Table A

Table  B

Table C

References

 

Table A QUADAS tool [As supplied by authors]

Item

Yes

No

Unclear

1. Was the spectrum of patients representative of the patients who will receive the test in practice?

( )

( )

( )

2. Were selection criteria clearly described?

( )

( )

( )

3. Is the reference standard likely to correctly classify the target condition?

( )

( )

( )

4. Is the time period between reference standard and index test short enough to be reasonably sure that the target condition did not change between the two tests?

( )

( )

( )

5. Did the whole sample or a random selection of the sample, receive verification using a reference standard of diagnosis?

( )

( )

( )

6. Did patients receive the same reference standard regardless of the index test results?

( )

( )

( )

7. Was the reference standard independent of the index test (i.e. the index test did not form part of the reference standard)?

( )

( )

( )

8. Was the execution of the index test described in sufficient detail to permit replication of the test?

( )

( )

( )

9. Was the execution of the reference standard described in sufficient detail to permit its replication?

( )

( )

( )

10. Were the index test results interpreted without knowledge of the results of the reference standard?

( )

( )

( )

11. Were the reference standard results interpreted without knowledge of the results of the index test?

( )

( )

( )

12. Were the same clinical data available when tests results were interpreted as would be available when the test is used in practice?

( )

( )

( )

13. Were uninterpretable/intermediate test results reported?

( )

( )

( )

14. Were withdrawals from the study explained?

( )

( )

( )

 

  

 

Table B QUADAS results of the 13 studies evaluating rK39 dipsticks included in the meta-analysis

Studies

Reference

QUADAS items

Total score*

1

2

3

4

5

6

7

8

9

10

11

12

13

14

Goswami et al, 2003

w15

No

Yes

U

U

No

Yes

Yes

Yes

No

Yes

Yes

n.a.

No

No

7

Chappuis et al, 2003

w16

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

U

Yes

n.a.

U

Yes

12

Sundar et al, 2002

w17

No

Yes

Yes

Yes

No

Yes

Yes

Yes

Yes

Yes

Yes

n.a.

U

No

9.5

Bern et al, 2000

w18

No

No

Yes

U

No

Yes

Yes

Yes

Yes

U

Yes

n.a.

U

No

7.5

Sundar et al, 1998

w19

Yes

Yes

Yes

Yes

No

No

Yes

Yes

Yes

Yes

U

n.a.

U

No

9

Zijltra et al, 2001

w20

No

Yes

Yes

Yes

No

Yes

Yes

Yes

No

U

Yes

n.a.

Yes

No

8.5

Schallig et al, 2002

w21

No

Yes

U

U

No

Yes

Yes

Yes

No

U

Yes

n.a.

U

No

7

Brandonisio et al, 2002

w22

No

Yes

Yes

Yes

No

Yes

Yes

Yes

No

U

Yes

n.a.

U

No

8

Carvalho et al, 2003

w23

No

Yes

Yes

Yes

No

Yes

Yes

Yes

Yes

Yes

Yes

n.a.

U

No

9.5

Sarker et al, 2003

w24

No

Yes

Yes

Yes

No

Yes

Yes

No

Yes

U

Yes

n.a.

U

No

8

Boelaert et al, 2004

w25

Yes

Yes

Yes

Yes

Yes

Yes

U

Yes

Yes

Yes

Yes

n.a.

U

Yes

12

Veeken et al, 2003

w26

No

Yes

Yes

Yes

U

Yes

Yes

No

No

U

U

n.a.

No

No

6.5

Iqbal et al, 2002

w27

No

No

Yes

Yes

No

No

Yes

Yes

Yes

U

No

n.a.

No

No

5.5

U, unclear; n.a., not assessed

*Reply to items: "yes" = 1; "unclear" = 1/2; "no" or "n.a" = 0; the QUADAS score was obtained by adding up the scores of the 14 items.

 

 

 

Table C QUADAS results of the 30 studies evaluating the DAT included in the meta-analysis

Studies

Reference

QUADAS items

Total score

1

2

3

4

5

6

7

8

9

10

11

12

13

14

Zijltra et al, 1992

w1

No

Yes

Yes

Yes

Yes

No

Yes

Yes

Yes

U

No

n.a.

No

No

7.5

Harith et al, 1987

w2

No

Yes

Yes

Yes

No

Yes

Yes

Yes

No

No

Yes

n.a.

No

No

7

Harith et al, 1986

w3

No

Yes

Yes

Yes

No

Yes

Yes

Yes

No

No

Yes

n.a.

No

No

7

Boelaert et al, 1999

w4

No

Yes

Yes

Yes

No

Yes

Yes

Yes

Yes

U

Yes

n.a.

Yes

Yes

10.5

Abdallah et al, 2004

w5

No

No

Yes

Yes

No

Yes

Yes

Yes

Yes

U

Yes

n.a.

No

No

7.5

Lito et al, 2002

w6

No

No

Yes

Yes

No

Yes

Yes

No

No

U

Yes

n.a.

No

No

5.5

Agarwal et al, 1996

w7

No

No

Yes

U

No

Yes

Yes

Yes

No

U

Yes

n.a.

No

No

6

Oskam et al, 1999

w8

No

Yes

Yes

Yes

No

Yes

Yes

Yes

No

U

Yes

n.a.

No

No

7.5

Garcez et al, 1996

w9

No

Yes

U

Yes

No

Yes

Yes

Yes

No

U

Yes

n.a.

No

No

7

Nyakundi et al, 1994

w10

U

U

Yes

Yes

Yes

No

No

No

Yes

Yes

No

n.a.

No

No

6

Singla et al, 1993

w11

No

Yes

U

Yes

No

Yes

Yes

Yes

No

U

Yes

n.a.

No

No

7

Zijlstra et al, 1991

w12

Yes

Yes

Yes

Yes

Yes

U

Yes

Yes

No

U

No

n.a.

No

No

8

Andrade et al, 1989

w13

No

No

U

Yes

No

Yes

Yes

Yes

No

U

Yes

n.a.

No

No

6

Abdel-Hameed et al, 1989

w14

No

Yes

Yes

Yes

No

Yes

Yes

No

U

U

Yes

n.a.

No

No

7

Chappuis et al, 2003

w16

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

U

Yes

n.a.

No

Yes

11.5

Bern et al, 2000

30

No

No

Yes

U

No

Yes

Yes

Yes

Yes

U

Yes

n.a.

U

No

7.5

Schallig et al, 2002

33

No

Yes

U

U

No

Yes

Yes

Yes

No

U

Yes

n.a.

No

No

6.5

Boelaert et al, 2004

37

Yes

Yes

Yes

Yes

Yes

Yes

U

Yes

Yes

Yes

Yes

n.a.

U

Yes

12

Veeken et al, 2003

38

No

Yes

Yes

Yes

No

Yes

No

No

No

U

U

n.a.

No

No

5

El-Safi et al, 1989

40

No

Yes

U

Yes

No

Yes

Yes

Yes

U

U

Yes

n.a.

No

No

7.5

De Korte et al, 1990

41

No

No

U

Yes

No

Yes

Yes

Yes

No

U

Yes

n.a.

No

No

6

Pal et al, 1991

42

No

Yes

Yes

Yes

No

Yes

Yes

Yes

No

U

Yes

n.a.

No

No

7.5

Sinha et al, 1994

43

No

No

U

U

No

Yes

Yes

Yes

No

U

Yes

n.a.

No

No

5.5

Jha et al, 1996

44

No

Yes

Yes

Yes

No

Yes

No

Yes

No

U

U

n.a.

No

No

6

Joshi et al, 1999

45

No

No

Yes

Yes

No

Yes

Yes

Yes

No

U

Yes

n.a.

No

No

6.5

Boelaert et al, 1999b

46

Yes

Yes

Yes

Yes

Yes

Yes

U

Yes

Yes

U

Yes

n.a.

No

Yes

11

Aoun et al, 2000

47

No

No

Yes

Yes

No

Yes

Yes

No

No

U

Yes

n.a.

No

No

5.5

Alam et al, 1996

48

No

Yes

U

Yes

No

Yes

Yes

No

Yes

U

Yes

n.a.

No

No

7

Bagchi et al, 1998

49

No

No

U

U

No

Yes

Yes

Yes

No

U

Yes

n.a.

No

No

5.5

Meredith et al, 1995

50

No

No

Yes

U

No

Yes

Yes

Yes

No

U

Yes

n.a.

No

No

6

U, unclear; n.a., not assessed

*Reply to items: "yes" = 1; "unclear" = 1/2; "no" or "n.a" = 0; the QUADAS score was obtained by adding up the scores of the 14 items.

 

 

  

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