Epicutaneous antigen exposure induces a Th17 response that drives airway inflammation after inhalation challenge -- He et al. 104 (40): 15817 Data Supplement - HTML Page - index.htslp -- Proceedings of the National Academy of Sciences

He et al. 10.1073/pnas.0706942104.

Supporting Figures

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SI Figure 7
SI Figure 8
SI Figure 9
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Fig. 7. Cytokine production by cells from mediastinal lymph nodes of i.p.-immunized mice.

Fig. 8. Intracellular IL-17A, IFN-g, and IL-4 staining of DO11.1 transgenic CD4⁺ cells stimulated with OVA323-339 peptide in the presence of skin-derived or splenic DCs. Numbers in quadrants indicate the percentages of stained cells. Results are representative of three experiments.

Fig. 9.

Intradermal injection of anti-TGFb inhibits the induction of IL-17 by skin-derived DCs. IL-17A, IL-4 and IFN-g secretion (A) and proliferation (B) by DO11.1 transgenic CD4⁺ cells stimulated with OVA peptide in the presence of DCs derived from skin injected with anti-TGFb or control IgG1 mAb. Columns and error bars in A represent mean ± SEM of three experiments and in B and triplicates of one experiment representative of three. *, P < 0.05.

Fig. 10. IL-17A mRNA expression in EC-sensitized skin of MyD88^-/-mice and WT Balb/C controls.