Table S1. Crystal structures of Arf family GTPases.
Protein | Nucleotide | Complex | NH2 terminus | Interswitch | Organism | Protein DataBank entry |
Arf1 | GDP | - | Capping | Retracted | Hsc | 1HUR/1RRG |
GDP | Sec7 + brefeldin A | Capping | Retracted | Hs | 1R8Q | |
GDP | Sec7 [E/K] mutant | Truncated | Exposed | Hs | 1R8S | |
- | Sec7 | Truncated | Exposed | Hs | NDb | |
GTP | - | Truncated | Exposed | Hs | 1O3Y | |
GTP | GGA1 Gat domain | Truncated | Exposed | Hs | 1J2J | |
Arf4 | GDP | - | Capping | Retracted | Hs | 1Z6Xa |
Arf5 | GDP | - | Partially truncated, capping | Retracted | Hs | 2B6Ha |
Arf2 | GDP-3'P | - | Capping | Retracted | Scd | 1MR3 |
Arf6 | GDP | - | Capping | Retracted | Hs | 1EOS |
GTPγS | - | Displaced | Exposed | Hs | 1HFV | |
GTP | Cholera toxin | Displaced | Exposed | Hs | 2A5F | |
Arl1 | GDP | - | Capping | Truncated | Sc | 1MOZ |
GDP-NH-P | Golgin grip domain | Truncated | Exposed | Rre | 1R4A | |
GTP | Golgin grip domain | Truncated | Exposed | Hs | 1UPT | |
Arl2 | GTP | PDEΔ | Displaced | Exposed | Mmf | 1KSG |
Arl3 | GDP | - | Capping | Retracted | Mm | 1FZQ |
Arl5A | GDP/GDP-3'P | - | Capping | Retracted | Hs | 1Z6Ya/1ZJ6 |
Arl5B | GDP | - | Capping | Retracted | Hs | 1YZGa |
Arl8A | GDP | - | Truncated | Exposed | Hs | 1ZD9a |
Arl8B | GDP | - | Truncated | Exposed | Hs | 2AL7a |
Sar1 | GDP | - | Capping | Retracted | Cgg | 1M2O |
Sar1 | GDP-NH-P | Sec23/Sec24 | Truncated | Exposed | Sc | 1F6B |
Hyphens indicate that the protein structure was solved for the isolated protein and not in complex with any other protein or drug. aThese PDB entries are unpublished structures from the Structural Genomics Consortium. bNot deposited in the Protein DataBank. cHomo sapiens. dSaccharomyces cerevisiae. eRattus rattus. fMus muscularis. gCricetulus griseus. |