Supporting information for Ray et al. (2003) Proc. Natl. Acad. Sci. USA, 10.1073/pnas.1031851100
Fig. 8.
Representative images obtained from hyperoxia-treated mice in the presence (A and B) or absence (C and D) of KGF. KGF maintained the ultrastructural morphology of the epithelial cells lining the alveolar spaces. Intact epithelial lining was routinely observed. However, disruption of the microvascular endothelium was often observed in the hyperoxic KGF-treated lungs (arrowheads in A and B). Hyperoxic conditions in the absence of KGF often showed areas of complete cellular disruption of both alveolar epithelium and microvascular endothelium (* in C). Type II cells displayed heterogeneous response to hyperoxic conditions with some cells showing preserved morphology (C) and other areas showing cell disruption (D). Blood vessel endothelium shown was mostly disrupted (arrowheads in D). TII, Type II cells; VL, blood vessel lumen. Bar in D is representative of all panels.