Rapid generation of a functional NK-cell compartment -- Prlic et al. 110 (6): 2024 Data Supplement -

Supplemental materials for: Prlic et al -- Blood

Blood, Vol. 110, Issue 6, 2024-2026, September 15, 2007

Rapid generation of a functional NK-cell compartment
Blood Prlic et al. 110: 2024

Supplemental materials for: Prlic et al

Files in this Data Supplement:

Figure S1. Rapid restoration of NK cell numbers in the bone marrow following irradiation and marrow grafting by IL-2 complex treatment (PDF, 31.9 KB) -
Irradiated bone marrow recipient mice (BMC mice) and (non-irradiated) B6 control mice were treated with IL-2 complex on day 2 and day 4 post bone marrow transfer. Bone marrow cells were analyzed on day 8 post bone marrow transfer and donor to host ratio of NK cells determined through congenic markers.
Figure S2. IL-2 alone and anti-IL-2 antibody (S4B6) alone do not cause expansion of the donor NK cell pool (PDF, 18 KB) -
Irradiated bone marrow recipients were left untreated, treated with IL-2 alone (1.5 mg), S4B6 alone (50 mg) or IL-2 complex on day 2 and 4 after bone marrow transfer. Neither IL-2 alone nor S4B6 alone increased the percentage of NK1.1+CD3- cells in the spleen (not shown). IL-2 complex treatment caused massive donor derived NK cell expansion, which was not observed in the two control groups.