Table 2. Cytogenetic abnormalities in activated premalignant B cells or T cells from Bad+/+ or Bad-/- mice 12–15 months after whole body γ-irradiation (400 rad)
|
| Metaphases analyzed | Abnormal metaphases | Total aberrations | Chromosome | Chromatid |
|
|
| ||
Breaks | Gaps | Breaks | Gaps | Fragments | Translocations | Other | |||||
+/+ | T cell | 40 | 10 (25%) | 12 (0.30/cell) | 2 | 1 | 1 | 0 | 4 | 2 | 2* |
-/- | T cell | 40 | 11 (27%) | 14 (0.35/cell) | 4 | 1 | 1 | 5 | 3 | 0 | 0 |
+/+ | B cell | 60 | 16 (27%) | 19 (0.32/cell) | 3 | 3 | 6 | 2 | 3 | 2 | 0 |
-/- | B cell | 60 | 17 (28%) | 22 (0.37/cell) | 4 | 1 | 7 | 4 | 4 | 2 | 0 |
*, Centric fusion.