Supplementary material for Toyota et al. (2000) Proc. Natl. Acad. Sci. USA 97 (2), pp. 710-715.
Table 2.
Summary of epigenetic and genetic alterations in 41 colorectal cancers with or without CpG island methylator phenotype (CIMP)Sample | CIMP | Methylation | Mutation | MSI | |||||
MINTs* | p16 | hMLH1 | K-RAS | p53 | TGF b RII | ||||
850 | + | 6 | Yes | Yes | No | No | No | + | |
852 | + | 6 | Yes | Yes | No | No | Exon 3 | + | |
637 | + | 5 | Yes | Yes | No | No | Exon 3 | + | |
91 | + | 6 | Yes | Yes | No | No | Exon 3 | + | |
391 | + | 6 | No | Yes | No | 239 (AAC to AAA) | Exon 3 | + | |
427 | + | 6 | Yes | No | 12 (GGT to GAT) | No | No | – | |
101 | + | 6 | Yes | No | 12 (GGT to AGT) | No | No | – | |
1491 | + | 5 | Yes | No | No | LOH | 439 (GCT to GTT) | – | |
742 | + | 4 | Yes | No | 12 (GGT to GTT) | No | No | – | |
99 | + | 3 | Yes | No | 12 (GGT to GTT) | No | No | – | |
874 | + | 4 | Yes | No | 13 (GGC to GAC) | No | No | – | |
297 | + | 4 | Yes | No | 13 (GGC to TGC) | No | No | – | |
630 | + | 4 | No | No | 12 (GGT to GTT) | No | 553 (TCG to ACG) | – | |
703 | + | 5 | No | No | 12 (GGT to TGT) | 282 (CGG to CAG) | No | – | |
558 | + | 4 | No | No | 12 (GGT to GCT) | No | No | – | |
396 | + | 5 | No | No | 12 (GGT to GTT) | 248 (CGG to TGG) | No | – | |
102 | + | 4 | No | No | No | No | No | – | |
1355 | + | 4 | No | No | 12 (GGT to GTT) | No | No | – | |
1454 | + | 4 | No | No | No | No | 439 (GCT to GTT) | – | |
965 | + | 3 | Yes | No | 13 (GGC to GAC) | 234 (TAC to TGC) | No | – | |
535 | + | 3 | Yes | No | 12 (GGT to GCT) | Exon 5 splice (AG to AC) | No | – | |
1258 | – | 0 | No | Yes | No | No | Exon 3 | + | |
733 | – | 1 | No | No | 12 (GGT to GAT/GCT) | 239 (AAC to ACC) | Exon 3 | + | |
76 | – | 0 | No | No | No | ND | ND | + | |
262 | – | 0 | No | No | No | 175 (CGC to CAC) | Exon 3 | + | |
80 | – | 0 | No | No | 12 (GGT to AGT) | No | No | – | |
478 | – | 1 | No | No | No | 273 (CGT to CAT) | No | – | |
98 | – | 0 | No | No | No | 196 (CGA to TGA) | No | – | |
92 | – | 0 | No | No | 12 (GGT to TGT) | No | No | – | |
836 | – | 0 | No | No | 12 (GGT to TGT) | LOH | No | – | |
546 | – | 1 | No | No | No | LOH | No | – | |
1290 | – | 0 | No | No | No | Exon 5, 10-bp insertion | No | – | |
833 | – | 0 | No | No | No | 282 (CGG to TGG) | No | – | |
872 | – | 0 | No | No | No | 175 (CGC to CAC) | 553 (TCG to ACG) | – | |
835 | – | 0 | No | No | No | 248 (CGG to CAG) | No | – | |
146 | – | 1 | No | No | No | 254 (ATC to AGC) | No | – | |
108 | – | 0 | No | No | No | LOH | No | – | |
281 | – | 1 | No | No | No | 282 (CGG to TGG) | No | – | |
300 | – | 0 | No | No | 12 (GGT to GAT) | 282 (CGG to TGG) | No | – | |
327 | – | 1 | No | No | No | 176 (TGC to TAC) | No | – | |
1225 | – | 0 | No | No | No | 173 (GTG to CTG) | No | – | |
ND, not determined.
*Of six.