A highly divergent microsatellite facilitating fast and accurate DRB haplotyping in humans and rhesus macaques -- Doxiadis et al. 104 (21): 8907 Data Supplement - HTML Page - index.htslp -- Proceedings of the National Academy of Sciences

Doxiadis et al. 10.1073/pnas.0702964104.

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Fig. 2. Phylogenetic analysis of Mamu-DRB exon 2 with the D6S2878 sequences superimposed. The tree was rooted by including the Caja-DRB*W1601 allele, and bootstrap values are shown. Identical or similar colors indicate identity or similarities of the D6S2878 composition. D6S2878 composition of Mamu-DRB1*0306 of Indian monkeys (Table 1, haplotype 11c,d) is shown.

Table 3. Gene frequencies and numbers of Mamu-DRB and HLA-DRB haplotypes tested by D6S2878

Mamu			HLA
hapl^a	#	gf^b (2n = 240)	hapl^a	#	gf^c
1a	43 (4)^d	0,104	DR8a	5 (2)^d	0.039
1b	4	0,004	DR8b	2 (2)	0.039
2	20 (2)	0,017	DR1a-DR103	42 (20)	0.094
3	1	0,004	DR1b	8 (2)	0.094
4	2	0,004	DR10	4	0.013
5	2	0,004	DR52-DR17a	34 (16)	0.111
6	2	0,004	-DR17b	12 (6)	0.111
7	1	0,004	-DR11a	25 (2)	0.134
8	3	0,004	-DR11b	2 (2)
9	1	0,004	-DR11c	6 (6)
10	4	0,008	-DR12a	1	0.023
11a	32	0,063	-DR12b	5 (2)
11b	7	0,017	-DR12c	1
11a or b^e		0,083	-DR13a	13 (6)	0.102
11c	7 (4)	0,004	-DR13b	16 (6)
11d	21	0,096	-DR13c	12 (4)
12	58 (2)	0,163	-DR14a	1	0.032
13	10	0,008	-DR14b	4 (2)
14	7 (4)	0,021	-DR14c	2 (2)
15a	7 (2)	0,033	DR53-DR4a	23 (6)	0.128
15b	2	0,008	-DR4b	2 (2)
16	3	0,029	-DR4c	11 (6)
17	7	0,025	-DR4d	2
18a	3	0,004	-DR4e	1
18b	2	0,004	-DR7	28 (12)	0.132
19a	5	0,071	-DR9	10 (2)	0.014
19b	3	0,013	DR51-DR15a1	5	0.107
20	1	0,008	-DR15a2	39 (16)
21a	20 (2)	0,050	-DR15b	4 (2)
21b	2	0,004	-DR16	2 (2)	0.036
22	14 (2)	0,042
other	n.t.	0,092	others	n.t.	0.035
total	294	1,000	total	322	1.000

^aMhc-DRB

haplotypes correspond to those defined in Table 1 and 2, respectively. ^bGene frequencies (gf) of Mamu-DRB haplotypes of the rhesus macaque breeding colony. ^cGene frequencies (gf) of caucasoid HLA-DRB haplotypes according to Marsh and coworkers (39). ^d () refer to # of homozygous typing cells included in the total #. ^eHaplotypes 9a and b could only be descriminated by D6S2878 genotyping and sequencing; n.t. not tested.