Fig. 8.
No epidermal proliferation in both K14-VEGF (vascular endothelial growth factor) and K14-Ang1 (angiopoietin 1) transgenic mice. (A) One representative section of ear from K14-AGF (angiopoietin-related growth factor) mice, controls and K14-VEGF mice. Edematous thickened ears from K14-AGF and K14-VEGF mice were detected. Arrows indicate the thickness of dermis and subcutaneous tissues in ear. It is noteworthy that markedly thickened epidermal layers in K14-AGF ear were detected, whereas no alteration in epidermal layers in K14-VEGF was observed. Intervals between open arrowheads indicate thickness of epidermal layers. (Scale bar = 200 μm.) (B) Comparison of hematoxylin/eosin-stained ears of K14-AGF and K14-Ang1 mice. Markedly thickened epidermal layer in K14-AGF mouse was detected, whereas no alteration of epidermal layer was seen in the K14-Ang1 mouse. (Scale bar = 10 μm.)