Supplementary material for Chang et al. (2000) Proc. Natl. Acad. Sci. USA 97 (8), 4291-4296.
Table 2.
Genes up-regulated by p21 inductionGenes | Accession no. | Balanced differential expression | Confirmed by* |
Secreted proteins and proteins associated with extracellular matrix | |||
Fibronectin 1 | X02761 | 5.7 | R |
Plasminogen activator inhibitor, type I | M14083 | 3.7 | R, N |
Plasminogen activator, tissue type | M15518 | 2.8 | R, Z |
Laminin b2 | X79683 | 2.1 |
|
Desmocollin 2a/bb | X56807 | 3.5 |
|
Podocalyxin-like protein | U97519 | 2 |
|
Activin A (inhibin bA) | J03634 | 2 | R |
Galectin 3 (Mac-2) | AB006780 | 2.4 | R, N |
Mac-2-binding protein | L13210 | 2 | R, N |
Prosaposin | J03077 | 2.9 | R, N |
CTGF (connective tissue growth factor) | M92934 | 3.3 | R, N |
Granulin/epithelin | AF055008 | 2.1 | R, N |
Cathepsin B | L04288 | 2.4 | N |
Tissue transglutaminase | M55153 | 2.5 | R, N, W |
P37NB (slit homolog) | U32907 | 2.1 |
|
Serum amyloid A protein precursor | M26152 | 4 | R, N, W |
Alzheimer's disease amyloid A4 protein precursor | D87675 | 2 | R, N |
Complement C3 precursor | K02765 | 5.9 | R, N |
Testican | X73608 | 2.1 | N |
Integrin b3 | M35999 | 2.1 | R, N |
Lysosomal proteins | |||
N-acetylgalactosamine-6-sulfate sulfatase | U06088 | 2.3 | N |
Acid a-glucosidase | X55079 | 2.4 | N |
Acid lipase A (cholesterol esterase) | X76488 | 2.1 | N |
Lysosomal pepstatin-insensitive protease (CLN2) | AF017456 | 2.5 |
|
Mitochondrial proteins | |||
Superoxide dismutase 2 | X07834 | 3.5 | R, N, W |
Metaxin | J03060 | 3.4 |
|
2,4-Dienoyl-CoA reductase | U78302 | 2 |
|
Other genes associated with stress response and signal transduction | |||
Ubiquitin-conjugating enzyme (UbcH8) | AF031141 | 2 |
|
Ubiquitin-specific protease 8 | D29956 | 2 |
|
RTP/Cap43/Drg1/Ndr1 (inducible by nickel, retinoids, homocysteine and ER stress) | D87953 | 2.5 |
|
C-193 muscle ankyrin-repeat nuclear protein (cytokine inducible) | X83703 | 3 |
|
LRP major vault protein associated with multidrug resistance | X79882 | 2.2 | N |
b-arrestin related HHCPA78 homolog (up-regulated by vitamin D3) | S73591 | 4.1 | N |
R-RAS | M14949 | 2.4 |
|
RAB 13 small GTPase | X75593 | 2.2 |
|
p66Shc | U73377 | 2 | R, N |
MK-STYX (MAP kinase phosphatase-like protein) | N75168 | 2 |
|
H73 nuclear antigen/MA-3 apoptosis-related/TIS (topoisomerase-inhibitor suppressed) | U96628 | 2.4 |
|
Other genes | |||
Natural killer cells protein 4 | M59807 | 4.4 | R |
TXK tyrosine kinase (T-cell specific) | L27071 | 3.8 |
|
X-linked PEST-containing transporter | U05321 | 2.1 |
|
AMP deaminase 2 | M91029 | 2 | N |
FIP2/HYPL huntingtin-interacting protein | AF061034 | 2 |
|
DNase I homolog | X90392 | 2.5 | N |
Transcription factor 11 | X77366 | 2 |
|
Histone H2A.2 | L19779 | 2.8 |
|
Histone H2B | AL021807 | 2.4 |
|
Genes with unknown function | |||
23808 | AF038192 | 2.1 |
|
CGI-147 | AA307912 | 2.1 | N |
EST | W89120 | 2.8 |
|
EST | AI026140 | 2.5 |
|
EST | AA218982 | 2.4 |
|
EST | W63684 | 2 |
|
*R, RT-PCR; N, Northern hybridization; W, Western blotting; Z, zymography.