Supplementary material for Toyota et al. (2000) Proc. Natl. Acad. Sci. USA 97 (2), pp. 710-715.
Table 4.
Summary of epigenetic and genetic alterations in 46 colorectal adenomas with or without CpG island methylator phenotype (CIMP)Sample | CIMP | Methylation | Mutations | |||
MINTs* | p16 | hMLH1 | K-RAS | p53 | ||
P46 | + | 6 | Yes | No | 12 (GGT to GAT) | 266 (GGA to GAA) |
P48 | + | 6 | Yes | No | No | No |
P7 | + | 6 | Yes | No | 12 (GGT to GAT) | No |
P1 | + | 5 | Yes | No | 12 (GGT to GTT) | No |
P6 | + | 5 | No | No | No | No |
P8 | + | 5 | No | No | No | No |
P30 | + | 5 | Yes | No | 12 (GGT to GAT) | No |
P11 | + | 5 | No | No | 13 (GGC to GAC) | No |
373 | + | 5 | No | No | 13 (GGC to GAC) | No |
336 | + | 5 | No | No | No | No |
1274 | + | 5 | No | No | No | No |
P49 | + | 4 | No | No | 13 (GGC to GAC) | No |
P41 | + | 4 | Yes | No | No | No |
P37 | + | 4 | No | No | 12 (GGT to GCT) | No |
1292 | + | 4 | Yes | No | 12 (GGT to GAT) | No |
351 | + | 4 | No | No | 12 (GGT to GAT) | No |
P9 | + | 4 | No | No | No | No |
P14 | + | 4 | Yes | No | 12 (GGT to GCT) | Exon 7 splice (AG to AA) |
P28 | + | 3 | Yes | No | 12 (GGT to GAT) | No |
P32 | + | 3 | Yes | No | 12 (GGT to GTT) | No |
P38 | + | 3 | Yes | No | 12 (GGT to GTT) | No |
P34 | + | 3 | Yes | No | 13 (GGC to GAC) | No |
1320 | – | 2 | No | No | No | No |
P24 | – | 1 | No | No | No | No |
P16 | – | 1 | No | No | No | 196 (CGA to TGA) |
P18 | – | 1 | No | No | No | No |
P45 | – | 1 | No | No | No | No |
P51 | – | 1 | No | No | No | No |
P22 | – | 1 | No | No | No | No |
P25 | – | 1 | No | No | 12 (GGT to GCT) | No |
303 | – | 1 | No | No | No | No |
478 | – | 0 | No | No | 12 (GGT to GAT) | No |
427 | – | 0 | No | No | No | 175 (CGC to CAC) |
P21 | – | 0 | No | No | No | 306 (CGA to TGA) |
P2 | – | 0 | No | No | No | Exon 6 splice (AG to GG) |
P29 | – | 0 | No | No | No | No |
P31 | – | 0 | No | No | No | 241 (TCC to TC) frame shift |
P42 | – | 0 | No | No | 12 (GGT to GTT) | No |
P43 | – | 0 | No | No | No | No |
P44 | – | 0 | No | No | No | No |
P50 | – | 0 | No | No | No | No |
391 | – | 0 | No | No | No | No |
733 | – | 0 | No | No | No | No |
535 | – | 0 | No | No | No | No |
363 | – | 0 | No | No | No | No |
*Of six.