Supplemental figure 1: Multiple sequence alignment of CHASE domains gi130677959\198-411 -NPSAIDQETFAEY--TARTAFERPLLSG-VAYAEKV-VNFEREMFE-RQHNWVIKT--M gi28301941\110-321 -HPPALDQDTFAVY--AARTSFERPLLSG-VAYAQRV-VHADRESFE-RQQGWIIKT--M gi12060392\86-298 -SPPAIDQDTFAKY--TARTSFERPLLNG-VAFAQRV-FHHEREMFE-SQQGWVMNT--M gi18421494\302-526 -IPSAIDQRTFEEY--TERTNFERPLTSG-VAYALKV-PHSEREKFE-KEHGWAIKK--M gi22353121\154-378 -EPWALDQQTFEDY--TEKTAFERPLTSG-VAYALRV-LHSEREKFE-KQQGWIIRK--M gi20279446\50-274 -NPSAIDQKTFEDF--TARTTFERPLMSG-VAYALKV-LHSERELFE-QKLGWKIKK--M gi9802528\163-389 -IPSAIDQRTFSEY--TDRTSFERPLTSG-VAYAMRV-LHSEREEFE-RQQGWTIRK--M gi20161916\151-377 -TPSAIDQMTFARY--AERTAFERPLTSG-VAYAVRV-THGEREQFE-RQQGWAIKK--M gi|14513877 --------------------AFERPLTSG-VAYGVKV-THAEREQFE-RQQGWSIKK--M gi|9415459 -------------------------------------------ETFE-RQHGWIMRT--M gi|33217468 ------------------------------------------------------------ gi|14823726 ------------------------------------------------------------ gi|7265090 --------------------------------------------QFE-TQQGWSIKR--M gi|16247084 ------------------------------------------------------------ gi23055097\38-240 -RNVAQLAAG-AAFSLERQISGSLSATYA-LAAILR--QAGTIKDFD-ALAAEMIRT--Y gi27364428\14-215 -SQVAMTQAK---NLEKELHTALIASTQI--LAVEVIQNNGNMENFE-EYAQEILSL--S gi13471907\45-248 -AKVNIIRAK-----LEGNINGNLQLVQGLVSAIDTE-PYMGQQRFA-SLAGNLFQQ--K gi15966662\49-253 -SEVADALNPIRSS-LESSVNGNIQLVRGLIATIETE-PDMQQQRFG-ELARSVFGA--G gi23027857\50-253 -NEASKLR-ASI----ESTINSNLQAVQGLVLVLNAF-PEPSQEEFA-SFAAPLFNQ--N gi23000375\48-254 -RVTVLEQLSQLRGLLENEINLSFHLTMGLLAYVAIE-PNISQQNFQ-LMAREIIAQ--S gi15601713\42-248 -RQQAKEDLSIVRFQLEAEILGDIYTVKG-LTTLLTLDPDLNIYQWE-PLSAAVIRN--S gi28900053\42-248 -QVEAKEQLSILRSNLEAVLMADIYKAST-LATLITLLPNSEEEELS-IAADRILNK--S gi27367985\42-248 -QREAKDQLSAIRSKLEAAIVSDIYIVSS-LATLISLHPNSNKQALD-QASEKILRK--G gi23013402\61-262 -SRLS-VLRAHLEYNLTAPLLISRGLVAQ--IILHDGLTD---AEFA-RAASLVIKD--Y gi23058768\88-299 -NSESVSRAEFDGY--THPL---LLRTQA-YSFALRV-SGAERAAFE-QRVRDEGLS--T gi26988822\85-301 -FSSEITPREFDGY--ARPL---LQRTLA-YAWAPRV-EAAQRAEFE-RLASAHTGP--G gi28869512\121-331 -FSHQVEQSEFNGF--VAPL---LLGTQA-YAWNPKV-TLAERSAFE-EQARKEGAA--G gi23468834\87-298 -YSHQVELSEFNGF--VAPL---LIGTQA-YAWNPRV-SQAERTAFE-RQLREEGSA--A gi22968449\79-295 -GERGITREVFRGYSKTRDIGAEFPGARG-FGFIRRV-PADREERFL-AEARADGWP--D gi15599307\77-286 -GEVHIDRELFRRYSLTRDIDREFPGARG-FGFIRRV-AAADEAGFL-RQARADGQP--E gi21885294\85-301 -SPEHFDYNDMQAYTQARDYKREFPGARG-FGLIIKV-EPNQTAAFL-DRMAAER-P--S gi21243225\83-298 -GSDIISRERFTLYSRSRDYPREFPGVLG-YGYIHRV-APADEAAFL-QAARADGAP--D gi21231797\83-298 -GSDVISRDRFTRYSRSRDYPREFPGVLG-YGYIHRV-AAADEAAFL-DAARADGAP--D gi23471793\76-296 -DLQHINSSQMGRYSKGRNIEKEYPGARG-FGFIRRV-AASDEAEFV-RRVREDGRP--D gi23030255\93-313 -ASTEVTRADYANYVKALQLDTKWPGVQG-IGYSIPI-EASQLEAHI-EAMRAQG----- gi23053590\87-308 -ASESVERHEFRDYVTALGLEESYRGIQG-VGFTQIV-PAARLQSHI-ESVRKEG----- gi32475880\90-306 -ASNSVSRAEWRTYFENSRFQEYYPGIQG-VGFSRVV-KADENDAFV-ESVRAEGFP--E gi24372138\85-305 -SSRGVTRSEWQTYVANARLSDYYPGIQG-LGFAELV-TPATLDEFT-QQVQQEGFS--D gi22982057\71-291 -ANGTIDRDRFRRYVGALNLDANFSGIHA-VGVVEWV-PAAQKAGHV-ARMREEGVP--G A 781615118115847756417111115317114377177374117117746418365771 B 868436774588488115836845572671464485784666557278871885486888 C 881872787112148868118881851218135444188812163118888484687888 D 847852556856811541228412112318214142183366227128864222281884 E 611861718554612824726765411226315588168236866246473282153666 gi130677959\198-411 DRGE----------------------PSPVRDEY----------APVIFSQD---SVSYL gi28301941\110-321 KHEP-----------------------SPAQDEY----------APVIYSQE---TISYI gi12060392\86-298 QREP-----------------------APPQVEY----------APVIFSQD---TVSYL gi18421494\302-526 ETEDQTV--------VQDCVPENF-DPAPIQDEY----------APVIFAQE---TVSHI gi22353121\154-378 DTEVQTL--------GQDLVPEKL-EPAPVQTEY----------APVIFAQK---TVSHI gi20279446\50-274 ETEDQSL--------VHDYNPEKL-QPSPVQDEY----------APVIFSQE---TVKHI gi9802528\163-389 YSLEQNPV------HKDDYDLEAL-EPSPVQEEY----------APVIFAQD---TVSHV gi20161916\151-377 YSSSNKKQSSPGPGP-GDAAVAEI---REPAEEY----------APVIFAQD---AYKHV gi|14513877 YXQNQEAVA-----GTRERRGRXV---REPAEEY----------APVIFAQD---AYKHV gi|9415459 NREA-----------------------APLQDEY----------APVIFSQD---TVSYL gi|33217468 --------------------------PSPPQDEY----------APVIYSQE---TVSYI gi|14823726 ---------------------------------------------PVIFSQD---TVSYL gi|7265090 DTMDQNPV------HEDXSVPDEL-EPSPIHEEY----------APVIFAQD---TISHV gi|16247084 ----------------------------------------------------------HV gi23055097\38-240 GGIS-----------------SLQLAPAGVMTT----------------IYPLA-GNEKA gi27364428\14-215 EVIS---------------------NLQLAPNG------------IIQFIYPLA-GNEKA gi13471907\45-248 SQLR---------------------NIAGAPDL------------VISLMYPME-GNEKA gi15966662\49-253 SQLR---------------------NIAAAPGL------------VVAMVYPLT-GNEKA gi23027857\50-253 TQLR---------------------NIAAAPGM------------VIKYMHPLE-GNEAA gi23000375\48-254 RNIR---------------------NLGLAPDN------------VLSYIYPLS-GNERA gi15601713\42-248 DHLR---------------------SLGIAPND------------VVAFSYPLP-QTNAL gi28900053\42-248 KHIT---------------------VIGIAEND------------VISHIFPTQ-GNERV gi27367985\42-248 KHLR---------------------VIGLARDD------------VVNYVYPWV-GNEGV gi23013402\61-262 DSVR---------------------NLTMSRGT------------VISAVYP-EAPNRAV gi23058768\88-299 FSVREL----------NARGELQL---ASARDEY----------VVVLYSQTQS-RLGSP gi26988822\85-301 YVIRDQ----------DAQGQWR---PASQRDHY----------FPVLYTQSSE-RPGLP gi28869512\121-331 YAIREL----------DENGALKV---AGVRNEY----------FPVRFIQTLS-KIPAP gi23468834\87-298 YAISEMD----------ENGALKAA---AVRNEY----------FPVRFIQTLS-DIPTP gi22968449\79-295 FAIA----------------------QFTPHEGER---------FVIQYIEPAQ-RNLKA gi15599307\77-286 FRIQ----------------------QLTPHDGER---------YVIQYIEPVA-RNGQA gi21885294\85-301 YNFQ--------------------IRQLTPHQDSL---------FVITYIEP-EQNNREA gi21243225\83-298 IHRR----------------------PLAPWDGER---------YMVLYFEPES-SGNRP gi21231797\83-298 IQRR----------------------LLAPWDGER---------FIVLYFEPES-SGNRP gi23471793\76-296 FSLS-------------------RLSGPGTRQGDR---------FIIQFIDPLD-RNVQA gi23030255\93-313 FPEY-------------------TVKPTEPREEY----------SAIIYLEPFDWRNQRA gi23053590\87-308 FPDY-------------------AIWPDREQEIH----------TSIIYLEPFSGRNLRA gi32475880\90-306 FDIR----------------------PDGERDVY----------TAIVYLEPFDWRNQRA gi24372138\85-305 FRIT----------------------PIGDRELY----------CVIKYLEPFDWRNQRA gi22982057\71-291 YTIL----------------------PEGQREDY----------APLVQREPYVGITQSS A 867847878878788885888777771548561177777777771111441677746445 B 754288888888888888888118124381677888888888888135752147831252 C 472328788888888833717668188178124188888888884616471182888681 D 486688888888888888888881586432452428888888885424222177142852 E 288866666666666666666664481856228366666666665525421125432221 gi130677959\198-411 ESLDMMSGEEDRENILR----ARETGKAVL-TSPFRLLE------THHLGVVLTFPVYKS gi28301941\110-321 EGLDVMSGEEDRENILR----ARATGKAVL-TRPFRLMS-------NHLGVVLTFPVYLV gi12060392\86-298 ARIDMMSGEEDRENIFR----ARTTGKAVL-TNPFRLLG------SNHLGVVLTFAVYRP gi18421494\302-526 VSVDMMSGEEDRENILR----ARASGKGVL-TSPFKLLK------SNHLGVVLTFAVYDT gi22353121\154-378 VSIDMMSGKEDRENILR----ARASGKGVL-TSPFKLLK------SNHLGVVLTFAVYNT gi20279446\50-274 ISVDMMSGKEDRDNILR----SRATGKGAL-TAPFPLLK------SNHLGVVLTFTVYKY gi9802528\163-389 VSLDMLSGKEDRENVLR----ARSSGKGVL-TAPFPLIK------TNRLGVILTFAVYKR gi20161916\151-377 ISFDMLSGNEDRDNILR----ARKSGKGVL-TAPFKLLN-------NRLGVILTYTVYKY gi|14513877 ISFDLLSGADDRDNVLR----ARESGKGVL-TAPFKLLN-------NRLGVISTYAVYKY gi|9415459 ARMDMMSGEEDRENILR----ARETGKPVL-TNPFRLLG------SNHLGVVLTFAVYRP gi|33217468 EGLDMMSGEEDRENILR----SRATGKAVL-TRPFRLMS-------NHLGVVLTFPVYLV gi|14823726 ARIDMMSGEEDQENILR----ARTTGKAVL-TNPFRLLG------SNHLGVVLTFAVYRP gi|7265090 ISIDVLSGKEDRENVLR----ARESGKGVL-TAPFRLLK------TNRLGVILTFAVYKR gi|16247084 ISVDMLSGKEDRENVLR----ARESGKGVL-TAPFRLLK------TNRLGVIKTFAVYKT gi23055097\38-240 IGHDLLSDPLRRTEAQR----AIESRQMTL-AGPFELRQGG-------VGAVGRLAVFLP gi27364428\14-215 IGHNLLKDDARKKEALS----AVESGKLTL-AGPFTLKQGG-------IGMVARRPVFLK gi13471907\45-248 IGLDYRKNEAQRTAALR----ARDHRVLVF-AGPVDLAQGG-------RGFIGRIPVFVP gi15966662\49-253 IGLDYRTNDKQRSSVMR----AVASGEMVL-AGPVDLVQGG-------RGLIGRFPVTT- gi23027857\50-253 IGLDFRATPAQKEAAER----AERTGQLVL-AGPVNLKQGG-------QGFIGRIPVFTY gi23000375\48-254 LGLDYRKNAKQWPAVQL----AISERRTVV-AGPVKLVQGG-------EAFISRTPIYRT gi15601713\42-248 LGLDYRTVPQQWQSIKK----AREIKQTFV-SGPVDLVQGG-------RALVIREPIFY- gi28900053\42-248 LGLDYRKVPAQWVQVQK----AKDIQEIFI-AGPVSLVQGG-------RGLIVRVPVFR- gi27367985\42-248 LGLDYKKEPAQWESIVK----AKTIEEIFI-AGPMELVQGG-------KALVARVPIFS- gi23013402\61-262 LGVDYHSKPDQWPSVER----AISSRKPVV-AGPVNLIQGG-------TALIGRVPVYMP gi23058768\88-299 LGYDLLAQPLRRSTLER----ADQLRSLAV-SQPMHLVGIE---PAYARGVLLVAPVLRE gi26988822\85-301 YGLDLAGQSEPQAALARALAPALAPGSMAV-SEPLALFDT----QSAERGLLMVAPVFSD gi28869512\121-331 SGFDVFSEPIRHCALER----ARLLKRIVA-TPRISLLALD---PSDIYGILLVAPVFSS gi23468834\87-298 AGFDIASEPVRRAALER----ARLLKRTVA-TPRIRLLSLE---PSDTYGILLVAPVFST gi22968449\79-295 VGLDIASEKNRREAALA----AIDTGQVRL-TGPITLVQAS---GDKSQSFLILLPIYRT gi15599307\77-286 LGLDIASEANRREAARA----ALETGQVRL-TGPITLVQAS---GLRQQSFLILMPIYRS gi21885294\85-301 VGVDIGSEAMRRKAALD----AAFNNDVRL-TAPITLVQAN---ERAQQGFLILMPVYKT gi21243225\83-298 LGIDIASEPRRRAAALQ----AARSGEPVM-TSPISLSGYR---IPNESGFLVLLAVYRE gi21231797\83-298 LGLDVASEPRRRIAAIA----AARSGQPTM-TSPVSLSGYQ---TPSEGGFLVLLPVYRE gi23471793\76-296 LGLDITSEEHRRDAALQ----AMRSGAATL-SAPITLLQDN---DDHMRAFLFLLPVYST gi23030255\93-313 FGYDMWSNPMRREAMAR----ARDNAEAAT-SGIITLVQET--DNNVQRGFLTYVPVYST gi23053590\87-308 FGYDMFSEQVRHAAMVR----ARDTGTVAL-SGKVRLVQET--GEREQAGVLSYLPIYAN gi32475880\90-306 FGFDMYSEATRRAAMDA----AVASGEPTI-SGVVKLVQET--EDDVQQGFLLYLPVFEN gi24372138\85-305 FGFDMCSEATRRSAILK----AITSGLPKV-SGKVTLVQET--PENTQAGVLMYVPLYRG gi22982057\71-291 PGFDTWSDPVRRAAMER----ARDSGMAAL-SGTVHLLIDA--DSDLRPGFIMYLPIYAS A 648153116314514417777417411531716116156777777533111351461168 B 112123555813843838888167366513811117141118888888726261711386 C 818188723858831311118188673822828568188878884288516131111328 D 415123118511711488888178326472813121142548887887531131422143 E 315128144412312846666143328436611817123216676582815271414385 gi130677959\198-411 SLPE--NPTV---EERIAATAGYLGGAFDVESLVENL---LGQLAGNQA---IVVHVYDI gi28301941\110-321 DLPN--DTAV---EDRVAATAGYLGGAFDVESLVENL---LRQLAGNQE---LVVNVYDV gi12060392\86-298 DLPA--DASV---EQRVEATIGYLGGAFDVESLVENL---LSKLAGNQD---IVVNVYDV gi18421494\302-526 SLPP--DATE---EQRVEATIGYLGASYDMPSLVEKL---LHQLASKQT---IAVDVYDT gi22353121\154-378 DLPP--EATR---EQRINATVGYLGASYDVPSLVEKL---LHQLASKQT---IAVNVYDT gi20279446\50-274 DLPP--DATP---EERIEATLGYLGASFDVPSLVERL---LEQLASKQK---IVVRLYDI gi9802528\163-389 DLPS--NATP---KERIEATNGYLGGVFDIESLVENL---LQQLASKQT---ILVNVYDI gi20161916\151-377 ELPA--YARP---HERIQAAIGYLGGIFDIQALVEKL---LKQLASQES---IMVNVYDT gi|14513877 ELPP--NATP---QDRIQAAIGYLGGIFDIEALVDKS---LHQLAGKQS---IMVNVYDT gi|9415459 DLPA--DASV---EQRVEATAGYLGGAFDVESLVENL---LSKLAGNQD---ILVNVYDV gi|33217468 DLPP--DAKV---EDRVAATAGYLGGAFDVESLVENL---LRQLAGNQE---LVVNVYDV gi|14823726 DLPA--DASV---EQRVEATIGYLGGGFDVESLVENL---LSKLAGNQD---IVVNVYDV gi|7265090 DLPS--NATP---NERIQATDGYLGGVFEIESLVEKL---LQQLASKQT---VLVNVYDT gi|16247084 DLPS--NATP---NERIQATDGYLGGVLDIESLVEKL---LQQLASKQT---ILVNVYDT gi23055097\38-240 EPGR--GE----------RFWGFVNVLMRLRDLLAASN-LEALDKGGYG--YELTRLNPD gi27364428\14-215 LQ----DK---------SEFWGFVSALILLENLIASSD-LQELQKDNLR--FQLSRIHPD gi13471907\45-248 TAGG--GD----------RFWGIVSAVVDVDRLYAAS----GLTDPDLD-IDVALTGKDA gi15966662\49-253 ------GP------EGGRRFWGVVSAVIDVDRLYRDS----GLSSPALD-IAIAGRDGTG gi23027857\50-253 ------NKQN-----NTKSSWGLLSTVIDLDRFYSAT----GITQFNET-LQLALRGKDA gi23000375\48-254 GM----DGKK-------GAYWGLASTVIDKDKLFTTA----GIYEVSKQ-IKLAIRGRDG gi15601713\42-248 ------DPP------KDTRYWGVLSVVMDWDSLLSAT----SIYSFGEH-FQVAIRGLDS gi28900053\42-248 ------DPPI------NKEYWGVISAVVDFDGLMRET----GVFDFSYH-YPLTIRGYDS gi27367985\42-248 ------DPPL------NSQYWGVCSAVLNFDSLLMDV----GFASFAYQ-YRVAIKGLDS gi23013402\61-262 DHGG--GE---------SRFFGLISVVIDLPKVFSAS----GLDAGMMS-MELAVRGHDG gi23058768\88-299 ------GEP---------RSYGYVMAVISMRQLLADG----LPDAFHDY---LSVRILDL gi26988822\85-301 ADPR--GAAV-----------GYVMALLSMRELVSDG----RPVAVDDN---LVVRITDP gi28869512\121-331 ERPS--------------ELRGYVSAVISLAQLMSVG------TAEQDN---LAVTMLDL gi23468834\87-298 GQPV--PQ-----------LRGYVTAVISLTQLMNVR------TAEQDN---LAVTMLDL gi22968449\79-295 LSTP--ETL----AERRAQAFGW----SYAPLNMPEV---LSGLVPNQD--RLALTLRDV gi15599307\77-286 GITP--PP------GPQRELEGF--GWSYAPLLTGEV--LAGLPIDNAA---IHLELSDV gi21885294\85-301 TTVP--QD----SRQRLEHLFGWSYATILINDVLNSV------AGLEND---VFLQISDI gi21243225\83-298 GMPL--QTP----QQRMLATSGWVYAPFSVEQMVRSA------LGERDD---VALDLSDR gi21231797\83-298 GMPL--QTP----QQRMDATTGWAYAPLSVKQMLEST------LGDRDD---VAISLSDR gi23471793\76-296 PEIP--TDI----AQRETSLIGWTYAPLAMREVMSNL------DPLNHR---LHLKLYDV gi23030255\93-313 RVIP--PTV----EERRTAFLGWVYAPFRAGNLMQGI-----LGSDDDQ---IHLDIYDG gi23053590\87-308 GKRL--DSV----QSRRSAIIGWVYSPFRMDDLMAGL-----FGGRANE---IDIEIYDG gi32475880\90-306 RETV--EEE----GQQLASVVGFVYAPFRTRDLMVGI-----RKSNLPD---IDFKIYDG gi24372138\85-305 QPM---TEV-----ERMQQAIGVVYALFRMNDLMQGIM-----GKRFSG---IKLAIYDG gi22982057\71-291 GETQ--ESVL----QRRAHITGWVYASFRMHDVMASL-----YGEQPAG---VSLAVYDG A 611777646677766156138111146535531135477717311543777746153116 B 881488375888888878621145141435352654258154487888786871524824 C 881888788888888888888111513212821785488888181871288817142616 D 885288676888863278758146128774866584488888887847588157282313 E 588866842866686246855171114114822182216666838887766618481111 gi130677959\198-411 TNASD-PLVMYG-----NQDEEADRSLSHE-----SKLDFGDPFRKHKMI---------- gi28301941\110-321 TNHSN-PLVMYG-----SEVPLGIPSPSHT-----YTLDFGDPLRKHQMV---------- gi12060392\86-298 TNASD-AMVLYG----PSSLDEQVPFLHVS------MLDFGDPFRKHEMR---------- gi18421494\302-526 TNTSG-LIKMYG-----SEIGDISEQHI-------SSLDFGDPSRNHEMH---------- gi22353121\154-378 TDKSA-PIKMYG-----DAANDTGLPRIS-------QLDFGDPSRKHEMH---------- gi20279446\50-274 TNHTY-PTKMYD-----SDVIASDDLHISN-------IDFGDPTRKHVMH---------- gi9802528\163-389 TNHSQ-PISMYG-----TNVSADGLERVSP-------LIFGDPLRKHEMR---------- gi20161916\151-377 TNESP--ISMYG-----DDTGS-GMCHVSV-------LNFGDPSRKHEMH---------- gi|14513877 TNEKP--ISMYG----SNDTGS-GMCQVST-------LNFG------------------- gi|9415459 TNASE-PMAMYG----SQTPDNK------------------------------------- gi|33217468 TNHSN-PLVMYG----SEVPL-GAPSPSHT-----CTLDFGDPFRNHHMI---------- gi|14823726 TNASE-PMALYG----PSIL--DEQVPLHV-----SMLDFGDPFRRHE------------ gi|7265090 TNQTH-SIPMYG----SDVSG-DEFYHVSF-------LNFGD------------------ gi|16247084 TNISH-PISMYG----SNVSG-DGLEHVSA-------LNFGDPFRRHEMR---------- gi23055097\38-240 TGRWESIARSD-------GPLQAPVESTID-------VPNG-TWKLA------------- gi27364428\14-215 TNQV---DVFYG-----ESISQDWISSQVT-----IDVPNNQ-WTLI------------- gi13471907\45-248 LGGAG--ERFFG---AGQVIAGNPVSAAVQ-------LPSG-SWQISAIP---------- gi15966662\49-253 RGG----PHFFG---DPAIFENAPVEMSVS-------LPGG-SWRMAAIP---------- gi23027857\50-253 KGAQG--QVFYG---DEALFHADAVLLEVS-------VPSG-SWQLAIL----------- gi23000375\48-254 LGAQG--DLISG---EGELFNERAVLQNVQ-------LPDG-RWQLA------------- gi15601713\42-248 RGSEG--DVFFG---EPRVFE-HAFAQENV------YFPYG-SWRIAVA----------- gi28900053\42-248 GGEYG--DMFFG----DPNQTGKLYAKEHV------HFPYG-GWSMAAY----------- gi27367985\42-248 EAEKG--AMIYG----DEATFNDAFVKERV------SFPYG-GWVLAVA----------- gi23013402\61-262 LGRLG--DMIRG---DESIFGRSPVEMEVS-------LPDG-TWIMA------------- gi23058768\88-299 STTDQ-HEVLFE----STNEPAQSDLSATR--------LVRMADHDYQVD---------- gi26988822\85-301 SGLQG-PVVLFD----SQN-PVAPLALASN-------QLLRLADHHFQLS---------- gi28869512\121-331 SSPAK-PEQVYQ----SPIAGLHNQLYASS--------LLSLGDRDYLVE---------- gi23468834\87-298 SSPEK-PEQVYQ----SPLPAIHNQLYASS--------LLNLGDRDYLVE---------- gi22968449\79-295 TNPAEAETVFTS----NTDCAAAECVTKTL-----TRSIFGRVWEIS------------- gi15599307\77-286 TGDGA-AVPFFV----NGAAA------PAQ-----RL--FGHMLRREIY----------- gi21885294\85-301 TEQTP--IEFFS--QEVKDTYDAALQQKLN-----LS-VFGRQWQLS------------- gi21243225\83-298 NEPTH---NFYR---SGTPASDSALRPPVV----RLLPIYGRTWVIT------------- gi21231797\83-298 EDTQH---TFYR---SGIAAPESMRRAAHT----QLLPIYGRTWVLT------------- gi23471793\76-296 -NEGR--QLIYQ---TPENDHDQEVLQTYA----FEREIYGRVWRMEVG----------- gi23030255\93-313 KTKQP-ESLLYS----SESAPLERNIPDLT--KEVSITLQGREWTLY------------- gi23053590\87-308 EEISE-KTLLHD---SDKIRFAGVMEAPLL--AIKRMEIAGRIWTVA------------- gi32475880\90-306 ESEST-ANLLYS----SHLPM---LRPASE-----GNADFVLTKQLHLR----------- gi24372138\85-305 SEANRTHLMFSS---DPKLPSSKDVFYQSQ-----LETMEGQVWRIDVSS---------- gi22982057\71-291 VAASD-AALLYRTPAANGWHA-PALMSANE-----YLVVDGRDWMLS------------- A 138587757314777748888888887658777776845111171617177777777777 B 827811867681888388878885284535888888831418317515718888888888 C 178888444436888818788877868128888888811684312343378888888888 D 468871888268881668868548888888888888872412637774888888888888 E 888388872254811757868888787888668888867824856587816666666666