Supporting information for Correia et al. (2003) Proc. Natl. Acad. Sci. USA, 10.1073/pnas.1131007100
Fig. 5.
Sequence identity among FNG proteins. Because of space limitations, only insect FNG proteins are aligned in Fig. 1 in the main text. This supporting figure, which also includes the predicted amino acid sequences, aligned by the PILE UP program of GCG 10, of all sequenced FNGs. Nonconserved amino-terminal and carboxyl-terminal regions are not shown. In cases where the available sequence is thought to be complete, the numbers for the first and last aa shown are indicated. Black boxes identify amino acids identical among all cloned FNG proteins and gray boxes identify amino acids identical among all insect FNGs, but not all vertebrate FNGs. Lines above the sequence letters demarcate the conserved sequence motifs identified in Fig. 2 in the main text. Letters above the sequence numbers identify the locations of missense mutations in Drosophila FNG and asterisks (*) above identify the locations of nonsense mutations (see Table 1in the main text). GenBank accession numbers for the sequences analyzed are as follows: Fruit fly (Drosophila melanogaster) AAF51658; Butterfly (Precis coenia/Junonia coenia); Grasshopper (Schistocerca gregaria) AAF17565.1; Mosquito (Anopheles gambiae) EAA11189.1; Mouse (Mus musculus) Radical NP_033079.1; Rat (Rattus norvegicus) Radical NP_068621.1; Human (Homo sapiens) Radical AAC51359.1; Chick (Gallus gallus) Radical AAC60107.1; Frog (Xenopus laevis) Radical AAB19226.1; Newt (Notophthalmus viridescens) Radical AAD10827.1; Human Manic CAB07511.l; Mouse Manic NP_032621.1; Rat Lunatic BAB63256.1; Mouse Lunatic NP_032520.1; Human Lunatic AAC51360.1; Chick Lunatic AAC60099.1; Frog Lunatic AAB19225.1; and Z. Fish (Danio rerio) Lunatic AAG12160.1.