Doxiadis et al. 10.1073/pnas.0702964104. |
Fig. 2. Phylogenetic analysis of Mamu-DRB exon 2 with the D6S2878 sequences superimposed. The tree was rooted by including the Caja-DRB*W1601 allele, and bootstrap values are shown. Identical or similar colors indicate identity or similarities of the D6S2878 composition. D6S2878 composition of Mamu-DRB1*0306 of Indian monkeys (Table 1, haplotype 11c,d) is shown.
Table 3. Gene frequencies and numbers of Mamu-DRB and HLA-DRB haplotypes tested by D6S2878
Mamu |
HLA | ||||
hapla | # | gfb (2n = 240) | hapla | # | gfc |
1a | 43 (4)d | 0,104 | DR8a | 5 (2)d | 0.039 |
1b | 4 | 0,004 | DR8b | 2 (2) | |
2 | 20 (2) | 0,017 | DR1a-DR103 | 42 (20) | 0.094 |
3 | 1 | 0,004 | DR1b | 8 (2) | |
4 | 2 | 0,004 | DR10 | 4 | 0.013 |
5 | 2 | 0,004 | DR52-DR17a | 34 (16) | 0.111 |
6 | 2 | 0,004 | -DR17b | 12 (6) | |
7 | 1 | 0,004 | -DR11a | 25 (2) | 0.134 |
8 | 3 | 0,004 | -DR11b | 2 (2) | |
9 | 1 | 0,004 | -DR11c | 6 (6) | |
10 | 4 | 0,008 | -DR12a | 1 | 0.023 |
11a | 32 | 0,063 | -DR12b | 5 (2) | |
11b | 7 | 0,017 | -DR12c | 1 | |
11a or be | 0,083 | -DR13a | 13 (6) | 0.102 | |
11c | 7 (4) | 0,004 | -DR13b | 16 (6) | |
11d | 21 | 0,096 | -DR13c | 12 (4) | |
12 | 58 (2) | 0,163 | -DR14a | 1 | 0.032 |
13 | 10 | 0,008 | -DR14b | 4 (2) | |
14 | 7 (4) | 0,021 | -DR14c | 2 (2) | |
15a | 7 (2) | 0,033 | DR53-DR4a | 23 (6) | 0.128 |
15b | 2 | 0,008 | -DR4b | 2 (2) | |
16 | 3 | 0,029 | -DR4c | 11 (6) | |
17 | 7 | 0,025 | -DR4d | 2 | |
18a | 3 | 0,004 | -DR4e | 1 | |
18b | 2 | 0,004 | -DR7 | 28 (12) | 0.132 |
19a | 5 | 0,071 | -DR9 | 10 (2) | 0.014 |
19b | 3 | 0,013 | DR51-DR15a1 | 5 | 0.107 |
20 | 1 | 0,008 | -DR15a2 | 39 (16) | |
21a | 20 (2) | 0,050 | -DR15b | 4 (2) | |
21b | 2 | 0,004 | -DR16 | 2 (2) | 0.036 |
22 | 14 (2) | 0,042 | |||
other | n.t. | 0,092 | others | n.t. | 0.035 |
total | 294 | 1,000 | total | 322 | 1.000 |
a
Mhc-DRBhaplotypes correspond to those defined in Table 1 and 2, respectively. bGene frequencies (gf) of Mamu-DRB haplotypes of the rhesus macaque breeding colony. cGene frequencies (gf) of caucasoid HLA-DRB haplotypes according to Marsh and coworkers (39). d () refer to # of homozygous typing cells included in the total #. eHaplotypes 9a and b could only be descriminated by D6S2878 genotyping and sequencing; n.t. not tested.