Supplementary material for Leemans et al., Proc. Natl. Acad. Sci. USA, 10.1073/pnas.210066997

Functional Classification

Representative genes for each of the functional classes are listed as follows.</>

00 Unknown function

01 Signal transduction:

 Cytoplasmic proteins involved in intracellular signaling/ MAP-kinases/cAMP, cGMP-dependent kinases/small GTP-ases/ras oncogene-like proteins/SH3-SH2-SH3 domain proteins

02 Transcriptional regulation:

Transcription factors such as homeodomain proteins, zinc finger proteins, ETS proteins, Pou domain proteins/nuclear hormone and steroid receptors/Polycomb- and Trithorax group proteins

03 Cell cycle:

 Cyclins/cyclin-dependent kinases

05

 Cytoskeleton/structural proteins: Proteins involved in cytoskeletal organization such as actin, actin filament-associated proteins, microtubule-associated proteins, dynein, kinesin/proteins involved in muscle contraction such as myosin, tropomyosin/yolk proteins/chorion proteins/nuclear envelope proteins

06 Metabolism

: General “housekeeping” proteins/enzymes/soluble calcium-binding proteins/pheromone-binding and odorant-binding proteins/ABC transporters/pigment proteins/antibacterial peptides/proteins involved in nucleotide synthesis/cytochromes

07 Translation:

 Ribosomal proteins/proteins involved in translational regulation/tRNA synthetases

08

 Heat shock proteins: Heat shock proteins and heat shock cognate proteins

09

 Transcription/replication/repair: RNA polymerases/TATA-binding factors/DNA polymerases/DNA helicases/proteins involved in DNA damage and repair

10 Proteolytic systems/ apoptosis:

Ubiquitinases/ubiquitin-activated enzymes/proteasome subunits/trypsin/serine proteases/proteins involved in apoptotic pathways

11

 Cell surface receptors/CAMs/ion channels: Transmembrane signaling receptors/glutamate receptors/GABA receptors/acetylcholine receptors/membrane associated antigens/transmembrane phosphatases and kinases/ion channel subunits/cell adhesion molecules/rhodopsins

12 Transposable elements:

F-, copia-, HET-A-, gypsy-, P-elements, transposable element-encoded ORFs

13 Chromatin structure:

DNA-binding proteins not involved in transcription/histones/nucleosome associated proteins/centrosome associated proteins/proteins involved in chromosomal segregation

14 RNA binding:

RNA helicases/proteins involved in RNA localization/RNA-binding proteins

15 Secreted proteins:

 Secreted signaling proteins/ligands