Table A

Table B

Table C
 

Table A Cases of meningococcal disease* from the Oxford record linkage study database, number of deaths within 30 days and case fatality rate per 100 000: people aged under 15 years, 1963-98
 
Time period
Cases admitted to hospital
  
All cases
No of cases
No of deaths
Case fatality rate (95% CI)
No of cases
Incidence per 100 000 population (95% CI)
No of deaths†
Case fatality rate (95% CI)
1963-68
28
2
7.1 (0.0 to 16.7)
  
29
3.5 (2.3 to 4.8)
3
10.3 (0.0 to 21.4)
1969-73
54
3
5.6 (0.0 to 11.7)
  
55
5.2 (3.8 to 6.6)
4
7.3 (0.4 to 14.1)
1974-78
67
5
7.5 (1.2 to 13.8)
  
68
3.2 (2.5 to 4.0)
6
8.8 (2.1 to 15.6)
1979-83
75
6
8.0 (1.9 to 14.1)
  
75
3.4 (2.6 to 4.2)
6
8.0 (1.9 to 14.1)
1984-88
100
11
11.0 (4.9 to 17.1)
  
104
4.6 (3.7 to 5.5)
15
14.4 (7.7 to 21.2)
1989-93
179
13
7.3 (3.5 to 11.1)
  
181
7.1 (6.0 to 8.1)
15
8.3 (4.3 to 12.3)
1994-98
276
16
5.8 (3.0 to 8.6)
  
278
10.4 (9.2 to 11.7)
18
6.5 (3.6 to 9.4)
1963-98
779
56
7.2 (5.4 to 9.0)
  
790
5.8 (5.4 to 6.2)
67
8.5 (6.5 to 10.4)
P value for trend‡    
0.49
    
<0.001
  
0.28

*International Classification of Diseases, 9th revision code 036 and 10th revision code A39.

†Includes 11 people who died outside hospital or who had no record of hospital admission.

‡P values refer to the change in annual rates 1963-98 from logistic regression modelling. Visual inspection of the annual incidence rates and further modelling show little change in incidence 1963-88 (P=0.36) and a significant increase 1989-98 (P<0.001).
 
 

Table B Cases of meningococcal disease* from the Oxford record linkage study database, number of deaths within 30 days and case fatality rate per 100 000: people aged 15-24 years, 1963-98
 
Time period
Cases admitted to hospital
  
All cases
No of cases
No of deaths
Case fatality rate (95% CI)
No of cases
Incidence per 100 000 population (95% CI)
No of deaths †
Case fatality rate (95% CI)
1963-68
4
0
0
  
4
0.7 (0.0 to 1.4)
0
0
1969-73
9
1
11.1 (0.0 to 31.6)
  
9
1.2 (0.4 to 2.0)
1
11.1 (0.0 to 31.6)
1974-78
15
0
0
  
15
1.1 (0.5 to 1.6)
0
0
1979-83
18
3
16.7 (0.0 to 33.9)
  
18
1.0 (0.5 to 1.5)
3
16.7 (0.0 to 33.9)
1984-88
31
2
6.5 (0.0 to 15.1)
  
32
1.6 (1.0 to 2.2)
3
9.4 (0.0 to 19.5)
1989-93
66
8
12.1 (4.2 to 20.0)
  
68
3.5 (2.7 to 4.4)
10
14.7 (6.3 to 23.1)
1994-98
97
9
9.3 (3.5 to 15.1)
  
98
5.7 (4.6 to 6.9)
10
10.2 (4.2 to 16.2)
1963-98
240
23
9.6 (5.9 to 13.3)
  
244
2.4 (2.1 to 2.7)
27
11.1 (7.1 to 15.0)
P value for trend‡    
0.61
    
<0.001
  
0.51

*International Classification of Diseases, 9th revision, code 036 and 10th revision code A39.

†Includes 4 people who died outside hospital or who had no record of hospital admission.

‡P values refer to the change in annual rates 1963-98 from logistic regression modelling. Visual inspection of the annual incidence rates and further modelling show little change in incidence 1963-88 (P=0.94) and a significant increase 1989-98 (P<0.001).
 

Table C Cases of meningococcal disease* from the Oxford record linkage study database, number of deaths within 30 days and case fatality rate per 100 000: people aged at least 25 years, 1963-98
 
 
Cases admitted to hospital
  
All cases
Time period
No of cases
No of deaths 
Case fatality rate (95% CI)
No of cases
Incidence per 100 000 population (95% CI)
No of deaths†
Case fatality rate (95% CI)
1963-68
9
3
33.3 (2.5 to 64.1)
  
9
0.4 (0.2 to 0.7)
3
33.3 (2.5 to 64.1)
1969-73
7
1
14.3 (0.0 to 40.2)
  
8
0.3 (0.1 to 0.5)
2
25.0 (0.0 to 55.0)
1974-78
26
7
26.9 (9.9 to 44.0)
  
28
0.5 (0.3 to 0.7)
9
32.1 (14.8 to 49.4)
1979-83
20
2
10.0 (0.0 to 23.1)
  
20
0.3 (0.2 to 0.5)
2
10.0 (0.0 to 23.1)
1984-88
16
3
18.8 (0.0 to 37.9)
  
16
0.2 (0.1 to 0.3)
3
18.8 (0.0 to 37.9)
1989-93
58
4
6.9 (0.4 to 13.4)
  
59
0.7 (0.5 to 0.9)
5
8.5 (1.4 to 15.6)
1994-98
91
16
17.6 (9.8 to 25.4)
  
97
1.1 (0.9 to 1.3)
22
22.7 (14.3 to 31.0)
1963-98
227
36
15.9 (11.1 to 20.6)
  
237
0.6 (0.5 to 0.7)
47
19.8 (14.8 to 24.9)
P value for trend‡    
0.18
    
<0.001
  
0.28

*International Classification of Diseases, 9th revision, code 036 and 10th revision code A39.

†Includes 10 people who died outside hospital or who had no record of hospital admission.

‡P values refer to the change in annual rates 1963-98 from logistic regression modelling. Visual inspection of the annual incidence rates and further modelling show little change in incidence 1963-88 (P=0.54) and a significant increase 1989-98 (P<0.001).