Identification of genomic classifiers that distinguish induction failure in T-lineage acute lymphoblastic leukemia: a report from the Children's Oncology Group -- Winter et al. 110 (5): 1429 Data Supplement -

Supplemental materials for Winter et al, Vol. 110, Issue 5, 1429-1438 -- Blood

Blood, Vol. 110, Issue 5, 1429-1438, September 1, 2007

Identification of genomic classifiers that distinguish induction failure in T-lineage acute lymphoblastic leukemia: a report from the Children's Oncology Group
Blood Winter et al. 110: 1429

Supplemental materials for Winter et al, Vol. 110, Issue 5, 1429-1438

Files in this Data Supplement:

Document 1. Participating institutions in the Children’s Oncology Group studies 8704, 9400, 9404, and 9900 (PDF, 42.2 KB)
Table S1. Genomic classifiers with diverse biological roles (PDF, 83.8 KB)
Figure S1. Intersection union testing of genes downregulated between IF patients and drug-resistant cell lines (JPG, 82 KB) -
Differential expression of 9 genomic classifiers (7 genes) that were down-regulated in intersection union testing between IF patients and drug-resistant cell lines. *Indicates multiple probes identified for the same gene (LAT and ANXA2).
Figure S2. Box-plot distributions for 9 genomic classifiers down-regulated for IF patients and T-ALL cell lines with resistance to DNR or ASP (JPG, 88.9 KB) -
(A) 201590_×_at (EST 3902323), (B) 202954_at (UBE2C), (C) 209881_s_at (LAT), (D) 210427_×_at (ANXA2), (E) 211005_at (LAT), (F) 213060_s_at (CHI3L2), (G) 213503_×_at (3902323), (H) 223307_at (CDCA3) and (I) 230493_at (FLJ20489). These data show differential expression in genes with shared downregulation in the IF cohort, as compared to the RE and CCR subsets.