Supplementary material for Chang et al. (2000) Proc. Natl. Acad. Sci. USA 97 (8), 4291-4296.

Table 2.

Genes up-regulated by p21 induction

Genes

Accession no.

Balanced differential expression

Confirmed by*

Secreted proteins and proteins associated with extracellular matrix

    Fibronectin 1

X02761

5.7

R

    Plasminogen activator inhibitor, type I

M14083

3.7

R, N

    Plasminogen activator, tissue type

M15518

2.8

R, Z

    Laminin b2

X79683

2.1

 

    Desmocollin 2a/bb

X56807

3.5

 

    Podocalyxin-like protein

U97519

2

 

    Activin A (inhibin bA)

J03634

2

R

    Galectin 3 (Mac-2)

AB006780

2.4

R, N

    Mac-2-binding protein

L13210

2

R, N

    Prosaposin

J03077

2.9

R, N

    CTGF (connective tissue growth factor)

M92934

3.3

R, N

    Granulin/epithelin

AF055008

2.1

R, N

    Cathepsin B

L04288

2.4

N

    Tissue transglutaminase

M55153

2.5

R, N, W

    P37NB (slit homolog)

U32907

2.1

 

    Serum amyloid A protein precursor

M26152

4

R, N, W

    Alzheimer's disease amyloid A4 protein precursor

D87675

2

R, N

    Complement C3 precursor

K02765

5.9

R, N

    Testican

X73608

2.1

N

    Integrin b3

M35999

2.1

R, N

Lysosomal proteins

    N-acetylgalactosamine-6-sulfate sulfatase

U06088

2.3

N

    Acid a-glucosidase

X55079

2.4

N

    Acid lipase A (cholesterol esterase)

X76488

2.1

N

    Lysosomal pepstatin-insensitive protease (CLN2)

AF017456

2.5

 

Mitochondrial proteins

    Superoxide dismutase 2

X07834

3.5

R, N, W

    Metaxin

J03060

3.4

 

    2,4-Dienoyl-CoA reductase

U78302

2

 

Other genes associated with stress response and signal transduction

    Ubiquitin-conjugating enzyme (UbcH8)

AF031141

2

 

    Ubiquitin-specific protease 8

D29956

2

 

    RTP/Cap43/Drg1/Ndr1 (inducible by nickel, retinoids, homocysteine and ER stress)

D87953

2.5

 

    C-193 muscle ankyrin-repeat nuclear protein (cytokine inducible)

X83703

3

 

    LRP major vault protein associated with multidrug resistance

X79882

2.2

N

    b-arrestin related HHCPA78 homolog (up-regulated by vitamin D3)

S73591

4.1

N

    R-RAS

M14949

2.4

 

    RAB 13 small GTPase

X75593

2.2

 

    p66Shc

U73377

2

R, N

    MK-STYX (MAP kinase phosphatase-like protein)

N75168

2

 

    H73 nuclear antigen/MA-3 apoptosis-related/TIS (topoisomerase-inhibitor suppressed)

U96628

2.4

 

Other genes

    Natural killer cells protein 4

M59807

4.4

R

    TXK tyrosine kinase (T-cell specific)

L27071

3.8

 

    X-linked PEST-containing transporter

U05321

2.1

 

    AMP deaminase 2

M91029

2

N

    FIP2/HYPL huntingtin-interacting protein

AF061034

2

 

    DNase I homolog

X90392

2.5

N

    Transcription factor 11

X77366

2

 

    Histone H2A.2

L19779

2.8

 

    Histone H2B

AL021807

2.4

 

Genes with unknown function

    23808

AF038192

2.1

 

    CGI-147

AA307912

2.1

N

    EST

W89120

2.8

 

    EST

AI026140

2.5

 

    EST

AA218982

2.4

 

    EST

W63684

2

 

*R, RT-PCR; N, Northern hybridization; W, Western blotting; Z, zymography.