Table S1. Crystal structures of Arf family GTPases.

Protein

Nucleotide

Complex

NH2 terminus

Interswitch

Organism

Protein DataBank entry

Arf1

GDP

-

Capping

Retracted

Hsc

1HUR/1RRG

 

GDP

Sec7 + brefeldin A

Capping

Retracted

Hs

1R8Q

 

GDP

Sec7 [E/K] mutant

Truncated

Exposed

Hs

1R8S

 

-

Sec7

Truncated

Exposed

Hs

NDb

 

GTP

-

Truncated

Exposed

Hs

1O3Y

 

GTP

GGA1 Gat domain

Truncated

Exposed

Hs

1J2J

Arf4

GDP

-

Capping

Retracted

Hs

1Z6Xa

Arf5

GDP

-

Partially truncated, capping

Retracted

Hs

2B6Ha

Arf2

GDP-3'P

-

Capping

Retracted

Scd

1MR3

Arf6

GDP

-

Capping

Retracted

Hs

1EOS

 

GTPγS

-

Displaced

Exposed

Hs

1HFV

 

GTP

Cholera toxin

Displaced

Exposed

Hs

2A5F

Arl1

GDP

-

Capping

Truncated

Sc

1MOZ

 

GDP-NH-P

Golgin grip domain

Truncated

Exposed

Rre

1R4A

 

GTP

Golgin grip domain

Truncated

Exposed

Hs

1UPT

Arl2

GTP

PDEΔ

Displaced

Exposed

Mmf

1KSG

Arl3

GDP

-

Capping

Retracted

Mm

1FZQ

Arl5A

GDP/GDP-3'P

-

Capping

Retracted

Hs

1Z6Ya/1ZJ6

Arl5B

GDP

-

Capping

Retracted

Hs

1YZGa

Arl8A

GDP

-

Truncated

Exposed

Hs

1ZD9a

Arl8B

GDP

-

Truncated

Exposed

Hs

2AL7a

Sar1

GDP

-

Capping

Retracted

Cgg

1M2O

Sar1

GDP-NH-P

Sec23/Sec24

Truncated

Exposed

Sc

1F6B

Hyphens indicate that the protein structure was solved for the isolated protein and not in complex with any other protein or drug.

aThese PDB entries are unpublished structures from the Structural Genomics Consortium.

bNot deposited in the Protein DataBank.

cHomo sapiens.

dSaccharomyces cerevisiae.

eRattus rattus.

fMus muscularis.

gCricetulus griseus.