058 7 0 negative regulation of small GTPase mediated signal transduction 0 51067 2 0 dihydropteridine metabolism 0 51078 1 0 meiotic nuclear envelope disassembly 0 51081 1 0 nuclear envelope disassembly 0 51082 68 15 unfolded protein binding 0 51084 7 3 posttranslational protein folding 0 51085 1 0 chaperone cofactor dependent protein folding 0 51087 10 3 chaperone binding 0 51090 7 1 regulation of transcription factor activity 0 51091 7 1 positive regulation of transcription factor activity 0 51092 2 1 activation of NF-kappaB transcription factor 0 51093 28 1 negative regulation of development 0 51094 1 0 positive regulation of development 0 51098 2 1 regulation of binding 0 51101 2 1 regulation of DNA binding 0 51119 49 6 sugar transporter activity 0 51123 2 0 transcriptional preinitiation complex formation 0 51124 14 1 synaptic growth at neuromuscular junction 0 51128 32 9 regulation of cell organization and biogenesis 0 51129 14 2 negative regulation of cell organization and biogenesis 0 51130 2 0 positive regulation of cell organization and biogenesis 0 51168 27 4 nuclear export 0 51169 71 8 nuclear transport 0 51170 53 4 nuclear import 0 51174 13 3 regulation of phosphorus metabolism 0 51177 1 0 meiotic sister chromatid cohesion 0 51179 2293 297 localization 0 51180 5 1 vitamin transport 0 51181 5 1 cofactor transport 0 51183 7 0 vitamin transporter activity 0 51184 12 2 cofactor transporter activity 0 51185 1 0 coenzyme transporter activity 0 51186 258 37 cofactor metabolism 0 51187 50 6 cofactor catabolism 0 51188 108 19 cofactor biosynthesis 0 51189 60 5 prosthetic group metabolism 0 51208 3 0 sequestering of calcium ion 0 51213 5 1 dioxygenase activity 0 51220 2 0 cytoplasmic sequestering of protein 0 51222 1 0 positive regulation of protein transport 0 51223 14 0 regulation of protein transport 0 51224 6 0 negative regulation of protein transport 0 51225 14 2 spindle assembly 0 51226 9 1 meiotic spindle assembly 0 51227 5 1 mitotic spindle assembly 0 51231 3 0 spindle elongation 0 51233 2 1 spindle midzone 0 51234 2202 289 establishment of localization 0 51235 21 1 maintenance of localization 0 51236 24 6 establishment of RNA localization 0 51237 5 0 maintenance of RNA localization 0 51238 3 0 sequestering of metal ion 0 51239 24 1 regulation of organismal physiological process 0 51240 1 0 positive regulation of organismal physiological process 0 51241 4 0 negative regulation of organismal physiological process 0 51242 172 24 positive regulation of cellular physiological process 0 51243 303 25 negative regulation of cellular physiological process 0 51244 1441 192 regulation of cellular physiological process 0 51246 151 34 regulation of protein metabolism 0 51247 2 0 positive regulation of protein metabolism 0 51248 32 3 negative regulation of protein metabolism 0 51252 58 17 regulation of RNA metabolism 0 51253 4 1 negative regulation of RNA metabolism 0 51258 26 8 protein polymerization 0 51259 1 0 protein oligomerization 0 51261 20 2 protein depolymerization 0 51262 1 0 protein tetramerization 0 51270 2 1 regulation of cell motility 0 51276 270 43 chromosome organization and biogenesis 0 51282 3 0 regulation of sequestering of calcium ion 0 51283 2 0 negative regulation of sequestering of calcium ion 0 51287 1 0 NAD binding 0 51290 1 0 protein heterotetramerization 0 51291 1 0 protein heterooligomerization 0 51293 12 1 establishment of spindle localization 0 51294 1 0 establishment of spindle orientation 0 51295 1 0 establishment of meiotic spindle localization 0 51297 17 5 centrosome organization and biogenesis 0 51298 2 1 centrosome duplication 0 51299 8 2 centrosome separation 0 51300 1 0 spindle pole body organization and biogenesis 0 51301 172 19 cell division 0 51303 4 1 establishment of chromosome localization 0 51304 3 0 chromosome separation 0 51305 2 1 chromosome movement towards spindle pole 0 51307 3 0 meiotic chromosome separation 0 51310 3 0 metaphase plate congression 0 51318 1 1 G1 phase 0 51319 1 0 G2 phase 0 51320 3 2 S phase 0 51321 227 12 meiotic cell cycle 0 51322 13 2 anaphase 0 51323 2 1 metaphase 0 51325 22 7 interphase 0 51327 227 12 M phase of meiotic cell cycle 0 51329 22 7 interphase of mitotic cell cycle 0 51336 14 3 regulation of hydrolase activity 0 51338 27 3 regulation of transferase activity 0 51339 3 1 regulation of lyase activity 0 51340 1 0 regulation of ligase activity 0 51345 2 0 positive regulation of hydrolase activity 0 51347 9 3 positive regulation of transferase activity 0 51348 2 0 negative regulation of transferase activity 0 51349 3 1 positive regulation of lyase activity 0 51351 1 0 positive regulation of ligase activity 0 51427 1 0 hormone receptor binding 0 51480 3 0 cytosolic calcium ion homeostasis 0 51482 3 0 "elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" 0 51489 1 0 regulation of filopodium formation 0 51503 2 1 adenine nucleotide transport 0 51567 1 0 histone H3-K9 methylation 0 51603 83 32 proteolysis during cellular protein catabolism 0 51606 53 7 detection of stimulus 0 51640 45 6 organelle localization 0 51641 685 115 cellular localization 0 51646 1 1 mitochondrion localization 0 51647 30 4 nucleus localization 0 51649 684 115 establishment of cellular localization 0 51651 1 0 maintenance of cellular localization 0 51653 12 1 spindle localization 0 51656 43 5 establishment of organelle localization 0 51657 1 0 maintenance of organelle localization 0 51658 1 0 maintenance of nucleus localization 0 51662 8 1 oocyte nucleus localization during oocyte axis determination (sensu Insecta) 0 51663 9 1 oocyte nucleus localization during oocyte axis determination 0 51674 332 41 localization of cell 0 51693 3 0 actin filament capping 0 51704 96 8 interaction between organisms 0 51705 93 8 behavioral interaction between organisms 0 51707 149 8 response to other organism 0 51726 209 38 regulation of cell cycle 0 51748 1 0 UDP-sugar pyrophosphorylase activity 0 51761 7 0 sesquiterpene metabolism 0 51762 3 0 sesquiterpene biosynthesis 0 51763 4 0 sesquiterpene catabolism 0 51765 1 0 inositol tetrakisphosphate kinase activity 0 51766 5 0 inositol trisphosphate kinase activity 0 51775 1 0 response to redox state 0 51780 3 0 behavioral response to nutrient 0 all 10391 1164 all 1