Table 2. Expression deconvolution phenotypes for 300 yeast strains (see ref. 12), sorted by severity.
Raw deconvolution results are presented in the blue columns. Order and severity of defects are presented in the yellow columns. These are calculated by first finding the geometric center of mass of the cell population (point c below), as described in the paper. Essentially, the fraction of cells in each phase is modeled as lying on the points G1, S, G2, M, and M/G1 below, and the center of mass of the population, c, is calculated. The order of timing is estimated as the angle t made between line oc and the x axis. The severity is estimated as the length of vector oc normalized by dividing by vector od to correct for the maximum severity allowable in direction oc using this geometric construction (delineated by the pentagon). The new normalized center of mass lies in direction oc at a position between c and the perimeter of the circle. Severity is therefore the length of the vector between the origin o and the normalized center of mass.