Table 4. Platelet counts in A/JCr mice i.v.-infected with CN and treated with 188Re-18B7 mAb 24-h postinfection

 

Group

Platelet per ml, ´ 108

Day 0

Day 2 posttreatment

Day 6 posttreatment

Day 13

posttreatment

Nontreated infected controls

5.8 (1.6)

2.6 (1.0)

P = 0.003*

1.5 (0.3)

P = 0.0001

1.7 (0.4)

P = 0.0002

100 m Ci of 188Re-18B7

5.7 (1.0)

P = 0.5

3.6 (0.8)

P = 0.045

2.2 (0.4)

P = 0.002

6.5 (1.5)

P = 0.1

200 m Ci of 188Re-18B7

5.7 (1.2)

P = 0.5

4.3 (0.9)

P = 0.05

1.7 (0.4)

P = 0.001

1.2 (0.3)

P = 0.0001

*P values were calculated by the Wilcoxon test, and all of the groups were compared with nontreated controls on the day of treatment. Numbers in parentheses are SD.3