Pereira et al. 10.1073/pnas.0611721104. |
Fig. 5. Focal hippocampal x-irradiation blocks exercise-induced CBV changes. Focal x-irradiation was performed as previously described (1). Briefly, anesthetized mice were placed in a stereotaxic frame and received three alternating-day exposures of 5 Gy of x-irradiation delivered through an opening in a lead shield, with the opening placed on a skull region above the hippocampus. Three months after the completion of x-irradiation, 4 mice that received x-irradiation and three sham controls were imaged in the exercise protocol. Results showed that, compared with the sham control group (black bars), exercise-induced CBV increases predominately in the entorhinal cortex (EC) and dentate gyrus (DG). Exercise-induced CBV increases were blocked in the x-irradiation group (light bars), with a statistically significant effect observed only in the dentate gyrus (asterisks).
1. Santarelli L, Saxe M, Gross C, Surget A., Battaglia F, Dulawa S, Weisstaub N, Lee J, Duman R, Arancio O, et al. (2003) Science 301:805-809.